Explanation in biology has long been characterized as being very different from explanation in other scientific disciplines, very much so from explanation in physics. One of the reasons was the existence in biology of explanation types that were unheard of in the physical sciences: teleological explanations (e.g. Hull 1974), evolutionary explanations (e.g. Mayr 1988), or even functional explanations (e.g. Neander 1991). More recently, and owing much to the rise of molecular biology, biological explanations have been depicted as mechanisms (e.g; Machamer, (...) Darden and Craver 2000). The aim of this volume is to shed some new light on the diversity of explanation types in biology. What are the different types of explanation that occur in biology? Are these types of explanation specific to particular sub-disciplines of biology, or to particular types of problems across biology? How do they relate to each another? Do they compete with one another for answering the same questions? Or do they complement each other, providing insights to different questions? What are the reasons for such diversity? Can this diversity be overcome by a broader unifying model of explanation or is it more profound and irreducible? Why? This volume aims at making sense of this diversity of types of explanations that are found in biology, of their relationship with one another. After all, explanation in biology may prove not only different from explanation in the physical sciences, but also much more diverse than originally anticipated. (shrink)

Dans Science, Perception and Reality, Sellars distingue l’image manifeste de l’homme et l’image scientifique de l’homme. La première est obtenue à partir de la façon dont nous prenons conscience de nous-mêmes comme humains dans le monde. La seconde correspond à ce que les différentes sciences nous amènent à postuler sur la manière dont l’homme est constitué. Van Fraassen, lui, étend au monde ces concepts...

In lieu of an abstract, here is a brief excerpt of the content:PostfacePhilippe-Joseph Salazar, Guest Editor"France: Current Writing in Philosophy and Rhetoric" could be a subtitle for this volume. As guest editor I have chosen the genre of the postface rather than that of the preface. I wanted to let writings speak for themselves, unhindered by the added filter of an introduction. Prefaces are either congratulatory or a contribution in disguise—or, worse, a puerile attempt to overshadow the rest. However, (...) by way of a summation, a few, brief remarks are in order.Some thirty years ago it would have been impossible to seek out and secure authors to write on this subject. Since then a sea change has taken place, attracting into the circles of the "rhetorical turn" many a willing partaker. In this new game, two circles gyrate and now and then rotate in unison or collide.One circle, let us call it belletristic, was set in motion by Marc Fumaroli when he released, in 1980, his epoch-making Âge de l'éloquence. It was as if a new chord had been struck, catching most by surprise, heralding the sudden irruption of new thinking about the mainstay of French culture, the "classical age," that is, the seventeenth century, the sacrosanct age of Racine, Descartes, Louis XIV, and Nicolas Poussin. Fumaroli's work in rhetoric, aesthetics, and social commentary went to the heart of French literature and culture: it offered an hermeneutic opportunity to run against the grain of structuralism and Bourdieusian analyses, while it simultaneously brought to [End Page 424] light "rhetorical" layers, both religious and civil, of French culture that militant secularism and social positivism had long cast aside as pernicious or preposterous. It also served as a powerful antidote to "cultural studies." His influence is deep and wide and long lasting. Nancy Struever, who alongside Fumaroli founded the International Society for the History of Rhetoric, draws on her intimate knowledge of the French school to provide here a profound and critical account of his work in which she underscores how Fumaroli transformed, from the standpoint of the history of rhetoric, the study of Western European culture and social life forms—the award of the Balzan Prize to Fumaroli came on the heels of his Histoire de la rhétorique dans l'Europe moderne. He has, for all intents and purposes, created the French school of rhetoric studies, which has nurtured an ever-growing circle of scholars, now in its second generation, with a relief cohort at the ready (Salazar 2007).The other circle took a while longer to gain balance and establish momentum. It concerns itself with the complex relation between philology and philosophy. Indeed, French classical philology had long been resistant to the presence of philosophy and so too philosophy to philology. This uneasy and reciprocal indifference or even distrust can be traced back to the Discourse on Method, in which Descartes invented French philosophical prose, as Pierre Cahné puts it, a situation later aggravated by the spell German metaphysics cast over French philosophy in the nineteenth century. However, it was the enduring presence of Hegel in the 1930s, together with the material and intellectual rescue French philosophers offered Heidegger after 1945, and a sustained interest in Nietzsche and Husserl, that created the conditions for a new dalliance between philology and philosophy. It has been a multifaceted game: some Hellenists, like Nicole Loraux and Marcel Detienne, chose to develop an anthropological meditation on ancient Greece, bringing forth, in the process, rhetorical categories that before them were mere indicators (mètis, epitaphios). On the periphery stood Émile Benveniste with his philological enquiry into Indo European words as mental structures—his Vocabulaire remains a constant source of inspiration. Latinists had a problem of their own: their commonly shared notion that Latin was not a philosophical language, together with their vociferous prejudice against non-Ciceronian Latin, had consigned medieval and Renaissance thinkers and modes of thinking to the bogs of impure language. However, Latin scholars such as Alain Michel sought to unravel the Roman aesthetics inherent in a rhetorical way of life; this school of new Latinists propelled a remarkable revival of Neo-Latinity, which has [End Page 425] had a long-lasting influence on Renaissance studies... (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Le Professeur Pierre Magnard n'a eu de cesse, au cours de son itinéraire intellectuel, où le pédagogue et le chercheur opérèrent toujours en synergie, de révéler, de construire et d'enrichir la tradition philosophique et théologique gréco-latine, notamment à travers l'étude du Néoplatonisme, de travailler à mieux faire connaître les auteurs des quinzième et seizième siècles, comme Nicolas de Cues, Marsile Ficin,Jean Pic de la Mirandole, Michel de Montaigne ou Charles de Bovelles, et d'y entretenir inlassablement la flamme de celui (...) qui demeurera à ses yeux un penseur phare : Blaise Pascal. Constitués en académie platonicienne une pléiade de chercheurs, issus de cet enseignement, a voulu en témoigner par quelques-unes de leurs avancées, manifestant la convergence de leur investigation sans prétendre en couvrir le champ. (shrink)

The year 2010 marks the one-hundredth anniversary of the Recherches de Science Religieuse and provides an opportunity for the journal to explore its past, present, and prospects for the twenty-first century. In order to celebrate the event, this special commemorative issue calls upon authors from many different fields. "Commemoration" involves not only examining the past, however rich it may be, but also taking up the challenge of analyzing the present and reflecting upon the future. In the first section, diverse approaches (...) -- theological, sociological or historical -- are applied to an in-depth diagnosis of the present. The second part is dedicated to memory: the founding years during the modernist crisis and the major stages in the development of the journal under various directors until today, among them, Henri de Lubac and Joseph Moingt. Finally, this special issue is rounded off by a series of broad perspectives tracing out paths for the future of the disciplines at the heart of theology and religious science today, thus remaining faithful to the journal's original mission of "research in movement". (shrink)

Written by a contemporary of Marx and one of the most influential subversive critics of modern European society, this work (1840) has become a classic of political thought through its critique of private property as the essential institution of Western culture as well as the root of its problems.

Developing earlier studies of the system of numbers in Mundurucu, this paper argues that the Mundurucu numeral system is far more complex than usually assumed. The Mundurucu numeral system provides indirect but insightful arguments for a modular approach to numbers and numerals. It is argued that distinct components must be distinguished, such as a system of representation of numbers in the format of internal magnitudes, a system of representation for individuals and sets, and one-to-one correspondences between the numerosity expressed by (...) the number and its metrics. It is shown that while many-number systems involve a compositionality of units, sets and sets composed of units, few-number languages, such as Mundurucu, do not have access to sets composed of units in the usual way. The nonconfigurational character of the Mundurucu language, which is related to a property for which we coin the term 'low compositionality power', accounts for this and explains the curious fact that Mundurucus make use of marked one-to-one correspondence strategies in order to overcome the limitations of the core system at the perceptual/motor interface of the language faculty. We develop an analysis of a particular construction, parallel numbers, which has not been studied before, elucidating the whole system. This analysis, we argue, sheds new light on classical philosophical, psychological and linguistic debates about numbers and numerals and their relation to language, and more particularly, sheds light on few-number languages. (shrink)

t. 1. La liberté des anciens -- t. 2. Naissances de la modernité -- t. 3. Lumières et romantisme -- t. 4. Les critiques de la modernité politique -- t. 5. Les philosophies politiques contemporaines (depuis 1945).

To this day, the study of the substratum of thought and its implied mechanisms is rarely directly addressed. Nowadays, systemic approaches based on introspective methodologies are no longer fashionable and are often overlooked or ignored. Most frequently, reductionist approaches are followed for deciphering the neuronal circuits functionally associated with cognitive processes. However, we argue that systemic studies of individual thought may still contribute to a useful and complementary description of the multimodal nature of perception, because they can take into account (...) individual diversity while still identifying the common features of perceptual processes. We propose to address this question by looking at one possible task for recognition of a “signifying sound”, as an example of conceptual grasping of a perceptual response. By adopting a mixed approach combining qualitative analyses of interviews based on introspection with quantitative statistical analyses carried out on the resulting categorization, this study describes a variety of mental strategies used by musicians to identify notes’ pitch. Sixty-seven musicians (music students and professionals) were interviewed, revealing that musicians utilize intermediate steps during note identification by selecting or activating cognitive bricks that help construct and reach the correct decision. We named these elements “mental anchorpoints”. Although the anchorpoints are not universal, and differ between individuals, they can be grouped into categories related to three main sensory modalities – auditory, visual and kinesthetic. Such categorization enabled us to characterize the mental representations that allow musicians to name notes in relationship to eleven basic typologies of anchorpoints. We propose a conceptual framework which summarizes the process of note identification in five steps, starting from sensory detection and ending with the verbalization of the note pitch, passing through the pivotal role of mental anchorpoints and mental representations. We found that musicians use multiple strategies and select individual combinations of mental anchorpoints belonging to these three different sensory modalities both in isolation and in combination. (shrink)

We investigate a system of two species exploiting a common resource. We consider both abiotic and biotic resources. We are interested in the asymmetric competition where a given consumer is the locally superior resource exploiter and the other is the locally inferior resource exploiter. They also interact directly via interference competition in the sense that LIE individuals can use two opposite strategies to compete with LSE individuals: we assume, in the first case, that LIE uses an avoiding strategy, i.e. LIE (...) individuals go to a non-competition patch to avoids competition with LSE individuals, and in the second one, LIE uses an aggressive strategy, i.e. being very aggressive so that LSE individuals have to go to a non-competition patch. We further assume that there is no resource in the non-competition patch so that individuals have to come back to the competition patch for their maintenance, and the migration process acts on a fast time scale in comparison with demography and competition processes. The models show that being aggressive is efficient for LIE’s survival and even provoke global extinction of the LSE and this result does not depend on the nature of resource. (shrink)

This work presents a mathematical model describing the interactions between the cross-shore structure of small pelagic fish population an their exploitation by coastal and offshore fisheries. The complete model is a system of seven ODE’s governing three stocks of small pelagic fish population moving and growing between three zones. Two types of fishing fleets are inter-acting with the fish population, industrial boats, constrained to offshore area, and artisanal boats, operating from the shore. Two time scales were considered and we use (...) aggregation methods that allow us to reduce the dimension of the model and to obtain an aggregated model, which is a four dimension one. The analysis of the aggregated model is performed. We discuss the possible equilibriums and their meaning in terms of fishery management. An interesting equilibrium state can be obtained for which we can expect coexistence and a stable equilibrium state between fish stocks and fishing efforts. Some identification parameters are also given in the discussion part of the model. (shrink)

Blood coagulation is regulated through a complex network of biochemical reactions of blood factors. The main acting enzyme is thrombin whose propagation in blood plasma leads to fibrin clot formation. Spontaneous clot formation is normally controlled through the action of different plasma inhibitors, in particular, through the thrombin binding by antithrombin. In the current study we develop a mathematical model of clot formation both in quiescent plasma and in blood flow and determine the analytical conditions on the antithrombin concentration corresponding (...) to different regimes of blood coagulation. (shrink)

The French school of theoretical biology has been mainly initiated in Poitiers during the sixties by scientists like J. Besson, G. Bouligand, P. Gavaudan, M. P. Schützenberger and R. Thom, launching many new research domains on the fractal dimension, the combinatorial properties of the genetic code and related amino-acids as well as on the genetic regulation of the biological processes. Presently, the biological science knows that RNA molecules are often involved in the regulation of complex genetic networks as effectors, e.g., (...) activators, inhibitors or hybrids. Examples of such networks will be given showing that there exist RNA “relics” that have played an important role during evolution and have survived in many genomes, whose probability distribution of their sub-sequences is quantified by the Shannon entropy, and the robustness of the dynamics of the networks they regulate can be characterized by the Kolmogorov–Sinaï dynamic entropy and attractor entropy. (shrink)

The present work is aimed at investigating the effects of myocardial infarction and ischemia on induction of ventricular fibrillation. Electrophysiologic effects of global and local ischemia (variation of the dispersion of refractory periods as well as conduction velocity) on initiation of reentry mechanisms was studied by means of computer simulations based on a cellular automata model of propagation of activation wave through a ventricular surface element. A local area of ischemia where effects of the dispersion of refractory periods are investigated (...) is then simulated. This is made using a Gaussian distribution characterized by its mean and standard deviation. These simulations show that ischemia is capable of initiating reentry phenomena which propagate through the whole ventricle; they are responsible for ventricular fibrillation which causes sudden cardiac death, even when ischemia only involves limited parts of the myocardium. Statistical study of the probability of reentries as a function of both of the size of ischemic zones and the rate of dispersion of refractory periods shows that the latter parameter is of primary importance in triggering cardiac reentries. (shrink)

The aim of this work was to compare experimental investigations on effects of lidocaine, calcium and, BRL 34915 on reentries to simulated data obtained by use of a model of propagation based on the Huygens' constriction method already described in previous works. Calcium and lidocaine effects are investigated on anisotropic conduction conditions. In both cases, reduction in conduction velocities are observed. In lidocaine case, a refractory area is located along the longitudinal axis. In agreement with experimental electrical mapping, the simulations (...) show that the stabilization of reentrant excitation is mainly due to the existence of this refractory area around which the reentrant circuit can develop. The experimental study shows that BRL 34915 has both arrhythmogenic and antiarrhythmic effects. A detailed electrophysiological analysis has shown that drug infusion act on normal cardiac cells by decreasing the relative and absolute refractory period. BRL 34915 action is simulated by a decrease in the refractory period showing that the time frequency of the reentrant activity is increased and that the spatial size where the reentry is developing is becoming smaller. These two effects are arrhythmogenic, the simulated data being so in good agreement with the experimental ones. (shrink)

Limitations of antiarrhythmic drugs on cardiac sudden death prevention appeared since the early 80's. The "Cardiac Arrhythmia Suppression Trial"(CAST) showed more recently that mortality was significantly higher inpatients treated with some particular antiarrhythmic drugs than in non-treated patients. In this field, our group recently demonstrated that a bolus of a Class 1B antiarrhythmic drug was able to trigger a ventricular fibrillation due to transient blocks induction. The aim of the present work was to systematically study, by use of the van (...) Capelle and Durrer (VCD) model which allows to simulate ventricular activation wave propagation, the link between arrhythmogenic effects and the ability of transient blocks to possibly degenerate in severe arrhythmias. A fragment of the ventricular wall is represented by an array of 16384elements electrically coupled. Effects of induction of one or several transient blocks, as the effects of their size and duration on possible induction of reentries have been studied. Results obtained show that various combinations between these different parameters may trigger reentries, ventricular tachycardia and/or more complex patterns assimilable to ventricular fibrillation. These results clearly evidence the fact that possible induction of transient blocks may directly be related to risk factor associated to arrhythmogenic effects of antiarrhythmic drugs. (shrink)

The involvement of developing countries in international clinical trials is necessary for the development of appropriate medicines for local populations. However, the absence of appropriate structures for ethical review represents a barrier for certain countries. Currently there is very little information available on existing structures dedicated to ethics in western and central Africa. This article briefly describes historical milestones in the development of networks dedicated to capacity building in ethical review in these regions and outlines the major conclusions of two (...) workshops on this issue, which were held in September and October 2002 in Libreville, Gabon, and Paris, France. The workshops were the culmination of collaboration between the African Malaria Network Trust (AMANET) and the Pan African Bioethics Initiative (PABIN). They produced an update on ethics organizations with regard to mission, function, activities, members, and contact people, in eight countries within the regions discussed. As a result of the commitment of mandated delegates, a further prominent outcome followed these workshops: the creation of national structures, where none existed before, dedicated to the ethical review of clinical trials. (shrink)

t. 1. Economie politique et philosophie sociale -- t. 2. Economie normative et philosophie morale -- t. 3. Science économique et philosophie des sciences -- t. 4. Leçons de philosophie économique.

Are conspiracy theory beliefs pathological? That depends on what is meant by "pathological." This paper begins by unpacking that ill-defined and value-laden term before making the case that widespread conspiracy theory belief should not be conceptualized through the “othering’ perspective of individual psychopathology. In doing so, it adopts a phenomenological perspective to argue that conspiracy theory beliefs can be reliably distinguished from paranoid delusions based on falsity, belief conviction, idiosyncrasy, and self-referentiality. A socio-epistemic model is then presented that characterizes the (...) broader phenomenon of conspiracy theory belief as a product of a sick society plagued by epistemic mistrust and vulnerability to misinformation that is ubiquitous in today’s post-truth world. Finally, it is proposed that for individuals, the harmfulness of conspiracy theory belief is less related to belief content as it is to belief conviction and degree of self-relevant consequentiality. Staging conspiracy theory belief in terms of ideological commitment offers a conceptual framework to estimate behavioral risks and test hypotheses about the effectiveness of interventions along a continuum of belief conviction and associated socio-epistemic dynamics. Interventions should target not only individuals, but the dysfunctional social conditions that give rise to the pervasive and enduring phenomenon of conspiracy theory belief. (shrink)

The involvement of developing countries in international clinical trials is necessary for the development of appropriate medicines fo.

Heart rate variability (HRV) is an indicator of the regulation of the heart, see Task Force (Circulation 93(5):1043–1065, 1996). This study compares the regulation of the heart in two cases of healthy subjects within real life situations: Marathon runners and shift workers. After an update on the state of the art on HRV processing, we specify our probabilistic model: We choose modeling heartbeat series by locally stationary Gaussian process (Dahlhaus in Ann Stat 25, 1997). HRV is then processed by the (...) combination of two statistical methods: (1) Continuous wavelet transform for calculating the spectral density energy in the high frequency (HF) and low frequency (LF) bands and (2) Change point analysis to detect changes of heart regulation. Next, we plot the variations of the HF and LF energy in extreme conditions for both populations. This puts in light, that physical activities (rest, moderate sport, marathon race) can be ordered in a logical continuum. This allows to define a new index based on HF and LF energy that is log HF + log LF which appears relevant to measure HR regulation. The results obtained are pertinent but have to be completed by further studies. (shrink)

Contient un panorama de tout ce qui a pu être dit ou pensé en Occident sur Dieu, le monde et l'homme. Expose la thèse selon laquelle l'histoire de la philosophie fut marquée par une métaphysique non aristotélicienne à travers certains Pères de l'Eglise et par le biais du courant mystique rhénan (Maître Eckart, Suso, Tauler et Nicolas de Cuse).

En cent ans, le mouvement évangélique a rallié à sa cause plus d’un quart des chrétiens dans le monde entier. Pour comprendre les mécanismes d’une trans-nationalisation religieuse de telle envergure, l’article suit la trame du pentecôtisme à travers quelques moments et lieux considérés comme des tournants décisifs dans son évolution. L’objectif est d’éclairer l’émergence de son esprit de réveil et, en parallèle, de cette fameuse «compétence caméléon» qui conduit le mouvement évangélique, dans ses variantes les plus récentes, à une conception (...) plus utilitariste de la foi. (shrink)

"This wonderfully eloquent and playful colloquy of two brilliant minds gives new life to the old notion of Dialogue, a sadly forgotten form now.... I "love" this book!