Results for 'Parkinson's disease'

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  1. Parkinson’s Disease Prediction Using Artificial Neural Network.Ramzi M. Sadek, Salah A. Mohammed, Abdul Rahman K. Abunbehan, Abdul Karim H. Abdul Ghattas, Majed R. Badawi, Mohamed N. Mortaja, Bassem S. Abu-Nasser & Samy S. Abu-Naser - 2019 - International Journal of Academic Health and Medical Research (IJAHMR) 3 (1):1-8.
    Parkinson's Disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking. Doctors do not know what causes it and finds difficulty in early diagnosing the presence of Parkinson’s disease. An artificial neural network system with back propagation algorithm is presented in this paper for (...)
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  2.  7
    Cognitive correlates of hallucinations and delusions in Parkinson’s disease.S. A. Factor, M. K. Scullin, A. B. Sollinger, J. O. Land, C. Wood-Siverio, L. Zanders, A. Freeman, D. L. Bliwise, W. M. McDonald & F. C. Goldstein - 2014 - Journal of the Neurological Sciences 347 (1-2):316–21.
    BACKGROUND: Hallucinations and delusions that complicate Parkinson’s disease could lead to nursing home placement and are linked to increased mortality. Cognitive impairments are typically associated with the presence of hallucinations but there are no data regarding whether such a relationship exists with delusions. OBJECTIVE: We hypothesized that hallucinations would be associated with executive and visuospatial disturbance. An exploratory examination of cognitive correlates of delusions was also completed to address the question of whether they differ from hallucinations. METHODS: 144 PD (...)
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  3.  13
    Temporally optimized patterned stimulation (TOPS®) as a therapy to personalize deep brain stimulation treatment of Parkinson’s disease.Michael S. Okun, Patrick T. Hickey, Andre G. Machado, Alexis M. Kuncel & Warren M. Grill - 2022 - Frontiers in Human Neuroscience 16.
    Deep brain stimulation is a well-established therapy for the motor symptoms of Parkinson’s disease, but there remains an opportunity to improve symptom relief. The temporal pattern of stimulation is a new parameter to consider in DBS therapy, and we compared the effectiveness of Temporally Optimized Patterned Stimulation to standard DBS at reducing the motor symptoms of PD. Twenty-six subjects with DBS for PD received three different patterns of stimulation while on medication and using stimulation parameters optimized for standard DBS. (...)
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  4.  86
    Freezing of gait in Parkinson's disease: disturbances in automaticity and control.Jochen Vandenbossche, N. Deroost, E. Soetens, D. Coomans, J. Spildooren, S. Vercruysse, A. Nieuwboer & E. Kerckhofs - 2012 - Frontiers in Human Neuroscience 6.
  5.  26
    Closed-Loop Deep Brain Stimulation to Treat Medication-Refractory Freezing of Gait in Parkinson’s Disease.Rene Molina, Chris J. Hass, Stephanie Cernera, Kristen Sowalsky, Abigail C. Schmitt, Jaimie A. Roper, Daniel Martinez-Ramirez, Enrico Opri, Christopher W. Hess, Robert S. Eisinger, Kelly D. Foote, Aysegul Gunduz & Michael S. Okun - 2021 - Frontiers in Human Neuroscience 15.
    Background: Treating medication-refractory freezing of gait in Parkinson’s disease remains challenging despite several trials reporting improvements in motor symptoms using subthalamic nucleus or globus pallidus internus deep brain stimulation. Pedunculopontine nucleus region DBS has been used for medication-refractory FoG, with mixed findings. FoG, as a paroxysmal phenomenon, provides an ideal framework for the possibility of closed-loop DBS.Methods: In this clinical trial, five subjects with medication-refractory FoG underwent bilateral GPi DBS implantation to address levodopa-responsive PD symptoms with open-loop stimulation. Additionally, (...)
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  6.  17
    Affective judgments by patients with Parkinson’s disease or chronic progressive multiple sclerosis.William W. Beatty, Donald E. Goodkin, William S. Weir, R. Dennis Staton, Nancy Monson & Patricia A. Beatty - 1989 - Bulletin of the Psychonomic Society 27 (4):361-364.
  7.  24
    “I Want to Do It, But I Want to Make Sure That I Do It Right.” Views of Patients with Parkinson’s Disease Regarding Early Stem Cell Clinical Trial Participation.Inmaculada de Melo-Martín, Michael Holtzman & Katrina S. Hacker - 2020 - AJOB Empirical Bioethics 11 (3):160-171.
  8.  19
    Square Biphasic Pulse Deep Brain Stimulation for Parkinson’s Disease: The BiP-PD Study.Sol De Jesus, Michael S. Okun, Kelly D. Foote, Daniel Martinez-Ramirez, Jaimie A. Roper, Chris J. Hass, Leili Shahgholi, Umer Akbar, Aparna Wagle Shukla, Robert S. Raike & Leonardo Almeida - 2019 - Frontiers in Human Neuroscience 13.
  9.  31
    Neurophysiological Correlates of Gait in the Human Basal Ganglia and the PPN Region in Parkinson’s Disease.Rene Molina, Chris J. Hass, Kristen Sowalsky, Abigail C. Schmitt, Enrico Opri, Jaime A. Roper, Daniel Martinez-Ramirez, Christopher W. Hess, Kelly D. Foote, Michael S. Okun & Aysegul Gunduz - 2020 - Frontiers in Human Neuroscience 14.
  10.  11
    Global Variability in Deep Brain Stimulation Practices for Parkinson’s Disease.Abhimanyu Mahajan, Ankur Butala, Michael S. Okun, Zoltan Mari & Kelly A. Mills - 2021 - Frontiers in Human Neuroscience 15.
    IntroductionDeep brain stimulation has become a standard treatment option for select patients with Parkinson’s disease. The selection process and surgical procedures employed have, to date, not been standardized.MethodsA comprehensive 58-question web-based survey was developed with a focus on DBS referral practices and peri-operative management. The survey was distributed to the Parkinson’s Foundation Centers of Excellence, members of the International Parkinson’s Disease and Movement Disorders Society, and the Parkinson Study Group between December 2015 and May 2016.ResultsThere were 207 individual (...)
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  11.  12
    Does Prefrontal Glutamate Index Cognitive Changes in Parkinson’s Disease?Isabelle Buard, Natalie Lopez-Esquibel, Finnuella J. Carey, Mark S. Brown, Luis D. Medina, Eugene Kronberg, Christine S. Martin, Sarah Rogers, Samantha K. Holden, Michael R. Greher & Benzi M. Kluger - 2022 - Frontiers in Human Neuroscience 16.
    IntroductionCognitive impairment is a highly prevalent non-motor feature of Parkinson’s disease. A better understanding of the underlying pathophysiology may help in identifying therapeutic targets to prevent or treat dementia. This study sought to identify metabolic alterations in the prefrontal cortex, a key region for cognitive functioning that has been implicated in cognitive dysfunction in PD.MethodsProton Magnetic Resonance Spectroscopy was used to investigate metabolic changes in the PFC of a cohort of cognitively normal individuals without PD, as well as PD (...)
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  12.  19
    Safety and Tolerability of Burst-Cycling Deep Brain Stimulation for Freezing of Gait in Parkinson’s Disease.Joshua K. Wong, Wei Hu, Ryan Barmore, Janine Lopes, Kathryn Moore, Joseph Legacy, Parisa Tahafchi, Zachary Jackson, Jack W. Judy, Robert S. Raike, Anson Wang, Takashi Tsuboi, Michael S. Okun & Leonardo Almeida - 2021 - Frontiers in Human Neuroscience 15.
    Background: Freezing of gait is a common symptom in Parkinson’s disease and can be difficult to treat with dopaminergic medications or with deep brain stimulation. Novel stimulation paradigms have been proposed to address suboptimal responses to conventional DBS programming methods. Burst-cycling deep brain stimulation delivers current in various frequencies of bursts, while maintaining an intra-burst frequency identical to conventional DBS.Objective: To evaluate the safety and tolerability of BCDBS in PD patients with FOG.Methods: Ten PD subjects with STN or GPi (...)
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  13.  19
    Defective preprogramming does not account for the clinical deficits of Parkinson's disease.Daniel M. Corcos, Kerstin D. Pfann & Aron S. Buchman - 1996 - Behavioral and Brain Sciences 19 (1):73-74.
  14.  19
    Deep Brain Stimulation of the Subthalamic Nucleus Improves Reward-Based Decision-Learning in Parkinson's Disease.Nelleke C. van Wouwe, K. R. Ridderinkhof, W. P. M. van den Wildenberg, G. P. H. Band, A. Abisogun, W. J. Elias, R. Frysinger & S. A. Wylie - 2011 - Frontiers in Human Neuroscience 5.
  15.  82
    STN Versus GPi Ddeep Brain Stimulation for Action and Rest Tremor in Parkinson’s Disease.Joshua K. Wong, Vyas T. Viswanathan, Kamilia S. Nozile-Firth, Robert S. Eisinger, Emma L. Leone, Anuj M. Desai, Kelly D. Foote, Adolfo Ramirez-Zamora, Michael S. Okun & Aparna Wagle Shukla - 2020 - Frontiers in Human Neuroscience 14.
  16.  8
    Parkinson’s disease with mild cognitive impairment may has a lower risk of cognitive decline after subthalamic nucleus deep brain stimulation: A retrospective cohort study.Hutao Xie, Quan Zhang, Yin Jiang, Yutong Bai & Jianguo Zhang - 2022 - Frontiers in Human Neuroscience 16:943472.
    BackgroundThe cognitive outcomes induced by subthalamic nucleus deep brain stimulation (STN-DBS) remain unclear, especially in PD patients with mild cognitive impairment (MCI). This study explored the cognitive effects of STN-DBS in PD patients with MCI.MethodsThis was a retrospective cohort study that included 126 PD patients who underwent STN-DBS; all patients completed cognitive and motor assessments before and at least 6 months after surgery. Cognitive changes were mainly evaluated by the Montreal cognitive assessment (MoCA) scale and the seven specific MoCA domains, (...)
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  17.  33
    Placebo Surgery for Parkinson's Disease: Do the Benefits Outweigh the Risks?Peter A. Clark - 2002 - Journal of Law, Medicine and Ethics 30 (1):58-68.
    In April 1999, Dr. Curt Freed of the University of Colorado in Denver and Dr. Stanley Fahn of Columbia Presbyterian Center in New York presented the results of a four-year, $5.7 million government-financed study using tissue from aborted fetuses to treat Parkinson’s disease at a conference of the American Academy of Neurology. The results of the first government-financed, placebo-controlled clinical study using fetal tissue showed that the symptoms of some Parkinson’s patients had been relieved. This research study involved forty (...)
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  18.  18
    Trading Vulnerabilities: Living with Parkinson’s Disease before and after Deep Brain Stimulation.Sara Goering, Anna Wexler & Eran Klein - 2021 - Cambridge Quarterly of Healthcare Ethics 30 (4):623-630.
    Implanted medical devices—for example, cardiac defibrillators, deep brain stimulators, and insulin pumps—offer users the possibility of regaining some control over an increasingly unruly body, the opportunity to become part “cyborg” in service of addressing pressing health needs. We recognize the value and effectiveness of such devices, but call attention to what may be less clear to potential users—that their vulnerabilities may not entirely disappear but instead shift. We explore the kinds of shifting vulnerabilities experienced by people with Parkinson’s disease (...)
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  19.  19
    Dopamine, Parkinson's disease, and volition.Jon C. Horvitz - 2002 - Behavioral and Brain Sciences 25 (5):586-586.
    Disruptions in dopamine transmission within the basal ganglia (BG) produce deficits in voluntary actions, that is, in the interface between cortically-generated goal representation and BG-mediated response selection. Under conditions of dopamine loss in humans and other animals, responses are impaired when they require internal generation, but are relatively intact when elicited by external stimuli.
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  20.  16
    Does neuronal loss in Parkinson's disease involve programmed cell death?Julie K. Andersen - 2001 - Bioessays 23 (7):640-646.
    Recently it has been hypothesized that apoptotic cell death is involved in several neuropathological conditions including Parkinson's disease (PD). Initial morphological studies assessing the presence of apoptosis in Parkinsonian brain tissues yielded mixed results. Based on more recent studies in human PD brains as well in animal and cell culture models of the disease, a picture is emerging, however, that strongly suggests that many of the molecular players thought to participate in this type of neuronal cell death (...)
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  21.  18
    Parkinson’s Disease Motor Subtypes Show Different Responses to Long-Term Subthalamic Nucleus Stimulation.Cuiping Xu, Ping Zhuang, Mark Hallett, Yuqing Zhang, Jianyu Li & Yongjie Li - 2018 - Frontiers in Human Neuroscience 12.
  22.  41
    Neural transplants for parkinson’s disease: what are the issues?Roger Barker - 2006 - Poiesis and Praxis 4 (2):129-143.
    Parkinson’s disease (PD) is a common neurodegenerative disorder of the nervous system that affects about 1 in 800 people and for which we have symptomatic but not curative therapies. At the core of the disease is the loss of a specific population of dopaminergic neurons within the brain, and replacement of dopamine through drug therapies has provided clinically significant benefit for many patients. However this therapy only ever offers a temporary amelioration of symptoms and with time this symptomatic (...)
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  23.  35
    Learning to live with Parkinson’s disease in the family unit: an interpretative phenomenological analysis of well-being.Laura J. Smith & Rachel L. Shaw - 2017 - Medicine, Health Care and Philosophy 20 (1):13-21.
    We investigated family members’ lived experience of Parkinson’s disease aiming to investigate opportunities for well-being. A lifeworld-led approach to healthcare was adopted. Interpretative phenomenological analysis was used to explore in-depth interviews with people living with PD and their partners. The analysis generated four themes: It’s more than just an illness revealed the existential challenge of diagnosis; Like a bird with a broken wing emphasizing the need to adapt to increasing immobility through embodied agency; Being together with PD exploring the (...)
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  24.  20
    People With Parkinson’s Disease and Freezing of Gait Show Abnormal Low Frequency Activity of Antagonistic Leg Muscles.Maria-Sophie Breu, Marlieke Schneider, Johannes Klemt, Idil Cebi, Alireza Gharabaghi & Daniel Weiss - 2022 - Frontiers in Human Neuroscience 15.
    ObjectiveFreezing of gait is detrimental to patients with idiopathic Parkinson’s disease. Its pathophysiology represents a multilevel failure of motor processing in the cortical, subcortical, and brainstem circuits, ultimately resulting in ineffective motor output of the spinal pattern generator. Electrophysiological studies pointed to abnormalities of oscillatory activity in freezers that covered a broad frequency range including the theta, alpha, and beta bands. We explored muscular frequency domain activity with respect to freezing, and used deep brain stimulation to modulate these rhythms (...)
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  25.  14
    Differentiation of Parkinson’s disease and Parkinsonism predominant multiple system atrophy in early stage by morphometrics in susceptibility weighted imaging.Qingguo Ren, Yihua Wang, Xiaona Xia, Jianyuan Zhang, Cuiping Zhao & Xiangshui Meng - 2022 - Frontiers in Human Neuroscience 16.
    Background and purposeWe previously established a radiological protocol to discriminate multiple system atrophy-parkinsonian subtype from Parkinson’s disease. However, we do not know if it can differentiate early stage disease. This study aimed to investigate whether the morphological and intensity changes in susceptibility weighted imaging of the lentiform nucleus could discriminate MSA-P from PD at early stages.MethodsWe retrospectively enrolled patients with MSA-P, PD and sex- and age-matched controls whose brain MRI included SWI, between January 2015 and July 2020 at (...)
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  26.  18
    Alienation and Authenticity in Parkinson's Disease and Its Treatment.Philip E. Mosley, Wayne Hall, Cynthia Forlini & Adrian Carter - 2014 - American Journal of Bioethics Neuroscience 5 (4):54-56.
    Why are some patients with Parkinson's disease unhappy about the outcome of deep brain stimulation (DBS)? Meccaci and Haselager (2014) attempt to answer this question by analyzing the seminal case...
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  27.  13
    Multi-Level Ethical Considerations of Artificial Intelligence Health Monitoring for People Living with Parkinson’s Disease.Anita Ho, Itai Bavli, Ravneet Mahal & Martin J. McKeown - forthcoming - AJOB Empirical Bioethics.
    Artificial intelligence (AI) has garnered tremendous attention in health care, and many hope that AI can enhance our health system’s ability to care for people with chronic and degenerative conditions, including Parkinson’s Disease (PD). This paper reports the themes and lessons derived from a qualitative study with people living with PD, family caregivers, and health care providers regarding the ethical dimensions of using AI to monitor, assess, and predict PD symptoms and progression. Thematic analysis identified ethical concerns at four (...)
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  28.  14
    Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation.Nicoló G. Pozzi, Chiara Palmisano, Martin M. Reich, Philip Capetian, Claudio Pacchetti, Jens Volkmann & Ioannis U. Isaias - 2022 - Frontiers in Human Neuroscience 16.
    Deep brain stimulation of the subthalamic nucleus or the globus pallidus is an established treatment for Parkinson’s disease that yields a marked and lasting improvement of motor symptoms. Yet, DBS benefit on gait disturbances in PD is still debated and can be a source of dissatisfaction and poor quality of life. Gait disturbances in PD encompass a variety of clinical manifestations and rely on different pathophysiological bases. While gait disturbances arising years after DBS surgery can be related to (...) progression, early impairment of gait may be secondary to treatable causes and benefits from DBS reprogramming. In this review, we tackle the issue of gait disturbances in PD patients with DBS by discussing their neurophysiological basis, providing a detailed clinical characterization, and proposing a pragmatic programming approach to support their management. (shrink)
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  29.  12
    Early Detection of Parkinson’s Disease by Using SPECT Imaging and Biomarkers.Bhanu Prasad, T. N. Nagabhushan & Gunjan Pahuja - 2019 - Journal of Intelligent Systems 29 (1):1329-1344.
    Precise and timely diagnosis of Parkinson’s disease is important to control its progression among subjects. Currently, a neuroimaging technique called dopaminergic imaging that uses single photon emission computed tomography (SPECT) with 123I-Ioflupane is popular among clinicians for detecting Parkinson’s disease in early stages. Unlike other studies, which consider only low-level features like gray matter, white matter, or cerebrospinal fluid, this study explores the non-linear relation between different biomarkers (SPECT + biological) using deep learning and multivariate logistic regression. Striatal (...)
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  30.  49
    Deep Brain Stimulation for Parkinson’s Disease During the COVID-19 Pandemic: Patient Perspective.Chencheng Zhang, Jing Zhang, Xian Qiu, Yingying Zhang, Zhengyu Lin, Peng Huang, Yixin Pan, Eric A. Storch, Bomin Sun & Dianyou Li - 2021 - Frontiers in Human Neuroscience 15.
    BackgroundPublic health guidelines have recommended that elective medical procedures, including deep brain stimulation surgery for Parkinson’s disease, should not be scheduled during the coronavirus pandemic to prevent further virus spread and overload on health care systems. However, delaying DBS surgery for PD may not be in the best interest of individual patients and is not called for in regions where virus spread is under control and inpatient facilities are not overloaded.MethodsWe administered a newly developed phone questionnaire to 20 consecutive (...)
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  31. Rapid Alleviation of Parkinson’s Disease Symptoms via Electrostimulation of Intrinsic Auricular Muscle Zones.Yusuf O. Cakmak, Hülya Apaydin, Güneş Kiziltan, Ayşegül Gündüz, Burak Ozsoy, Selim Olcer, Hakan Urey, Ozgur O. Cakmak, Yasemin G. Ozdemir & Sibel Ertan - 2017 - Frontiers in Human Neuroscience 11.
  32.  23
    Bradykinesia in Parkinson's disease and cocontraction activity in dystonia are unlikely to be due to adaptive changes in the CNS.A. Berardelli, R. Agostino, A. Currà & M. Manfredi - 1996 - Behavioral and Brain Sciences 19 (1):69-69.
  33.  34
    Animal models of Parkinson's disease.Ranjita Betarbet, Todd B. Sherer & J. Timothy Greenamyre - 2002 - Bioessays 24 (4):308-318.
  34.  17
    Altered Inhibitory Mechanisms in Parkinson’s Disease: Evidence From Lexical Decision and Simple Reaction Time Tasks.Alban Letanneux, Jean-Luc Velay, François Viallet & Serge Pinto - 2021 - Frontiers in Human Neuroscience 15.
    IntroductionAlthough the motor signs of Parkinson’s disease are well defined, nonmotor symptoms, including higher-level language deficits, have also been shown to be frequent in patients with PD. In the present study, we used a lexical decision task to find out whether access to the mental lexicon is impaired in patients with PD, and whether task performance is affected by bradykinesia.Materials and MethodsParticipants were 34 nondemented patients with PD, either without medication or under optimum medication. A total of 19 age-matched (...)
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  35.  19
    Effects of Exercise on Parkinson’s Disease: A Meta-Analysis of Brain Imaging Studies.Jingwen Li, Jian Guo, Weijuan Sun, Jinjin Mei, Yiying Wang, Lihong Zhang, Jianyun Zhang, Jing Gao, Kaiqi Su, Zhuan Lv, Xiaodong Feng & Ruiqing Li - 2022 - Frontiers in Human Neuroscience 16.
    BackgroundExercise is increasingly recognized as a key component of Parkinson’s disease treatment strategies, but the underlying mechanism of how exercise affects PD is not yet fully understood.ObjectiveThe activation likelihood estimation method is used to study the mechanism of exercise affecting PD, providing a theoretical basis for studying exercise and PD, and promoting the health of patients with PD.MethodsRelevant keywords were searched on the PubMed, Cochrane Library, and Web of Science databases. Seven articles were finally included according to the screening (...)
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  36.  23
    Deep Brain Stimulation for Parkinson’s Disease: Why Earlier Use Makes Shared Decision Making Important.Jaime Montemayor, Harini Sarva, Karen Kelly-Blake & Laura Y. Cabrera - 2022 - Neuroethics 15 (2):1-11.
    Introduction As deep brain stimulation (DBS) has shifted to being used earlier during Parkinson’s disease (PD), data is lacking regarding patient specific attitudes, preferences, and factors which may influence the timing of and decision to proceed with DBS in the United States. This study aims to identify and compare attitudes and preferences regarding the earlier use of DBS in Parkinson’s patients who have and have not undergone DBS. Methods We developed an online survey concerning attitudes about DBS and its (...)
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  37.  56
    Mortality of Parkinson's disease by Hoehn–Yahr stage from community‐based and clinic series [Keelung Community‐based Integrated Screening (KCIS) no. 17)].Horng-Huei Liou, Chia-Yun Wu, Yueh-Hsia Chiu, Amy Ming-Fang Yen, Rong-Chi Chen, Ta-Fu Chen, Chih-Chuan Chen, Yuarn-Chung Hwang, Ying-Rong Wen & Tony Hsiu-Hsi Chen - 2009 - Journal of Evaluation in Clinical Practice 15 (4):587-591.
  38.  36
    ‘Woe Betides Anybody Who Tries to Turn me Down.’ A Qualitative Analysis of Neuropsychiatric Symptoms Following Subthalamic Deep Brain Stimulation for Parkinson’s Disease.Philip E. Mosley, Katherine Robinson, Terry Coyne, Peter Silburn, Michael Breakspear & Adrian Carter - 2019 - Neuroethics 14 (1):47-63.
    Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson’s disease can lead to the development of neuropsychiatric symptoms. These can include harmful changes in mood and behaviour that alienate family members and raise ethical questions about personal responsibility for actions committed under stimulation-dependent mental states. Qualitative interviews were conducted with twenty participants following subthalamic DBS at a movement disorders centre, in order to explore the meaning and significance of stimulation-related neuropsychiatric symptoms amongst a purposive sample of (...)
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  39. Impaired peripheral detection mechanisms in Parkinson's disease.A. Weinstein & T. Troscianko - 1996 - In Enrique Villanueva (ed.), Perception. Ridgeview. pp. 142-142.
  40.  31
    The factor structure of the SF‐36 in Parkinson's disease.Pauline Banks & Colin R. Martin - 2009 - Journal of Evaluation in Clinical Practice 15 (3):460-463.
  41.  15
    Sensory Re-weighting for Postural Control in Parkinson’s Disease.Kelly J. Feller, Robert J. Peterka & Fay B. Horak - 2019 - Frontiers in Human Neuroscience 13:437406.
    Postural instability in Parkinson’s disease (PD) is characterized by impaired postural responses to transient perturbations, increased postural sway in stance and difficulty transitioning between tasks. In addition, some studies suggest that loss of dopamine in the basal ganglia due to PD results in difficulty using proprioceptive information for motor control. Here, we quantify the ability of subjects with PD and age-matched control subjects to use and re-weight sensory information for postural control during steady-state conditions of continuous rotations of the (...)
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  42.  56
    Subthalamic high-beta oscillation informs the outcome of deep brain stimulation in patients with Parkinson's disease.Po-Lin Chen, Yi-Chieh Chen, Po-Hsun Tu, Tzu-Chi Liu, Min-Chi Chen, Hau-Tieng Wu, Mun-Chun Yeap, Chih-Hua Yeh, Chin-Song Lu & Chiung-Chu Chen - 2022 - Frontiers in Human Neuroscience 16:958521.
    BackgroundThe therapeutic effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD) is related to the modulation of pathological neural activities, particularly the synchronization in the β band (13–35 Hz). However, whether the local β activity in the STN region can directly predict the stimulation outcome remains unclear.ObjectiveWe tested the hypothesis that low-β (13–20 Hz) and/or high-β (20–35 Hz) band activities recorded from the STN region can predict DBS efficacy.MethodsLocal field potentials (LFPs) were (...)
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  43.  12
    Perceptions on using surplus embryos for the treatment of Parkinson’s disease among the Swedish population: a qualitative study.Jennifer Drevin & Åsa Grauman - 2022 - BMC Medical Ethics 23 (1):1-9.
    BackgroundHuman embryonic stem cells are currently used for developing treatment against Parkinson’s disease (PD). However, the use of ES cells is surrounded with moral concerns. Research regarding the public's attitudes can form an important basis for policymaking. The aim was to explore the perceptions of the public on using donated human embryos for developing treatment of Parkinson’s Disease.MethodsSemi-structured individual qualitative interviews were conducted with 11 members of the general population in Sweden. Interviews were analyzed with thematic content analyses.ResultsFour (...)
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  44.  20
    Sham Neurosurgery in Parkinson's Disease: Ethical at the Time.John C. Fletcher - 2003 - American Journal of Bioethics 3 (4):54-56.
  45.  33
    Event-based prospective memory in patients with Parkinson’s disease: the effect of emotional valence.G. Mioni, L. Meligrana, P. G. Rendell, L. Bartolomei, F. Perini & F. Stablum - 2015 - Frontiers in Human Neuroscience 9:147807.
    The present study investigated the effect of Parkinson’s disease (PD) on prospective memory (PM) tasks by varying the emotional content of the PM actions. Twenty-one older adults with PD and 25 healthy older adults took part in the present study. Participants performed three virtual days in the Virtual Week task. On each virtual day, participants performed actions with positive, negative or neutral content. Immediately following each virtual day, participants completed a recognition task to assess their retrospective memory for the (...)
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  46.  27
    Emotional processing in Parkinson’s disease and schizophrenia: evidence for response bias deficits in PD.Ilona P. Laskowska, Ludwika Gawryś, Szymon Łęski & Dariusz Koziorowski - 2015 - Frontiers in Psychology 6.
  47.  17
    Abnormal Phase Coupling in Parkinson’s Disease and Normalization Effects of Subthreshold Vestibular Stimulation.Soojin Lee, Aiping Liu, Z. Jane Wang & Martin J. McKeown - 2019 - Frontiers in Human Neuroscience 13.
  48.  53
    Programming of subthalamic nucleus deep brain stimulation for Parkinson’s disease with sweet spot-guided parameter suggestions.Simon Nordenström, Katrin Petermann, Ines Debove, Andreas Nowacki, Paul Krack, Claudio Pollo & T. A. Khoa Nguyen - 2022 - Frontiers in Human Neuroscience 16:925283.
    Deep Brain Stimulation (DBS) is an effective treatment for advanced Parkinson’s disease. However, identifying stimulation parameters, such as contact and current amplitudes, is time-consuming based on trial and error. Directional leads add more stimulation options and render this process more challenging with a higher workload for neurologists and more discomfort for patients. In this study, a sweet spot-guided algorithm was developed that automatically suggested stimulation parameters. These suggestions were retrospectively compared to clinical monopolar reviews. A cohort of 24 Parkinson’s (...)
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  49.  25
    Ethical concerns around privacy and data security in AI health monitoring for Parkinson’s disease: insights from patients, family members, and healthcare professionals.Itai Bavli, Anita Ho, Ravneet Mahal & Martin J. McKeown - forthcoming - AI and Society:1-11.
    Artificial intelligence (AI) technologies in medicine are gradually changing biomedical research and patient care. High expectations and promises from novel AI applications aiming to positively impact society raise new ethical considerations for patients and caregivers who use these technologies. Based on a qualitative content analysis of semi-structured interviews and focus groups with healthcare professionals (HCPs), patients, and family members of patients with Parkinson’s Disease (PD), the present study investigates participant views on the comparative benefits and problems of using human (...)
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  50.  18
    Cognitive Impairment in Parkinson’s Disease Is Reflected with Gradual Decrease of EEG Delta Responses during Auditory Discrimination.Bahar Güntekin, Lütfü Hanoğlu, Dilan Güner, Nesrin H. Yılmaz, Fadime Çadırcı, Nagihan Mantar, Tuba Aktürk, Derya D. Emek-Savaş, Fahriye F. Özer, Görsev Yener & Erol Başar - 2018 - Frontiers in Psychology 9.
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