The ethical issues in conducting research on preventing HIV infection are among the most complex of any area of human subjects research. This article is an update of a 1987 article that addressed potential conflicts between research design and ethics with respect to AIDS prevention among injecting drug users. The present article reviews current ethical issues that arise in the design and conduct of HIV/AIDS prevention research focused on injecting drug users.

Philosophers and ethicists debate this controversial moral principle illustrating its application to current moral dilemmas such as war, suicide, nuclear power, affirmative action, and morphine use for terminal cancer patients.

It is very common these days to come across the claim that the notions of mental content and linguistic meaning are normative notions. In the work of many philosophers, it plays a pivotal role. Saul Kripke made it the centerpiece of his influential discussion of Wittgenstein’s treatment of rulefollowing and private language; he used it to argue that the notions of meaning and content cannot be understood in naturalistic terms. Kripke’s formulations tend to be in terms of the notion of (...) linguistic meaning, but his argumentative strategy makes it clear that he holds both versions of the claim.... (shrink)

The Universe is One places the ancient synthesis of Stoicism, Platonism, Judaism, and Christianity in active dialogue with modern process science in order to conjoin science, philosophy, and theology into the human quest for meaning. Paul A. Olivier proposes a comprehensive theory of knowledge, which he expands into a theory of life, correlating modern process science and the western-Judeo-Christian heritage into a grand theory of the Universe. He brings together the ideas of influential thinkers from the world of science (...) with those from the world of New Testament studies. Olivier clearly explains concepts from diverse fields to construct a satisfying theory of knowledge and life. He accomplishes this through an examination of the dominance of polarity in all aspects of the universe, such as chaos and order, predictability and unpredictability. Through this complex blend of opposites Olivier develops his theory as an interaction of Word and Spirit that provides the Universe with everything necessary to account for its creation and ongoing evolution. The Universe continually creates and sustains itself out of its own internal necessity coupled paradoxically with the fluidity of its own inherent unpredictability. (shrink)

Should a principle of charity be applied to the interpretation of the colour concepts exercised in visual experience? We think not. We shall argue, for one thing, that the grounds for applying a principle of charity are lacking in the case of colour concepts. More importantly, we shall argue that attempts at giving the experience of colour a charitable interpretation either fail to respect obvious features of that experience or fail to interpret it charitably, after all. Charity to visual experience (...) is therefore no motive for resisting the natural, Galilean response to a scientific understanding of light and vision. The best interpretation of colour experience ends up convicting it of widespread and systematic error. (shrink)

An irrealist conception of a given region of discourse is the view that no real properties answer to the central predicates of the region in question. Any such conception emerges, invariably, as the result of the interaction of two forces. An account of the meaning of the central predicates, along with a conception of the sorts of property the world may contain, conspire to show that, if the predicates of the region are taken to express properties, their extensions would have (...) to be deemed uniformly empty. The question then becomes whether the predicates are best understood as expressing properties, and hence as founded on error, or whether they ought to be understood along non-factualist lines.z Historically, irrealist models were developed primarily in connection with evaluative discourse, although as physicalism has flourished and as reductionist programs have failed, their application has been extended to many other domains. Indeed, it is one of the more influential suggestions in contemporary philosophy of mind that they apply even to ordinary belief/desire psychology. A correct understanding of the semantics and metaphysics of content-based psychology leaves us, so the proponents of the in-. (shrink)

L'étude de la communication peut offrir une perspective sur le contexte de la théologie, un examen de sa structure, et une reflexion sur son contenu. La communication est primordiale pour la société contemporaine, affectant la façon dont les gens utilisent leur temps, façonnant les informations qu'ils reçoivent, influençant la manière dont ils pensent , et les rendant plus soupçonneux vis à vis de l'autorité. L'histoire de la théologie montre les effets des formes de communication, reflétant la narration, la rhétorique, et (...) les structures polémiques des cultures orales, aussi bien que les instruments analytiques de l'écriture et l'imprimerie. Finalement, l'étude de la communication suggère une façon différente de considérer des sujets théologiques traditionnels. Le salut divin, par exemple, peut se concentrer sur la communication en interprètant l'histoire du salut comme une histoire de l'auto-communication de Dieu et la restauration de la communication humaine. (shrink)

John Calvin drew from patristic authors in a selective manner. His preference for the theological perspectives of Augustine is readily evident. Nevertheless, while he resonated with the doctrine of Augustine, he touted the interpretive and homiletic labors of John Chrysostom. Even though Calvin’s Institutes of the Christian Religion critiqued Chrysostom’s understanding of grace and free will, the Antiochene bishop is the most frequently referenced patristic author within Calvin’s commentaries. Calvin composed a preface to a projected edition of Chrysostom’s homilies (Praefatio (...) in Chrysostomi Homilias). This preface argued for the necessity of reaching the general public with secondary aids along with the scriptures, explained Calvin’s esteem for Chrysostom’s homilies above other patristic texts, and acknowledged the theological dissimilarities that separated his views from Chrysostom’s. The Praefatio’s assessments reveal Calvin’s own hermeneutical, pastoral, and theological priorities. Calvin’s evaluations of Chrysostom and the other fathers are a window into his own interpretive concerns, homiletical aims, and dogmatic emphases. (shrink)

In the fourth Immanuel Kant Lecture, Quine summons the specter of Kant’s Ding an sich, the thing in itself. Clearly antithetical to his naturalism, Quine quickly dismisses it as having feet of clay. Despite this short shrift, it is worth examining what he did say about the Ding an sich—in the Kant Lectures, in “Things and Their Place in Theories”, and in “Structure and Nature”. I offer a critical reading of these passages in the context of Quine’s proxy functions, ontological (...) relativity, and structure. I argue that Quine uses the Ding an sich as a foil for his anti-metaphysical, deflationary structuralism—a view that grounds objectivity in true statements, without any transcendental notion of objects, without the Ding an sich. (shrink)

These essays examine the ways in which the consideration of ethical questions is shaped by the structures of knowledge and communication at work in clinical ...

In this article I offer an extended, critical review of the analytic theology project. In the first part of the article, I investigate the origins and rise of analytic theology. I also offer some initial insights into the nature of analytic theology, based on some of what its chief proponents understand analytic theology to be. In the second part of the article, I summarize and evaluate some of the major contributions that already have been made within analytic theology. In the (...) third and final section of the article, I evaluate the analytic theology project as a whole, testing its compatibility with certain methods and movements within the Christian theological tradition. Based on this discussion, I then begin to narrate the advantages of construing analytic theology more narrowly, as a dogmatic project committed to articulating and defending Christian doctrine in rational pursuit of genuine theological knowledge and truth. My final claim is that analytic theologians should continue to engage in bold, speculative inquiry into the nature of the divine as well as related divine matters, and thus remain committed to developing and defending theology as a dogmatic and speculative enterprise. By doing so, analytic theologians will help fortify and elevate the contemporary theological enterprise as a whole. (shrink)

In the decade that followed 1972, the journal _boundary 2_ consistently published many of the most distinguished and most influential statements of an emerging literary postmodernism. Recognizing postmodernism as a dominant force in culture, particularly in the literary and narrative imagination, the journal appeared when literary critical study in the United States was in a period of theory-induced ferment. The fundamental relations between postmodernism and poststructuralism were being initially examined and the effort to formulate a critical sense of the postmodern (...) was underway. In this volume, Paul A. Bové, the current editor of _boundary 2_, has gathered many of those foundational essays and, as such, has assembled a basic text in the history of postmodernism. Essays by noted cultural and literary theorists join with Bové’s contemporary preface to represent the important and unique moment in recent intellectual history when postmodernism was no longer seen primarily as an architectural term, had not yet come to describe the wide range of culture it does now, but was finding power and place in the literary realm. These essays show that the history of postmodernism and its attendant critical theories are both more complex and more deeply bound with literary criticism than often is acknowledged today. _Early Postmodernism_ demonstrates not only the significance of these literary studies, but also the role played by literary critical postmodernism in making possible newer forms of critical and cultural studies. _Contributors_. Barry Alpert, Charles Altieri, David Antin, Harold Bloom, Paul A. Bové, Hélène Cixous, Gerald Gillespie, Ihab Hassan, Joseph N. Riddel, William, V. Spanos, Catharine R. Stimpson, Cornel West. (shrink)

Rhodopsin, upon activation by light, transduces the photon signal by activation of the G‐protein, transducin. The well‐studied rhodopsin/transducin system serves as a model for the understanding of signal transduction by the large class of G‐protein‐coupled receptors. The interactive form of rhodopsin, R*, is conformationally similar or identical to rhodopsin's photolysis intermediate Metarhodopsin II (MII). Formation of MII requires deprotonation of rhodopsin's protonated Schiff base which appears to facilitate some opening of the rhodopsin structure. This allows a change in conformation at (...) rhodopsin's cytoplasmic surface that provides binding sites for transducin. Rhodopsin's 2nd, 3rd and putative 4th cytoplasmic loops bind transducin at sites including transducin's 5 kDa carboxyl‐terminal region. Site‐specific mutagenesis of rhodopsin is being used to distinguish sites on rhodopsin's surface that are important in binding transducin from those that function in activating transducin. These observations are consistent with and extend studies on the action of other G‐protein‐coupled receptors and their interactions with their respective G proteins. (shrink)

Reply to Schiffer's comment on Externalism and Inference.

Following Oliver Ramsbotham’s observation that conflict resolution and analysis have not taken radical disagreement seriously enough, and in light of his lament that he has not yet found an adequate philosophy of radical disagreement, this article claims that the philosophy of Alasdair MacIntyre provides some coreelements of any adequate philosophy of radical disagreement. MacIntyre’s theory suggests that the problem of radical disagreement is in fact more radical thanRamsbotham affirms. Ramsbotham’s account of the strategic engagement of discourses (SED) approach is critiqued (...) in light of MacIntyre’s diagnosis of radical disagreement, which calls into question its theoretical and philosophical basis. The main problem is held to be that of internal radical disagreement, which SED appears to skirt over. This is elucidated through a brief exploration of two philosophical approaches to moral-political disagreement in relation to Israeli peace activism and the Colombian conflict. (shrink)

Südarabien im Altertum: Kommentierte Bibliographie der Jahre 1997 bis 2011. By Walter W. Müller. Epigraphische Forschungen auf der Arabischen Halbinsel, vol. 6. Tübingen: Wasmuth, 2014. Pp. vii + 187. €19.80.

Compatibilism combines an externalist view of mental content with a doctrine of privileged self‐knowledge. The essay presents a reductio of compatibilism by arguing that if compatibilism were true, we would be in a position to know certain facts about the world a priori, facts that no one can reasonably believe are knowable a priori. Whether this should be taken to cast doubt on externalism or privileged self‐knowledge is not discussed. Consideration is given to the ’empty case’—the case in which a (...) thinker expresses what he takes to be a genuine thought concerning a natural kind but where there is in fact no relevant natural kind, so that the putative natural kind term fails to refer. It is argued that, in such a case, on an externalist conception of natural kind terms, the thinker is deluded in taking himself to be expressing a complete thought, and that such delusions are not compatible with privileged self‐knowledge. (shrink)

Kalle Pihlainen’s book reworks seven essays published over the last dozen years. Pihlainen’s Preface and Hayden White’s Foreword articulate a cri de cœur. Both fear that something important has been missed. White’s Foreword somewhat cryptically characterizes Pihlainen’s book as “metacritical,” and locates Pihlainen in the role of being a “serious reader” for the community of theorists of history. What does it mean to be a “serious” reader? White never says. But following White’s hint, Pihlainen can be read as updating Marx’s (...) conception of the task of unmasking sources of alienation by focusing on the reasons for the estrangement of histories from a wider audience. For him, “the core case is that the ‘historical’ nature of history itself needs to be acknowledged”. It remains unacknowledged so long as the source of meaning in history continues to be displaced. For even those who emphasize narrative form tend to talk as if meanings were imposed by some factor other than human intervention, as if form magically imbues content with significance. But this is one more symptom, if such is needed, of collective bad faith, a denial that only people make meaning. By taking disembodied literary forms as repositories of significance, responsibility for meaning is once again deflected or deferred. In this key regard, Pihlainen’s claim to place “decided emphasis on its [historical theory’s] ethical-political momentum” signals that the issues he intends to foreground are not epistemological or discursive. Pihlainen rightly suspects that all the talk of “narrativism” and “discourse” serves only to evade confronting the truly difficult moral and political challenges that writing represents. His various chapters identify these evasions and the challenges that remain. (shrink)

Preface: The dog's bollocks-- at the media dinner party -- Introduction: "The Marx brothers", "The Elvis of cultural theory", and other media clichés -- The mediated imp of the perverse -- Žižek's tickling shtick -- Big (Br)other : psychoanalysing the media -- Understanding the media : the sublime objectification of ideology -- The media's violence -- The joker's little shop of ideological horrors -- Conclusion: Don't just do it : negative dialectics in the age of Nike.

_Gendered Agents_, edited by Silvestra Mariniello andPaul A. Bové, presents essays by influential feminist theorists who challenge traditional Western epistemology and suggest new directions for feminism. By examining both literary and historical discourses, such critics as Gayatri Spivak, Hortense Spillers, and Lauren Berlant assess questions of sexuality, ethics, race, psychoanalysis, subjectivity, and identity. Gathered from various issues of the journal _boundary 2_, the essays in _Gendered Agents_ seek to transform the model of Western academic knowledge by restructuring its priorities and (...) values. In the introduction, Mariniello urges feminists to begin anew but take as their starting place the achievements of feminism and feminist theory: an understanding of language that considers the implications of silence, the motivation to decompartmentalize experience, and the acknowledgement that everything is political._ _Challenging both a canonical organization of knowledge and the persistently self-referential "ghettoization" of feminism, contributors subsequently tackle subjects as diverse as pre-Marxist France, the American fetus, black intellectuals, queer nationality, and the art of literary interpretation. _Contributors_. Lauren Berlant, Karen Brennan, Margaret Cohen, Nancy Fraser, Elizabeth Freeman, Carol Jacobs, Silvestra Mariniello, Larysa Mykyta, Laura Rice, Ivy Schweitzer, Doris Sommer, Hortense J. Spillers, Gayatri Chakravorty Spivak, Judith Wilt. (shrink)

When Benjamin Franklin suggested that man is by nature a tool-making animal, he summed up what was for his fellow Americans the common sense of the matter. It is not, then, surprising that, when Britain's colonists in North America broke with the mother country over the issue of an unrepresentative parliament's right to tax and govern the colonies, they defended their right to the property they owned on the ground that it was in a most thorough-going sense an extension of (...) themselves: the fruits of their own labor. This understanding they learned from John Locke, who based the argument of his Two Treatises of Government on the unorthodox account of providence and of man's place within the natural world that Sir Francis Bacon had been the first to articulate. All of this helps explain why the framers of the American constitution included within it a clause giving sanction to property in ideas of practical use. (shrink)

The 'Phillips curve' represents the inverse relationship between inflation & unemployment, & is a central concept in macroeconomic analysis. This volume offers an assessment of how more sophisticated analysis of prices & wage setting & inflation expectations have changed the nature of the curve.