21 found
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  1.  32
    Solidarity and Community Engagement in Global Health Research.Bridget Pratt, Phaik Yeong Cheah & Vicki Marsh - 2020 - American Journal of Bioethics 20 (5):43-56.
    Community engagement (CE) is gaining prominence in global health research. A number of ethical goals–spanning the instrumental, intrinsic, and transformative–have been ascribed to CE in global health research. This paper draws attention to an additional transformative value that CE is not typically linked to but that seems very relevant: solidarity. Both are concerned with building relationships and connecting parties that are distant from one another. This paper first argues that furthering solidarity should be recognized as another ethical goal for CE (...)
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  2.  19
    Data Access Committees.Jan Piasecki & Phaik Yeong Cheah - 2020 - BMC Medical Ethics 21 (1):1-8.
    BackgroundSharing de-identified individual-level health research data is widely promoted and has many potential benefits. However there are also some potential harms, such as misuse of data and breach of participant confidentiality. One way to promote the benefits of sharing while ameliorating its potential harms is through the adoption of a managed access approach where data requests are channeled through a Data Access Committee (DAC), rather than making data openly available without restrictions. A DAC, whether a formal or informal group of (...)
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  3.  53
    Motivations and perceptions of community advisory boards in the ethics of medical research: the case of the Thai-Myanmar border.Michael Parker, Francois Nosten, Nicholas P. J. Day, Nicholas J. White, Phaik Kin Cheah, Phaik Yeong Cheah & Khin Maung Lwin - 2014 - BMC Medical Ethics 15 (1).
    BackgroundCommunity engagement is increasingly promoted as a marker of good, ethical practice in the context of international collaborative research in low-income countries. There is, however, no widely agreed definition of community engagement or of approaches adopted. Justifications given for its use also vary. Community engagement is, for example, variously seen to be of value in: the development of more effective and appropriate consent processes; improved understanding of the aims and forms of research; higher recruitment rates; the identification of important ethical (...)
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  4.  16
    Exploitation and community engagement: Can Community Advisory Boards successfully assume a role minimising exploitation in international research?Bridget Pratt, Khin Maung Lwin, Deborah Zion, Francois Nosten, Bebe Loff & Phaik Yeong Cheah - 2013 - Developing World Bioethics 15 (1):18-26.
    It has been suggested that community advisory boards can play a role in minimising exploitation in international research. To get a better idea of what this requires and whether it might be achievable, the paper first describes core elements that we suggest must be in place for a CAB to reduce the potential for exploitation. The paper then examines a CAB established by the Shoklo Malaria Research Unit under conditions common in resource-poor settings – namely, where individuals join with a (...)
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  5.  18
    Ownership of individual-level health data, data sharing, and data governance.Jan Piasecki & Phaik Yeong Cheah - 2022 - BMC Medical Ethics 23 (1):1-9.
    Background The ownership status of individual-level health data affects the manner in which it is used. In this paper we analyze two competing models of the ownership status of the data discussed in the literature recently: private ownership and public ownership. Main body In this paper we describe the limitations of these two models of data ownership with respect to individual-level health data, in particular in terms of ethical principles of justice and autonomy, risk mitigation, as well as technological, economic, (...)
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  6. Exploitation and community engagement: Can Community Advisory Boards successfully assume a role minimising exploitation in international research?Bridget Pratt, Khin Maung Lwin, Deborah Zion, Francois Nosten, Beatrice Loff & Phaik Yeong Cheah - unknown
     
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  7.  27
    Community engagement and ethical global health research.Bipin Adhikari, Christopher Pell & Phaik Yeong Cheah - 2020 - Global Bioethics 31 (1):1-12.
    Community engagement is increasingly recognized as a critical element of medical research, recommended by ethicists, required by research funders and advocated in ethics guidelines. The benefits of community engagement are often stressed in instrumental terms, particularly with regard to promoting recruitment and retention in studies. Less emphasis has been placed on the value of community engagement with regard to ethical good practice, with goals often implied rather than clearly articulated. This article outlines explicitly how community engagement can contribute to ethical (...)
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  8.  17
    Closing the translation gap for justice requirements in international research.Bridget Pratt, Deborah Zion, Khin Maung Lwin, Phaik Yeong Cheah, Francois Nosten & Bebe Loff - 2012 - Journal of Medical Ethics 38 (9):552-558.
    Bioethicists have long debated the content of sponsors and researchers' obligations of justice in international clinical research. However, there has been little empirical investigation as to whether and how obligations of responsiveness, ancillary care, post-trial benefits and research capacity strengthening are upheld in low- and middle-income country settings. In this paper, the authors argue that research ethics guidelines need to be more informed by international research practice. Practical guidance on how to fulfil these obligations is needed if research groups and (...)
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  9.  32
    Research ethics and artificial intelligence for global health: perspectives from the global forum on bioethics in research.James Shaw, Joseph Ali, Caesar A. Atuire, Phaik Yeong Cheah, Armando Guio Español, Judy Wawira Gichoya, Adrienne Hunt, Daudi Jjingo, Katherine Littler, Daniela Paolotti & Effy Vayena - 2024 - BMC Medical Ethics 25 (1):1-9.
    Background The ethical governance of Artificial Intelligence (AI) in health care and public health continues to be an urgent issue for attention in policy, research, and practice. In this paper we report on central themes related to challenges and strategies for promoting ethics in research involving AI in global health, arising from the Global Forum on Bioethics in Research (GFBR), held in Cape Town, South Africa in November 2022. Methods The GFBR is an annual meeting organized by the World Health (...)
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  10.  23
    Linking international clinical research with stateless populations to justice in global health.Bridget Pratt, Deborah Zion, Khin Maung Lwin, Phaik Yeong Cheah, Francois Nosten & Bebe Loff - 2014 - BMC Medical Ethics 15 (1):49.
    In response to calls to expand the scope of research ethics to address justice in global health, recent scholarship has sought to clarify how external research actors from high-income countries might discharge their obligation to reduce health disparities between and within countries. An ethical framework—‘research for health justice’—was derived from a theory of justice (the health capability paradigm) and specifies how international clinical research might contribute to improved health and research capacity in host communities. This paper examines whether and how (...)
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  11.  35
    Challenges arising when seeking broad consent for health research data sharing: a qualitative study of perspectives in Thailand.Phaik Yeong Cheah, Nattapat Jatupornpimol, Borimas Hanboonkunupakarn, Napat Khirikoekkong, Podjanee Jittamala, Sasithon Pukrittayakamee, Nicholas P. J. Day, Michael Parker & Susan Bull - 2018 - BMC Medical Ethics 19 (1):86.
    Research funders, regulatory agencies, and journals are increasingly expecting that individual-level data from health research will be shared. Broad consent to such sharing is considered appropriate, feasible and acceptable in low- and middle-income settings, but to date limited empirical research has been conducted to inform the design of such processes. We examined stakeholder perspectives about how best to seek broad consent to sharing data from the Mahidol Oxford Tropical Medicine Research Unit, which implemented a data sharing policy and broad consent (...)
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  12.  29
    Art and theatre for health in rural Cambodia.Chea Nguon, Lek Dysoley, Chan Davoeung, Yok Sovann, Nou Sanann, Ma Sareth, Pich Kunthea, San Vuth, Kem Sovann, Kayna Kol, Chhouen Heng, Rouen Sary, Thomas J. Peto, Rupam Tripura, Renly Lim & Phaik Yeong Cheah - 2018 - Global Bioethics 29 (1):16-21.
    ABSTRACTThis article describes our experience using art and theatre to engage rural communities in western Cambodia to understand malaria and support malaria control and elimination. The project was a pilot science–arts initiative to supplement existing engagement activities conducted by local authorities. In 2016, the project was conducted in 20 villages, involved 300 community members and was attended by more than 8000 people. Key health messages were to use insecticide-treated bed-nets and repellents, febrile people should attend village malaria workers, and to (...)
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  13.  31
    Sharing Individual-Level Health Research Data: Experiences, Challenges and a Research Agenda.Phaik Yeong Cheah, Nicholas P. J. Day, Michael Parker & Susan Bull - 2017 - Asian Bioethics Review 9 (4):393-400.
    Since January 2016, the Mahidol Oxford Tropical Medicine Research Unit has trialled a data-sharing policy where requests to access research datasets are processed through a Data Access Committee. In this paper, we share our experiences establishing data management systems and data-sharing infrastructure including a data-sharing policy, data access committee and related procedures. We identified a number of practical and ethical challenges including requests for datasets collected without specific or broad consent to data sharing and requests from pharmaceutical companies for data (...)
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  14.  36
    The ethics of using placebo in randomised controlled trials: a case study of a Plasmodium vivax antirelapse trial.Phaik Yeong Cheah, Norbert Steinkamp, Lorenz von Seidlein & Ric N. Price - 2018 - BMC Medical Ethics 19 (1):19.
    The use of placebos in randomised controlled trials is a subject of considerable ethical debate. In this paper we present a set of considerations to evaluate the ethics of placebo controlled trials that includes: social value of the study; need for a randomised controlled trial and placebo; standards of care; risks of harm due to administration of placebo and the harm benefit balance; clinical equipoise; and double standards. We illustrate the application of these considerations using a case study of a (...)
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  15.  13
    Ethical issues in Nipah virus control and research: addressing a neglected disease.Tess Johnson, Euzebiusz Jamrozik, Tara Hurst, Phaik Yeong Cheah & Michael J. Parker - forthcoming - Journal of Medical Ethics.
    Nipah virus is a priority pathogen that is receiving increasing attention among scientists and in work on epidemic preparedness. Despite this trend, there has been almost no bioethical work examining ethical considerations surrounding the epidemiology, prevention, and treatment of Nipah virus or research that has already begun into animal and human vaccines. In this paper, we advance the case for further work on Nipah virus disease in public health ethics due to the distinct issues it raises concerning communication about the (...)
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  16.  10
    The challenges and potential solutions of achieving meaningful consent amongst research participants in northern Thailand: a qualitative study.Rachel C. Greer, Nipaphan Kanthawang, Jennifer Roest, Carlo Perrone, Tri Wangrangsimakul, Michael Parker, Maureen Kelley & Phaik Yeong Cheah - 2023 - BMC Medical Ethics 24 (1):1-12.
    Background Achieving meaningful consent can be challenging, particularly in contexts of diminished literacy, yet is a vital part of participant protection in global health research. Method We explored the challenges and potential solutions of achieving meaningful consent through a qualitative study in a predominantly hill tribe ethnic minority population in northern Thailand, a culturally distinctive population with low literacy. Semi-structured interviews were conducted with 37 respondents who had participated in scrub typhus clinical research, their family members, researchers and other key (...)
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  17.  28
    Are Children Always Vulnerable Research Participants?Phaik Yeong Cheah & Michael Parker - 2015 - Asian Bioethics Review 7 (2):151-163.
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  18.  21
    The proxy dilemma: Informed consent in paediatric clinical research ‐ a case study of Thailand.Sheila Varadan, Salin Sirinam, Kriengsak Limkittikul & Phaik Yeong Cheah - 2022 - Developing World Bioethics 22 (4):288-297.
    Informed consent is an essential requirement for the ethical conduct of research. It is also a necessary requirement for the lawful conduct of research. Informed consent provides a legal basis to enrol human subjects in clinical research. In paediatric research, where children do not generally enjoy a presumption of competence, a legal representative must authorise a child's enrolment. Determining who should act on behalf of the child is a matter of law, rather than ethical principle. But, if national laws are (...)
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  19.  19
    Response to Open Peer Commentaries on “Solidarity and Community Engagement in Global Health Research”.Bridget Pratt, Phaik Yeong Cheah & Vicki Marsh - 2020 - American Journal of Bioethics 20 (8):W14-W16.
    Volume 20, Issue 8, August 2020, Page W14-W16.
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  20.  10
    The proxy dilemma: Informed consent in paediatric clinical research ‐ a case study of Thailand.Sheila Varadan, Salin Sirinam, Kriengsak Limkittikul & Phaik Yeong Cheah - 2022 - Developing World Bioethics 22 (4):288-297.
    Informed consent is an essential requirement for the ethical conduct of research. It is also a necessary requirement for the lawful conduct of research. Informed consent provides a legal basis to enrol human subjects in clinical research. In paediatric research, where children do not generally enjoy a presumption of competence, a legal representative must authorise a child's enrolment. Determining who should act on behalf of the child is a matter of law, rather than ethical principle. But, if national laws are (...)
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  21.  11
    The proxy dilemma: Informed consent in paediatric clinical research ‐ a case study of Thailand.Sheila Varadan, Salin Sirinam, Kriengsak Limkittikul & Phaik Yeong Cheah - 2022 - Developing World Bioethics 22 (4):288-297.
    Informed consent is an essential requirement for the ethical conduct of research. It is also a necessary requirement for the lawful conduct of research. Informed consent provides a legal basis to enrol human subjects in clinical research. In paediatric research, where children do not generally enjoy a presumption of competence, a legal representative must authorise a child's enrolment. Determining who should act on behalf of the child is a matter of law, rather than ethical principle. But, if national laws are (...)
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