Results for 'P. S. P. Genetics Study Group'

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  1.  96
    Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.Günter U. Höglinger, Nadine M. Melhem, Dennis W. Dickson, Patrick M. A. Sleiman, Li-San Wang, Lambertus Klei, Rosa Rademakers, Rohan de Silva, Irene Litvan, David E. Riley, John C. van Swieten, Peter Heutink, Zbigniew K. Wszolek, Ryan J. Uitti, Jana Vandrovcova, Howard I. Hurtig, Rachel G. Gross, Walter Maetzler, Stefano Goldwurm, Eduardo Tolosa, Barbara Borroni, Pau Pastor, P. S. P. Genetics Study Group, Laura B. Cantwell, Mi Ryung Han, Allissa Dillman, Marcel P. van der Brug, J. Raphael Gibbs, Mark R. Cookson, Dena G. Hernandez, Andrew B. Singleton, Matthew J. Farrer, Chang-En Yu, Lawrence I. Golbe, Tamas Revesz, John Hardy, Andrew J. Lees, Bernie Devlin, Hakon Hakonarson, Ulrich Müller & Gerard D. Schellenberg - unknown
    Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for (...)
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  2.  73
    Seeking consent to genetic and genomic research in a rural Ghanaian setting: a qualitative study of the MalariaGEN experience. [REVIEW]P. Tindana, S. Bull, L. Amenga-Etego, J. Vries, R. Aborigo, K. Koram, D. Kwiatkowski & M. Parker - 2012 - BMC Medical Ethics 13 (1):15-15.
    Seeking consent for genetic and genomic research can be challenging, particularly in populations with low literacy levels, and in emergency situations. All of these factors were relevant to the MalariaGEN study of genetic factors influencing immune responses to malaria in northern rural Ghana. This study sought to identify issues arising in practice during the enrolment of paediatric cases with severe malaria and matched healthy controls into the MalariaGEN study.
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  3. Managing Incidental Findings in Human Subjects Research: Analysis and Recommendations.Susan M. Wolf, Frances P. Lawrenz, Charles A. Nelson, Jeffrey P. Kahn, Mildred K. Cho, Ellen Wright Clayton, Joel G. Fletcher, Michael K. Georgieff, Dale Hammerschmidt, Kathy Hudson, Judy Illes, Vivek Kapur, Moira A. Keane, Barbara A. Koenig, Bonnie S. LeRoy, Elizabeth G. McFarland, Jordan Paradise, Lisa S. Parker, Sharon F. Terry, Brian Van Ness & Benjamin S. Wilfond - 2008 - Journal of Law, Medicine and Ethics 36 (2):219-248.
    No consensus yet exists on how to handle incidental fnd-ings in human subjects research. Yet empirical studies document IFs in a wide range of research studies, where IFs are fndings beyond the aims of the study that are of potential health or reproductive importance to the individual research participant. This paper reports recommendations of a two-year project group funded by NIH to study how to manage IFs in genetic and genomic research, as well as imaging research. We (...)
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  4.  19
    A chromosome bin map of 2148 expressed sequence tag loci of wheat homoeologous group 7.K. G. Hossain, V. Kalavacharla, G. R. Lazo, J. Hegstad, M. J. Wentz, P. M. A. Kianian, K. Simons, S. Gehlhar, J. L. Rust, R. R. Syamala, K. Obeori, S. Bhamidimarri, P. Karunadharma, S. Chao, O. D. Anderson, L. L. Qi, B. Echalier, B. S. Gill, A. M. Linkiewicz, A. Ratnasiri, J. Dubcovsky, E. D. Akhunov, J. Dvořák, Miftahudin, K. Ross, J. P. Gustafson, H. S. Radhawa, M. Dilbirligi, K. S. Gill, J. H. Peng, N. L. V. Lapitan, R. A. Greene, C. E. Bermudez-Kandianis, M. E. Sorrells, O. Feril, M. S. Pathan, H. T. Nguyen, J. L. Gonzalez-Hernandez, E. J. Conley, J. A. Anderson, D. W. Choi, D. Fenton, T. J. Close, P. E. McGuire, C. O. Qualset & S. F. Kianian - unknown
    The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level (...)
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  5.  20
    Group 3 chromosome bin maps of wheat and their relationship to rice chromosome 1.J. D. Munkvold, R. A. Greene, C. E. Bermudez-Kandianis, C. M. La Rota, H. Edwards, S. F. Sorrells, T. Dake, D. Benscher, R. Kantety, A. M. Linkiewicz, J. Dubcovsky, E. D. Akhunov, J. Dvořák, Miftahudin, J. P. Gustafson, M. S. Pathan, H. T. Nguyen, D. E. Matthews, S. Chao, G. R. Lazo, D. D. Hummel, O. D. Anderson, J. A. Anderson, J. L. Gonzalez-Hernandez, J. H. Peng, N. Lapitan, L. L. Qi, B. Echalier, B. S. Gill, K. G. Hossain, V. Kalavacharla, S. F. Kianian, D. Sandhu, M. Erayman, K. S. Gill, P. E. McGuire, C. O. Qualset & M. E. Sorrells - unknown
    The focus of this study was to analyze the content, distribution, and comparative genome relationships of 996 chromosome bin-mapped expressed sequence tags accounting for 2266 restriction fragments on the homoeologous group 3 chromosomes of hexaploid wheat. Of these loci, 634, 884, and 748 were mapped on chromosomes 3A, 3B, and 3D, respectively. The individual chromosome bin maps revealed bins with a high density of mapped ESTs in the distal region and bins of low density in the proximal region (...)
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  6.  33
    A Rationale in Support of Uncontrolled Donation after Circulatory Determination of Death.Kevin G. Munjal, Stephen P. Wall, Lewis R. Goldfrank, Alexander Gilbert, Bradley J. Kaufman & on Behalf of the New York City Udcdd Study Group Nancy N. Dubler - 2012 - Hastings Center Report 43 (1):19-26.
    Most donated organs in the United States come from brain dead donors, while a small percentage come from patients who die in “controlled,” or expected, circumstances, typically after the family or surrogate makes a decision to withdraw life support. The number of organs available for transplant could be substantially if donations were permitted in “uncontrolled” circumstances–that is, from people who die unexpectedly, often outside the hospital. According to projections from the Institute of Medicine, establishing programs permitting “uncontrolled donation after circulatory (...)
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  7.  71
    The view of Hong Kong parents on secondary use of dried blood spots in newborn screening program.L. L. Hui, E. A. S. Nelson, H. B. Deng, T. Y. Leung, C. H. Ho, J. S. C. Chong, G. P. G. Fung, J. Hui & H. S. Lam - 2022 - BMC Medical Ethics 23 (1):1-10.
    Background Residual dried blood spots (rDBS) from newborn screening programmes represent a valuable resource for medical research, from basic sciences, through clinical to public health. In Hong Kong, there is no legislation for biobanking. Parents’ view on the retention and use of residual newborn blood samples could be cultural-specific and is important to consider for biobanking of rDBS. Objective To study the views and concerns on long-term storage and secondary use of rDBS from newborn screening programmes among Hong Kong (...)
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  8.  16
    Railing Against Realism: Philosophy and To The Lighthouse.S. P. Rosenbaum - 1983 - Philosophy and Literature 7 (1):89-91.
    In lieu of an abstract, here is a brief excerpt of the content:Notes and Fragments RAILING AGAINST REALISM: PHILOSOPHY AND TO THE LIGHTHOUSE by S. P. ROSENBAUM The argument of Graheim Parkes's "Imagining Reality in To the Lighthouse" is described by its author as "a railing against the realist position" (p. 35) as he understands it primarily in my article "The Philosophical Reedism ofVirginia Woolf." ' Apart from the question of whemer railing is a useful way of conducting an inquiry (...)
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  9.  57
    Analysis of expressed sequence tag loci on wheat chromosome group 4. Miftahudin, K. Ross, X. -F. Ma, A. A. Mahmoud, J. Layton, M. A. Rodriguez Milla, T. Chikmawati, J. Ramalingam, O. Feril, M. S. Pathan, G. Surlan Momirovic, S. Kim, K. Chema, P. Fang, L. Haule, H. Struxness, J. Birkes, C. Yaghoubian, R. Skinner, J. McAllister, V. Nguyen, L. L. Qi, B. Echalier, B. S. Gill, A. M. Linkiewicz, J. Dubcovsky, E. D. Akhunov, J. Dvořák, M. Dilbirligi, K. S. Gill, J. H. Peng, N. L. V. Lapitan, C. E. Bermudez-Kandianis, M. E. Sorrells, K. G. Hossain, V. Kalavacharla, S. F. Kianian, G. R. Lazo, S. Chao, O. D. Anderson, J. Gonzalez-Hernandez, E. J. Conley, J. A. Anderson, D. -W. Choi, R. D. Fenton, T. J. Close, P. E. McGuire, C. O. Qualset, H. T. Nguyen & J. P. Gustafson - unknown
    A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, (...)
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  10.  30
    Description and Prescription in Linguistic Ethics.P. S. Wadia - 1964 - Philosophical Studies (Dublin) 13:66-73.
    IN this note I propose to make some general remarks concerning the analytical forays carried out into moral discourse by some leading figures in the modern ‘linguistic’ tradition. The philosophers I am going to speak of, may all be said to be attempting some sort of ‘descriptive’ analysis, but my thesis is that philosophers such as Toulmin and Baier are attempting something that is significantly different from what a philosopher such as Nowell-Smith is attempting. I will suggest, in the following (...)
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  11. Philosophy of Science: Part II, A Study of the Division and Nature of Various Groups of Sciences. [REVIEW]S. P. - 1964 - Review of Metaphysics 17 (3):482-483.
    The purpose of this text is to fill a "gap" in college courses or independent study. "Science" is here understood in a broad sense, so that theology and philosophy, as well as physical, human and cultural sciences, fall under the term. The book is an attempt to determine the limits and interconnections of the various sciences. The author's analysis does not seem to fit his intention, because it is either too sketchy to provide a beginner with much insight, or (...)
     
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  12.  15
    The Cultural Production of Everyday Ethics in Two University STEM Labs.Eric P. S. Baumer, Olivia Lee, Isabel Barone, Amin Hosseiny Marani, Adam Heidebrink-Bruno & Allison Mickel - 2023 - Bulletin of Science, Technology and Society 43 (1-2):3-17.
    How do ethics show up in the everyday behaviors and conversations of researchers in a scientific laboratory? How does the microcosmic culture of the laboratory shape researchers’ understandings of scientific ethics? We, an interdisciplinary team representing anthropology, computer science, and rhetorical studies, investigated these questions in two university STEM labs. Similar to previous work mapping out the epistemic cultures, we sought to understand the ethical cultures of these research groups. We observed their lab meetings for several months and conducted interviews (...)
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  13.  20
    A 2600-locus chromosome bin map of wheat homoeologous group 2 reveals interstitial gene-rich islands and colinearity with rice. [REVIEW]E. J. Conley, V. Nduati, J. L. Gonzalez-Hernandez, A. Mesfin, M. Trudeau-Spanjers, S. Chao, G. R. Lazo, D. D. Hummel, O. D. Anderson, L. L. Qi, B. S. Gill, B. Echalier, A. M. Linkiewicz, J. Dubcovsky, E. D. Akhunov, J. Dvořák, J. H. Peng, N. L. V. Lapitan, M. S. Pathan, H. T. Nguyen, X. -F. Ma, Miftahudin, J. P. Gustafson, R. A. Greene, M. E. Sorrells, K. G. Hossain, V. Kalavacharla, S. F. Kianian, D. Sidhu, M. Dilbirligi, K. S. Gill, D. W. Choi, R. D. Fenton, T. J. Close, P. E. McGuire, C. O. Qualset & J. A. Anderson - unknown
    The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the (...)
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  14.  11
    The evolution of mating‐type switching for reproductive assurance.Bart P. S. Nieuwenhuis & Simone Immler - 2016 - Bioessays 38 (11):1141-1149.
    Alternative ways to ensure mate compatibility, such as hermaphroditism and the breakdown of self‐incompatibility, evolved repeatedly when finding a mating partner is difficult. In a variety of microorganisms where compatibility is determined by mating‐types, a highly regulated form of universal compatibility system called mating‐type switching has evolved several times. This sophisticated system allows for the genetic adjustment of the mating type during asexual growth, and it most likely evolved for reproductive assurance of immotile species under low densities. In this review, (...)
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  15. Changes in Physical Activity and Depressive Symptoms During COVID-19 Lockdown: United States Adult Age Groups.Amy Chan Hyung Kim, James Du & Damon P. S. Andrew - 2022 - Frontiers in Psychology 13.
    This study investigates: the changes in three major health-related factors—physical activity, non-physical-activity health behavior, and depressive symptoms, and how changes in physical activity were associated with changes in one’s depressive symptoms among young adults, middle-aged adults, and older adults while controlling non-physical-activity health behavior and sociodemographic characteristics among young, middle-aged, and older adults before and after the COVID-19 outbreak lockdown in the United States. A total of 695 participants completed an online questionnaire via MTurk, and participants were asked to (...)
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  16.  28
    Ethical Principles, Process, and the Work of Bioethics Commissions.Daniel P. Sulmasy - 2017 - Hastings Center Report 47 (S1):50-53.
    Shortly after the Presidential Commission for the Study of Bioethical Issues was constituted in 2010 and days before the commission members were to join a conference call to discuss possible topics for their deliberation, Craig Venter held a press conference announcing that his lab had created a synthetic chromosome for a species of mycoplasma and had inserted this genetic material into organisms of another species of mycoplasma (the genes of which had been deactivated), transforming the host species into the (...)
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  17.  22
    Human Genetics Studies: The Case for Group Rights.Laura S. Underkuffler - 2007 - Journal of Law, Medicine and Ethics 35 (3):383-395.
    During the past 20 years, the importance of human genetic information has exploded. Whether sought for medical treatment, disease prediction studies, cultural studies, or the general study of human origins, human genetic information is now viewed as crucial for scientific research and general attempts at human understanding.With the importance of genetic information have come bitter battles over its control. The demonstrated power of human genetic information has moved the issue of its “ownership” from the realm of musty academic musings (...)
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  18.  21
    Human Genetics Studies: The Case for Group Rights.Laura S. Underkuffler - 2007 - Journal of Law, Medicine and Ethics 35 (3):383-395.
    In this essay, the author focuses on an underlying theoretical issue which she believes seriously affects our collective response to the idea of group rights in the genetic-control context. That issue is to what extent are our responses to claims of group rights hampered by our bringing to the table a model which is structured to acknowledge only individual concerns? Put another way, to what extent are our objections to group rights in this context a product of (...)
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  19.  30
    Dobzhansky and Dreyfus’s Group: The Introduction of Natural Population Genetics Studies in Brazil (1943–1960).José Franco Monte Sião & Lilian Al-Chueyr Pereira Martins - 2020 - Perspectives on Science 28 (2):244-276.
    An important center in which genetic research started and was carried out in Brazil during the 20thcentury was situated at the Faculty of Philosophy, Sciences and Linguistics of the University of São Paulo, led by André Dreyfus (1897–1952). Beginning in 1943, the Ukrainian geneticist Theodosius Dobzhansky (1900–1975) visited Dreyfus’s group four times. This paper evaluates the impact of Dobzhansky’s visits on the studies of genetics and evolution developed by the members of Dreyfus’s group during the 1940s and (...)
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  20.  41
    The acceptability among French lay persons of ending the lives of damaged newborns.N. Teisseyre, I. D. dos Reis, P. C. Sorum & E. Mullet - 2009 - Journal of Medical Ethics 35 (11):701-708.
    Background: Lay persons’ judgements of the acceptability of the not uncommon practice of ending the life of a damaged neonate have not been studied. Methods: A convenience sample of 1635 lay people in France rated how acceptable it would be for a physician to end a neonate’s life—by withholding care, withdrawing care, or active euthanasia—in 54 scenarios in which the neonate was diagnosed either with perinatal asphyxia or a genetic abnormality. The scenarios were all combinations of four factors: three levels (...)
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  21.  50
    Changes in Students’ Views about Nature of Scientific Inquiry at a Science Camp.G. Leblebicioglu, D. Metin, E. Capkinoglu, P. S. Cetin, E. Eroglu Dogan & R. Schwartz - 2017 - Science & Education 26 (7-9):889-917.
    Although nature of science and nature of scientific inquiry are related to each other, they are differentiated as NOS is being more related to the product of scientific inquiry which is scientific knowledge whereas NOSI is more related to the process of SI. Lederman et al. determined eight NOSI aspects for K-16 context. In this study, a science camp was conducted to teach scientific inquiry and NOSI to 24 6th and 7th graders. The core of the program was guided (...)
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  22. Ethical reasoning in mixed nurse-physician groups.S. Holm, P. Gjersoe, G. Grode, O. Hartling, K. E. Ibsen & H. Marcussen - 1996 - Journal of Medical Ethics 22 (3):168-173.
    OBJECTIVES: To study the ethical reasoning of nurses and physicians, and to assess whether or not modified focus groups are a valuable tool for this purpose. DESIGN: Discussion of cases in modified focus groups, each consisting of three physicians and three nurses. The discussion was taped and analysed by content analysis. SETTING: Five departments of internal medicine at Danish hospitals. SAMPLE: Seven discussion groups. MAIN MEASUREMENTS: Ethical content of statements, style of statements, time used by each participant. RESULTS: Danish (...)
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  23.  20
    The Double-Edged Helix: Social Implications of Genetics in a Diverse Society.Joseph S. Alper, Catherine Ard, Adrienne Asch, Peter Conrad, Jon Beckwith, American Cancer Society Research Professor of Microbiology and Molecular Genetics Jon Beckwith, Harry Coplan Professor of Social Sciences Peter Conrad & Lisa N. Geller - 2002
    The rapidly changing field of genetics affects society through advances in health-care and through implications of genetic research. This study addresses the impacts of new genetic discoveries and technologies on different segments of today's society. The book begins with a chapter on genetic complexity, and subsequent chapters discuss moral and ethical questions arising from today's genetics from the perspectives of health care professionals, the media, the general public, special interest groups and commercial interests.
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  24. Recruiting and Educating Participants for Enrollment in HIV-Vaccine Research: Ethical Implications of the Results of an Empirical Investigation.S. Sifunda, P. Reddy, N. Naidoo, S. James & D. Buchanan - 2014 - Public Health Ethics 7 (1):78-85.
    The study reports on the results of an empirical investigation of the education and recruitment processes used in HIV vaccine trials conducted in South Africa. Interviews were conducted with 21 key informants involved in HIV vaccine research in South Africa and three focus groups of community advisory board members. Data analysis identified seven major themes on the relationship between education and recruitment: the process of recruitment, the combined dual role of educators and recruiters, conflicts perceived by field staff, pressure (...)
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  25.  25
    Exploring the Gray Area: Similarities and Differences in Questionable Research Practices (QRPs) Across Main Areas of Research.Mads P. Sørensen & Tine Ravn - 2021 - Science and Engineering Ethics 27 (4):1-33.
    This paper explores the gray area of questionable research practices (QRPs) between responsible conduct of research and severe research misconduct in the form of fabrication, falsification, and plagiarism (Steneck in SEE 12(1): 53–57, 2006). Up until now, we have had very little knowledge of disciplinary similarities and differences in QRPs. The paper is the first systematic account of variances and similarities. It reports on the findings of a comprehensive study comprising 22 focus groups on practices and perceptions of QRPs (...)
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  26.  11
    Toward Pleomorphic Reconfigurable Robots for Optimum Coverage.S. M. Bhagya P. Samarakoon, M. A. Viraj J. Muthugala, Mohan R. Elara & Selva Kumaran - 2021 - Complexity 2021:1-10.
    Buildings are constructed for accommodating living and industrial needs. Floor cleaning robots have been developed to cater to the demand of these buildings. Area coverage and coverage time are crucial performance factors of a floor cleaning robot. Reconfigurable tiling robots have been introduced over fixed shape robots to improve area coverage in floor cleaning applications compared to robots with fixed morphologies. However, area coverage and coverage time of a tiling robot compromised one another. This study proposes a novel concept (...)
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  27.  37
    Are you sure about that? Eliciting confidence ratings may influence performance on Raven's progressive matrices.Kit S. Double & Damian P. Birney - 2017 - Thinking and Reasoning 23 (2):190-206.
    Confidence ratings have often been integrated into reasoning and intelligence tasks as a means for assessing meta-reasoning processes. Although it is often assumed that eliciting these judgements throughout reasoning tasks has no effect on the underlying performance outcomes, this is yet to be established empirically. The current study examines whether eliciting CR from participants during a fluid-reasoning task influences their performance and how this effect is moderated by their initial self-confidence in their own reasoning abilities. In a first experiment, (...)
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  28.  59
    Can the written information to research subjects be improved?--an empirical study.E. Bjorn, P. Rossel & S. Holm - 1999 - Journal of Medical Ethics 25 (3):263-267.
    OBJECTIVES: To study whether linguistic analysis and changes in information leaflets can improve readability and understanding. DESIGN: Randomised, controlled study. Two information leaflets concerned with trials of drugs for conditions/diseases which are commonly known were modified, and the original was tested against the revised version. SETTING: Denmark. PARTICIPANTS: 235 persons in the relevant age groups. MAIN MEASURES: Readability and understanding of contents. RESULTS: Both readability and understanding of contents was improved: readability with regard to both information leaflets and (...)
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  29.  13
    Vincristine pharmacokinetics and response to vincristine monotherapy in an up-front window study of the Dutch Childhood Leukaemia Study Group.E. Groninger, T. De Boer, P. Koopmans, D. Uges, W. Sluiter, A. J. P. Veerman, W. A. Kamps & S. De Graaf - unknown
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  30.  56
    Neurotrauma and the rule of rescue.S. Honeybul, G. R. Gillett, K. M. Ho & C. R. P. Lind - 2011 - Journal of Medical Ethics 37 (12):707-710.
    The rule of rescue describes the powerful human proclivity to rescue identified endangered lives, regardless of cost or risk. Deciding whether or not to perform a decompressive craniectomy as a life-saving or ‘rescue’ procedure for a young person with a severe traumatic brain injury provides a good example of the ethical tensions that occur in these situations. Unfortunately, there comes a point when the primary brain injury is so severe that if the patient survives they are likely to remain severely (...)
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  31.  65
    Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases. [REVIEW]Brian T. Helfand, Kimberly A. Roehl, Phillip R. Cooper, Barry B. McGuire, Liesel M. Fitzgerald, Geraldine Cancel-Tassin, Jean-Nicolas Cornu, Scott Bauer, Erin L. Van Blarigan, Xin Chen, David Duggan, Elaine A. Ostrander, Mary Gwo-Shu, Zuo-Feng Zhang, Shen-Chih Chang, Somee Jeong, Elizabeth T. H. Fontham, Gary Smith, James L. Mohler, Sonja I. Berndt, Shannon K. McDonnell, Rick Kittles, Benjamin A. Rybicki, Matthew Freedman, Philip W. Kantoff, Mark Pomerantz, Joan P. Breyer, Jeffrey R. Smith, Timothy R. Rebbeck, Dan Mercola, William B. Isaacs, Fredrick Wiklund, Olivier Cussenot, Stephen N. Thibodeau, Daniel J. Schaid, Lisa Cannon-Albright, Kathleen A. Cooney, Stephen J. Chanock, Janet L. Stanford, June M. Chan, John Witte, Jianfeng Xu, Jeannette T. Bensen, Jack A. Taylor & William J. Catalona - unknown
    © 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare (...)
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  32.  21
    Deletion mapping of homoeologous group 6-specific wheat expressed sequence tags.H. S. Randhawa, M. Dilbirligi, D. Sidhu, M. Erayman, D. Sandhu, S. Bondareva, S. Chao, G. R. Lazo, O. D. Anderson, Miftahudin, J. P. Gustafson, B. Echalier, L. L. Qi, B. S. Gill, E. D. Akhunov, J. Dvořák, A. M. Linkiewicz, A. Ratnasiri, J. Dubcovsky, C. E. Bermudez-Kandianis, R. A. Greene, M. E. Sorrells, E. J. Conley, J. A. Anderson, J. H. Peng, N. L. V. Lapitan, K. G. Hossain, V. Kalavacharla, S. F. Kianian, M. S. Pathan, H. T. Nguyen, T. R. Endo, T. J. Close, P. E. McGuire, C. O. Qualset & K. S. Gill - unknown
    To localize wheat ESTs on chromosomes, 882 homoeologous group 6-specific ESTs were identified by physically mapping 7965 singletons from 37 cDNA libraries on 146 chromosome, arm, and sub-arm aneuploid and deletion stocks. The 882 ESTs were physically mapped to 25 regions flanked by 23 deletion breakpoints. Of the 5154 restriction fragments detected by 882 ESTs, 2043 were localized to group 6 chromosomes and 806 were mapped on other chromosome groups. The number of loci mapped was greatest on chromosome (...)
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  33.  27
    Treatment of depression in the elderly with repetitive transcranial magnetic stimulation using theta-burst stimulation: Study protocol for a randomized, double-blind, controlled trial.Leandro Valiengo, Bianca S. Pinto, Kalian A. P. Marinho, Leonardo A. Santos, Luara C. Tort, Rafael G. Benatti, Bruna B. Teixeira, Cristiane S. Miranda, Henriette B. Cardeal, Paulo J. C. Suen, Julia C. Loureiro, Renata A. R. Vaughan, Roberta A. M. P. F. Dini Mattar, Maíra Lessa, Pedro S. Oliveira, Valquíria A. Silva, Wagner Farid Gattaz, André R. Brunoni & Orestes Vicente Forlenza - 2022 - Frontiers in Human Neuroscience 16.
    IntroductionTranscranial magnetic stimulation is a consolidated procedure for the treatment of depression, with several meta-analyses demonstrating its efficacy. Theta-burst stimulation is a modification of TMS with similar efficacy and shorter session duration. The geriatric population has many comorbidities and a high prevalence of depression, but few clinical trials are conducted specifically for this age group. TBS could be an option in this population, offering the advantages of few side effects and no pharmacological interactions. Therefore, our aim is to investigate (...)
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  34.  17
    Mitochondrial uncoupling proteins regulate angiotensin‐converting enzyme expression: crosstalk between cellular and endocrine metabolic regulators suggested by RNA interference and genetic studies.Sukhbir S. Dhamrait, Cecilia Maubaret, Ulrik Pedersen-Bjergaard, David J. Brull, Peter Gohlke, John R. Payne, Michael World, Birger Thorsteinsson, Steve E. Humphries & Hugh E. Montgomery - 2016 - Bioessays 38 (S1):107-118.
    Uncoupling proteins (UCPs) regulate mitochondrial function, and thus cellular metabolism. Angiotensin‐converting enzyme (ACE) is the central component of endocrine and local tissue renin–angiotensin systems (RAS), which also regulate diverse aspects of whole‐body metabolism and mitochondrial function (partly through altering mitochondrial UCP expression). We show that ACE expression also appears to be regulated by mitochondrial UCPs. In genetic analysis of two unrelated populations (healthy young UK men and Scandinavian diabetic patients) serum ACE (sACE) activity was significantly higher amongst UCP3‐55C (rather than (...)
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  35.  47
    Vulnerability in palliative care research: findings from a qualitative study of black Caribbean and white British patients with advanced cancer.J. Koffman, M. Morgan, P. Edmonds, P. Speck & I. J. Higginson - 2009 - Journal of Medical Ethics 35 (7):440-444.
    Introduction: Vulnerability is a poorly understood concept in research ethics, often aligned to autonomy and consent. A recent addition to the literature represents a taxonomy of vulnerability developed by Kipnis, but this refers to the conduct of clinical trials rather than qualitative research, which may raise different issues. Aim: To examine issues of vulnerability in cancer and palliative care research obtained through qualitative interviews. Method: Secondary analysis of qualitative data from 26 black Caribbean and 19 white British patients with advanced (...)
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  36.  35
    "Do-not-resuscitate" orders in patients with cancer at a children's hospital in Taiwan.T. -H. Jaing, P. -K. Tsay, E. -C. Fang, S. -H. Yang, S. -H. Chen, C. -P. Yang & I. -J. Hung - 2007 - Journal of Medical Ethics 33 (4):194-196.
    Objectives: To quantify the use of do-not-resuscitate orders in a tertiary-care children’s hospital and to characterise the circumstances in which such orders are written.Design: Retrospective study conducted in a 500-bed children’s hospital in Taiwan.Patients: The course of 101 patients who died between January 2002 and December 2005 was reviewed. The following data were collected: age at death, gender, disease and its status, place of death and survival. There were 59 males and 42 females with a median age of 103 (...)
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  37.  29
    The Effects of Environmental Factors on the Behavior of Chinese Managers in the Information Age in China.Wing S. Chow, Jane P. Wu & Allan K. K. Chan - 2009 - Journal of Business Ethics 89 (4):629-639.
    This paper examines the effects of environmental factors on the ethical behavior of managers using computers at work in Mainland China. In this study, environmental factors refer to senior management, peer groups, company policies, professional practices, and legal considerations. Ethical behaviors include attitudes to disclosure, protection of privacy, conflict of interest, personal conduct, social responsibility, and integrity. A questionnaire survey was used for data collection, and 125 mainland Chinese managers participated in the study. The results show that peer (...)
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  38.  68
    Making decisions for hospitalized older adults: ethical factors considered by family surrogates.J. Fritsch, S. Petronio, P. R. Helft & A. M. Torke - 2013 - Journal of Clinical Ethics 24 (2):125-134.
    BackgroundHospitalized older adults frequently have impaired cognition and must rely on surrogates to make major medical decisions. Ethical standards for surrogate decision making are well delineated, but little is known about what factors surrogates actually consider when making decisions.ObjectivesTo determine factors surrogate decision makers consider when making major medical decisions for hospitalized older adults, and whether or not they adhere to established ethical standards.DesignSemi-structured interview study of the experience and process of decision making.SettingA public safety-net hospital and a tertiary (...)
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  39.  9
    Athletes’ religiosity: How it plays a role in athletes’ anxiety and life satisfaction.Tri S. Guntoro & Miftah F. P. Putra - 2022 - HTS Theological Studies 78 (1):8.
    Many studies related to religious and sports issues have been carried out. However, there are limited studies, especially those related to religiosity, anxiety and life satisfaction. To cope with this situation, this study aims to: (1) assess the religiosity, anxiety and life satisfaction of athletes; (2) determine the role of gender and the type of sport in those constructs and (3) establish the correlations between the constructs. The study involved 244 elite athletes from Papua province of Indonesia, with (...)
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  40.  17
    Top 10 health care ethics challenges facing the public: views of Toronto bioethicists.J. Breslin, S. MacRae, J. Bell & P. Singer - 2005 - BMC Medical Ethics 6 (1).
    BackgroundThere are numerous ethical challenges that can impact patients and families in the health care setting. This paper reports on the results of a study conducted with a panel of clinical bioethicists in Toronto, Ontario, Canada, the purpose of which was to identify the top ethical challenges facing patients and their families in health care. A modified Delphi study was conducted with twelve clinical bioethicist members of the Clinical Ethics Group of the University of Toronto Joint Centre (...)
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  41.  34
    Family and community concerns about post-mortem needle biopsies in a Muslim society.Emily S. Gurley, Shahana Parveen, M. Saiful Islam, M. Jahangir Hossain, Nazmun Nahar, Nusrat Homaira, Rebeca Sultana, James J. Sejvar, Mahmudur Rahman & Stephen P. Luby - 2011 - BMC Medical Ethics 12 (1):10.
    Background: Post-mortem needle biopsies have been used in resource-poor settings to determine cause of death and there is interest in using them in Bangladesh. However, we did not know how families and communities would perceive this procedure or how they would decide whether or not to consent to a post-mortem needle biopsy. The goal of this study was to better understand family and community concerns and decision-making about post-mortem needle biopsies in this low-income, predominantly Muslim country in order to (...)
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  42.  45
    Pragmatism and Developmentalism in Brazilian Educational Thought in the 1950s/1960.Ana Waleska P. C. Mendonça, Libânia Nacif Xavier, Vera Lucia Alves Breglia, Miriam Waidenfeld Chaves, Maria Teresa Cavalcanti de Oliveira, Cecília Neves Lima & Pablo S. M. Bispo Dos Santos - 2005 - Studies in Philosophy and Education 24 (6):471-498.
    This article proposes to analyse some aspects of the appropriation of New School thinking in Brazil, particularly Deweyan pragmatism, in the 1950s and 1960s. The analysis is based on the assumption that the developmentalist ideology that punctuated the debate on the economic, political and social restructuring of the country in these two decades constituted fertile ground for the return and expansion of pragmatist thinking amongst Brazilian educators, articulating itself, sometimes in contradictory ways, with this ideology. The focus of the analysis (...)
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  43.  15
    Reduced Environmental Stimulation in Anorexia Nervosa: An Early-Phase Clinical Trial.Sahib S. Khalsa, Scott E. Moseman, Hung-Wen Yeh, Valerie Upshaw, Beth Persac, Eric Breese, Rachel C. Lapidus, Sheridan Chappelle, Martin P. Paulus & Justin S. Feinstein - 2020 - Frontiers in Psychology 11.
    Reduced Environmental Stimulation Therapy (REST) alters the balance of sensory input to the nervous system by systematically attenuating sensory signals from visual, auditory, thermal, tactile, vestibular, and proprioceptive channels. Previous research from our group has shown that REST via floatation acutely reduces anxiety and blood pressure while simultaneously heightening interoceptive awareness in clinically anxious populations. Anorexia nervosa (AN) is an eating disorder characterized by elevated anxiety, distorted body representation, and abnormal interoception, raising the question of whether REST might positively (...)
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  44.  28
    Disease lesion mimics of maize: A model for cell death in plants.Gurmukh S. Johal, Scot H. Hulbert & Steven P. Briggs - 1995 - Bioessays 17 (8):685-692.
    A class of maize mutants, collectively known as disease lesion mimics, display discrete disease‐like symptoms in the absence of pathogens. It is intriguing that a majority of these lesion mimics behave as dominant gain‐of‐function mutations. The production of lesions is strongly influenced by light, temperature, developmental state and genetic background. Presently, the biological significance of this lesion mimicry is not clear, although suggestions have been made that they may represent defects in the plants' recognition of, or response to, pathogens. One (...)
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  45.  12
    Associations Between Employment Changes and Mental Health: US Data From During the COVID-19 Pandemic.Cillian P. McDowell, Matthew P. Herring, Jeni Lansing, Cassandra S. Brower & Jacob D. Meyer - 2021 - Frontiers in Psychology 12.
    Objectives: To examine associations of changing employment conditions, specifically switching to working from home or job loss, with mental health, using data collected during the COVID-19 pandemic.Methods: Data from 2,301 US adults in employment prior to COVID-19 were collected April 3rd−7th, 2020. Participants reported whether their employment remained unchanged, they were WFH when they had not been before, or they had lost their job due to the pandemic. Outcomes were symptoms of depression, anxiety, stress, loneliness, and positive mental health assessed (...)
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  46. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.David C. Whitcomb, Jessica LaRusch, Alyssa M. Krasinskas, Lambertus Klei, Jill P. Smith, Randall E. Brand, John P. Neoptolemos, Markus M. Lerch, Matt Tector, Bimaljit S. Sandhu, Nalini M. Guda, Lidiya Orlichenko, Samer Alkaade, Stephen T. Amann, Michelle A. Anderson, John Baillie, Peter A. Banks, Darwin Conwell, Gregory A. Coté, Peter B. Cotton, James DiSario, Lindsay A. Farrer, Chris E. Forsmark, Marianne Johnstone, Timothy B. Gardner, Andres Gelrud, William Greenhalf, Jonathan L. Haines, Douglas J. Hartman, Robert A. Hawes, Christopher Lawrence, Michele Lewis, Julia Mayerle, Richard Mayeux, Nadine M. Melhem, Mary E. Money, Thiruvengadam Muniraj, Georgios I. Papachristou, Margaret A. Pericak-Vance, Joseph Romagnuolo, Gerard D. Schellenberg, Stuart Sherman, Peter Simon, Vijay P. Singh, Adam Slivka, Donna Stolz, Robert Sutton, Frank Ulrich Weiss, C. Mel Wilcox, Narcis Octavian Zarnescu, Stephen R. Wisniewski, Michael R. O'Connell, Michelle L. Kienholz, Kathryn Roeder & M. Micha Barmada - unknown
    Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele (...)
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  47.  1
    “Safer to plant corn and beans”? Navigating the challenges and opportunities of agricultural diversification in the U.S. Corn Belt.Rebecca Traldi, Lauren Asprooth, Emily M. Usher, Kristin Floress, J. Gordon Arbuckle, Megan Baskerville, Sarah P. Church, Ken Genskow, Seth Harden, Elizabeth T. Maynard, Aaron William Thompson, Ariana P. Torres & Linda S. Prokopy - forthcoming - Agriculture and Human Values:1-20.
    Agricultural diversification in the Midwestern Corn Belt has the potential to improve socioeconomic and environmental outcomes by buffering farmers from environmental and economic shocks and improving soil, water, and air quality. However, complex barriers related to agricultural markets, individual behavior, social norms, and government policy constrain diversification in this region. This study examines farmer perspectives regarding the challenges and opportunities for both corn and soybean production and agricultural diversification strategies. We analyze data from 20 focus groups with 100 participants (...)
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  48.  37
    What ethical and legal principles should guide the genotyping of children as part of a personalised screening programme for common cancer?N. Hallowell, S. Chowdhury, A. E. Hall, P. Pharoah, H. Burton & N. Pashayan - 2014 - Journal of Medical Ethics 40 (3):163-167.
    Increased knowledge of the gene–disease associations contributing to common cancer development raises the prospect of population stratification by genotype and other risk factors. Individual risk assessments could be used to target interventions such as screening, treatment and health education. Genotyping neonates, infants or young children as part of a systematic programme would improve coverage and uptake, and facilitate a screening package that maximises potential benefits and minimises harms including overdiagnosis. This paper explores the potential justifications and risks of genotyping children (...)
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  49.  26
    Returning Individual Research Results from Digital Phenotyping in Psychiatry.Francis X. Shen, Matthew L. Baum, Nicole Martinez-Martin, Adam S. Miner, Melissa Abraham, Catherine A. Brownstein, Nathan Cortez, Barbara J. Evans, Laura T. Germine, David C. Glahn, Christine Grady, Ingrid A. Holm, Elisa A. Hurley, Sara Kimble, Gabriel Lázaro-Muñoz, Kimberlyn Leary, Mason Marks, Patrick J. Monette, Jukka-Pekka Onnela, P. Pearl O’Rourke, Scott L. Rauch, Carmel Shachar, Srijan Sen, Ipsit Vahia, Jason L. Vassy, Justin T. Baker, Barbara E. Bierer & Benjamin C. Silverman - 2024 - American Journal of Bioethics 24 (2):69-90.
    Psychiatry is rapidly adopting digital phenotyping and artificial intelligence/machine learning tools to study mental illness based on tracking participants’ locations, online activity, phone and text message usage, heart rate, sleep, physical activity, and more. Existing ethical frameworks for return of individual research results (IRRs) are inadequate to guide researchers for when, if, and how to return this unprecedented number of potentially sensitive results about each participant’s real-world behavior. To address this gap, we convened an interdisciplinary expert working group, (...)
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  50.  70
    Ethical aspects of undergoing a predictive genetic testing for Huntington's disease.P. Lilja Andersson, N. Juth, A. Petersen, C. Graff & A. -K. Edberg - 2013 - Nursing Ethics 20 (2):0969733012452686.
    The aim of this study was to describe the experiences of undergoing a presymptomatic genetic test for the hereditary and fatal Huntington’s disease, using a case study approach. The study was based on 18 interviews with a young woman and her husband from the decision to undergo the test, to receiving the results and trying to adapt to them, which were analysed using a life history approach. The findings show that the process of undergoing a presymptomatic test (...)
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