Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

In all domains of life, transmembrane proteins from the ATP‐binding cassette (ABC) transporter family drive the translocation of diverse substances across lipid bilayers. In pathogenic fungi, the ABC transporters of the pleiotropic drug resistance (PDR) subfamily confer antibiotic resistance and so are of interest as therapeutic targets. They also drive the quest for understanding how ABC transporters can generally accommodate such a wide range of substrates. The Pdr5 transporter from baker's yeast is representative of the PDR group and, ever since (...) its discovery more than 30 years ago, has been the subject of extensive functional analyses. A new perspective of these studies has been recently provided in the framework of the first electron cryo‐microscopy structures of Pdr5, as well as emergent applications of machine learning in the field. Taken together, the old and the new developments have been used to propose a mechanism for the transport process in PDR proteins. This mechanism involves a “flippase” step that moves the substrates from one leaflet of the bilayer to the other, as a central element of cellular efflux. (shrink)

We remember in social contexts. We reminisce about the past together, collaborate to remember shared experiences, and, even when we are alone, we remember in the context of our communities and cultures. Taking an interdisciplinary approach throughout, this text comprehensively covers collaborative remembering across the fields of developmental psychology, cognitive psychology, social psychology, discourse processing, philosophy, neuropsychology, design, and media studies. It highlights points ofoverlap and contrast across the many disciplinary perspectives and, with its sections on "Approaches of Collaborative Remembering" (...) and "Applications of Collaborative Remembering", also connects basic and applied research.Written with late-stage undergraduates and early-stage graduates in mind, the book is also a valuable tool for memory specialists and academics in the fields of psychology, cognitive science and philosophy who are interested in collaborative memory research. (shrink)

Bering's argument that human beings are endowed with a cognitive system dedicated to forming illusory representations of psychological immortality relies on the claim that children's beliefs in the afterlife are not the result of religious teaching. We suggest four reasons why this claim is unsatisfactory.

We examine the impact of employing a female, versus a male, leader on future (t + 1) donations and operating margin using a sample of 4387 unique nonprofit organizations (NPOs) between 2011 and 2014. Using two-stage and matched sample designs, we find that NPOs headed by female leaders report higher future operating margins but lower future donations. We interpret these findings to mean that female leaders are more focused on fiscal responsibility than fundraising. We also find that female leaders with (...) past fundraising experience attenuate lower future donations, and at commercial nonprofits, female leaders with prior for-profit experience contribute to even higher operating margins. Moreover, while female leaders identified as the founder of the organization increase future donations, they have no effect on future operating margins. Collectively, the results of our study should increase nonprofit boards’ confidence in hiring female leaders thereby narrowing the gender disparity in leadership in the nonprofit sector. This study expands the extant literature by providing initial evidence on the effects of female leaders in NPOs thereby contributing to research exploring gender, diversity, management, and nonprofit executives. (shrink)

Social media applications such as Twitter, YouTube and Facebook have attained huge popularity, with more than three billion people and organizations predicted to have a social networking account by 2015. Social media offers a rapid avenue of communication with the public and has potential benefits for communicable disease control and surveillance. However, its application in everyday public health practice raises a number of important issues around confidentiality and autonomy. We report here a case from local level health protection where the (...) friend of an individual with meningococcal septicaemia used a social networking site to notify potential contacts. (shrink)

Dispositional forgiveness is positively associated with many facets of wellbeing and has protective implications against depression and anxiety in adolescents. However, little work has been done to examine neurobiological aspects of forgiveness as they relate to clinical symptoms. In order to better understand the neural mechanisms supporting the protective role of forgiveness in adolescents, the current study examined the middle frontal gyrus, which comprises the majority of the dorsolateral prefrontal cortex and is associated with cognitive regulation, and its relationship to (...) forgiveness and clinical symptoms in a sample of healthy adolescents. In this cross-sectional study, larger MFG volume was significantly associated with higher self-reported dispositional forgiveness scores and lower levels of depressive and anxiety symptoms. Forgiveness mediated the relationship between MFG volume and both depressive and anxiety symptom levels. The mediating role of forgiveness in the relationship between MFG volume and clinical symptoms suggests that one way that cognitive regulation strategies supported by this brain region may improve adolescent mental health is via increasing a capacity for forgiveness. The present study highlights the relevance of forgiveness to neurobiology and their relevance to emotional health in adolescents. Future longitudinal studies should focus on the predictive quality of the relationship between forgiveness, brain volume and clinical symptoms and the effects of forgiveness interventions on these relationships. (shrink)

Focusing on corporate responsibility (CR) toward employees, this article discusses how multilayered institutional logics affect the relationship between the firm and its employee stakeholders. It considers what constitutes CR toward employees and explores the institutional logics that can shape whether employers treat their employees as merely means to a strategic end or as ends in themselves. Specifically, the article examines market-, state-, professional-, and firm-based institutional logics that influence how employers treat their employees. The conclusion suggests that external institutional logics (...) both enable and constrain firms to adopt a more instrumental relationship with their employees. However, some forms of organizational identity may generate firm-based institutional logics that enable firms to resist these pressures. Suggestions for future research focusing on the institutional and organizational drivers behind understanding CR toward employees are offered. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 20 (2000) 239-240 [Access article in PDF] News and Views Korean Temple Burnings and Vandalism: The Response of the Society for Buddhist-Christian Studies Harry L. WellsHumboldt State UniversityOver the course of the last decade a fairly large number of Buddhist temples in South Korea have been destroyed or damaged by fire by misguided Christian fundamentalists. More recently, Buddhist statues have been identified as idols, and attacked and (...) decapitated in the name of Jesus. Arrests are hard to effect, as the arsonists and vandals work by stealth of night. In 1998, the Society for Buddhist-Christian Studies announced its support for our Buddhist brothers and sisters and our disgust at such violent misuse of the name of Jesus. At the 1998 Board meeting, an ad hoc committee was set up to explore and develop strategies which would further address the situation. Below are some actions which have occurred during 1999. A Letter from Our President: The following letter of protest was sent on the Society's behalf on January 25, 1999 to the Prime Minister of the Republic of Korea and other governmental officials plus Korean church leaders and organizations. A second letter was sent to the U.S. State Department and the headquarters of various church bodies in the U.S. as well as the National Council of Churches. The Society for Buddhist-Christian Studies wishes to register its deepest sadness and most profound protest regarding the numerous acts of arson and malicious destruction done to Buddhist temples by misinformed and intolerant fundamentalist Christian groups throughout the Republic of South Korea. Professor Frank Tedesco of Sejong University first drew the attention of the Society to these incidents in an article he published in 1997 in Buddhist-Christian Studies, the journal of the Society for Buddhist-Christian Studies. More recently, two more Buddhist temples have been burned by fundamentalist Christians, seven hundred Buddhist images have been decapitated, and the Roman Catholic Cathedral was also burned because it contained images. All members of the Society for Buddhist-Christian Studies, both Christian and Buddhist, are embarrassed that such acts have been done in the name of [End Page 239] Jesus Christ, a name that demands that all persons should live in justice and peace, not sectarian stupidity and religious fanaticism. The small, but vocal, number of fundamentalist Christians in Korea who defend such actions as blows against pagan idolatry are simply wrong. Their actions are contrary to the core of Christian teaching and practice, which is that all persons are to be treated with love, justice, and respect. There is no excuse for intra-religious violence in Buddhist or Christian teaching and practice. Accordingly, the Society for Buddhist-Christian Studies not only deplores fundamentalist Christian attacks against Korean Buddhist temples, images, and persons, we ask that the government of Korea actively seek out all groups and persons engaged in violent actions against our Buddhist brothers and sisters and bring them to justice according to the laws of the Republic of Korea. May the peace at the heart of the Christian tradition and the heart of the Buddha's Dharma heal the minds of the violent so that all human beings may one day live as brothers and sisters in accord and dialogue. Paul O. Ingram, President A Section on the International Association for Religious Freedom Website Robert Traer, General Secretary of the International Association for Religious Freedom, graciously agreed to allow the Society to post a section on their website about the Buddhist-Christian tensions in Korea. His hope reflects the hope of our Society, that incidents of vandalism will cease and dialogue efforts increase. This page presently includes the summary account written by a SBCS member, Dr. Frank Tedesco, photos, and an introductory statement by our Society. Visit the site! A Call for Monetary Contributions The Society initiated a contributions drive to collect funds to send to Korea as a symbolic gesture of support of our Buddhist brothers and sisters whose temples and images have been attacked by extremist Christian vandals... (shrink)

This book demonstrates how children's imagination makes a continuing contribution to their cognitive and emotional development.

This dissertation serves as a monograph on the moral and social implications of a utilitarian-based system of health care which recognizes and takes rights seriously. Though the design and claims are stated primarily in terms of utilitarianism, admittedly, there are elements of communitarian, deontological, and rights theories which have been incorporated. ;Such a commingling of theoretical elements, under the claim of being utilitarian, may seem ambiguous, however, it is my contention that such inclusions only serve to enhance the plausible nature (...) of this sphere-specific form of utilitarianism and the adjudication of rights. Additionally, though there are other components of theories included, the basis of utilitarianism still serves as the foundation by which all other actions, decisions, and values are judged. ;While it is true that utilitarianism offers a standard for all areas of life, the idea of examining a sphere or environment of utility, in this case, the utility associated with the sphere of health care, allows for the good to be clearly defined. One primary weakness of classical utilitarianism is that it ignores, or at least does not do full justice to, the notion of personal responsibility or sense of obligation. If the only duty or requirement is to produce some obscure sense of the "greatest good" or the "greatest happiness," the question of how the good is identified and who is to have the good remains unanswered by the traditional utilitarian construct. ;The classical view of utilitarianism is too broad in its scope of defining "the greatest good" or realm of value. But to narrow the area of value to a particular sphere or environment allows for the utility and associated rights in question to be identified, the value measured, and the success more easily interpreted. ;While maintaining the general premise of utilitarianism, that is, "the greatest good for the greatest number," the notion is not from some nebulous concept or subjective position about life or feelings in general. This sphere-specific position also acknowledges and defines the "rights" of the individual within the particular sphere being considered, in this case, the sphere of health care. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist Meditation for the Recovery of the Womanist Self, or Sitting on the Mat Self-Love RealizedMelanie L. HarrisIn this essay, I will argue that Womanist-Buddhist dialogue is beneficial not only for advancing theory in our respective disciplines, but for the practice of social justice. In the dialogues for which we gathered, we followed a process of learning inspired by chavruse, the method of Torah and Talmudic study found in (...) yeshivas, in which one reads a text with friends, in order to see and understand in ways that would be impossible for individuals alone. The mutually constitutive project of Womanist-Buddhist engagement with Buddhist texts has helped to shift the boundaries within Womanist religious thought and Buddhist studies. We are grateful for the trust—essential to any healthy dialogue—embodied in our work together, and for the deep humility and honor that has been shown by all who are engaged in the process.The Buddhist "self": A Womanist PerspectiveIn a conversation with a friend recently, I was encouraged to hold on to the humanness that suffering teaches by being fully present with a broken heart. My grief was offered tea, and I was invited to join in the depths of suffering for a "spell," sharing stories of strength and longing, through a process of healing meditation. I hear this invitation echoed in essays by Alice Walker in We Are the Ones We've Been Waiting For: Inner Light in a Time of Darkness, as well as in the work of Jan Willis. Both scholars are committed to telling the truths in women's stories and uncovering the "true self" through spiritual means. Here, I present some reflections on how engaging Buddhist texts as a Womanist scholar opens up a new perspective on the Womanist theme of self-love and how this can shift our understanding of the Buddhist self.The "Buddhist self," you say? Although Buddhism insists there is "no self"? Yes! The concept of no-self in Buddhism is often equated with "dissolving" the self; I would argue that Buddhist contemplative practices can be seen and experienced as form of healthy self-love and self-care, necessary to sustain activists' work for compassionate justice. According to Walker's definition, a Womanist "Loves herself. Regardless."1 To consider Buddhist meditation as a strategy of self-love and social justice [End Page 67] helps us to see why so many African American women are turning toward Buddhism as a religious orientation.Buddhist meditation invites one to overcome oppression and transform the self and the community, by raising consciousness through a true turning or shifting of mind, in a manner that produces clarity of thought and inner peace. As the Buddhist nun Pema Chödrön has observed, most people who are not raised Buddhist come to Buddhism because they are suffering and trying desperately to get out of dukkha. However, when confronted with the First Noble Truth that suffering is just part of life, many people turn away from meditation, pack up their sitting mats, and return home to habitual patterns.Sitting still on the mat for a long time, for any length of time really, seems to most beginners like an otherworldly commitment—unless of course, one has reason to stay, reason to change. As Willis has observed, most people of African descent do have reason.2 She says Buddhism offers at least three major gifts to African Americans—I would add Womanists here—and to all people of color who have experienced historical traumas such as slavery, exploitation, and cultural genocide. They are: (1) confidence in our humanity—a special gift to a people who have endured four hundred years of slavery and oppression, in which the very essence of our humanity was consistently ravaged; (2) a way of being in the world that emphasizes self-love and inner and communal wholeness; and (3) a method for dealing with the frustrations, disappointments, and anger left behind by multilayered oppressions. Rather than negating the self, and everyone else around, by succumbing to practices of patriarchy, or by falling into the traps of internalized oppression, or by pulling out our hair after upsetting meetings, or by indulging... (shrink)

This anthology promotes a new vision: American Philosophy as complex and constantly changing, enlivened by historically marginalized, yet never silent, voices.

This paper uses Albert Camus to provide insight into understanding the New Left from an empirical psychological perspective and a normative ethical perspective. In the process we show how Students for a Democratic Society (SDS) moved from rebels to revolutionaries.

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 22 (2002) 127-131 [Access article in PDF] Beyond the Usual Alternatives in Buddhist-Christian Dialogue: A Trinitarian Pluralist Approach Harry L. Wells Humboldt State University When I was first asked to present this paper, I was concerned about the assignment —"Beyond the Usual Alternatives." I was told that the usual alternatives were exclusivism, inclusivism, and pluralism. I consider myself a pluralist, so how was I to go beyond (...) what I thought was the best paradigm? But I must make clear that I am a pluralist in the camp of Raimundo Panikkar and not of John Hick, the latter's approach being one that Panikkar has clearly "gone beyond" in my estimation. While pondering the dilemma of how to approach this paper, I auspiciously reencountered the breathtaking profundity of early Christian writings on the nature of reality as Trinitarian. What I found there was an incredibly dynamic notion of reality that refuses to be reductionistic to dualistic modes of analysis. I will do two main things in this paper: I will discuss the Christian experience and understanding of "the mystery of the Living God," including the Trinity and the Christ. In doing this, I will draw upon the book The Roots of Christian Mysticism, by Olivier Clement (New York: New City Press, 1993), whose exposition of these things has been one of rare clarity and wisdom. I will then reflect upon how the Christian Trinitarian reality can serve as a Christian framework for understanding pluralism and interreligious dialogue. If these reflections manage to move us beyond our usual alternatives, it is because they capture a profundity that early Christians knew was eternal and among us. The Mystery of the Living God God is always hidden and universal. That is the mystery of the Living God. Because all things spring forth from God, the world both hides and reveals God's being. God's being is expressed in particular relations that both reveal and conceal; God's being can never be objectified, though it is the horizon in which all things are situated. That is why we can only speak of the living God, as an encounter with God. As Clement points out: "The inexhaustible nature of transcendence is expressed in the profusion of creatures. The universe is the first Bible. Each being manifests the creative word [End Page 127] [the Logos of God] which gives it its identity and attracts it. Each being manifests a dynamic idea, something willed by God. Ultimately each thing is a created name of him who cannot be named" (Clement, p. 27).But to say "willed by God" in a Christian context does not mean a closed monotheism, with a notion of Supreme Being existing objectively independent of the creation. In its very heart, Christianity says God is inexhaustible communion.Dionysius the Areopagite, a pseudonym of an early-fifth-century Christian writer, wrote a treatise called "Divine Names." In it, he speaks of how from all eternity, God lives and reigns in glory, with each ray of glory being a divine Name, and these Names are innumerable. Early Christian writers spoke of these as the powers or energies that spring forth from the unapproachable nature of God that give each created reality, or each emerging manifestation, both its density and transparency. In other words, all things spring forth within God and are modes of the divine presence, receiving its density or particular identity, while clearly being transparent, arising in God. Each creature, each entity names in its own peculiar fashion the divine Names. To say, "from all eternity, God lives and reigns in glory" is to recognize that the very inexhaustible communion that is the cosmos arises from all eternity in the very nature of God. As Gregory Nazianzen proclaims in his work "Dogmatic Poems":... Everything that exists prays to thee And to thee every creature that can read thy universe Sends up a hymn of silence. In thee alone all things dwell. With a single impulse all things find their goal in thee. Thou art the purpose of every creature. Thou art... (shrink)

The appeal to expert opinion is an argument form that uses the verdict of an expert to support a position or hypothesis. A previous scheme-based treatment of the argument form is formalized within a Bayesian network that is able to capture the critical aspects of the argument form, including the central considerations of the expert's expertise and trustworthiness. We propose this as an appropriate normative framework for the argument form, enabling the development and testing of quantitative predictions as to how (...) people evaluate this argument, suggesting that such an approach might be beneficial to argumentation research generally. We subsequently present two experiments as an example of the potential for future research in this vein, demonstrating that participants' quantitative ratings of the convincingness of a proposition that has been supported with an appeal to expert opinion were broadly consistent with the predictions of the Bayesian model. (shrink)

Does hindsight knowledge make research seem more ethical and predictable? In line with the notion of hindsight bias, students in 3 experiments knowing the outcome of an animal experiment judged the results as more foreseeable and ethical relative to students who did not know the outcome. Via self to other comparisons, students evaluate themselves more favorably compared to a peer but exhibited hindsight bias in doing so. Uniquely, the findings reveal the possibility that students deem themselves to be more skeptical (...) and objective than their peers. Implications for teaching animal ethics and for Institutional Review Boards are discussed. (shrink)

The title of this volume -- Logic, God and Metaphysics -- is carefully chosen and, at the same time, descriptive of its main focus. In the twentieth century, the interests of most philosophers and theologians have fallen into only one of the three areas indicated -- logic, god or metaphysics. Since much of Anglo-American philosophy in this century has been analytic and antimetaphysical because of the influence of positivism, there have been few attempts at continuing metaphysical inquiry. In the early (...) part of the century, the logical atomists combined logic and metaphysics by arguing that the structure of reality is mirrored isomorphically in the structure of a formal, logically perfect, truth-functional language, but their effort was short-lived. Alfred North Whitehead and process philosophers have focused upon god and metaphysics but usually by adopting terminology and distinctions which are unique to certain systems -- making rigorous, logical analysis difficult or impossible. The papers included in this volume are illustrative of the application of careful, rigorous logical analysis to do critical philosophy of religion and what has been called constructive metaphysics. (shrink)

Taxometric analyses were applied to the construct of psychopathy (as measured by the Psychopathy Checklist) and to several variables reflecting antisocial childhood, adult criminality, and criminal recidivism. Subjects were 653 serious offenders assessed or treated in a maximum-security institution. Results supported the existence of a taxon underlying psychopathy. Childhood problem behaviors provided convergent evidence for the existence of the taxon. Adult criminal history variables were continuously distributed and were insufficient in themselves to detect the taxon.

As the field of vascularized composite allotransplantation (VCA) continues to evolve and technological approaches improve, VCA programs must focus on promoting greater consistency in psychosocial assessment across programs to support the equitable selection of patients. Based on a summary of published reports of VCA, we address the ethical considerations raised by the present heterogeneity of approaches to psychosocial assessment, including weighing risks and benefits, informed consent and the role of decisional capacity, and potential or perceived bias in the assessment process. (...) We propose transparency of process across the field and encourage VCA programs to work collaboratively to share approaches to psychosocial assessment both pre- and posttransplant to promote health equity. (shrink)

Bayesian probability has recently been proposed as a normative theory of argumentation. In this article, we provide a Bayesian formalisation of the ad Hitlerum argument, as a special case of the ad hominem argument. Across three experiments, we demonstrate that people's evaluation of the argument is sensitive to probabilistic factors deemed relevant on a Bayesian formalisation. Moreover, we provide the first parameter-free quantitative evidence in favour of the Bayesian approach to argumentation. Quantitative Bayesian prescriptions were derived from participants' stated subjective (...) probabilities (Experiments 1 and 2), as well as from frequency information explicitly provided in the experiment (Experiment 3). Participants' stated evaluations of the convincingness of the argument were well matched to these prescriptions. (shrink)

Across two studies, a wide age range of participants was interviewed about the nature of death. All participants were living in rural Madagascar in a community where ancestral beliefs and practices are widespread. In Study 1, children (8–17 years) and adults (19–71 years) were asked whether bodily and mental processes continue after death. The death in question was presented in the context of a narrative that focused either on the corpse or on the ancestral practices associated with the afterlife. Participants (...) aged 8 years and older claimed that death brings an end to most bodily and mental processes. Nevertheless, particularly in the context of the religious narrative, they claimed that certain mental processes continue even after death. This assertion of an afterlife was more evident among adults than children, especially with respect to cognitive processes, such as knowing and remembering. In Study 2, 5‐ and 7‐year‐olds were asked similar questions in connection with the death of a bird and a person. Seven‐year‐olds consistently claimed that bodily and mental processes cease at death, whereas 5‐year‐olds were unsystematic in their replies. Together, the two studies replicate and extend findings obtained with Western children showing that, in the course of development, different conceptions of death are elaborated—a biological conception in which death terminates living processes and a religious conception in which death marks the beginning of a new form of spiritual existence. (shrink)