As a novelist who self‐consciously identified with the Romantic school of literature, Ayn Rand was intensely concerned with an individual's choices. For Rand man is a being of self‐made soul in two senses. By his specific choices, man necessarily creates the kind of person he becomes: the basic premises and values that move him. And man's faculty of volition gives him the power to (re)shape his soul in the image of his moral ideal. This chapter examines why, given the nature (...) of man's free will, Rand holds that an individual by his choices develops an implicit philosophy. To do this, the chapter considers three crucial issues in Rand's thought: her accounts of self‐esteem, of sense of life, and of psycho‐epistemology. Rand discusses the fact that the rationality or irrationality of an individual's social environment can encourage thought or encourage mental passivity and evasion. (shrink)

Ayn Rand is perhaps most widely known as an uncompromising advocate of laissez‐faire capitalism. This chapter focuses on Rand's account of some of the crucial philosophical premises implicit in the operations of a free market. It covers briefly the basic approach to knowledge and values that Rand argues is implicitly embedded in the operations of a free market. The chapter then moves to a discussion of her view of how this approach plays out: that it is the producers of economic (...) values (not the consumers) who govern the operations of a free market. Next, it explores Rand idea that statist systems are not alternative forms of economic production but simply the destruction, partial or total, of producers. Finally, the chapter sketches Rand's views on the relation of philosophy to economics and discusses her evaluations of some free‐market economists. (shrink)

An individual’s accountability to oneself leads to self-regulatory behaviour. A field experiment afforded an opportunity to test this relation, given that external accountability conditions were absent. A single group pre-test/post-test design was used to test the hypothesis. A group of full-time resident management students, n ≈ 550, take four meals during the day in the institute mess. As a part of the experiment, food wastage in the form of leftovers on the plates of subjects was measured. As a pre-test, the (...) measurement occurred at two levels. Subjects could see how much they are adding to the total waste by looking at a weighing scale placed under a waste basket, and they could also see the total waste data for each of the four meals for the day and a day earlier displayed at a prominent place. After 105 days, the weighing scale under the basket was removed, and as a post-test measurement, the total waste data for the four meals were noted down for another 72 days. A manipulation test indicated that the experiment has had the desired effect of invoking self-accountability in subjects during the pre-test phase, and diluting it during the post-test phase. Time series analysis of pre-test and post-test data indicated that the wastage data decreased in the pre-test phase. However, the post-test waste data showed an increase over a period of time. The results indicate that accountability conditions like social norms invoke self-accountability cognition leading to self-regulatory behaviours in individuals. (shrink)

We usually think nothing of our practice of ‘giving up’ on someone who has behaviors or attitudes that are morally criticizable—after all, it is my prerogative to choose with whom I will associate, and exclusion seems to be an unobjectionable part of my toolkit of social sanctions. However, this paper will argue that it is in many cases impermissible to give up on a morally unpleasant person—in fact, it would be to make an unjustified exception for oneself.

The Supreme Court’s Dobbs v. Jackson Women’s Health Organization decision, first leaked to the public on 2 May 2022 and officially released on 24 June 2022, overturned Roe v. Wade and thereby determined that abortion is no longer a federally protected right under the Constitution. Instead, the decision gives individual states the right to regulate abortion. Since the Dobbs decision first leaked, our institution has received numerous requests for permanent contraception from individuals stating that their motivation to pursue permanent contraception (...) was influenced by the Dobbs decision and concerns about their reproductive autonomy. Discussions with patients seeking permanent contraception since the Supreme Court’s leaked decision have led us to ask ourselves, is legislative anxiety an indication for surgery? This article presents a case series consisting of a convenience sample of 17 young, nulliparous individuals who sought out permanent contraception in the six months following the leak of the Dobbs decision. Healthcare professionals often feel discomfort in offering permanent contraception to young and nulliparous individuals. Accordingly, we discuss pertinent legal issues, review relevant ethical considerations, and offer a framework for these discussions intended to empower the consulting healthcare professional to center the bodily autonomy of every patient regardless of age, parity, or indication for permanent contraception. (shrink)

Research represents an avenue through which patients can contribute to the knowledge base surrounding their condition. However, persons with dementia cannot legally consent to participation in most scientific research. One possible avenue to preserve patient autonomy in the sphere of research is through an advance planning document. Scholars of medicine, ethics, and law have largely approached this topic from a theoretical angle, compelling the authors to develop and implement a tangible research-specific advance planning tool. In order to inform the creation (...) of this novel legal instrument, the present study leveraged semistructured telephone interviews with cognitively intact older adults in the Upper Connecticut River Valley region of New Hampshire. Participants were prompted to reflect on their attitudes toward participation in scientific research, should they develop dementia. They were also asked to consider the possibility of incorporating research into their advance planning regime, their preferred format for a research-specific advance planning tool, and the potential relationship between an advance planning tool and their surrogate decision maker in the context of research participation. Qualitative analysis was employed to extract themes from interview responses, revealing a pervasive desire for an advance planning tool that embraces specificity, flexibility, practicality, and the integral role of the surrogate decision maker. Ultimately, through collaboration with physicians and an elder law attorney in the region, these findings were translated into a research-specific advance planning component within the Dartmouth Dementia Directive. (shrink)

Many kinds of multifunctional regulatory proteins have been identified that perform distinct biochemical functions in the nucleus, the cytoplasm, or both. Here we describe the recent discovery by Hall et al. (2004)1 of a new type of multifunctional protein: a metabolic enzyme that doubles as a transcription factor. This enzyme, Arg5,6, functions as a catalytic enzyme in ornithine biosynthesis and also binds and regulates the promoters of nuclear and mitochondrial genes. It may also regulate precursor mRNA metabolism. We discuss how (...) proteins that serve as both metabolic enzymes and transcription factors might have evolved. BioEssays 27:467–471, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

It is now a well-documented statistic that Asian women between the ages of 15–35 are two to three times more vulnerable to suicide and self-harm than their non-Asian counterparts (Soni-Raleigh, 1996). The article will summarize the findings of the research report Growing Up Young, Asian and Female in Britain (Newham Asian Women's Project, 1998), which aimed to explore the reasons why young Asian women self-harmed and to evaluate the service responses they were given. It also made recommendations aimed at decreasing (...) the high prevalence of suicide and self-harm among young Asian women. The article concludes by reflecting upon the impact and service developments that have been made since the report was published. (shrink)

Imbalance in the pH of water reduces this precious resource as an extremely dangerous liquid for human health and plants’ growth. Change in the pH levels of the drinkable water has majorly raised concern towards diverse health issues like heart problems, infant mortality rates, pigmentation of skin, and cholera outbreaks. Therefore, it is necessary to keep a check on essential water quality components that include acidic/basic nature of water. As per the US Environmental Protection Agency, the drinkable water should have (...) a pH level ranging from 6.5 to 8.5. Two sample situates have been identified wherever highly reported pollutants levels were found and have been analyzed through artificial intelligence techniques. It can be observed that wavelet denoised signals fed into the least squares support vector regression and M5 prime regression tree predicted more accurately on the basis of the performance errors that are as follows: root mean squared error ; mean squared error ; mean absolute error. On the basis of these errors, the coefficient of determination/goodness of fit simulated for the prototypes is developed in this study. RMSE outcomes diminish on the whole on applying the training and forecasting data-division via WLSSVR and WM5pRT as compared with fitting the normalized data through LSSVR and M5pRT. These performance measures are essential to analyze the concentration levels of pH in the river streams at the identified sites of study. Thus, the observed pattern from this study may help for future estimation of the quality of water at their sources so that it prohibits the further increase in either acidic or basic salts which prove to be lethal for the environment. Thus, these predictors would be helpful towards formulation of strategies for protection of ecosystem and human health. (shrink)

We consider the structures $$, $$, $$, and $$ where $\mathbb {Z}$ is the additive group of integers, $\mathrm {SF}^{\mathbb {Z}}$ is the set of $a \in \mathbb {Z}$ such that $v_{p} < 2$ for every prime p and corresponding p-adic valuation $v_{p}$, $\mathbb {Q}$ and $\mathrm {SF}^{\mathbb {Q}}$ are defined likewise for rational numbers, and $<$ denotes the natural ordering on each of these domains. We prove that the second structure is model-theoretically wild while the other three structures are (...) model-theoretically tame. Moreover, all these results can be seen as examples where number-theoretic randomness yields model-theoretic consequences. (shrink)

The paper considers two-agent order acceptance scheduling problems with different scheduling criteria. Two agents have a set of jobs to be processed by a single machine. The processing time and due date of each job are known in advance. In the order accepting scheduling problem, jobs are allowed to be rejected. The objective of the problem is to maximize the net revenue while keeping the weighted number of tardy jobs for the second agent within a predetermined value. A mixed-integer linear (...) programming formulation is provided to obtain the optimal solution. The problem is considered as an NP-hard problem. Therefore, MILP can be used to solve small problem instances optimally. To solve the problem instances with realistic size, heuristic and metaheuristic algorithms have been proposed. A heuristic method is used to determine and secure a quick solution while the metaheuristic based on particle swarm optimization is designed to obtain the near-optimal solution. A numerical experiment is piloted and conducted on the benchmark instances that could be obtained from the literature. The performances of the proposed algorithms are tested through numerical experiments. The proposed PSO can obtain the solution within 0.1% of the optimal solution for problem instances up to 60 jobs. The performance of the proposed PSO is found to be significantly better than the performance of the heuristic. (shrink)

FAO has a unique and essential rolein addressing the ethical problems facinghumanity and in making these problems intoopportunities for practical resolution. A broadrange of ethical issues in agriculture,fisheries, and forestry were identified byanalysis of the literature and by interviewswith FAO staff. Issues include sharing accessto and preserving natural resources,introduction of new technology, conservatismover the use of genetic engineering, ethics inanimal agriculture, access to information, foodsecurity, sustainable rural development,ensuring participation of all people indecision making and in receiving benefits ofagriculture, reducing corruption, (...) andinvolvement of private and public sectors indecision making. Rather than viewing theseissues as problems, they should be viewed asopportunities for debate, learning aboutothers' views, and resolution. The UnitedNations has an important role to play in howdecisions are made in the global ethical debatein food and agriculture. The ethical role ofFAO is to promote global food security,balanced conservation, management andutilization of natural resources, andsustainable rural development. FAO should fullyand publicly assume its ethicalresponsibilities, gathering and sharinginformation on ethics in its areas of mandate,acting as an interactive forum, and providingexpert guidance on policy options and choicesbased on practical ethical analysis. (shrink)

In a perfect world, physicians and drug producers would have only one goal: to advance the health of their patients. Unfortunately, ours is not a perfect world. While every physician’s prime responsibility—by oath and by law—is to the patient, every pharmaceutical producer’s first and foremost obligation, by design, is to shareholders and employees. Their ultimate objectives are diagonally diverse. This situation calls for a code of ethics to govern the marketing and prescription of pharmaceuticals. This paper attempts to identifythe business (...) practices prevailing in the Indian pharmaceutical industry, in order to provide a basis for constructing an appropriate code of ethics. The research is based on surveys or in-depth interviews of physicians, patients, retail pharmacists, and drug manufacturers. (shrink)

This paper delves into a two-agent scheduling problem in which two agents are competing for a single resource. Each agent has a set of jobs to be processed by a single machine. The processing time, release time, weight, and the due dates of each job are known in advance. Both agents have their objectives, which are conflicting in nature. The first agent tries to minimize the total completion time, while the second agent tries to minimize the number of tardy jobs. (...) The two agents’ scheduling problem, an NP-hard problem, has a wide variety of applications ranging from the manufacturing industry to the cloud computing service provider. Due to the wide applicability, each variation of the problem requires a different algorithm, adapted according to the user’s requirements. This paper provides mathematical models, heuristic algorithms, and two nature-based metaheuristic algorithms to solve the problem. The algorithm’s performance was gauged against the optimal solution obtained from the AMPL-CPLEX solver for both solution quality and computational time. The outlined metaheuristics produce a solution that is comparable with a short computational time. The proposed metaheuristics even have a better solution than the CPLEX solver for medium-size problems, whereas the computation times are much less than the CPLEX solvers. (shrink)

This is the first scholarly study of Atlas Shrugged, covering in detail the historical, literary, and philosophical aspects of Ayn Rand's magnum opus. Topics explored in depth include the history behind the novel's creation, publication, and reception; its nature as a romantic novel; and its presentation of a radical new philosophy.

The essays in this collection treat historical, literary, and philosophical topics related to Ayn Rand's Anthem, an anti-utopia fantasy set in the future. The first book-length study on Anthem, this collection covers subjects such as free will, political freedom, and the connection between freedom and individual thought and privacy.

Ayn Rand's first novel, We the Living, offers an early form of the author's nascent philosophy—the philosophy Rand later called Objectivism. Robert Mayhew's collection of entirely new essays brings together pre-eminent scholars of Rand's writing. In part a history of We the Living, from its earliest drafts to the Italian film later based upon it, Mayhew's collection goes on to explore the enduring significance of Rand's first novel as a work both of philosophy and of literature.

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)