BET proteins such as Brd3 and Brd4 are chromatin‐associated factors, which control gene expression programs that promote inflammation and cancer. The Nrf2 transcription factor is a master regulator of genes that protect the organism against xenobiotic attack and oxidative stress. Nrf2 has demonstrated anti‐inflammatory activity and can support cancer cell malignancy. This review describes the discovery, mechanism and biomedical implications of the regulatory interplay between Nrf2 and BET proteins. Both Nrf2 and BET proteins are established drug targets. Small molecules that (...) either activate or suppress these proteins are currently tested in clinical trials. The crosstalk between Nrf2 and BET proteins may have important, and until now overlooked, implications for the therapeutic effects of these drugs. Based on the information covered in this review, it should be possible to design combinatorial treatment strategies for cancer and inflammatory diseases, which may improve the efficacy of targeting a Nrf2 or BET proteins individually. (shrink)

The forms of liberal government that emerged after World War II are in the midst of a profound crisis. In I Am the People, Partha Chatterjee reconsiders the concept of popular sovereignty in order to explain today’s dramatic outburst of movements claiming to speak for “the people.” To uncover the roots of populism, Chatterjee traces the twentieth-century trajectory of the welfare state and neoliberal reforms. Mobilizing ideals of popular sovereignty and the emotional appeal of nationalism, anticolonial movements ushered (...) in a world of nation-states while liberal democracies in Europe guaranteed social rights to their citizens. But as neoliberal techniques shrank the scope of government, politics gave way to technical administration by experts. Once the state could no longer claim an emotional bond with the people, the ruling bloc lost the consent of the governed. To fill the void, a proliferation of populist leaders have mobilized disaffected groups into a battle that they define as the authentic people against entrenched oligarchy. Once politics enters a spiral of competitive populism, Chatterjee cautions, there is no easy return to pristine liberalism. Only a counter-hegemonic social force that challenges global capital and facilitates the equal participation of all peoples in democratic governance can achieve significant transformation. Drawing on thinkers such as Antonio Gramsci, Michel Foucault, and Ernesto Laclau and with a particular focus on the history of populism in India, I Am the People is a sweeping, theoretically rich account of the origins of today’s tempests. (shrink)

Philosophical issues such as reality and appearance, God and world, self and not-self, rebirth and immortality, free will and determination, mysticism, etc., have been examined by eastern and western philosophers as far back as the sages of Upanishads (700 BCE) in the East, and Plato (400 BCE) in the West. However, there was no significant communication among the philosophers of the East and West perhaps until the eighteenth century. Arthur Schopenhauer (1788-1860) was one of the first among the great western (...) philosophers to recognize the value of Indian philosophies. Despite the lack of communication there are striking similarities of concepts and issues addressed by Indian and western philosophies. Also interesting is how similar are the mystical versions of different religions of the East and West. The author, Dr. Arun Chatterjee, has attempted to bring out the similarities and differences in various chapters of this book dealing with different topics. Among Indian philosophies the focus is on Vedanta philosophy and the views of Sri Aurobindo (1872-1950). The views of Swami Vivekananda (1863-1902) also are presented. Other Indian philosophies such as Sankhya and Buddhism are discussed briefly. Among western religions Judaism, Christianity, and Islam are discussed. (shrink)

The primary theme of this book is related to library and information science. The book is arranged into several chapters related to specific issues in knowledge organization and information dissemination. Library and Information science is a rapidly growing specialized field which is currently demanding ever more attention due to tremendous growth in data, information, and knowledge across the world. Therefore, to cater the growing need of library science professionals, and increasing demand for knowledge resources, this book has been compiled from (...) the research works undertaken independently and jointly by the authors containing several chapters dedicated to various aspects of LIS. Although most of the chapters have appeared as working papers in pre-print versions available in various public repositories which could be accessed via the internet, the authors have painstakingly undertook the effort to compile their works together in a formidable format for ready reference to current developments in the LIS profession. Some of the chapters have been thoroughly revised and reedited to give a fresh look to the theme and topics under discussion. (shrink)

The work of three present-day Sankritist-philosophers, _God and the World's Arrangement_ allows readers to engage directly with writings of the classical Indian philosophers Śaṅkara and Vācaspati, as well as some of their most acute critics, on the question of whether the existence of a creator God can be known by reason alone. Carefully selected and annotated with the needs of students foremost in mind, these new translations will be of interest to anyone wishing to see up close a newly set (...) gem of our philosophical inheritance from global antiquity. (shrink)

Compliance is a key concept in health care and affects all areas of health care including diabetes. Non-compliance has previously been a label attached to many patients without much thought having been given to the causes of poor compliance. Over the last few decades there has been a large volume of research focusing on compliance that has exposed the multitude of factors affecting compliance. Even the definition is not clear cut and so comparability between studies is not without difficulties. A (...) better understanding of the factors affecting compliance, including the doctor/patient relationship, has allowed the evolution of “concordance”. Concordance views the patient as being the equal of the healthcare provider and as having a right to make informed decisions. In a condition such as diabetes, which has many potential long term complications, it is vital that concordance is embraced in the healthcare system in order to improve care. (shrink)

When I first started to think about the neural basis of aesthetic experiences in the late 1990s, little was written on the topic. Unlike other domains of psychology, such as attention, or perception, or memory, aesthetics had not gained purchase in cognitive neuroscience. In fact, aesthetics was barely visible in psychology itself despite being rooted in Fechner's writings over a hundred years earlier. In 1999, papers by Zeki (1999) and Ramachandran and Hirstein (1999) were initial forays into scientific aesthetics by (...) established neuroscientists. While undeniably important as initial markers for the field, their papers were but a first step. They were speculative and did not offer a framework for a systematic research program. Scholars in the humanities latched on to these initial papers, in ways that were detrimental to the field. For the most part, they ignored subsequent careful experimental work done by neuroscientists, as if neuroaesthetics began and ended in 1999 (Chatterjee, 2011). Missing in early discussions was a basic question: what would a framework that could guide experimental progress in the neuroscience of aesthetics entail? (shrink)

Recent experimental research has revealed surprising patterns in people's intuitions about free will and moral responsibility. One limitation of this research, however, is that it has been conducted exclusively on people from Western cultures. The present paper extends previous research by presenting a cross-cultural study examining intuitions about free will and moral responsibility in subjects from the United States, Hong Kong, India and Colombia. The results revealed a striking degree of cross-cultural convergence. In all four cultural groups, the majority of (...) participants said that (a) our universe is indeterministic and (b) moral responsibility is not compatible with determinism. (shrink)

The Nyãya philosophy is primarily concerned with the conditions of valid thought and the means of acquiring true knowledge of objects. Its ultimate end, like that of the other systems of Indian philosophy, is liberation-a state of pure existence- which is free from both pleasure and pain. For the attainment of this liberation, a true knowledge of objects is the surest means. Hence the theory of knowledge is the very foundation of the Nyãya system. The Nyãya Theory of Knowledge is (...) the first systematic, critical and comparative treatment of the Nyãya epistemology. It reveals how, as a thorough-going realistic view of the universe, the Nyãya philosophy supplies an important Eastern parallel to the triumphant modern Realism of the West, and contains anticipations of as well as possible alternatives to many contemporary realistic theories. This book is important as much for the correct understanding of ancient Indian philosophy, as for the evaluation of modern Western philosophy. (shrink)

Arthāpatti does not depend on observation of pervasion or background belief. It is certain in the sense that when S cognizes P through postulation, no other epistemic instrument would invalidate P. The Naiyāyika tries to reduce postulation to anumāna and/or tarka. I shall argue that it is neither. Due to its explanatory role, one may think that postulation plays an essential role in lakṣaṇā or indication. But this too is a misconception. Both tarka and lakṣaṇā depend on observation and background (...) knowledge. Neither of them has the epistemic certainty postulation enjoys. I think, due to its observation-independent nature and certainty, postulation can be seen as the source of the knowledge of the truths of reason. (shrink)

Articles chiefly on Hindu philosophy and some on western philosophy.

How can a manager or an organization refine and enrich its global mindset orientation? A radically different frame of aligning people, strategy and purpose may be through the extension and enrichment of a global mindset rather than strategy or structure. This article explores the concept of global mindset from a new perspective and forwards a number of specific action frames for managers to reflect on. The article contends that the negative effects of contemporary globalization can only be overcome through the (...) enrichment of global vision of managers everywhere. As for applicability, the article argues that mindset development can only contribute to the sustainability of organizations and societies. (shrink)

How can a manager or an organization refine and enrich its global mindset orientation? A radically different frame of aligning people, strategy and purpose may be through the extension and enrichment of a global mindset rather than strategy or structure. This article explores the concept of global mindset from a new perspective and forwards a number of specific action frames for managers to reflect on. The article contends that the negative effects of contemporary globalization can only be overcome through the (...) enrichment of global vision of managers everywhere. As for applicability, the article argues that mindset development can only contribute to the sustainability of organizations and societies. (shrink)

The meaning of the term ‘tarka’ is not clear in the modern literature on Classical Indian Philosophy. This paper will review different modern readings of this term and try to show that what the Nyāyasūtra and its classical commentaries called a ‘tarka’ should be understood as the following: a tarka is a cognitive act that validates a content (of a doubt or a cognition or a speech-act) by demonstrating its logical fitness or invalidates a content by demonstrating its logical unfitness. (...) A tarka can act as a metatheory too. Generating certainty is, according to the Classical Nyāya, a job assigned to an epistemic instrument ( pramāṇa ). It fails to do so when there arises a doubt regarding it. The moment a tarka dispels the doubt, the epistemic instrument generates certainty. Tarkas of different types will be exemplified by critically analyzing Gaṅgeśa’s applications of tarka in his magnum opus Tattvacintāmaṇi . These examples will clarify the definition of tarka formulated in this paper. (shrink)

When somebody speaks metaphorically, the primary meanings of their words cannot get semantically connected. Still metaphorical uses succeed in conveying the message of the speaker, since lakṣaṇā, a meaning-generating faculty of language, yields the suitable secondary meanings. Gaṅgeśa claims that lakṣaṇā is a faculty of words themselves. One may argue: “Words have no such faculty. In these cases, the hearer uses observation-based inference. They have observed that sometimes competent speakers use the word w in order to mean s, when p, (...) the primary meaning of w does not make any semantic sense. In all such cases, s is actually related to p. After having observed this, when the hearer hears the utterance of w, and realizes that w’s primary meaning p is semantically unfit for the sentence-meaning, they infer on the basis of their prior observation that ‘the competent speaker must mean s by uttering w’. Thus lakṣaṇā becomes a success.” This apparently well-argued reduction does not stand the critical examination; neither in Gaṅgeśa’s framework, nor even in the general theory of language. For one can compose and interpret potentially infinite novel sentences based on lakṣaṇā while the observational inferences one can make are finite. Gaṅgeśa says very clearly that as far as the secondary meaning is concerned, no prior observation is required. This paper will argue that not only does language yield secondary meanings through lakṣaṇā, but it also restricts the use of secondary meanings; for one cannot mean just anything by saying something. Lakṣaṇā is a creative function with infinite potential within the limits set up by the language faculty. (shrink)

A mahāvidyā inference is used for establishing another inference. Its Reason is normally an omnipresent property. Its Target is defined in terms of a general feature that is satisfied by different properties in different cases. It assumes that there is no case that has the absence of its Target. The main defect of a mahāvidyā inference μ is a counterbalancing inference that can be formed by a little modification of μ. The discovery of its counterbalancing inference can invalidate such an (...) inference. This paper will argue that Cantor’s diagonal argument too shares some features of the mahāvidyā inference. A diagonal argument has a counterbalanced statement. Its main defect is its counterbalancing inference. Apart from presenting an epistemological perspective that explains the disquiet over Cantor’s proof, this paper would show that both the mahāvidyā and diagonal argument formally contain their own invalidators. (shrink)

A mahāvidyā inference is used for establishing another inference. Its Reason is normally an omnipresent property. Its Target is defined in terms of a general feature that is satisfied by different properties in different cases. It assumes that there is no case that has the absence of its Target. The main defect of a mahāvidyā inference μ is a counterbalancing inference that can be formed by a little modification of μ. The discovery of its counterbalancing inference can invalidate such an (...) inference. This paper will argue that Cantor’s diagonal argument too shares some features of the mahāvidyā inference. A diagonal argument has a counterbalanced statement. Its main defect is its counterbalancing inference. Apart from presenting an epistemological perspective that explains the disquiet over Cantor’s proof, this paper would show that both the mahāvidyā and diagonal argument formally contain their own invalidators. (shrink)

The classical Indian variety of history may be called ‘istory’. It is not completely true that no real importance was attached to istory in classical India. But much of oral istorical literature is lost since—perhaps—narrating istory was considered a performance. Unlike historical narratives, istorical narratives are presentative, not representative. Istory can be understood as a system of narrating past events that has a purpose and poetic beauty. Finally, the paper will argue that istory is based on cognitive tools of two (...) types: epistemic tools such as testimony, inference, tarka and aesthetic tools. Thus, it has a hybrid cognitive method. (shrink)

A speaker utters the grammatically correct phrase ‘x y’, and the hearer understands its meaning. The Naiyāyika claims that the only epistemic instrument that generates the semantic connection between the meaning of x and the meaning of y is testimony. This connection is essentially the phrase-meaning. The Vaiśeṣika wants inference to generate this connection. After presenting the Vaiśeṣika view on this topic, this paper will argue that, the hearer considers the generic categories of |x| and |y|, and infers their ontic (...) relation which finally will figure in the testimonial cognition. For example, when John tells Smith that ‘Jones smokes’, Smith first cognizes the meanings of the words, i.e., the individual called Jones and the activity of smoking. Then Smith infers that ‘John intends to say that the activity of smoking inheres in Jones, since an activity inheres in an individual.’ Thus, inherence which appears as the sematic connection is inferred in this case. If John is a reliable speaker, Smith will have a piece of testimonial knowledge. This is how the Vaiśeṣika’s inference could possibly support linguistic creativity. (shrink)

Brahmānanda Sarasvatī has written an elaborate comment on the following inference cited in Advaitasiddhi: attribute etc. are identical to and different from attributee etc. since they are co-referential. There he wants to prove that every significant case of attribution is a case of identity that coexists with a difference between two demarcators. The identity that coexists with difference is called ‘equality’. This paper will argue that in each case of equality, the realist ontology chooses either identity over difference or the (...) reverse. In the case of ‘the black pot’, the realist ontology prefers difference over identity. In the case of ‘the qualified object is the mere object’, the same ontology prefers identity over difference. Accordingly the ontological ‘entity’ gets projected. This is perhaps because the realist ontology is guided by Ockham’s razor and the grammatical classification of objects. (shrink)

The strainer tests the strength of a definition of a particular kind. Suppose the definition D is stated in terms of an absence, and x is a definiendum of D. The strainer collects each x-token or x-individual that dissatisfies D in a specific case. Then, all the x-individuals put together would be equivalent to the type x. Hence—one would be forced to conclude that—in a sense, x dissatisfies D. This is a case of under-application of D, since, despite being a (...) definiendum of D, x dissatisfies D. Therefore, D would be too narrow. Similarly, the strainer may detect over-application too. By using the strainer, Raghunātha Śiromaṇi demonstrated that Gaṅgeśa’s conclusive definition of pervasion had a defect, and redefined pervasion. The strainer test is based on intuitive principles. It may disqualify a definition that has an absence in its definiens. Therefore, strainer-proofing becomes an important consideration that must be borne in mind every time we formulate such a definition. (shrink)

This book provides a detailed analysis of classical and modern Indian views on consciousness along with their related meditative methods. It offers a critical analysis of three distinct trends of Indian thought.

An absence and its locus are the same ontological entity. But the cognition of the absence is different from the cognition of the locus. The cognitive difference is caused by a query followed by a cognitive process of introspection. The moment one perceptually knows y that contains only one thing, z, one is in a position to conclude that y contains the absence of any non-z. After having a query as to whether y has x one revisits one’s knowledge of (...) y containing z and comes to know that x is absent from y. Thus the knowledge of the absence of x logically follows from the knowledge of y containing z through the mediation of a query. This analysis goes against the thesis according to which an absence is an irreducible entity that is to be known through senses, and is inspired by the Mīmāṃsā views, especially the Prābhākara views, on absence and its cognition. (shrink)

The relevance of the guna theory to applications of Western management practice is seen in this paper as an insight holding capacity to guide managerial behaviour. In its essence, the guna theory depicts values which constitute human personality into a sattwa-rajas delineation of deepened understanding, giving direction to action and which, in turn, illustrates negative values likely to cause obstruction. For managers to appreciate this level of understanding, while simultaneously sensing those values which inhibit purposeful action, may be regarded as (...) containing strength in a more intuitive, subjective way than values of moral judgement adopted to guide managerial action in the West. As such, the guna theory has deep relevance in the face of egotistical, contractual or legal values, so often defining the parameters of Western management. (shrink)

Philosophers have long debated whether, if determinism is true, we should hold people morally responsible for their actions since in a deterministic universe, people are arguably not the ultimate source of their actions nor could they have done otherwise if initial conditions and the laws of nature are held fixed. To reveal how non-philosophers ordinarily reason about the conditions for free will, we conducted a cross-cultural and cross-linguistic survey (N = 5,268) spanning twenty countries and sixteen languages. Overall, participants tended (...) to ascribe moral responsibility whether the perpetrator lacked sourcehood or alternate possibilities. However, for American, European, and Middle Eastern participants, being the ultimate source of one’s actions promoted perceptions of free will and control as well as ascriptions of blame and punishment. By contrast, being the source of one’s actions was not particularly salient to Asian participants. Finally, across cultures, participants exhibiting greater cognitive reflection were more likely to view free will as incompatible with causal determinism. We discuss these findings in light of documented cultural differences in the tendency toward dispositional versus situational attributions. (shrink)