Results for 'P. S. P. Genetics Study Group'

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  1.  3
    Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.Günter U. Höglinger, Nadine M. Melhem, Dennis W. Dickson, Patrick M. A. Sleiman, Li-San Wang, Lambertus Klei, Rosa Rademakers, Rohan de Silva, Irene Litvan, David E. Riley, John C. van Swieten, Peter Heutink, Zbigniew K. Wszolek, Ryan J. Uitti, Jana Vandrovcova, Howard I. Hurtig, Rachel G. Gross, Walter Maetzler, Stefano Goldwurm, Eduardo Tolosa, Barbara Borroni, Pau Pastor, P. S. P. Genetics Study Group, Laura B. Cantwell, Mi Ryung Han, Allissa Dillman, Marcel P. van der Brug, J. Raphael Gibbs, Mark R. Cookson, Dena G. Hernandez, Andrew B. Singleton, Matthew J. Farrer, Chang-En Yu, Lawrence I. Golbe, Tamas Revesz, John Hardy, Andrew J. Lees, Bernie Devlin, Hakon Hakonarson, Ulrich Müller & Gerard D. Schellenberg - unknown
    Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for (...)
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  2.  38
    Seeking consent to genetic and genomic research in a rural Ghanaian setting: a qualitative study of the MalariaGEN experience. [REVIEW]P. Tindana, S. Bull, L. Amenga-Etego, J. Vries, R. Aborigo, K. Koram, D. Kwiatkowski & M. Parker - 2012 - BMC Medical Ethics 13 (1):15-15.
    Seeking consent for genetic and genomic research can be challenging, particularly in populations with low literacy levels, and in emergency situations. All of these factors were relevant to the MalariaGEN study of genetic factors influencing immune responses to malaria in northern rural Ghana. This study sought to identify issues arising in practice during the enrolment of paediatric cases with severe malaria and matched healthy controls into the MalariaGEN study.
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  3.  12
    Human Genetics Studies: The Case for Group Rights.Laura S. Underkuffler - 2007 - Journal of Law, Medicine and Ethics 35 (3):383-395.
    During the past 20 years, the importance of human genetic information has exploded. Whether sought for medical treatment, disease prediction studies, cultural studies, or the general study of human origins, human genetic information is now viewed as crucial for scientific research and general attempts at human understanding.With the importance of genetic information have come bitter battles over its control. The demonstrated power of human genetic information has moved the issue of its “ownership” from the realm of musty academic musings (...)
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  4.  10
    Human Genetics Studies: The Case for Group Rights.Laura S. Underkuffler - 2007 - Journal of Law, Medicine and Ethics 35 (3):383-395.
    In this essay, the author focuses on an underlying theoretical issue which she believes seriously affects our collective response to the idea of group rights in the genetic-control context. That issue is to what extent are our responses to claims of group rights hampered by our bringing to the table a model which is structured to acknowledge only individual concerns? Put another way, to what extent are our objections to group rights in this context a product of (...)
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  5.  11
    Dobzhansky and Dreyfus’s Group: The Introduction of Natural Population Genetics Studies in Brazil (1943–1960).José Franco Monte Sião & Lilian Al-Chueyr Pereira Martins - 2020 - Perspectives on Science 28 (2):244-276.
    An important center in which genetic research started and was carried out in Brazil during the 20thcentury was situated at the Faculty of Philosophy, Sciences and Linguistics of the University of São Paulo, led by André Dreyfus (1897–1952). Beginning in 1943, the Ukrainian geneticist Theodosius Dobzhansky (1900–1975) visited Dreyfus’s group four times. This paper evaluates the impact of Dobzhansky’s visits on the studies of genetics and evolution developed by the members of Dreyfus’s group during the 1940s and (...)
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  6. Group 3 chromosome bin maps of wheat and their relationship to rice chromosome 1.J. D. Munkvold, R. A. Greene, C. E. Bermudez-Kandianis, C. M. La Rota, H. Edwards, S. F. Sorrells, T. Dake, D. Benscher, R. Kantety, A. M. Linkiewicz, J. Dubcovsky, E. D. Akhunov, J. Dvořák, Miftahudin, J. P. Gustafson, M. S. Pathan, H. T. Nguyen, D. E. Matthews, S. Chao, G. R. Lazo, D. D. Hummel, O. D. Anderson, J. A. Anderson, J. L. Gonzalez-Hernandez, J. H. Peng, N. Lapitan, L. L. Qi, B. Echalier, B. S. Gill, K. G. Hossain, V. Kalavacharla, S. F. Kianian, D. Sandhu, M. Erayman, K. S. Gill, P. E. McGuire, C. O. Qualset & M. E. Sorrells - unknown
    The focus of this study was to analyze the content, distribution, and comparative genome relationships of 996 chromosome bin-mapped expressed sequence tags accounting for 2266 restriction fragments on the homoeologous group 3 chromosomes of hexaploid wheat. Of these loci, 634, 884, and 748 were mapped on chromosomes 3A, 3B, and 3D, respectively. The individual chromosome bin maps revealed bins with a high density of mapped ESTs in the distal region and bins of low density in the proximal region (...)
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  7.  1
    A chromosome bin map of 2148 expressed sequence tag loci of wheat homoeologous group 7.K. G. Hossain, V. Kalavacharla, G. R. Lazo, J. Hegstad, M. J. Wentz, P. M. A. Kianian, K. Simons, S. Gehlhar, J. L. Rust, R. R. Syamala, K. Obeori, S. Bhamidimarri, P. Karunadharma, S. Chao, O. D. Anderson, L. L. Qi, B. Echalier, B. S. Gill, A. M. Linkiewicz, A. Ratnasiri, J. Dubcovsky, E. D. Akhunov, J. Dvořák, Miftahudin, K. Ross, J. P. Gustafson, H. S. Radhawa, M. Dilbirligi, K. S. Gill, J. H. Peng, N. L. V. Lapitan, R. A. Greene, C. E. Bermudez-Kandianis, M. E. Sorrells, O. Feril, M. S. Pathan, H. T. Nguyen, J. L. Gonzalez-Hernandez, E. J. Conley, J. A. Anderson, D. W. Choi, D. Fenton, T. J. Close, P. E. McGuire, C. O. Qualset & S. F. Kianian - unknown
    The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level (...)
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  8. A 2600-locus chromosome bin map of wheat homoeologous group 2 reveals interstitial gene-rich islands and colinearity with rice. [REVIEW]E. J. Conley, V. Nduati, J. L. Gonzalez-Hernandez, A. Mesfin, M. Trudeau-Spanjers, S. Chao, G. R. Lazo, D. D. Hummel, O. D. Anderson, L. L. Qi, B. S. Gill, B. Echalier, A. M. Linkiewicz, J. Dubcovsky, E. D. Akhunov, J. Dvořák, J. H. Peng, N. L. V. Lapitan, M. S. Pathan, H. T. Nguyen, X. -F. Ma, Miftahudin, J. P. Gustafson, R. A. Greene, M. E. Sorrells, K. G. Hossain, V. Kalavacharla, S. F. Kianian, D. Sidhu, M. Dilbirligi, K. S. Gill, D. W. Choi, R. D. Fenton, T. J. Close, P. E. McGuire, C. O. Qualset & J. A. Anderson - unknown
    The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the (...)
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  9.  28
    Analysis of expressed sequence tag loci on wheat chromosome group 4. Miftahudin, K. Ross, X. -F. Ma, A. A. Mahmoud, J. Layton, M. A. Rodriguez Milla, T. Chikmawati, J. Ramalingam, O. Feril, M. S. Pathan, G. Surlan Momirovic, S. Kim, K. Chema, P. Fang, L. Haule, H. Struxness, J. Birkes, C. Yaghoubian, R. Skinner, J. McAllister, V. Nguyen, L. L. Qi, B. Echalier, B. S. Gill, A. M. Linkiewicz, J. Dubcovsky, E. D. Akhunov, J. Dvořák, M. Dilbirligi, K. S. Gill, J. H. Peng, N. L. V. Lapitan, C. E. Bermudez-Kandianis, M. E. Sorrells, K. G. Hossain, V. Kalavacharla, S. F. Kianian, G. R. Lazo, S. Chao, O. D. Anderson, J. Gonzalez-Hernandez, E. J. Conley, J. A. Anderson, D. -W. Choi, R. D. Fenton, T. J. Close, P. E. McGuire, C. O. Qualset, H. T. Nguyen & J. P. Gustafson - unknown
    A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, (...)
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  10.  14
    Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases. [REVIEW]Brian T. Helfand, Kimberly A. Roehl, Phillip R. Cooper, Barry B. McGuire, Liesel M. Fitzgerald, Geraldine Cancel-Tassin, Jean-Nicolas Cornu, Scott Bauer, Erin L. Van Blarigan, Xin Chen, David Duggan, Elaine A. Ostrander, Mary Gwo-Shu, Zuo-Feng Zhang, Shen-Chih Chang, Somee Jeong, Elizabeth T. H. Fontham, Gary Smith, James L. Mohler, Sonja I. Berndt, Shannon K. McDonnell, Rick Kittles, Benjamin A. Rybicki, Matthew Freedman, Philip W. Kantoff, Mark Pomerantz, Joan P. Breyer, Jeffrey R. Smith, Timothy R. Rebbeck, Dan Mercola, William B. Isaacs, Fredrick Wiklund, Olivier Cussenot, Stephen N. Thibodeau, Daniel J. Schaid, Lisa Cannon-Albright, Kathleen A. Cooney, Stephen J. Chanock, Janet L. Stanford, June M. Chan, John Witte, Jianfeng Xu, Jeannette T. Bensen, Jack A. Taylor & William J. Catalona - unknown
    © 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare (...)
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  11. Cutting Through the Surface. Philosophical Approaches to Bioethics.T. Takala, P. Herrisone-Kelly & S. Holm (eds.) - 2009 - Rodopi.
    This book examines the role of philosophy and philosophers in bioethics. Academics often see bioethical studies as too practical while decision makers tend to see them as too theoretical. The purpose of this collection of new essays by an international group of distinguished scholars is to explore the troubled relationship between theory and practice in the ethical assessment of medicine, health care, and new medical and genetic technologies. The book is divided into six parts. In the first part, philosophers (...)
     
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  12.  67
    Managing Incidental Findings in Human Subjects Research: Analysis and Recommendations.Susan M. Wolf, Frances P. Lawrenz, Charles A. Nelson, Jeffrey P. Kahn, Mildred K. Cho, Ellen Wright Clayton, Joel G. Fletcher, Michael K. Georgieff, Dale Hammerschmidt, Kathy Hudson, Judy Illes, Vivek Kapur, Moira A. Keane, Barbara A. Koenig, Bonnie S. LeRoy, Elizabeth G. McFarland, Jordan Paradise, Lisa S. Parker, Sharon F. Terry, Brian Van Ness & Benjamin S. Wilfond - 2008 - Journal of Law, Medicine and Ethics 36 (2):219-248.
    No consensus yet exists on how to handle incidental fnd-ings in human subjects research. Yet empirical studies document IFs in a wide range of research studies, where IFs are fndings beyond the aims of the study that are of potential health or reproductive importance to the individual research participant. This paper reports recommendations of a two-year project group funded by NIH to study how to manage IFs in genetic and genomic research, as well as imaging research. We (...)
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  13.  7
    Vincristine pharmacokinetics and response to vincristine monotherapy in an up-front window study of the Dutch Childhood Leukaemia Study Group.E. Groninger, T. De Boer, P. Koopmans, D. Uges, W. Sluiter, A. J. P. Veerman, W. A. Kamps & S. De Graaf - unknown
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  14.  24
    Description and Prescription in Linguistic Ethics.P. S. Wadia - 1964 - Philosophical Studies (Dublin) 13:66-73.
    IN this note I propose to make some general remarks concerning the analytical forays carried out into moral discourse by some leading figures in the modern ‘linguistic’ tradition. The philosophers I am going to speak of, may all be said to be attempting some sort of ‘descriptive’ analysis, but my thesis is that philosophers such as Toulmin and Baier are attempting something that is significantly different from what a philosopher such as Nowell-Smith is attempting. I will suggest, in the following (...)
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  15. The view of Hong Kong parents on secondary use of dried blood spots in newborn screening program.L. L. Hui, E. A. S. Nelson, H. B. Deng, T. Y. Leung, C. H. Ho, J. S. C. Chong, G. P. G. Fung, J. Hui & H. S. Lam - 2022 - BMC Medical Ethics 23 (1):1-10.
    Background Residual dried blood spots from newborn screening programmes represent a valuable resource for medical research, from basic sciences, through clinical to public health. In Hong Kong, there is no legislation for biobanking. Parents’ view on the retention and use of residual newborn blood samples could be cultural-specific and is important to consider for biobanking of rDBS. Objective To study the views and concerns on long-term storage and secondary use of rDBS from newborn screening programmes among Hong Kong Chinese (...)
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  16. Changes in Physical Activity and Depressive Symptoms During COVID-19 Lockdown: United States Adult Age Groups.Amy Chan Hyung Kim, James Du & Damon P. S. Andrew - 2022 - Frontiers in Psychology 13.
    This study investigates: the changes in three major health-related factors—physical activity, non-physical-activity health behavior, and depressive symptoms, and how changes in physical activity were associated with changes in one’s depressive symptoms among young adults, middle-aged adults, and older adults while controlling non-physical-activity health behavior and sociodemographic characteristics among young, middle-aged, and older adults before and after the COVID-19 outbreak lockdown in the United States. A total of 695 participants completed an online questionnaire via MTurk, and participants were asked to (...)
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  17.  35
    Aquinas on Being. By Anthony Kenny. Oxford: Clarendon Press, 2002. Pp. x+ 212. Price not given. Before and after Avicenna: Proceedings of the First Conference of the Avicenna Study Group. Edited by David C. Reisman, with the assistance of Ahmed H. al. [REVIEW]Rahim Leiden, Islamic Humanism By Lenn E. Goodman & Letting Go - 2004 - Philosophy East and West 54 (2):277-278.
    In lieu of an abstract, here is a brief excerpt of the content:Books ReceivedAquinas on Being. By Anthony Kenny. Oxford: Clarendon Press, 2002. Pp. x + 212. Price not given.Before and after Avicenna: Proceedings of the First Conference of the Avicenna Study Group. Edited by David C. Reisman, with the assistance of Ahmed H. al Rahim. Leiden: Brill, 2003. Pp. xix + 302. Price not given.Beside Still Waters: Jews, Christians, and the Way of the Buddha. Edited by Harold (...)
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  18. Comparative Quantitative Genetics: Evolution of the G Matrix.S. J. Steppan, P. C. Phillips & D. Houle - 2002 - Trends in Ecology and Evolution 17 (7):320-327.
    Quantitative genetics provides one of the most promising frameworks with which to unify the fields of macroevolution and microevolution. The genetic variance–covariance matrix (G) is crucial to quantitative genetic predictions about macroevolution. In spite of years of study, we still know little about how G evolves. Recent studies have been applying an increasingly phylogenetic perspective and more sophisticated statistical techniques to address G matrix evolution. We propose that a new field, comparative quantitative genetics, has emerged. Here we (...)
     
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  19. Ethical reasoning in mixed nurse-physician groups.S. Holm, P. Gjersoe, G. Grode, O. Hartling, K. E. Ibsen & H. Marcussen - 1996 - Journal of Medical Ethics 22 (3):168-173.
    OBJECTIVES: To study the ethical reasoning of nurses and physicians, and to assess whether or not modified focus groups are a valuable tool for this purpose. DESIGN: Discussion of cases in modified focus groups, each consisting of three physicians and three nurses. The discussion was taped and analysed by content analysis. SETTING: Five departments of internal medicine at Danish hospitals. SAMPLE: Seven discussion groups. MAIN MEASUREMENTS: Ethical content of statements, style of statements, time used by each participant. RESULTS: Danish (...)
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  20.  5
    Ethical reasoning in mixed nurse-physician groups.S. Holm, P. Gjersøe, G. Grode, O. Hartling & K. E. Ibsen - 1996 - Journal of Medical Ethics 22 (3):168-173.
    OBJECTIVES: To study the ethical reasoning of nurses and physicians, and to assess whether or not modified focus groups are a valuable tool for this purpose. DESIGN: Discussion of cases in modified focus groups, each consisting of three physicians and three nurses. The discussion was taped and analysed by content analysis. SETTING: Five departments of internal medicine at Danish hospitals. SAMPLE: Seven discussion groups. MAIN MEASUREMENTS: Ethical content of statements, style of statements, time used by each participant. RESULTS: Danish (...)
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  21. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.David C. Whitcomb, Jessica LaRusch, Alyssa M. Krasinskas, Lambertus Klei, Jill P. Smith, Randall E. Brand, John P. Neoptolemos, Markus M. Lerch, Matt Tector, Bimaljit S. Sandhu, Nalini M. Guda, Lidiya Orlichenko, Samer Alkaade, Stephen T. Amann, Michelle A. Anderson, John Baillie, Peter A. Banks, Darwin Conwell, Gregory A. Coté, Peter B. Cotton, James DiSario, Lindsay A. Farrer, Chris E. Forsmark, Marianne Johnstone, Timothy B. Gardner, Andres Gelrud, William Greenhalf, Jonathan L. Haines, Douglas J. Hartman, Robert A. Hawes, Christopher Lawrence, Michele Lewis, Julia Mayerle, Richard Mayeux, Nadine M. Melhem, Mary E. Money, Thiruvengadam Muniraj, Georgios I. Papachristou, Margaret A. Pericak-Vance, Joseph Romagnuolo, Gerard D. Schellenberg, Stuart Sherman, Peter Simon, Vijay P. Singh, Adam Slivka, Donna Stolz, Robert Sutton, Frank Ulrich Weiss, C. Mel Wilcox, Narcis Octavian Zarnescu, Stephen R. Wisniewski, Michael R. O'Connell, Michelle L. Kienholz, Kathryn Roeder & M. Micha Barmada - unknown
    Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele (...)
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  22.  20
    Changes in Students’ Views about Nature of Scientific Inquiry at a Science Camp.G. Leblebicioglu, D. Metin, E. Capkinoglu, P. S. Cetin, E. Eroglu Dogan & R. Schwartz - 2017 - Science & Education 26 (7-9):889-917.
    Although nature of science and nature of scientific inquiry are related to each other, they are differentiated as NOS is being more related to the product of scientific inquiry which is scientific knowledge whereas NOSI is more related to the process of SI. Lederman et al. determined eight NOSI aspects for K-16 context. In this study, a science camp was conducted to teach scientific inquiry and NOSI to 24 6th and 7th graders. The core of the program was guided (...)
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  23.  44
    Experiences with community engagement and informed consent in a genetic cohort study of severe childhood diseases in Kenya.V. M. Marsh, D. M. Kamuya, A. M. Mlamba, T. N. Williams & S. S. Molyneux - 2010 - BMC Medical Ethics 11 (1):13-13.
    BackgroundThe potential contribution of community engagement to addressing ethical challenges for international biomedical research is well described, but there is relatively little documented experience of community engagement to inform its development in practice. This paper draws on experiences around community engagement and informed consent during a genetic cohort study in Kenya to contribute to understanding the strengths and challenges of community engagement in supporting ethical research practice, focusing on issues of communication, the role of field workers in 'doing ethics' (...)
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  24.  54
    Ethical aspects of undergoing a predictive genetic testing for Huntington's disease.P. Lilja Andersson, N. Juth, A. Petersen, C. Graff & A. -K. Edberg - 2013 - Nursing Ethics 20 (2):0969733012452686.
    The aim of this study was to describe the experiences of undergoing a presymptomatic genetic test for the hereditary and fatal Huntington’s disease, using a case study approach. The study was based on 18 interviews with a young woman and her husband from the decision to undergo the test, to receiving the results and trying to adapt to them, which were analysed using a life history approach. The findings show that the process of undergoing a presymptomatic test (...)
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  25. Deletion mapping of homoeologous group 6-specific wheat expressed sequence tags.H. S. Randhawa, M. Dilbirligi, D. Sidhu, M. Erayman, D. Sandhu, S. Bondareva, S. Chao, G. R. Lazo, O. D. Anderson, Miftahudin, J. P. Gustafson, B. Echalier, L. L. Qi, B. S. Gill, E. D. Akhunov, J. Dvořák, A. M. Linkiewicz, A. Ratnasiri, J. Dubcovsky, C. E. Bermudez-Kandianis, R. A. Greene, M. E. Sorrells, E. J. Conley, J. A. Anderson, J. H. Peng, N. L. V. Lapitan, K. G. Hossain, V. Kalavacharla, S. F. Kianian, M. S. Pathan, H. T. Nguyen, T. R. Endo, T. J. Close, P. E. McGuire, C. O. Qualset & K. S. Gill - unknown
    To localize wheat ESTs on chromosomes, 882 homoeologous group 6-specific ESTs were identified by physically mapping 7965 singletons from 37 cDNA libraries on 146 chromosome, arm, and sub-arm aneuploid and deletion stocks. The 882 ESTs were physically mapped to 25 regions flanked by 23 deletion breakpoints. Of the 5154 restriction fragments detected by 882 ESTs, 2043 were localized to group 6 chromosomes and 806 were mapped on other chromosome groups. The number of loci mapped was greatest on chromosome (...)
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  26.  63
    Creating a stem cell donor: A case study in reproductive genetics.Jeffrey P. Kahn & Anna C. Mastroianni - 2004 - Kennedy Institute of Ethics Journal 14 (1):81-96.
    : During the nearly 10 years since its introduction, preimplantation genetic diagnosis (PGD) has been used predominantly to avoid giving birth to a child with identified genetic disease. Recently, PGD was used by a couple not only to test IVF-created embryos for genetic disease, but also to test for a nondisease trait related to immune compatibility with a child in the family in need of an hematopoetic stem cell transplant. This article describes the case, raises some ethical and policy issues, (...)
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  27.  24
    The acceptability among French lay persons of ending the lives of damaged newborns.N. Teisseyre, I. D. dos Reis, P. C. Sorum & E. Mullet - 2009 - Journal of Medical Ethics 35 (11):701-708.
    Background: Lay persons’ judgements of the acceptability of the not uncommon practice of ending the life of a damaged neonate have not been studied. Methods: A convenience sample of 1635 lay people in France rated how acceptable it would be for a physician to end a neonate’s life—by withholding care, withdrawing care, or active euthanasia—in 54 scenarios in which the neonate was diagnosed either with perinatal asphyxia or a genetic abnormality. The scenarios were all combinations of four factors: three levels (...)
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  28. Models of data and theoretical hypotheses: a case-study in classical genetics.Marion Vorms - 2010 - Synthese 190 (2):293-319.
    Linkage (or genetic) maps are graphs, which are intended to represent the linear ordering of genes on the chromosomes. They are constructed on the basis of statistical data concerning the transmission of genes. The invention of this technique in 1913 was driven by Morgan's group's adoption of a set of hypotheses concerning the physical mechanism of heredity. These hypotheses were themselves grounded in Morgan's defense of the chromosome theory of heredity, according to which chromosomes are the physical basis of (...)
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  29.  49
    Can the written information to research subjects be improved?--an empirical study.E. Bjorn, P. Rossel & S. Holm - 1999 - Journal of Medical Ethics 25 (3):263-267.
    OBJECTIVES: To study whether linguistic analysis and changes in information leaflets can improve readability and understanding. DESIGN: Randomised, controlled study. Two information leaflets concerned with trials of drugs for conditions/diseases which are commonly known were modified, and the original was tested against the revised version. SETTING: Denmark. PARTICIPANTS: 235 persons in the relevant age groups. MAIN MEASURES: Readability and understanding of contents. RESULTS: Both readability and understanding of contents was improved: readability with regard to both information leaflets and (...)
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  30.  18
    Are you sure about that? Eliciting confidence ratings may influence performance on Raven's progressive matrices.Kit S. Double & Damian P. Birney - 2017 - Thinking and Reasoning 23 (2):190-206.
    Confidence ratings have often been integrated into reasoning and intelligence tasks as a means for assessing meta-reasoning processes. Although it is often assumed that eliciting these judgements throughout reasoning tasks has no effect on the underlying performance outcomes, this is yet to be established empirically. The current study examines whether eliciting CR from participants during a fluid-reasoning task influences their performance and how this effect is moderated by their initial self-confidence in their own reasoning abilities. In a first experiment, (...)
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  31.  10
    An experimental study of Guthrie's theory of reinforcement.J. P. Seward - 1942 - Journal of Experimental Psychology 30 (3):247.
  32.  28
    Perceptions of the effectiveness of ethical guidelines: an international study of physicians. [REVIEW]D. C. Malloy, P. Sevigny, T. Hadjistavropoulos, M. Jeyaraj, E. Fahey McCarthy, M. Murakami, S. Paholpak, Y. Lee & I. Park - 2009 - Medicine, Health Care and Philosophy 12 (4):373-383.
    The intent of ethics is to establish a set of standards that will provide a framework to modify, regulate, and possibly enhance moral behaviour. Eleven focus groups were conducted with physicians from six culturally distinct countries to explore their perception of formalized, written ethical guidelines (i.e., codes of ethics, credos, value and mission statements) that attempt to direct their ethical practice. Six themes emerged from the data: lack of awareness, no impact, marginal impact, other codes or value statements supersede, personal (...)
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  33.  33
    Vulnerability in palliative care research: findings from a qualitative study of black Caribbean and white British patients with advanced cancer.J. Koffman, M. Morgan, P. Edmonds, P. Speck & I. J. Higginson - 2009 - Journal of Medical Ethics 35 (7):440-444.
    Introduction: Vulnerability is a poorly understood concept in research ethics, often aligned to autonomy and consent. A recent addition to the literature represents a taxonomy of vulnerability developed by Kipnis, but this refers to the conduct of clinical trials rather than qualitative research, which may raise different issues. Aim: To examine issues of vulnerability in cancer and palliative care research obtained through qualitative interviews. Method: Secondary analysis of qualitative data from 26 black Caribbean and 19 white British patients with advanced (...)
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  34.  27
    "Do-not-resuscitate" orders in patients with cancer at a children's hospital in Taiwan.T. -H. Jaing, P. -K. Tsay, E. -C. Fang, S. -H. Yang, S. -H. Chen, C. -P. Yang & I. -J. Hung - 2007 - Journal of Medical Ethics 33 (4):194-196.
    Objectives: To quantify the use of do-not-resuscitate orders in a tertiary-care children’s hospital and to characterise the circumstances in which such orders are written.Design: Retrospective study conducted in a 500-bed children’s hospital in Taiwan.Patients: The course of 101 patients who died between January 2002 and December 2005 was reviewed. The following data were collected: age at death, gender, disease and its status, place of death and survival. There were 59 males and 42 females with a median age of 103 (...)
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  35.  6
    Treatment of depression in the elderly with repetitive transcranial magnetic stimulation using theta-burst stimulation: Study protocol for a randomized, double-blind, controlled trial.Leandro Valiengo, Bianca S. Pinto, Kalian A. P. Marinho, Leonardo A. Santos, Luara C. Tort, Rafael G. Benatti, Bruna B. Teixeira, Cristiane S. Miranda, Henriette B. Cardeal, Paulo J. C. Suen, Julia C. Loureiro, Renata A. R. Vaughan, Roberta A. M. P. F. Dini Mattar, Maíra Lessa, Pedro S. Oliveira, Valquíria A. Silva, Wagner Farid Gattaz, André R. Brunoni & Orestes Vicente Forlenza - 2022 - Frontiers in Human Neuroscience 16.
    IntroductionTranscranial magnetic stimulation is a consolidated procedure for the treatment of depression, with several meta-analyses demonstrating its efficacy. Theta-burst stimulation is a modification of TMS with similar efficacy and shorter session duration. The geriatric population has many comorbidities and a high prevalence of depression, but few clinical trials are conducted specifically for this age group. TBS could be an option in this population, offering the advantages of few side effects and no pharmacological interactions. Therefore, our aim is to investigate (...)
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  36.  14
    Exploring the Gray Area: Similarities and Differences in Questionable Research Practices (QRPs) Across Main Areas of Research.Mads P. Sørensen & Tine Ravn - 2021 - Science and Engineering Ethics 27 (4):1-33.
    This paper explores the gray area of questionable research practices between responsible conduct of research and severe research misconduct in the form of fabrication, falsification, and plagiarism : 53–57, 2006). Up until now, we have had very little knowledge of disciplinary similarities and differences in QRPs. The paper is the first systematic account of variances and similarities. It reports on the findings of a comprehensive study comprising 22 focus groups on practices and perceptions of QRPs across main areas of (...)
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  37.  48
    Culture and Whistleblowing An Empirical Study of Croatian and United States Managers Utilizing Hofstede's Cultural Dimensions.A. Assad Tavakoli, John P. Keenan & B. Cranjak-Karanovic - 2003 - Journal of Business Ethics 43 (1-2):49-64.
    Leaders and managers of today's multinational corporations face a plethora of problems and issues directly attributable to the fact that they are operating in an international context. With work-sites, plants and/or customers based in another country, or even several countries, representing a vast spectrum of cultural differences, international trade and offshore operations, coupled with increased globalisation in respect to political, social and economic realities, contribute to new dilemmas that these leaders must deal with. Not the least of these being a (...)
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  38. Recruiting and Educating Participants for Enrollment in HIV-Vaccine Research: Ethical Implications of the Results of an Empirical Investigation.S. Sifunda, P. Reddy, N. Naidoo, S. James & D. Buchanan - 2014 - Public Health Ethics 7 (1):78-85.
    The study reports on the results of an empirical investigation of the education and recruitment processes used in HIV vaccine trials conducted in South Africa. Interviews were conducted with 21 key informants involved in HIV vaccine research in South Africa and three focus groups of community advisory board members. Data analysis identified seven major themes on the relationship between education and recruitment: the process of recruitment, the combined dual role of educators and recruiters, conflicts perceived by field staff, pressure (...)
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  39.  17
    Genetic 'Risk Carriers' and Lifestyle 'Risk Takers'. Which Risks Deserve our Legal Protection in Insurance?Ine Van Hoyweghen, Klasien Horstman & Rita Schepers - 2007 - Health Care Analysis 15 (3):179-193.
    Over the past years, one of the most contentious topics in policy debates on genetics has been the use of genetic testing in insurance. In the rush to confront concerns about potential abuses of genetic information, most countries throughout Europe and the US have enacted genetics-specific legislation for insurance. Drawing on current debates on the pros and cons of a genetics-specific legislative approach, this article offers empirical insight into how such legislation works out in insurance practice. To (...)
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  40.  30
    Religiosity and Group-Binding Moral Concerns.Jordan P. LaBouff, Matthew Humphreys & Megan Johnson Shen - 2017 - Archive for the Psychology of Religion 39 (3):263-282.
    _ Source: _Page Count 20 Research by Graham and Haidt suggests that beliefs, rituals, and other social aspects of religion establish moral communities. As such, they suggest religion is most strongly associated with the group-focused “binding” moral foundations of ingroup/loyalty, authority/respect, and purity/sanctity. Two studies tested this hypothesis, investigating the role of political orientation in these relationships. These studies supported our hypothesis that general religiosity is positively associated with each of the group-focused moral foundations, even when controlling for (...)
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  41.  40
    Neurotrauma and the rule of rescue.S. Honeybul, G. R. Gillett, K. M. Ho & C. R. P. Lind - 2011 - Journal of Medical Ethics 37 (12):707-710.
    The rule of rescue describes the powerful human proclivity to rescue identified endangered lives, regardless of cost or risk. Deciding whether or not to perform a decompressive craniectomy as a life-saving or ‘rescue’ procedure for a young person with a severe traumatic brain injury provides a good example of the ethical tensions that occur in these situations. Unfortunately, there comes a point when the primary brain injury is so severe that if the patient survives they are likely to remain severely (...)
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  42. Chromosome bin map of expressed sequence tags in homoeologous group 1 of hexaploid wheat and homoeology with rice and arabidopsis.J. H. Peng, H. Zadeh, G. R. Lazo, J. P. Gustafson, S. Chao, O. D. Anderson, L. L. Qi, B. Echalier, B. S. Gill, M. Dilbirligi, D. Sandhu, K. S. Gill, R. A. Greene, M. E. Sorrells, E. D. Akhunov, J. Dvořák, A. M. Linkiewicz, J. Dubcovsky, K. G. Hossain, V. Kalavacharla, S. F. Kianian, A. A. Mahmoud, Miftahudin, E. J. Conley, J. A. Anderson, M. S. Pathan, H. T. Nguyen, P. E. McGuire, C. O. Qualset & N. L. V. Lapitan - unknown
    A total of 944 expressed sequence tags generated 2212 EST loci mapped to homoeologous group 1 chromosomes in hexaploid wheat. EST deletion maps and the consensus map of group 1 chromosomes were constructed to show EST distribution. EST loci were unevenly distributed among chromosomes 1A, 1B, and ID with 660, 826, and 726, respectively. The number of EST loci was greater on the long arms than on the short arms for all three chromosomes. The distribution of ESTs along (...)
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  43.  14
    An examination of two groups of Georg Hartmann sixteenth-century astrolabes and the tables used in their manufacture.John P. Lamprey - 1997 - Annals of Science 54 (2):111-142.
    Summary Examples of two groups of astrolabes manufactured by Georg Hartmann (1489?1564) were examined for design and manufacturing accuracy. Study of the instruments indicates that Hartmann was a precision manufacturer and early user of workshop production techniques. Hartmann's instruments and written instructions were directly influenced by the writing of Johann Stöffler (1452?1531), and the astrolabes and work of Regiomontanus (1436?76).
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  44.  15
    A study on the ethics of microallocation of scarce resources in health care.P. A. C. Fortes - 2002 - Journal of Medical Ethics 28 (4):266-269.
    Objectives: This study attempts to analyse the ethical dilemmas arising from the microallocation of scarce health care resources, in terms of deontology and utilitarianism.Methods: A group of 395 people were interviewed in the region of Diadema, greater San Paulo, Brazil, while visiting patients in the only state hospital in town. Each interviewee was given a list of eight simulated emergencies . In each of the eight cases the interviewee had to choose which of the two patients described, both (...)
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  45.  35
    Children's Acquisition of the English Past‐Tense: Evidence for a Single‐Route Account From Novel Verb Production Data.Ryan P. Blything, Ben Ambridge & Elena V. M. Lieven - 2018 - Cognitive Science 42 (S2):621-639.
    This study adjudicates between two opposing accounts of morphological productivity, using English past-tense as its test case. The single-route model posits that both regular and irregular past-tense forms are generated by analogy across stored exemplars in associative memory. In contrast, the dual-route model posits that regular inflection requires use of a formal “add -ed” rule that does not require analogy across regular past-tense forms. Children saw animations of an animal performing a novel action described with a novel verb. Past-tense (...)
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  46.  1
    Toward Pleomorphic Reconfigurable Robots for Optimum Coverage.S. M. Bhagya P. Samarakoon, M. A. Viraj J. Muthugala, Mohan R. Elara & Selva Kumaran - 2021 - Complexity 2021:1-10.
    Buildings are constructed for accommodating living and industrial needs. Floor cleaning robots have been developed to cater to the demand of these buildings. Area coverage and coverage time are crucial performance factors of a floor cleaning robot. Reconfigurable tiling robots have been introduced over fixed shape robots to improve area coverage in floor cleaning applications compared to robots with fixed morphologies. However, area coverage and coverage time of a tiling robot compromised one another. This study proposes a novel concept (...)
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  47.  57
    A National Study of Ethics Committees.Glenn McGee, Joshua P. Spanogle, Arthur L. Caplan & David A. Asch - 2001 - American Journal of Bioethics 1 (4):60-64.
    Conceived as a solution to clinical dilemmas, and now required by organizations for hospital accreditation, ethics committees have been subject only to small-scale studies. The wide use of ethics committees and the diverse roles they play compel study. In 1999 the University of Pennsylvania Ethics Committee Research Group (ECRG) completed the first national survey of the presence, composition, and activities of U.S. healthcare ethics committees (HECs). Ethics committees are relatively young, on average seven years in operation. Eighty-six percent (...)
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  48.  8
    Brouwer's Intuitionism.Walter P. Van Stigt - 1990 - North Holland.
    Dutch Mathematician Luitzen Egbertus Jan Brouwer was a rebel. His doctoral thesis... was the manifesto of an angry young man taking on the mathematical establishment on all fronts. In a short time he established a world-wide reputation for himself; his genius and originality were acknowledged by the great mathematicians of his time... The Intuitionist-Formalist debate became a personal feud between the mathematical giants Brouwer and Hilbert, and ended in 1928 with the expulsion of Brouwer from the editorial board of the (...)
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  49.  14
    Practical Genetic Counselling. By P. S. Harper. (Wright, Bristol, 1981.) £12.50. [REVIEW]A. W. Johnston - 1982 - Journal of Biosocial Science 14 (2):252-252.
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  50.  9
    Parental Control over Mate Choice to Prevent Marriages with Out-group Members.Abraham P. Buunk, Thomas V. Pollet & Shelli Dubbs - 2012 - Human Nature 23 (3):360-374.
    The present research examined how a preference for influencing the mate choice of one’s offspring is associated with opposition to out-group mating among parents from three ethnic groups in the Mexican state of Oaxaca: mestizos (people of mixed descent, n = 103), indigenous Mixtecs (n = 65), and blacks (n = 35). Nearly all of the men in this study were farmworkers or fishermen. Overall, the level of preferred parental influence on mate choice was higher than in Western (...)
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