Whipple disease is a rare, infectious, disease first described from a single case by Whipple in 1907. As well as characterising the clinical and pathological features of the condition, Whipple made two suggestions regarding its aetiology. These were either than the disease was caused by an infectious agent, or that it was of metabolic origin. As the disease is now thought to be caused by infection with the bacterium Tropheryma whipplei, historical reviews of the history of the disease typically mention (...) only the first of these suggestions. In this paper, we therefore revisit Whipple’s other theory. We argue that a diverse and often successful research programme was developed around this mechanism of disease causation which gave rise to many useful findings on the condition. In the later parts of this article, we then turn to discuss the surprising neglect of this period of Whipple disease research in the current literature, and conclude by offering a brief reconstruction of this early history suitable for use in a technical context. (shrink)

Dorian Gray pays a hefty price for years of sin and vice in this completely unabridged edition of The Picture of Dorian Gray.

Placing the question -- Patristic Precedents -- Moltmann's perichoretic spaces for God and creation -- No place for the spirit? Jean-Luc Marion's placial refusal -- Notes toward a Trinitarian theology of Place.

In spite of the considerable literature nowadays existing on the issue of the moral exclusion of nonhuman animals, there is still work to be done concerning the characterization of the conceptual framework with which this question can be appraised. This paper intends to tackle this task. It starts by defining speciesism as the unjustified disadvantageous consideration or treatment of those who are not classified as belonging to a certain species. It then clarifies some common misunderstandings concerning what this means. Next, (...) it rejects the idea that there are different kinds of speciesism. Such an idea may result from confusion because there are (1) different ways in which speciesism can be defended; and (2) different speciesist positions, that is, different positions that assume speciesism among their premises. Depending on whether or not these views assume other criteria for moral consideration apart from speciesism, they can be combined or simple speciesist positions. But speciesism remains in all cases the same idea. Finally, the paper examines the concept of anthropocentrism, the disadvantageous treatment or consideration of those who are not members of the human species. This notion must be conceptually distinguished from speciesism and from misothery (aversion to nonhuman animals). Anthropocentrism is shown to be refuted because it either commits a petitio principia fallacy or it falls prey to two arguments: the argument from species overlap (widely but misleadingly known as “argument from marginal cases”) and the argument from relevance. This rebuttal identifies anthropocentrism as a speciesist view. (shrink)

Engaging and thought-provoking, this book examines how we see and treat animals and argues that we should extend equal rights to all species, human and non-human alike. Our world is plighted by 'isms' - racism, sexism and ageism to name a few - but we have one more to add: speciesism. Speciesism is a form of discrimination against those who don't belong to a certain species and it is a concept which raises controversial questions over humanity's very complicated relationship with (...) animals. Forgetting that humans are animals too, this mindset allows us to see animals as objects, rather than individuals with their own interests and with the ability to feel and suffer. This book questions all of these assumptions. Human feelings of superiority have allowed us to feel entitled to own animals as pets, to eat them, to use them for entertainment and to treat them with unkindness and cruelty. Looking at both the use of animals for the production of food, as well as the suffering of wild animals, this book advocates for society to seriously take into account the interests of all animals and argues that we have a duty to treat animals with much greater care, consideration and respect. For all who care about the rights and welfare of animals, this book is essential reading. (shrink)

Rousseau avait tout lieu, dans la controverse qui oppose au xviii e siècle partisans et pourfendeurs des voyages d’éducation, de prendre position contre ces voyages, suivant en cela les déclarations de Béat de Muralt, qu’il approuvait dans une large mesure. Nous constatons pourtant qu’en abordant « la question des voyages », l’auteur de l’Émile se voit obligé, tout en condamnant cette « mode », à la manière de Muralt, d’opérer un glissement théorique et de conférer à l’expérience du voyage, comme (...) expérience critique de la pluralité et de la liberté, une place essentielle dans son système, place rendue nécessaire par sa théorie des affects politiques. (shrink)

Oscar Masotta (Buenos Aires, 1930- Barcelona, 1979) is all but forgotten now, except perhapsin the field of Lacanian studies. This is because in the 1970s,Masotta would challenge the master psychoanalyst on hisown turf, creating his own post-Lacanian school of psychoanalysisin Barcelona. But in 1965, aged just 27, Masottataught at the University of Buenos Aires, lectured at theDi Tella, and edited a book series on communication andmedia. A product of the newly open post-Perón era." Page 91.. This is the first (...) exhibition organized with materials from the archive Juan Acha, and includes reactivations of non-object-based art and artistic documentation. (shrink)

The basis for ‘sound’ medical opinion has moved from clinical opinion to evidence based research. This article will comment on the basis on which evidence in clinical medicine is collected and, indeed, what actually constitutes evidence. It is suggested that the definition of guidelines arising from evidence-based medicine may lead to false conclusion and, as noted by Sir Douglas Black, whilst ‘guidelines can of course be helpful in clear-cut situations; [but] these are the minority in actual practice’.

This article tries to define what discrimination is and to understand in particular detail its most important instances: those in which the satisfaction of interests is at stake. These cases of discrimination will be characterized in terms of deprivations of benefits. In order to describe and classify them we need to consider three different factors: the benefits of which discriminatees are deprived, the criteria according to which such benefits are denied or granted, and the justification that such deprivation of benefits (...) may have (or lack). This definition intends to present discrimination as a concept that may be useful not only to examine certain social phenomena, but also, more widely, to ethical theory in general. (shrink)

Insofar as development implies economic growth, the term 'sustainable development' appears to some as a contradiction in terms. However, such conclusions still lack a thorough examination of the conceptual structure of the two terms between which there is a purported contradiction. In order to address this issue, the present paper scrutinises some of the assumptions which underwrite the ideologies of sustainability and of development. It is argued that there are key assumptions which both ideas have in common, and that sustainable (...) development is thus perfectly coherent on a conceptual level. It is alternatives which retain either term (such as 'sustainable degrowth') that are embroiled in paradox. The paper then examines two concepts for criticising the ideology of economic growth in other terms: dépense and conviviality. It is argued that the latter is preferable to the former for the purpose of developing post-sustainable critiques of growth. (shrink)

I argue that a standard formulation of hinge epistemology is host to epistemic relativism and show that two leading hinge approaches (Coliva’s acceptance account and Pritchard’s nondoxastic account) are vulnerable to a form of incommensurability that leads to relativism. Building on both accounts, I introduce a new, minimally epistemic conception of hinges that avoids epistemic relativism and rationally resolves hinge disagreements. According to my proposed account, putative cases of epistemic incommensurability are rationally resolvable: hinges are propositions that are the objects (...) of our belief-like attitudes and are rationally revisable in virtue of our overarching commitment to avoid systematic deception in our epistemic practices. (shrink)

Reconstruction is a central notion in Dewey’s account of inquiry and in his metaphilosophical commitments. In his work, Dewey made a call for reconstruction of philosophy, in the reconstruction of central notions of the discipline, like knowledge, logic, truth, the good, reason, and experience. Inquiry itself is reconstructive, according to Dewey, involving the transformation of an indeterminate situation into one which is determinate and understood. Dewey’s philosophical views should therefore be of interest to those taking part in the recent turn (...) towards revisionary philosophical methodologies, like conceptual engineering, explication, and amelioration. In light of the recent developments in revisionary methodologies, I aim to explore Dewey’s conception of concepts in relation to the conceptual engineering literature, suggesting that it provides a useful conception of concepts for conceptual engineering, and to suggest a Deweyan model of philosophical inquiry where concepts are the objects of inquiry. In both cases, I hope to show a productive interaction between Dewey’s ideas and contemporary discussions of conceptual engineering. (shrink)

An individual's health, genetic, or environmental-exposure data, placed in an online repository, creates a valuable shared resource that can accelerate biomedical research and even open opportunities for crowd-sourcing discoveries by members of the public. But these data become “immortalized” in ways that may create lasting risk as well as benefit. Once shared on the Internet, the data are difficult or impossible to redact, and identities may be revealed by a process called data linkage, in which online data sets are matched (...) to each other. Reidentification, the process of associating an individual's name with data that were considered deidentified, poses risks such as insurance or employment discrimination, social stigma, and breach of the promises often made in informed-consent documents. At the same time, re-ID poses risks to researchers and indeed to the future of science, should re-ID end up undermining the trust and participation of potential research participants. The ethical challenges of online data sharing are heightened as so-called big data becomes an increasingly important research tool and driver of new research structures. Big data is shifting research to include large numbers of researchers and institutions as well as large numbers of participants providing diverse types of data, so the participants’ consent relationship is no longer with a person or even a research institution. In addition, consent is further transformed because big data analysis often begins with descriptive inquiry and generation of a hypothesis, and the research questions cannot be clearly defined at the outset and may be unforeseeable over the long term. In this article, we consider how expanded data sharing poses new challenges, illustrated by genomics and the transition to new models of consent. We draw on the experiences of participants in an open data platform—the Personal Genome Project—to allow study participants to contribute their voices to inform ethical consent practices and protocol reviews for big-data research. (shrink)

Este trabajo analiza algunas de las dimensiones fundamentales de la influencia de la obra temprana de Martin Heidegger sobre la teoría política de Hannah Arendt. Como se sabe, la pensadora judía cursó algunos de sus más cruciales años universitarios bajo la tutoría del profesor alemán. En tal sentido, tanto la perspectiva hermenéutico-fenomenológica como los conceptos de “mundo” y praxis resultaron decisivos para definir, junto con la experiencia del totalitarismo, el sentido y la profundidad de la teoría política arendtiana. En líneas (...) generales, se espera que la investigación permita no solo entender varias de las nociones centrales del pensamiento de Arendt dentro de su horizonte de sentido original, sino además visibilizar algunas de las potencialidades que la obra temprana de Heidegger posee a la hora de repensar la política y la pluralidad humana. (shrink)

Excerpt from Kants Kritischer Idealismus: Als Grundlage von Erkenntnistheorie und Ethik Sukzession: a) Substanz. Psychische Substanz. Sub stanz und Apperzeption. B) Kausalität. 0) Wechsel wirkung. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in (...) the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)