Results for 'Parkinson's disease'

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  1. Parkinson’s Disease Prediction Using Artificial Neural Network.Ramzi M. Sadek, Salah A. Mohammed, Abdul Rahman K. Abunbehan, Abdul Karim H. Abdul Ghattas, Majed R. Badawi, Mohamed N. Mortaja, Bassem S. Abu-Nasser & Samy S. Abu-Naser - 2019 - International Journal of Academic Health and Medical Research (IJAHMR) 3 (1):1-8.
    Parkinson's Disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking. Doctors do not know what causes it and finds difficulty in early diagnosing the presence of Parkinson’s disease. An artificial neural network system with back propagation algorithm is presented in this paper for (...)
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  2.  10
    Dopamine, Parkinson's disease, and volition.Jon C. Horvitz - 2002 - Behavioral and Brain Sciences 25 (5):586-586.
    Disruptions in dopamine transmission within the basal ganglia (BG) produce deficits in voluntary actions, that is, in the interface between cortically-generated goal representation and BG-mediated response selection. Under conditions of dopamine loss in humans and other animals, responses are impaired when they require internal generation, but are relatively intact when elicited by external stimuli.
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  3.  5
    Trading Vulnerabilities: Living with Parkinson’s Disease before and after Deep Brain Stimulation.Sara Goering, Anna Wexler & Eran Klein - 2021 - Cambridge Quarterly of Healthcare Ethics 30 (4):623-630.
    Implanted medical devices—for example, cardiac defibrillators, deep brain stimulators, and insulin pumps—offer users the possibility of regaining some control over an increasingly unruly body, the opportunity to become part “cyborg” in service of addressing pressing health needs. We recognize the value and effectiveness of such devices, but call attention to what may be less clear to potential users—that their vulnerabilities may not entirely disappear but instead shift. We explore the kinds of shifting vulnerabilities experienced by people with Parkinson’s disease (...)
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  4. Parkinson’s disease with mild cognitive impairment may has a lower risk of cognitive decline after subthalamic nucleus deep brain stimulation: A retrospective cohort study.Hutao Xie, Quan Zhang, Yin Jiang, Yutong Bai & Jianguo Zhang - 2022 - Frontiers in Human Neuroscience 16.
    BackgroundThe cognitive outcomes induced by subthalamic nucleus deep brain stimulation remain unclear, especially in PD patients with mild cognitive impairment. This study explored the cognitive effects of STN-DBS in PD patients with MCI.MethodsThis was a retrospective cohort study that included 126 PD patients who underwent STN-DBS; all patients completed cognitive and motor assessments before and at least 6 months after surgery. Cognitive changes were mainly evaluated by the Montreal cognitive assessment scale and the seven specific MoCA domains, including visuospatial/executive function, (...)
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  5.  17
    Learning to live with Parkinson’s disease in the family unit: an interpretative phenomenological analysis of well-being.Laura J. Smith & Rachel L. Shaw - 2017 - Medicine, Health Care and Philosophy 20 (1):13-21.
    We investigated family members’ lived experience of Parkinson’s disease aiming to investigate opportunities for well-being. A lifeworld-led approach to healthcare was adopted. Interpretative phenomenological analysis was used to explore in-depth interviews with people living with PD and their partners. The analysis generated four themes: It’s more than just an illness revealed the existential challenge of diagnosis; Like a bird with a broken wing emphasizing the need to adapt to increasing immobility through embodied agency; Being together with PD exploring the (...)
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  6.  8
    Parkinson’s Disease Motor Subtypes Show Different Responses to Long-Term Subthalamic Nucleus Stimulation.Cuiping Xu, Ping Zhuang, Mark Hallett, Yuqing Zhang, Jianyu Li & Yongjie Li - 2018 - Frontiers in Human Neuroscience 12.
  7.  22
    Placebo Surgery for Parkinson's Disease: Do the Benefits Outweigh the Risks?Peter A. Clark - 2002 - Journal of Law, Medicine and Ethics 30 (1):58-68.
    In April 1999, Dr. Curt Freed of the University of Colorado in Denver and Dr. Stanley Fahn of Columbia Presbyterian Center in New York presented the results of a four-year, $5.7 million government-financed study using tissue from aborted fetuses to treat Parkinson’s disease at a conference of the American Academy of Neurology. The results of the first government-financed, placebo-controlled clinical study using fetal tissue showed that the symptoms of some Parkinson’s patients had been relieved. This research study involved forty (...)
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  8.  19
    Benefits, risks and ethical considerations in translation of stem cell research to clinical applications in Parkinson's disease.Z. Master, M. McLeod & I. Mendez - 2007 - Journal of Medical Ethics 33 (3):169-173.
    Stem cells are likely to be used as an alternate source of biological material for neural transplantation to treat Parkinson’s disease in the not too distant future. Among the several ethical criteria that must be fulfilled before proceeding with clinical research, a favourable benefit to risk ratio must be obtained. The potential benefits to the participant and to society are evaluated relative to the risks in an attempt to offer the participants a reasonable choice. Through examination of preclinical studies (...)
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  9.  3
    Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation.Nicoló G. Pozzi, Chiara Palmisano, Martin M. Reich, Philip Capetian, Claudio Pacchetti, Jens Volkmann & Ioannis U. Isaias - 2022 - Frontiers in Human Neuroscience 16.
    Deep brain stimulation of the subthalamic nucleus or the globus pallidus is an established treatment for Parkinson’s disease that yields a marked and lasting improvement of motor symptoms. Yet, DBS benefit on gait disturbances in PD is still debated and can be a source of dissatisfaction and poor quality of life. Gait disturbances in PD encompass a variety of clinical manifestations and rely on different pathophysiological bases. While gait disturbances arising years after DBS surgery can be related to (...) progression, early impairment of gait may be secondary to treatable causes and benefits from DBS reprogramming. In this review, we tackle the issue of gait disturbances in PD patients with DBS by discussing their neurophysiological basis, providing a detailed clinical characterization, and proposing a pragmatic programming approach to support their management. (shrink)
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  10.  3
    People With Parkinson’s Disease and Freezing of Gait Show Abnormal Low Frequency Activity of Antagonistic Leg Muscles.Maria-Sophie Breu, Marlieke Schneider, Johannes Klemt, Idil Cebi, Alireza Gharabaghi & Daniel Weiss - 2022 - Frontiers in Human Neuroscience 15.
    ObjectiveFreezing of gait is detrimental to patients with idiopathic Parkinson’s disease. Its pathophysiology represents a multilevel failure of motor processing in the cortical, subcortical, and brainstem circuits, ultimately resulting in ineffective motor output of the spinal pattern generator. Electrophysiological studies pointed to abnormalities of oscillatory activity in freezers that covered a broad frequency range including the theta, alpha, and beta bands. We explored muscular frequency domain activity with respect to freezing, and used deep brain stimulation to modulate these rhythms (...)
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  11.  6
    Early Detection of Parkinson’s Disease by Using SPECT Imaging and Biomarkers.Bhanu Prasad, T. N. Nagabhushan & Gunjan Pahuja - 2019 - Journal of Intelligent Systems 29 (1):1329-1344.
    Precise and timely diagnosis of Parkinson’s disease is important to control its progression among subjects. Currently, a neuroimaging technique called dopaminergic imaging that uses single photon emission computed tomography with 123I-Ioflupane is popular among clinicians for detecting Parkinson’s disease in early stages. Unlike other studies, which consider only low-level features like gray matter, white matter, or cerebrospinal fluid, this study explores the non-linear relation between different biomarkers using deep learning and multivariate logistic regression. Striatal binding ratios are obtained (...)
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  12.  28
    Rapid Alleviation of Parkinson’s Disease Symptoms via Electrostimulation of Intrinsic Auricular Muscle Zones.Yusuf O. Cakmak, Hülya Apaydin, Güneş Kiziltan, Ayşegül Gündüz, Burak Ozsoy, Selim Olcer, Hakan Urey, Ozgur O. Cakmak, Yasemin G. Ozdemir & Sibel Ertan - 2017 - Frontiers in Human Neuroscience 11.
  13.  3
    Effects of Exercise on Parkinson’s Disease: A Meta-Analysis of Brain Imaging Studies.Jingwen Li, Jian Guo, Weijuan Sun, Jinjin Mei, Yiying Wang, Lihong Zhang, Jianyun Zhang, Jing Gao, Kaiqi Su, Zhuan Lv, Xiaodong Feng & Ruiqing Li - 2022 - Frontiers in Human Neuroscience 16.
    BackgroundExercise is increasingly recognized as a key component of Parkinson’s disease treatment strategies, but the underlying mechanism of how exercise affects PD is not yet fully understood.ObjectiveThe activation likelihood estimation method is used to study the mechanism of exercise affecting PD, providing a theoretical basis for studying exercise and PD, and promoting the health of patients with PD.MethodsRelevant keywords were searched on the PubMed, Cochrane Library, and Web of Science databases. Seven articles were finally included according to the screening (...)
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  14.  38
    Mortality of Parkinson's disease by Hoehn–Yahr stage from community‐based and clinic series [Keelung Community‐based Integrated Screening (KCIS) no. 17)].Horng-Huei Liou, Chia-Yun Wu, Yueh-Hsia Chiu, Amy Ming-Fang Yen, Rong-Chi Chen, Ta-Fu Chen, Chih-Chuan Chen, Yuarn-Chung Hwang, Ying-Rong Wen & Tony Hsiu-Hsi Chen - 2009 - Journal of Evaluation in Clinical Practice 15 (4):587-591.
  15.  1
    Differentiation of Parkinson’s disease and Parkinsonism predominant multiple system atrophy in early stage by morphometrics in susceptibility weighted imaging.Qingguo Ren, Yihua Wang, Xiaona Xia, Jianyuan Zhang, Cuiping Zhao & Xiangshui Meng - 2022 - Frontiers in Human Neuroscience 16.
    Background and purposeWe previously established a radiological protocol to discriminate multiple system atrophy-parkinsonian subtype from Parkinson’s disease. However, we do not know if it can differentiate early stage disease. This study aimed to investigate whether the morphological and intensity changes in susceptibility weighted imaging of the lentiform nucleus could discriminate MSA-P from PD at early stages.MethodsWe retrospectively enrolled patients with MSA-P, PD and sex- and age-matched controls whose brain MRI included SWI, between January 2015 and July 2020 at (...)
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  16.  3
    Altered Inhibitory Mechanisms in Parkinson’s Disease: Evidence From Lexical Decision and Simple Reaction Time Tasks.Alban Letanneux, Jean-Luc Velay, François Viallet & Serge Pinto - 2021 - Frontiers in Human Neuroscience 15.
    IntroductionAlthough the motor signs of Parkinson’s disease are well defined, nonmotor symptoms, including higher-level language deficits, have also been shown to be frequent in patients with PD. In the present study, we used a lexical decision task to find out whether access to the mental lexicon is impaired in patients with PD, and whether task performance is affected by bradykinesia.Materials and MethodsParticipants were 34 nondemented patients with PD, either without medication or under optimum medication. A total of 19 age-matched (...)
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  17.  4
    Deep Brain Stimulation for Parkinson’s Disease: Why Earlier Use Makes Shared Decision Making Important.Jaime Montemayor, Harini Sarva, Karen Kelly-Blake & Laura Y. Cabrera - 2022 - Neuroethics 15 (2):1-11.
    Introduction As deep brain stimulation (DBS) has shifted to being used earlier during Parkinson’s disease (PD), data is lacking regarding patient specific attitudes, preferences, and factors which may influence the timing of and decision to proceed with DBS in the United States. This study aims to identify and compare attitudes and preferences regarding the earlier use of DBS in Parkinson’s patients who have and have not undergone DBS. Methods We developed an online survey concerning attitudes about DBS and its (...)
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  18.  16
    Freezing of gait in Parkinson's disease: disturbances in automaticity and control.Jochen Vandenbossche, N. Deroost, E. Soetens, D. Coomans, J. Spildooren, S. Vercruysse, A. Nieuwboer & E. Kerckhofs - 2012 - Frontiers in Human Neuroscience 6.
  19.  30
    Neural transplants for parkinson’s disease: what are the issues?Roger Barker - 2006 - Poiesis and Praxis 4 (2):129-143.
    Parkinson’s disease (PD) is a common neurodegenerative disorder of the nervous system that affects about 1 in 800 people and for which we have symptomatic but not curative therapies. At the core of the disease is the loss of a specific population of dopaminergic neurons within the brain, and replacement of dopamine through drug therapies has provided clinically significant benefit for many patients. However this therapy only ever offers a temporary amelioration of symptoms and with time this symptomatic (...)
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  20.  6
    Deep Brain Stimulation for Parkinson’s Disease During the COVID-19 Pandemic: Patient Perspective.Chencheng Zhang, Jing Zhang, Xian Qiu, Yingying Zhang, Zhengyu Lin, Peng Huang, Yixin Pan, Eric A. Storch, Bomin Sun & Dianyou Li - 2021 - Frontiers in Human Neuroscience 15.
    BackgroundPublic health guidelines have recommended that elective medical procedures, including deep brain stimulation surgery for Parkinson’s disease, should not be scheduled during the coronavirus pandemic to prevent further virus spread and overload on health care systems. However, delaying DBS surgery for PD may not be in the best interest of individual patients and is not called for in regions where virus spread is under control and inpatient facilities are not overloaded.MethodsWe administered a newly developed phone questionnaire to 20 consecutive (...)
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  21.  5
    Alienation and Authenticity in Parkinson's Disease and Its Treatment.Philip E. Mosley, Wayne Hall, Cynthia Forlini & Adrian Carter - 2014 - American Journal of Bioethics Neuroscience 5 (4):54-56.
  22.  9
    Sensory Re-weighting for Postural Control in Parkinson’s Disease.Kelly J. Feller, Robert J. Peterka & Fay B. Horak - 2019 - Frontiers in Human Neuroscience 13.
    Postural instability in Parkinson’s disease (PD) is characterized by impaired postural responses to transient perturbations, increased postural sway in stance and difficulty transitioning between tasks. In addition, some studies suggest that loss of dopamine in the basal ganglia due to PD results in difficulty using proprioceptive information for motor control. Here, we quantify the ability of subjects with PD and age-matched control subjects to use and re-weight sensory information for postural control during steady-state conditions of continuous rotations of the (...)
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  23.  83
    The ethics of sham surgery in Parkinson's disease: Back to the future?Teresa Swift & Richard Huxtable - 2013 - Bioethics 27 (4):175-185.
    Despite intense academic debate in the recent past over the use of ‘sham surgery’ control groups in research, there has been a recent resurgence in their use in the field of neurodegenerative disease. Yet the primacy of ethical arguments in favour of sham surgery controls is not yet established. Preliminary empirical research shows an asymmetry between the views of neurosurgical researchers and patients on the subject, while different ethical guidelines and regulations support conflicting interpretations. Research ethics committees faced with (...)
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  24.  12
    Does neuronal loss in Parkinson's disease involve programmed cell death?Julie K. Andersen - 2001 - Bioessays 23 (7):640-646.
  25.  24
    Animal models of Parkinson's disease.Ranjita Betarbet, Todd B. Sherer & J. Timothy Greenamyre - 2002 - Bioessays 24 (4):308-318.
  26.  19
    ‘Woe Betides Anybody Who Tries to Turn me Down.’ A Qualitative Analysis of Neuropsychiatric Symptoms Following Subthalamic Deep Brain Stimulation for Parkinson’s Disease.Philip E. Mosley, Katherine Robinson, Terry Coyne, Peter Silburn, Michael Breakspear & Adrian Carter - 2019 - Neuroethics 14 (1):47-63.
    Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson’s disease can lead to the development of neuropsychiatric symptoms. These can include harmful changes in mood and behaviour that alienate family members and raise ethical questions about personal responsibility for actions committed under stimulation-dependent mental states. Qualitative interviews were conducted with twenty participants following subthalamic DBS at a movement disorders centre, in order to explore the meaning and significance of stimulation-related neuropsychiatric symptoms amongst a purposive sample of (...)
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  27.  2
    Cognitive Impairment in Parkinson’s Disease Is Reflected with Gradual Decrease of EEG Delta Responses during Auditory Discrimination.Bahar Güntekin, Lütfü Hanoğlu, Dilan Güner, Nesrin H. Yılmaz, Fadime Çadırcı, Nagihan Mantar, Tuba Aktürk, Derya D. Emek-Savaş, Fahriye F. Özer, Görsev Yener & Erol Başar - 2018 - Frontiers in Psychology 9.
  28.  12
    Bradykinesia in Parkinson's disease and cocontraction activity in dystonia are unlikely to be due to adaptive changes in the CNS.A. Berardelli, R. Agostino, A. Currà & M. Manfredi - 1996 - Behavioral and Brain Sciences 19 (1):69-69.
  29. Cognitive correlates of hallucinations and delusions in Parkinson’s disease.S. A. Factor, M. K. Scullin, A. B. Sollinger, J. O. Land, C. Wood-Siverio, L. Zanders, A. Freeman, D. L. Bliwise, W. M. McDonald & F. C. Goldstein - 2014 - Journal of the Neurological Sciences 347 (1-2):316–21.
    BACKGROUND: Hallucinations and delusions that complicate Parkinson’s disease could lead to nursing home placement and are linked to increased mortality. Cognitive impairments are typically associated with the presence of hallucinations but there are no data regarding whether such a relationship exists with delusions. OBJECTIVE: We hypothesized that hallucinations would be associated with executive and visuospatial disturbance. An exploratory examination of cognitive correlates of delusions was also completed to address the question of whether they differ from hallucinations. METHODS: 144 PD (...)
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  30.  11
    Sham Neurosurgery in Parkinson's Disease: Ethical at the Time.John C. Fletcher - 2003 - American Journal of Bioethics 3 (4):54-56.
  31.  12
    Emotional processing in Parkinson’s disease and schizophrenia: evidence for response bias deficits in PD.Ilona P. Laskowska, Ludwika Gawryś, Szymon Łęski & Dariusz Koziorowski - 2015 - Frontiers in Psychology 6.
  32.  5
    Abnormal Phase Coupling in Parkinson’s Disease and Normalization Effects of Subthreshold Vestibular Stimulation.Soojin Lee, Aiping Liu, Z. Jane Wang & Martin J. McKeown - 2019 - Frontiers in Human Neuroscience 13.
  33.  4
    Closed-Loop Deep Brain Stimulation to Treat Medication-Refractory Freezing of Gait in Parkinson’s Disease.Rene Molina, Chris J. Hass, Stephanie Cernera, Kristen Sowalsky, Abigail C. Schmitt, Jaimie A. Roper, Daniel Martinez-Ramirez, Enrico Opri, Christopher W. Hess, Robert S. Eisinger, Kelly D. Foote, Aysegul Gunduz & Michael S. Okun - 2021 - Frontiers in Human Neuroscience 15.
    Background: Treating medication-refractory freezing of gait in Parkinson’s disease remains challenging despite several trials reporting improvements in motor symptoms using subthalamic nucleus or globus pallidus internus deep brain stimulation. Pedunculopontine nucleus region DBS has been used for medication-refractory FoG, with mixed findings. FoG, as a paroxysmal phenomenon, provides an ideal framework for the possibility of closed-loop DBS.Methods: In this clinical trial, five subjects with medication-refractory FoG underwent bilateral GPi DBS implantation to address levodopa-responsive PD symptoms with open-loop stimulation. Additionally, (...)
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  34.  3
    Pragmatic Language Disorder in Parkinson’s Disease and the Potential Effect of Cognitive Reserve.Sonia Montemurro, Sara Mondini, Matteo Signorini, Anna Marchetto, Valentina Bambini & Giorgio Arcara - 2019 - Frontiers in Psychology 10.
  35.  8
    Assistive HCI-Serious Games Co-design Insights: The Case Study of i-PROGNOSIS Personalized Game Suite for Parkinson’s Disease.Sofia Balula Dias, José Alves Diniz, Evdokimos Konstantinidis, Theodore Savvidis, Vicky Zilidou, Panagiotis D. Bamidis, Athina Grammatikopoulou, Kosmas Dimitropoulos, Nikos Grammalidis, Hagen Jaeger, Michael Stadtschnitzer, Hugo Silva, Gonçalo Telo, Ioannis Ioakeimidis, George Ntakakis, Fotis Karayiannis, Estelle Huchet, Vera Hoermann, Konstantinos Filis, Elina Theodoropoulou, George Lyberopoulos, Konstantinos Kyritsis, Alexandros Papadopoulos, Anastasios Depoulos, Dhaval Trivedi, Ray K. Chaudhuri, Lisa Klingelhoefer, Heinz Reichmann, Sevasti Bostantzopoulou, Zoe Katsarou, Dimitrios Iakovakis, Stelios Hadjidimitriou, Vasileios Charisis, George Apostolidis & Leontios J. Hadjileontiadis - 2021 - Frontiers in Psychology 11.
    Human-Computer Interaction and games set a new domain in understanding people’s motivations in gaming, behavioral implications of game play, game adaptation to player preferences and needs for increased engaging experiences in the context of HCI serious games. When the latter relate with people’s health status, they can become a part of their daily life as assistive health status monitoring/enhancement systems. Co-designing HCI-SGs can be seen as a combination of art and science that involves a meticulous collaborative process. The design elements (...)
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  36.  2
    Perceptions on using surplus embryos for the treatment of Parkinson’s disease among the Swedish population: a qualitative study.Jennifer Drevin & Åsa Grauman - 2022 - BMC Medical Ethics 23 (1):1-9.
    BackgroundHuman embryonic stem cells are currently used for developing treatment against Parkinson’s disease. However, the use of ES cells is surrounded with moral concerns. Research regarding the public's attitudes can form an important basis for policymaking. The aim was to explore the perceptions of the public on using donated human embryos for developing treatment of Parkinson’s Disease.MethodsSemi-structured individual qualitative interviews were conducted with 11 members of the general population in Sweden. Interviews were analyzed with thematic content analyses.ResultsFour categories (...)
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  37.  12
    What are the focal points in bioethics literature? Examining the discussions about everyday ethics in Parkinson’s disease.Natalie Zizzo, Emily Bell & Eric Racine - 2017 - Clinical Ethics 12 (1):19-23.
  38. Cognitive Impairment and Dementia in Parkinson's Disease.Murat Emre (ed.) - 2010 - Oxford University Press UK.
    Parkinson's disease has long been perceived as a pure motor disorder, partly due to its initial description by James Parkinson, who suggested that "senses and intellect remain intact", and partly due to the fact that patients with PD did not survive long, before effective treatment became available. As the survival time of patients with Parkinson's disease has substantially increased due to modern treatment, it has become apparent that cognitive deficits and dementia are also frequent features, especially (...)
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  39.  43
    Sham surgery controls: intracerebral grafting of fetal tissue for Parkinson's disease and proposed criteria for use of sham surgery controls.R. L. Albin - 2002 - Journal of Medical Ethics 28 (5):322-325.
    Sham surgery is a controversial and rarely used component of randomised clinical trials evaluating surgical interventions. The recent use of sham surgery in trials evaluating efficacy of intracerebral fetal tissue grafts in Parkinson’s disease has highlighted the ethical concerns associated with sham surgery controls. Macklin, and Dekkers and Boer argue vigorously against use of sham surgery controls. Macklin presents a broad argument against sham surgery controls while Dekkers and Boer present a narrower argument that sham surgery is unnecessary in (...)
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  40.  19
    Sham neurosurgery in patients with Parkinson's disease: is it morally acceptable?W. Dekkers - 2001 - Journal of Medical Ethics 27 (3):151-156.
    For a few decades, patients with Parkinson's disease have been treated with intracerebral transplantations of fetal mesencephalic tissue. The results of open trials have been variable. Double blind, placebo-controlled studies have recently been started in order to further investigate the efficacy of this new medical technique. In this paper we challenge the need for sham surgery in neurotransplantation research on PD patients. Considerations regarding the research subjects' informed consent, therapeutic misconception, the integrity of the human body, and the (...)
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  41.  40
    Potential subjects' responses to an ethics questionnaire in a phase I study of deep brain stimulation in early Parkinson's disease.Stuart G. Finder, Mark J. Bliton, Chandler E. Gill, Thomas L. Davis, Peter E. Konrad & P. D. Charles - 2012 - Journal of Clinical Ethics 23 (3):207-216.
    Background Central to ethically justified clinical trial design is the need for an informed consent process responsive to how potential subjects actually comprehend study participation, especially study goals, risks, and potential benefits. This will be particularly challenging when studying deep brain stimulation and whether it impedes symptom progression in Parkinson’s disease, since potential subjects will be Parkinson’s patients for whom deep brain stimulation will likely have therapeutic value in the future as their disease progresses.Method As part of an (...)
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  42.  2
    Does Motor Symptoms Asymmetry Predict Motor Outcome of Subthalamic Deep Brain Stimulation in Parkinson's Disease Patients?Francesco Bove, Francesco Cavallieri, Anna Castrioto, Sara Meoni, Emmanuelle Schmitt, Amélie Bichon, Eugénie Lhommée, Pierre Pélissier, Andrea Kistner, Eric Chevrier, Eric Seigneuret, Stephan Chabardès, Franco Valzania, Valerie Fraix & Elena Moro - 2022 - Frontiers in Human Neuroscience 16.
    BackgroundIn Parkinson's disease, the side of motor symptoms onset may influence disease progression, with a faster motor symptom progression in patients with left side lateralization. Moreover, worse neuropsychological outcomes after subthalamic nucleus deep brain stimulation have been described in patients with predominantly left-sided motor symptoms. The objective of this study was to evaluate if the body side of motor symptoms onset may predict motor outcome of bilateral STN-DBS.MethodsThis retrospective study included all consecutive PD patients treated with bilateral (...)
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  43.  7
    The Effect of Dopaminergic Replacement Therapy on Creative Thinking and Insight Problem-Solving in Parkinson's Disease Patients.Carola Salvi, Emily K. Leiker, Beatrix Baricca, Maria A. Molinari, Roberto Eleopra, Paolo F. Nichelli, Jordan Grafman & Joseph E. Dunsmoor - 2021 - Frontiers in Psychology 12.
    Parkinson's disease patients receiving dopaminergic treatment may experience bursts of creativity. Although this phenomenon is sometimes recognized among patients and their clinicians, the association between dopamine replacement therapy in PD patients and creativity remains underexplored. It is unclear, for instance, whether DRT affects creativity through convergent or divergent thinking, idea generation, or a general lack of inhibition. It is also unclear whether DRT only augments pre-existing creative attributes or generates creativity de novo. Here, we tested a group of (...)
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  44.  4
    BeatWalk: Personalized Music-Based Gait Rehabilitation in Parkinson’s Disease.Valérie Cochen De Cock, Dobromir Dotov, Loic Damm, Sandy Lacombe, Petra Ihalainen, Marie Christine Picot, Florence Galtier, Cindy Lebrun, Aurélie Giordano, Valérie Driss, Christian Geny, Ainara Garzo, Erik Hernandez, Edith Van Dyck, Marc Leman, Rudi Villing, Benoit G. Bardy & Simone Dalla Bella - 2021 - Frontiers in Psychology 12.
    Taking regular walks when living with Parkinson’s disease has beneficial effects on movement and quality of life. Yet, patients usually show reduced physical activity compared to healthy older adults. Using auditory stimulation such as music can facilitate walking but patients vary significantly in their response. An individualized approach adapting musical tempo to patients’ gait cadence, and capitalizing on these individual differences, is likely to provide a rewarding experience, increasing motivation for walk-in PD. We aim to evaluate the observance, safety, (...)
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  45.  5
    Global Variability in Deep Brain Stimulation Practices for Parkinson’s Disease.Abhimanyu Mahajan, Ankur Butala, Michael S. Okun, Zoltan Mari & Kelly A. Mills - 2021 - Frontiers in Human Neuroscience 15.
    IntroductionDeep brain stimulation has become a standard treatment option for select patients with Parkinson’s disease. The selection process and surgical procedures employed have, to date, not been standardized.MethodsA comprehensive 58-question web-based survey was developed with a focus on DBS referral practices and peri-operative management. The survey was distributed to the Parkinson’s Foundation Centers of Excellence, members of the International Parkinson’s Disease and Movement Disorders Society, and the Parkinson Study Group between December 2015 and May 2016.ResultsThere were 207 individual (...)
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  46.  3
    The Role of Social Cognition Abilities in Parkinson's Disease in the Era of COVID-19 Emergency.Alessandra Dodich, Costanza Papagno, Luca Turella, Claudia Meli, Francesca Zappini, Pamela Narduzzi, Alessandro Gober, Enrica Pierotti & Marika Falla - 2021 - Frontiers in Psychology 12.
    Introduction: Parkinson's Disease is characterized by motor and non-motor symptoms, among which deficits in social cognition might affect ~20% of patients. This study aims to evaluate the role of social cognitive abilities in the perceived impact of COVID-19 emergency, and the effects of lockdown measures on patients' social network and caregivers' burden.Methods: Fourteen PD patients performed a neuropsychological battery including sociocognitive tasks before the introduction of COVID-19 restrictive measures. A structured interview through an online platform was performed in (...)
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  47.  1
    Deep Brain Stimulation of the Subthalamic Nucleus Influences Facial Emotion Recognition in Patients With Parkinson’s Disease: A Review.Caroline Wagenbreth, Maria Kuehne, Hans-Jochen Heinze & Tino Zaehle - 2019 - Frontiers in Psychology 10.
    Parkinson´s disease (PD) is a neurodegenerative disorder characterized by motor symptoms following dopaminergic depletion in the substantia nigra. Besides motor impairments however, several non-motor detriments can have the potential to considerably impact subjectively perceived quality of life in patients. Particularly emotion recognition of facial expressions has been shown to be affected in PD, and especially the perception of negative emotions like fear, anger or disgust is impaired. While emotion processing generally refers to automatic implicit as well as conscious explicit (...)
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  48.  5
    The Effects of Working Memory Updating Training in Parkinson’s Disease: A Feasibility and Single-Subject Study on Cognition, Movement and Functional Brain Response.Lois Walton, Magdalena Eriksson Domellöf, Carl-Johan Boraxbekk, Erik Domellöf, Louise Rönnqvist, David Bäckström, Lars Forsgren & Anna Stigsdotter Neely - 2021 - Frontiers in Psychology 11.
    In Parkinson’s disease, the fronto-striatal network is involved in motor and cognitive symptoms. Working memory updating training engages this network in healthy populations, as observed by improved cognitive performance and increased striatal BOLD signal. This two-part study aimed to assess the feasibility of WM updating training in PD and measure change in cognition, movement and functional brain response in one individual with PD after WM updating training. A feasibility and single-subject study were performed in which patients with PD completed (...)
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  49.  1
    Does Prefrontal Glutamate Index Cognitive Changes in Parkinson’s Disease?Isabelle Buard, Natalie Lopez-Esquibel, Finnuella J. Carey, Mark S. Brown, Luis D. Medina, Eugene Kronberg, Christine S. Martin, Sarah Rogers, Samantha K. Holden, Michael R. Greher & Benzi M. Kluger - 2022 - Frontiers in Human Neuroscience 16.
    IntroductionCognitive impairment is a highly prevalent non-motor feature of Parkinson’s disease. A better understanding of the underlying pathophysiology may help in identifying therapeutic targets to prevent or treat dementia. This study sought to identify metabolic alterations in the prefrontal cortex, a key region for cognitive functioning that has been implicated in cognitive dysfunction in PD.MethodsProton Magnetic Resonance Spectroscopy was used to investigate metabolic changes in the PFC of a cohort of cognitively normal individuals without PD, as well as PD (...)
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  50.  22
    The factor structure of the SF‐36 in Parkinson's disease.Pauline Banks & Colin R. Martin - 2009 - Journal of Evaluation in Clinical Practice 15 (3):460-463.
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