After yeast cells commit to the cell cycle in a process called START, genes required for DNA synthesis are expressed in late G1. Periodicity is mediated by a hexameric sequence, known as a MCB element, present in all DNA synthesis gene promoters. A complex that specifically binds MCBs has been identified. One polypeptide in the MCB complex is Swi6, a transcription factor that together with Swi4 also binds G1 cyclin promoters and participates in a positive feedback loop at START. The (...) finding that Swi6 is directly involved in both START and DNA synthesis gene control suggest a model in which Swi6, activated through its participation in START, serves as the central transcription factor in coordinating late G1 gene expression. The mechanism may be conserved in all eukaryotic cells. (shrink)

Art in Three Dimensions is a collection of essays by one of the most eminent figures in philosophy of art.

The articles in this volume focus upon Boethius's extant works: his De arithmetica and a fragmentary De musica, his translations and commentaries on logic, his five theological texts, and, of course, his Consolation of Philosophy.

Intellectual character education has been primarily expressed in terms of educating for intellectual virtues (EFIV). This aim of teaching intellectual virtues has received some challenges, such as how it fails to articulate adequate action guidance through exemplarist pedagogy, and how it neglects the pervasiveness of intellectual vice among students. To respond to these challenges, this paper considers the aim of educating against intellectual vices (EAIV) – teaching students not to develop intellectual vices or weakening those that they have already developed (...) – which comes with the emergence of vice epistemology. More specifically, I look at how negative epistemic exemplars can be used as a classroom strategy for EAIV, and demonstrate how this could address the aforementioned weaknesses of EFIV. (shrink)

We listen to a cacophony of voices instructing us how to think and feel about nature, including our own bodies. The news media, wildlife documentaries, science magazines, and environmental NGOs are among those clamouring for our attention. But are we empowered by all this knowledge or is our dependence on various epistemic communities allowing our thoughts, sentiments and activities to be unduly governed by others? Drawing on over 30 years on research into the 'social constitution of nature', Making Sense of (...) Nature shows that what we call 'nature' is made sense of for us in ways that make it central to social order, social change and social dissent. By utilising insights and extended examples from anthropology, cultural studies, human geography, philosophy, politics, sociology, science studies, this interdisciplinary text asks whether we can better make sense of nature for ourselves, and thus participate more meaningfully in momentous decisions about the future of life - human and non-human - on the planet. This book shows how 'nature' can be made sense of without presuming its naturalness. The challenge is not so much to rid ourselves of the idea of nature and its 'collateral concepts' (such as genes) but instead, we need to be more alert to how, why and with what effects ideas about 'nature' get fashioned and deployed in specific situations. (shrink)

This is a very important contribution to the slowly emerging literature on psychoanalysis and time. By examining the influences on Freud's thinking about time and the development of what were his mostly implicit ideas about temporality, Kelly Noel-Smith offers a lively and impeccably scholarly new way of understanding the background to current developments in psychoanalytic theory and practice." - Professor Stephen Frosh, Birkbeck, University of London, UK. "Dr Noel-Smith displays deep knowledge of Freud's oeuvre, the relevant Ancient Greek (...) sources that Freud drew upon, and modern philosophical thought. Her expertise is synthesized into a well-organized inquiry into what Freud thought about time. I learned a huge amount from reading this clear, well-informed and profound exposition." - Professor Charles Stewart, University College London, UK. Time and timelessness are fundamental principles of psychoanalysis yet Freud does not present a consolidated theory of temporality. In this book Kelly Noel-Smith pieces together Freud's scattered 'hints' and 'suspicions' about time and its negative, timelessness. She traces a careful temporal trail through Freud's published works and his daunting Nachlass, and provides a compelling reason as to why Freud kept his remarkable thoughts about time to himself. Kelly Noel-Smith combines a career in law with an academic interest in psychoanalysis and philosophy. (shrink)

A collection of philosophical and aesthetic essays, influenced by Bernard Stiegler, which focuses on the techno-cultural artefact in order to critique, engage, or respond to, an aspect of digital culture.

In this essay, I am concerned with the representation of groups in popular culture. My interest has to do with the politics of representing people. The couplet beauty/nonbeauty (or, more specifically, beauty/ugliness) frequently figures importantly in the representation of groups, including most notably, for my purposes, ethnic and racial minorities. This couplet can be politically significant because beauty is often associated in our culture with moral goodness. . . . Thus, beauty and non beauty can serve as a basis for (...) political rhetoric. . . . If one concept of human beauty (which is connected to ideas of goodness) sees beauty as the instantiation or near approximation of the concept human being, then the related idea of human ugliness (which is connected with ideas of moral degradation) is rooted in problematic exemplifications of the concept of the human. These "problematic exemplifications" can take many forms. The two that will preoccupy me in this essay are the imperfect exemplifications of the human found in the popular genres of horror and humor. (shrink)

Y a-t-il une psychanalyse chrétienne? Cette question a-t-elle un sens? Un croyant souffrant doit-il ou non s'assurer que son psychanalyste est lui-même croyant pour protéger sa foi? Autrement dit, comment l'analyse intègre-t-elle ou modifie-t-elle une donnée religieuse? Faire une analyse, c'est accepter de traverser le tragique de sa propre vie. En raison du dévoilement de la vérité que ce processus met en œuvre, le patient voit se dégager devant lui la perspective d'un désir dont la nouvelle mesure est infinie. Ce (...) désir avait été comblé par des objets qui, jusque-là, semblaient le satisfaire. Puis, le symptôme surgit, déstabilise, perturbe les petits arrangements que le patient s'était autorisés. Première ou dernière scène de son tragique? Dans le huis clos théâtral qu'est la séance analytique, le patient-acteur reprend et parle toute son histoire. Comme à son insu, il se voit contraint de redéfinir ce qui donne sens à sa vie : sens religieux? sens éthique? Bref, tout ce qui échappe à l'analyse et que, paradoxe imprévisible, elle évoque et convoque... Pourtant, un point restera toujours aveugle pour lui, à l'instar d'Œdipe qui, les yeux crevés, poursuit son chemin. C'est peut-être en ce même point - tragique-aveugle - que l'homme reconnaît sous une lumière nouvelle que son histoire personnelle rejoint la détresse commune et ordinaire de toute l'humanité. (shrink)

Galen Strawson and Saul Smilansky have offered a well-known argument that free will does not exist because the control involved is so robust that it would require influence over an infinite series of prior decisions. (Strawson 1986, 1994, 2002, Smilansky 2000, 2002) Unfortunately, while this metaphysical argument has attracted widespread attention, it has garnered few adherents. Thus, in order to improve the metaphysical argument against free will, I offer a new interpretation of the argument, its fundamental principle, and its relationship (...) to incompatibilism. I demonstrate that the central principle of the argument is just as defensible as the central principle of one of the major arguments for incompatibilism (namely, Robert Kane's argument from ‘ultimate responsibility' in Kane 1996). Therefore, the metaphysical argument against free will deserves much more respect than it currently receives. (shrink)

Excerpt from La Logique de Hegel S'il n'en est pas de meme chez nous on peut du moins remar quer que le nom de Hegel, qui naguere encore semblait tout a fait oublie, se rencontre assez frequemment sous la plume de nos philosophes les plus autorises. M. Fouillee, en particulier, le cite a maintes reprises'dans ses deux derniers livres Le Mouvement posuiviste et Le Mouvement idealiste. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find (...) more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

Prescriptive rules guide human behavior across various domains of community life, including law, morality, and etiquette. What, specifically, are rules in the eyes of their subjects, i.e., those who are expected to abide by them? Over the last sixty years, theorists in the philosophy of law have offered a useful framework with which to consider this question. Some, following H. L. A. Hart, argue that a rule’s text at least sometimes suffices to determine whether the rule itself covers a case. (...) Others, in the spirit of Lon Fuller, believe that there is no way to understand a rule without invoking its purpose — the benevolent ends which it is meant to advance. In this paper we ask whether people associate rules with their textual formulation or their underlying purpose. We find that both text and purpose guide people’s reasoning about the scope of a rule. Overall, a rule’s text more strongly contributed to rule infraction decisions than did its purpose. The balance of these considerations, however, varied across experimental conditions: In conditions favoring a spontaneous judgment, rule interpretation was affected by moral purposes, whereas analytic conditions resulted in a greater adherence to textual interpretations. In sum, our findings suggest that the philosophical debate between textualism and purposivism partly reflects two broader approaches to normative reasoning that vary within and across individuals. Keywords: , the concept of law, rules, legal psychology, Hart, Fuller. (shrink)

Understanding Ethics introduces the frameworks of moral philosophy to analyse contemporary moral issues and perennial human dilemmas.While the early chapters ...

According to spacetime state realism, the fundamental ontology of a quantum mechanical world consists of a state-valued field evolving in four-dimensional spacetime. One chief advantage it claims over rival wave-function realist views is its natural compatibility with relativistic quantum field theory. I argue that the original density operator formulation of SSR cannot be extended to QFTs where the local observables form type III von Neumann algebras. Instead, I propose a new formulation of SSR in terms of a presheaf of local (...) state spaces dual to the net of local observables studied by algebraic QFT. 1Introduction2Spacetime State Realism in Quantum Field Theory 2.1Equivalence thesis3Entanglement and the Type III Property 3.1No-Go Lemma 13.2No-Go Lemma 24State Space Axioms for Quantum Field Theory 4.1Revised equivalence thesis5Discussion. (shrink)

Childcare robots are being manufactured and developed with the long term aim of creating surrogate carers. While total childcare is not yet being promoted, there are indications that it is 'on the cards'. We examine recent research and developments in childcare robots and speculate on progress over the coming years by extrapolating from other ongoing robotics work. Our main aim is to raise ethical questions about the part or full-time replacement of primary carers. The questions are about human rights, privacy, (...) robot use of restraint, deception of children and accountability. But the most pressing ethical issues throughout the paper concern the consequences for the psychological and emotional wellbeing of children. We set these in the context of the child development literature on the pathology and causes of attachment disorders. We then consider the adequacy of current legislation and international ethical guidelines on the protection of children from the overuse of robot care. (shrink)

Noel Carroll, film scholar and philosopher, offers the first serious look at the aesthetics of horror. In this book he discusses the nature and narrative structures of the genre, dealing with horror as a "transmedia" phenomenon. A fan and serious student of the horror genre, Carroll brings to bear his comprehensive knowledge of obscure and forgotten works, as well as of the horror masterpieces. Working from a philosophical perspective, he tries to account for how people can find pleasure in (...) having their wits scared out of them. What, after all, are those "paradoxes of the heart" that make us want to be horrified? (shrink)

Standard approaches to ontological simplicity focus either on the number of things or types a theory posits or on the number of fundamental things or types a theory posits. In this paper, I suggest a ground-theoretic approach that focuses on the number of something else. After getting clear on what this approach amounts to, I motivate it, defend it, and complete it.

Among the most well-known accounts of events is Jaegwon Kim’s exemplification theory, which identifies each event with a property exemplification. Two of the most influential rival event theorists have urged rejecting exemplificationism on the basis of the charge that it ultimately conflates events with facts [Lombard : Events: A Metaphysical Study. Routledge & Kegan Paul; Bennett :Events and their Names. Hackett Publishing Company]. In response, I offer a detailed examination of Lombard and Bennett’s arguments that exemplificationism undermines the event/fact distinction. (...) I then develop and defend a modified version of Kim’s account that overcomes this objection, and so constitutes a more plausible exemplification theory of events. (shrink)

Higher courts sometimes assess the constitutionality of law by working through a concrete case, other times by reasoning about the underlying question in a more abstract way. Prior research has found that the degree of concreteness or abstraction with which an issue is formulated can influence people's prescriptive views: For instance, people often endorse punishment for concrete misdeeds that they would oppose if the circumstances were described abstractly. We sought to understand whether the so-called ‘abstract/concrete paradox’ also jeopardizes the consistency (...) of judicial reasoning. In a series of experiments, both lay and professional judges sometimes reached opposite conclusions when reasoning about concrete cases versus the underlying issues formulated in abstract terms. This effect emerged whether participants reasoned with broad principles, such as human dignity, or narrow rules, and was largest among individuals high in trait empathy. Finally, to understand whether people reflectively endorse the discrepancy between abstract and concrete resolutions, we examined their reactions when evaluating both, either simultaneously or sequentially. These approaches revealed no single pattern across lay and expert populations, or exploratory and confirmatory studies. Taken together, our studies suggest that empathic concern plays a greater role in guiding the judicial resolution of concrete cases than in illuminating judges' professed standards—which may result in concrete decisions in violation of their own abstract principles. (shrink)

A major obstacle facing interpreters of quantum field theory is a proliferation of different theoretical frameworks. This article surveys three of the main available options—Lagrangian, Wightman, and algebraic QFT—and examines how they are related. Although each framework emphasizes different aspects of QFT, leading to distinct strengths and weaknesses, there is less tension between them than commonly assumed. Given the limitations of our current knowledge and the need for creative new ideas, I urge philosophers to explore puzzles, tools, and techniques from (...) all three approaches. (shrink)

The statue and the lump of clay that constitutes it fail to share all of their kind and modal properties. Therefore, by Leibniz’s Law, the statue is not the lump. Question: What grounds the kind and modal differences between the statue and the lump? In virtue of what is it that the lump of clay, but not the statue, can survive being smashed? This is the grounding problem. Now a number of solutions to the grounding problem require that we substantially (...) revise our view of reality. In this paper, I provide a solution to this problem that does not require such a revision. I then show how my solution to the grounding problem can solve a related problem and answer a related question. The upshot is that the solution I offer is not only non-revisionary, but also fruitful. (shrink)

Jill North argues that Hamiltonian mechanics provides the most spare -- and hence most accurate -- account of the structure of a classical world. We point out some difficulties for her argument, and raise some general points about attempts to minimize structural commitments.

Jecker et al. (2024) propose seven ethical principles to guide international bioethics conferencing, applying them to the selection of Qatar as the location for the 2024 World Congress of Bioethics...

Plans to automate killing by using robots armed with lethal weapons have been a prominent feature of most US military forces? roadmaps since 2004. The idea is to have a staged move from ?man-in-the-loop? to ?man-on-the-loop? to full autonomy. While this may result in considerable military advantages, the policy raises ethical concerns with regard to potential breaches of International Humanitarian Law, including the Principle of Distinction and the Principle of Proportionality. Current applications of remote piloted robot planes or drones offer (...) lessons about how automated weapons platforms could be misused by extending the range of legally questionable, targeted killings by security and intelligence forces. Moreover, the alleged moral disengagement by remote pilots will only be exacerbated by the use of autonomous robots. Leaders in the international community need to address the difficult legal and moral issues now, before the current mass proliferation of development reaches fruition. (shrink)

Candidates for fundamental physical laws rarely, if ever, employ higher than second time derivatives. Easwaran sketches an enticing story that purports to explain away this puzzling fact and thereby provides indirect evidence for a particular set of metaphysical theses used in the explanation. I object to both the scope and coherence of Easwaran's account, before going on to defend an alternative, more metaphysically deflationary explanation: in interacting Lagrangian field theories, it is either impossible or very hard to incorporate higher than (...) second time derivatives without rendering the vacuum state unstable. The so-called Ostrogradski instability represents a powerful constraint on the construction of new field theories and supplies a novel, largely overlooked example of non-causal explanation in physics. (shrink)

These essays are the fruit of many years' research by one of the world's leading Hobbes scholars. Noel Malcolm offers not only succinct introductions to Hobbes 's life and thought, but also path-breaking studies of many different aspects of his political philosophy, his scientific and religious theories, his relations with his contemporaries, the sources of his ideas, the printing history of his works, and his influence on European thought.