Rationing in healthcare remains very much a taboo topic. Before COVID-19, it rarely received public attention, even when it occurred in everyday practices, mainly in the form of implicit rationing, as it continues to do today. There are different definitions, types and levels of healthcare rationing, according to different perspectives. With the aim of contributing to a more coherent debate on such a highly emotional healthcare issue as rationing, here are provided a number of reflections from a patient advocate perspective (...) which are specifically focused on bedside rationing, the most troublesome level, both for patients and clinicians, particularly in regard to cancer care. Oncology, with its numerous expensive therapies and increasing number of patients, is undeniably one of the main areas contributing to the increase in healthcare costs. However, the fixed budgets of today's publicly financed health systems cannot allow unlimited access to the potentially beneficial treatments to all patients. Bedside rationing constitutes the last phase of many decision-making processes occurring at different interrelated levels (macro-levels), both inside and outside healthcare systems, which implicitly and inevitably result in a bottleneck determined by the upstream decisions themselves. Shifting from implicit to explicit bedside rationing essentially means moving from a paternalistic to a citizen-before-patient approach; this implies, first of all, a cultural change. Practical bedside rationing is an ethically complex topic, but one that needs to be urgently addressed in a transparent and open debate. In this scenario, the oncological community – patients, patient advocates and clinicians – can and should play an important role. (shrink)

The field of consciousness studies has long benefitted from the investigation of non- ordinary states of consciousness, both spontaneous and facilitated by mind-altering agents. In the present study, I look at the implications of spontaneous near-death experiences and experiences facilitated by the dissociative anaesthetic ketamine. These experiences reputedly have similar phenomenologies, such as a feeling of dying, motion through darkness, entering another realm, visions of light, and a sense of separation from the physical body. To assess whether ketamine and near-death (...) experiences really are similar, I undertake a systematic comparison of 36 accounts of NDE-like experiences under ketamine with 36 accounts of NDE that resulted from cardiac arrest or other life-threatening circumstances in which wakefulness was maintained . The results suggest that ketamine and near- death experiences are indeed similar, which might be taken to imply that NDEs have a purely chemical or psychophysiological basis. However, this conclusion is not inevitable, and I draw upon the intriguing 'spatial' or 'situated' characteristic of ketamine and near-death experiences to suggest an alternative to both neuropsychological reductionism and a straightforward post-mortem survival theory. To develop the idea of a dynamic interrelation of consciousness and 'place', I draw on contemporary Japanese philosophies of body-mind. (shrink)

The paper aims to investigate the meaning of historicity in the light of Ágnes Heller’s interpretation of history as ‘being-in-common’. By touching on the problem of the modern world’s axiological pluralism, the issue of the legitimation of moral theories and the dilemma of morals, the paper analyses Heller’s conception of human goodness as an incontrovertible, inexplicable and mysterious ‘fact’ that is able to illuminate the path of human life and determine the opening of the individual onto the world with the (...) same wonder that marks the beginning of any philosophical attitude. (shrink)

Ce texte a déjà paru dans Tradurre. Pratiche, teorie, strumenti, n° 10, Primavera 2016. F. Scotto, Il senso del suono. Traduzione poetica e ritmo, Roma, Donzelli, 2013, 224 p. Ce mot « rythme » ne m'est pas clair. Je ne l'emploie jamais. Paul Valéry Nel suo vastissimo trattato Critique du rythme. Anthropologie historique du langage, Henri Meschonnic si sofferma sulla scorretta etimologia che fonda il mito del ritmo, ossia quella che ricollega il ῥυθμός al movimento del mare : seguendo - (...) Recensions. (shrink)

This study assessed self-reported health-related quality of life and psychological adjustment in 43 adolescents and young adults with congenital melanocytic nevi and examined associations with sociodemographic variables, characteristics of the CMN, perceived social reactions, and cognitive emotion regulation strategies. Outcome measures included the Pediatric Quality of Life Inventory™ 4.0 and the Strengths and Difficulties Questionnaire. Findings suggest impaired psychosocial health and psychological adjustment in youth with CMN compared to community norms. Impairments were associated with higher age of participants, lower socioeconomic (...) status, visibility of the skin lesion, perceived stigmatization, poorer perceived social support, and maladaptive cognitive emotion regulation strategies, but not with sex of participants, extent of the skin lesion, and surgical removal of the nevus. Implications for clinical practice and future research are discussed. (shrink)

By the end of the seventeenth century, high culture had banished astrology as a mixture of superstition and imposture. The great astrological treatises of the past - in particular the Ptolemaic Tetrabiblos (whose very authenticity was cast into doubt) - stopped being published; a hodgepodge of minor writings, mostly preserved in manuscript form, lay mouldering in oblivion in the far recesses of libraries. It was only in the latter decades of the eighteenth century that the learned world began once again (...) to pay attention to the ancient art, when historians of ancient religions and science began to realize the impossibility of exploring their subjects without taking into account a presence that could be neither denied nor underestimated. The history of astrology then began to take shape as a specific field of study, and historicophilological research was able to employ it as a tool for penetrating the tie between mythos and logos, at the origin of western civilization. Along with the image of the Greek miracle, an overly simplistic and schematic definition of reason and science began to decline. It was necessary to isolate, as Hermann Usener sought to do, the “wild germ of science” and to acknowledge the fact that logic and magic bloom on the same stem, as Aby Warburg has often reminded us, with reference to Jean Paul. (shrink)

In a letter to Lorenzo di Pierfrancesco dei Medici, dating from 1477 to 1478, the Platonist philosopher Marsilio Ficino develops the classical theme of the correspondence between man and cosmos on the basis of the astrological techniques. The inner heaven, a term of the relationship between macrocosm and microcosm, takes the form of what astrologers call the birth theme: the series of astral positions at the moment of birth and related to its place. Taking up Origen’s theme of the inner (...) heavens, he systematically applies the theory of planet-signs to deciphering underlying themes of individual personality. (shrink)

O artigo apresenta o livro O fogo e o relato. Ensaios sobre criação, escrita, arte e livros, do filósofo italiano Giorgio Agamben, discutindo alguns dos limiares poéticos do seu pensamento político. Parte-se de alguns dos debates subentendidos de Agamben com Jacques Derrida sobre linguagem e literatura, passa-se pelo ato poético como ato de resistência, define-se a potência inoperante presente em gestos de interrupção discursiva e chega-se à discussão sobre vida e obra em contexto biopolítico. Seguindo a ordem dos capítulos, mas (...) sem pretender esgotá-los, o pressuposto do artigo é de que o italiano, que tem a poesia e a literatura geralmente vinculada a uma espécie de “primeira fase” de sua obra, também na série biopolítica nomeada Homo Sacer lançou mão da poesia e da literatura como forte estratégia de resistência e abertura de limiares ante a lógica que se desenha do poder soberano. Se, por um lado, o livro pode ser lido como formando um círculo hermenêutico, os capítulos, por outro lado, permitem ao leitor perceber as principais linhas em que filosofia, literatura, poesia e política se entrecruzam para o pensador italiano. Por isso, também, recorreu-se à relação direta de alguns argumentos expostos em O fogo e o relato tanto com noções e argumentos presentes em outros livros de Agamben, quanto pontualmente com outros interlocutores. (shrink)

ObjectiveProcessing Speed, the ability to perceive and react fast to stimuli in the environment, has been shown to be impaired in children with attention deficit hyperactivity disorder. However, it is unclear whether PS can be improved following targeted treatments for ADHD. Here we examined potential changes in PS following application of transcranial electric stimulation combined with cognitive training in children with ADHD. Specifically, we examined changes in PS in the presence of different conditions of mental fatigue.MethodsWe used a randomized double-blind (...) active-controlled crossover study of 19 unmedicated children with ADHD. Participants received either anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex or transcranial random noise stimulation, while completing CT, and the administration order was counterbalanced. PS was assessed before and after treatment using the MOXO-CPT, which measures PS in the presence of various conditions of mental fatigue and cognitive load.ResultstRNS combined with CT yielded larger improvements in PS compared to tDCS combined with CT, mainly under condition of increased mental fatigue. Further improvements in PS were also seen in a 1-week follow up testing.ConclusionThis study provides initial support for the efficacy of tRNS combined with CT in improving PS in the presence of mental fatigue in pediatric ADHD. (shrink)

info:eu-repo/semantics/publishedVersion.

A comunicação busca encontrar o que seria o salão literário de Dona Leonor de Almeida, Marquesa de Alorna. Nesta revisitação, constatamos a emergência de uma sociabilidade heterossexual onde a conversação se eleva a arte.Elegemos o Palácio Fronteira como o salão em português. Propomos que o emblemático Palácio Fronteira, em São Domingos de Benfica, subsuma todos os outros salões que sabemos terem existido – sem esquecermos nunca da iniciática função dos outeiros de Chelas.Conhecemos Alcipe romanticamente “épica” cuja vida mergulhada na caótica (...) época de transição histórica é evocada pelos mais diversos testemunhos da elite que a frequenta. Contactamo-la sobretudo no discurso directo em que a sua palavra poética fala. No salão de Benfica também se assiste ao declínio do discurso normativo-eclesiástico e se constata a emergência da afirmação da mulher enquanto ser de beleza, pensamento, vontade e poder. Alcipe não se afirma apenas enquanto uma culta aglutinadora de gente de espírito da sua geração, mas como alguém que, além de ter sabido impor a opinião poética vanguardista do seu tempo, possui igualmente ideias políticas próprias e, pese embora os mal-entendidos do seu tempo, pretende partilhar da solução dos problemas. (shrink)

Business Ethics, the Environment &Responsibility, EarlyView.

The philosophy of literature, as developed by analytical philosophers, places the values of literature, implicitly or explicitly, at the centre of its core debates. Is literature an honorific (value-laden) concept or a descriptive one? What is literary interpretation if not primarily the uncovering of deeper significance and interest in works of literature? What about the pursuit of truth and knowledge? Is it not one of the most valued aspirations of literature? And can readers of novels not sharpen their moral sensibility, (...) their empathy, their understanding of human weakness, desires and follies, by engaging with the lives of fictional characters? Can the great works of fiction or poetry or drama not offer enduring psychological rewards, not just in the pleasures of literary artifice but in having the imagination stretched through immersion in worlds and possibilities well beyond the banalities of everyday life? These are some of the debates, even if no final resolution has emerged. Are there such distinctive literary values as implied in these debates? Is it possible to generalize across literary genres or are there only, at best, values of poetry, the novel, the short story, drama? And how are individual works to be evaluated? Are there objective values or only values relative to individual readers or "communities"? Is there a canon of great works, and if so, how is it constructed? How do moral values relate to literary values? Can great works be immoral? These are live issues for the philosopher of literature. (shrink)

The discovery of participation of astrocytes as active elements in glutamatergic tripartite synapses (composed by functional units of two neurons and one astrocyte) has led to the construction of models of cognitive functioning in the human brain, focusing on associative learning, sensory integration, conscious processing and memory formation/retrieval. We have modelled human cognitive functions by means of an ensemble of functional units (tripartite synapses) connected by gap junctions that link distributed astrocytes, allowing the formation of intra- and intercellular calcium waves (...) that putatively mediate large-scale cognitive information processing. The model contains a diagram of molecular mechanisms present in tripartite synapses and contributes to explain the physiological bases of cognitive functions. It can be potentially expanded to explain emotional functions and psychiatric phenomena. (shrink)

Introduction: Physical distancing under the coronavirus disease 2019 pandemic had a significant impact on lifestyles, including exercise routines. In this study, we examined the relationship between mental health and addictive behaviors, such as excessive exercise and the use of image and performance enhancing drugs across 12 sport disciplines.Materials and methods: A large cross-sectional sample of the adult population was surveyed. The mean age was 33.09. The number of male participants was 668. The use of IPEDs was assessed in conjunction with (...) psychometric measures such as the Exercise Addiction Inventory and the Appearance Anxiety Inventory. The participants were grouped into activity group and non-activity group according to the presence or absence of their exercise habits. The results were compared between these groups, as well as across sport disciplines, while taking into account the relationship between different psychological measures and IPEDs consumption.Results: The frequency of IPEDs use was higher among AG than NAG, although AG participants reported less history of addictions than NAG. The logistic regression analysis revealed that scores equal to or above cutoff points, in both the EAI and AAI, predicted the IPEDs use. Regarding the differences across the various sport disciplines, those who were involved in practicing Weight Lifting and Cross Fit were found to be more at risk of excessive exercising and more inclined to use a wide range of IPEDs.Conclusions: Although exercise could help to increase well-being and prevent addictions during the COVID-19 pandemic, our results show that those in the AG are particularly vulnerable to excessive IPEDs use. Sport disciplines associated with higher EAI and AAI scores have also shown a higher tendency to excessive IPEDs use. Furthermore, the factor of having above the cutoff scores in EAI or AAI in each sport could indicate larger IPEDs consumption regardless of the discipline. In light of the current findings, it is necessary to better define the “non-excessive” levels of exercise in various sport disciplines and an adequate intake of IPEDs to ensure the safety and well-being of people during a pandemic. (shrink)

SummaryThis study examines local heterogeneity in the aptitude of Sardinian mothers towards late reproduction, and explores its temporal persistence and association with both post-reproductive longevity and propensity to consanguineous marriage. Data on women's fertility from 1961 and birth records for 1980–1996 from Vital Statistics were analysed by means of the following indicators: the incidence of old mothers at last childbirth, female mortality at 80 years of age and over and the proportion of consanguineous marriages. A variable kernel-smoothing method was used (...) to create interpretable representations of the true spatial structure of the indicators, and to highlight areas of higher than expected intensity. In particular, an area of reproductive and post-reproductive longevity was identified where the traits combine with a higher tendency to relatedness. Intriguingly, this area corresponds approximately to the geographically and historically well defined central-eastern zone, which was the refuge of Sardinians during past invasions, and overlaps the Ogliastra region, which has been widely studied for its genetic homogeneity. (shrink)

The logic of discovering and that of justifying have been a permanent source of debate in mathematics, because of their different and apparently contradictory features within the processes of production of mathematical sentences. In fact, a fundamental unity appears as soon as one investigates deeply the phenomenology of conjecturing and proving using concrete examples. In this paper it is shown that abduction, in the sense of Peirce, is an essential unifying activity, ruling such phenomena. Abduction is the major ingredient in (...) a theoretical model suitable for describing the tran-sition from the conjecturing to the proving phase. In the paper such a model is introduced and worked out to test Lakatos' machinery of proofs and refutations from a new point of view. Abduction and its categorical counter-part, adjunction, allow to explain within a unifying framework most of the phenomenology of conjectures and proofs, encompassing also the method of Greek analysis-synthesis. (shrink)

The 21st century is characterized by an unpredictable and challenging work environment, and the Intrapreneurial Self-Capital (ISC) career and life construct can be seen as a core of individual intrapreneurial resources that enables people to cope with ongoing challenges, changes, and transitions founding innovative solutions when confronted with the constraints imposed by such an environment. The ISC is a challenging construct since it can enhance behavior and attitudes through specific training, unlike personality traits, which are considered substantially stable in the (...) literature. Against this background, the present study examined the relationship between ISC and well-being (hedonic well-being and eudaimonic well-being) controlling for the effects of personality traits. The Big Five Questionnaire (BFQ), the Intrapreneurial Self-Capital Scale (ISCS), the Satisfaction With Life Scale (SWLS), and the Flourishing Scale (FS) were administered to 258 Italian workers. Hierarchical regression analyses showed that ISC explained a percentage of incremental variance beyond that explained by personality traits in relation to both life satisfaction and flourishing. These results indicate that ISC is a key resource for hedonic well-being and eudaimonic well-being and that it offers new research and intervention opportunities. (shrink)

Recreational Drugs European Network (ReDNet) project aims to use the Psychonaut Web Mapping Project database (Psychonaut Web Mapping Group, 2009) containing novel psychoactive compounds usually not mentioned in the scientific literature and thus unknown to clinicians as a unique source of information. The database will be used to develop an integrated ICT prevention approach targeted at vulnerable individuals and focused on novel synthetic and herbal compounds and combinations. Particular care will be taken in keeping the health professionals working directly with (...) young people showing problematic behaviors regularly updated in terms of novel compounds and combinations as well. A user-friendly project website will be developed aimed primarily at delivering the information/prevention approaches, but will also be a way of communicating with project partners and relevant stakeholders (e.g. thematic forum facilities, instant messages, blogs, video chat, wikiblog, newsletters distributed via mailing list). The website will support various ICT prevention tools, including an SMS alert service. Different areas and sections will be aimed specifically at the different target groups. -/- . (shrink)