It is widely held that a successful theory of the mind will be neuroscientific. In this paper we ask, first, what this claim means, and, secondly, whether it is true. In answer to the first question, we argue that the claim is ambiguous between two views--one plausible but unsubstantive, and one substantive but highly controversial. In answer to the second question, we argue that neither the evidence from neuroscience itself nor from other scientific and philosophical considerations supports the controversial view.

Gold & Stoljar argue that there are two (often confused) neuron doctrines, one trivial and the other radical, with only the latter having the consequence that non-neuroscientific sciences of the mind will be discarded. They also attempt to show that there is no evidence supporting the radical doctrine. It is argued here that their dichotomy is artificial and misrepresents modern approaches to understanding the neuroscientific correlates of cognition and behavior.

As presently implemented, the neuron doctrine (ND) portrays the brain's neurons and chemical synapses as fundamental components in a computer-like switching circuit, supporting a view of brain = mind = computer. However, close examination reveals individual neurons to be far more complex than simple switches, with enormous capacity for intracellular information processing (e.g., in the internal cytoskeleton). Other poorly appreciated factors (gap junctions, apparent randomness, dendritic-dendritic processing, possible quantum computation, the living state) also suggest that the ND grossly oversimplifies (...) neuronal functions. In the quest to understand consciousness, the presently implemented ND may throw out the baby with the bath water. (shrink)

Neuronal remodeling is a conserved mechanism that eliminates unwanted neurites and can include the loss of cell bodies. In these processes, a key role for glial cells in events from synaptic pruning to neuron elimination has been clearly identified in the last decades. Signals sent from dying neurons or neurites to be removed are received by appropriate glial cells. After receiving these signals, glial cells infiltrate degenerating sites and then, engulf and clear neuronal debris through phagocytic mechanisms. There are (...) few identified or proposed signals and receptors involved in neuron‐glia crosstalk, which induces the transformation of glial cells to phagocytes during neuronal remodeling in Drosophila. Many of these signaling pathways are conserved in mammals. Here, we particularly emphasize the role of Orion, a recently identified neuronal CX3C chemokine‐like secreted protein, which induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling. Although, chemokine signaling was not described previously in insects we propose that chemokine‐like involvement in neuron/glial cell interaction is an evolutionarily ancient mechanism. (shrink)

We focus on the thesis that action understanding is a function of the mirror neuron system. According to our opinion, understanding is a process that runs through hermeneutic circles from the “Vorverständnis” (“previous understanding”) to steps of deeper understanding. Our critique relates to the narrow neuroscientific definition of action understanding as the capacity to recognize several movements as belonging to one action. After a reconstruction of the model's developments, we will challenge the claims of the model by Rizzolatti and (...) Sinigaglia (2010). By analyzing the relation between the experimental results and its interpretation, we will conclude that there is no proof that mirror neuron activity leads to action understanding. (shrink)

A central issue of cognitive neuroscience is to understand how a large collection of coupled neurons combines external signals with internal memories into new coherent patterns of meaning. An external stimulus localized at some input spreads over a large assembly of coupled neurons, building up a collective state univocally corresponding to the stimulus. Thus, the synchronization of spike trains of many individual neurons is the basis of a coherent perception. Based on recent investigations of homoclinic chaotic systems and their synchronization, (...) a novel conjecture for the dynamics of single neurons and, consequently, for neuron assemblies is formulated. Homoclinic chaos is proposed as a suitable way to code information in time by trains of equal spikes occurring at apparently erratic times. In order to classify the set of different perceptions, the percept space can be given a metric structure by introducing a distance measure between distinct percepts. The distance in percept space is conjugate to the duration of the perception in the sense that an uncertainty relation in percept space is associated with time-limited perceptions. This coding of different percepts by synchronized spike trains entails fundamental quantum features which are not restricted to microscopic phenomena. It is conjectured that they are related to the details of the perceptual chain rather than depending on Planck's action. (shrink)

A central issue of cognitive neuroscience is to understand how a large collection of coupled neurons combines external signals with internal memories into new coherent patterns of meaning. An external stimulus localized at some input spreads over a large assembly of coupled neurons, building up a collective state univocally corresponding to the stimulus. Thus, the synchronization of spike trains of many individual neurons is the basis of a coherent perception. Based on recent investigations of homoclinic chaotic systems and their synchronization, (...) a novel conjecture for the dynamics of single neurons and, consequently, for neuron assemblies is formulated. Homoclinic chaos is proposed as a suitable way to code information in time by trains of equal spikes occurring at apparently erratic times. In order to classify the set of different perceptions, the percept space can be given a metric structure by introducing a distance measure between distinct percepts. The distance in percept space is conjugate to the duration of the perception in the sense that an uncertainty relation in percept space is associated with time-limited perceptions. This coding of different percepts by synchronized spike trains entails fundamental quantum features which are not restricted to microscopic phenomena. It is conjectured that they are related to the details of the perceptual chain rather than depending on Planck's action. (shrink)

Up until only a few decades ago, not many scholars recognized scientific dignity in the problem of consciousness. In the last few years this scenario has changed. The rapid development of non-invasive research techniques that explore cerebral functions has not only increased our knowledge on the correlations between mental processes and cerebral structures, but it has fed our hopes for the possibility of facing the ancient and elusive question about the mind-brain relationship with a new way of thinking. The meeting (...) between neurosciences and phenomenology represents one of the most promising frontiers of current research. Neurophenomenology , a paradigm of research inaugurated by the Chilean neuroscientist Francisco Varela, tries to indicate a remedy to the various explicatory philosophical and scientific gaps, establishing a methodological and epistemological bridge between the so-called phenomenological reports in “first person” and the scientific evidence in “third person,” incorporating the experience on neurodynamic levels in an explicit and rigorous way and, above all, avoiding every alternative in the direction of any form of ontological reduction. (shrink)

All of our information about the world is derived from the function of our senses, and thus they are the principal source of all our knowledge. This was recognized explicitly by early Greek philosophers, remained an important point of discussion for nineteenth‐century philosophers, and continues to be a key issue for present‐day philosophers, psychologists, and neuroscientists. It is a key issue in cognitive science because, by initiating the processes that store and evaluate information, sensory information transmission can be considered a (...) cognitive initiator. In a very real sense, who we are and how we see the world are the result of the experiences that are mediated by our sensory systems. These are some of the reasons why the study of sensory systems has occupied such a prominent place in modern cognitive neuroscience. (shrink)

Opera is a performing art in which music plays the leading role, and the acting of singers has a synergistic effect with the music. The mirror neuron system represents the neurophysiological mechanism underlying the coupling of perception and action. Mirror neuron activity is modulated by the appropriateness of actions and clarity of intentions, as well as emotional expression and aesthetic values. Therefore, it would be reasonable to assume that an opera performance induces mirror neuron activity in the (...) audience so that the performer effectively shares an embodied performance with the audience. However, it is uncertain which aspect of opera performance induces mirror neuron activity. It is hypothesized that although auditory stimuli could induce mirror neuron activity, audiovisual perception of stage performance is the primary inducer of mirror neuron activity. To test this hypothesis, this study sought to correlate opera performance with brain activity as measured by electroencephalography in singers while watching an opera performance with sounds or while listening to an aria without visual stimulus. We detected mirror neuron activity by observing that the EEG power in the alpha frequency band was selectively decreased in the frontal-central-parietal area when watching an opera performance. In the auditory condition, however, the alpha-band power did not change relative to the resting condition. This study illustrates that the audiovisual perception of an opera performance engages the mirror neuron system in its audience. (shrink)

Anders, Rudi They dance in view, they dance in secret. And yet they dance together...

A recent single cell mRNA sequencing study by Dueck et al. compares neuronal transcriptomes to the transcriptomes of adipocytes and cardiomyocytes. Single cell ‘omic approaches such as those used by the authors are at the leading edge of molecular and biophysical measurement. Many groups are currently employing single cell sequencing approaches to understand cellular heterogeneity in cancer and during normal development. These single cell approaches also are beginning to address long‐standing questions regarding nervous system diversity. Beyond an innate interest in (...) cataloging cell type diversity in the brain, single cell neuronal diversity has important implications for neurotypic neural circuit function and for neurological disease. Herein, we review the authors’ methods and findings, which most notably include evidence of unique expression profiles in some single neurons. (shrink)

Gold & Stoljar's target article is important because it shows the limitations of neurobiological theories of the mind more powerfully than previous philosophical criticisms, especially those that focus on the subjective nature of experience and those that use considerations from philosophy of language to argue for the holism of the mental. They use less controversial assumptions and clearer arguments, the conclusions of which are applicable to the whole of neuroscience. Their conclusions can be applied to psychiatry to argue that, contrary (...) to many researchers' assumptions, the approaches to both understanding and treating mental disorders must be interdisciplinary. (shrink)

The concept of the receptive field, first articulated by Hartline, is central to visual neuroscience. The receptive field of a neuron encompasses the spatial and temporal properties of stimuli that activate the neuron, and, as Hubel and Wiesel conceived of it, a neuron’s receptive field is static. This makes it possible to build models of neural circuits and to build up more complex receptive fields out of simpler ones. Recent work in visual neurophysiology is providing evidence that (...) the classical receptive field is an inaccurate picture. The receptive field seems to be a dynamic feature of the neuron. In particular, the receptive field of neurons in V1 seems to be dependent on the properties of the stimulus. In this paper, we review the history of the concept of the receptive field and the problematic data. We then consider a number of possible theoretical responses to these data. (shrink)

This review article discusses Andrzej Bielecki’s book _Models of Neurons and Perceptrons: Selected Problems and Challenges_, as published by Springer International Publishing. This work exemplifies “philosophy in science” by adopting a broad, multidisciplinary perspective for the issues related to the simulation of neurons and neural networks, and the author has addressed many of the important philosophical assumptions that are entangled in this area of modeling. Bielecki also raises several important methodological issues about modeling. This book is recommended for any philosophers (...) who wish to learn more about the current state of neural modeling and find inspiration for a deeper philosophical reflection on the subject. (shrink)

At the global as well as local scales, some of the geometry of types of neuron arbors—both dendrites and axons—appears to be self-organizing: Their morphogenesis behaves like flowing water, that is, fluid dynamically; waterflow in branching networks in turn acts like a tree composed of cords under tension, that is, vector mechanically. Branch diameters and angles and junction sites conform significantly to this model. The result is that such neuron tree samples globally minimize their total volume—rather than, for (...) example, surface area or branch length. In addition, the arbors perform well at generating the cheapest topology interconnecting their terminals: their large-scale layouts are among the best of all such possible connecting patterns, approaching 5% of optimum. This model also applies comparably to arterial and river networks. S1063-651X 99 16205-6.. (shrink)

The trivial neuron doctrine (TND) holds that psychology merely depends on neurobiology. The radical neuron doctrine (RND) goes further and claims that psychology is superfluous in that neuroscience can “replace it.” Popular among RND notions of “replacement” is “reduction,” and in our commentary we challenge Gold & Stoljar (G&S) to make clear their distinction between merely depends on (TND) and is reducible to (RND). G&S give us a TND–RND distinction that is a distinction without a difference; a defensible (...) TND–RND distinction must have a metaphysical basis. We suggest a denial of compositionalism as such a basis. (shrink)

This chapter offers a brief review of theories on mirror neuron development, highlighting different models. These models focus on either the role of genetic mechanisms or the contributions of experience and of learning processes in shaping the brain circuits involved in action–perception coupling. As an alternative, the chapter proposes an epigenetic model for mirror neuron development, explaining how such a model can help to elucidate, within a unifying explanatory framework, the emergence, diversity, and functional reuse of mirror neurons. (...) Lastly, a related evolutionary scenario is sketched in which epigenetic regulation, genetic assimilation/the Baldwin effect, and niche construction play crucial roles in mirror neuron evolution. (shrink)

G&S describe the radical neuron doctrine in a number of slightly different ways, and we think this hides an important distinction. On the one hand, the radical neuron doctrine is supposed to have the consequence "that a successful theory of the mind will make no reference to anything like the concepts of linguistics or the psychological sciences as we currently understand them", and so Chomskyan linguistics "is doomed from the beginning" (sect. 2.2.2, paras. 2,3).[1] (Note that `a successful (...) theory' must be read as `any successful theory', else the inference will fail.) On the other hand, the radical neuron doctrine is said to be the claim "that emergent psychological properties can be explained by low-level neurobiological properties" (sect. 2.3, para. 3). It is clear from the context that this can be more faithfully rendered as: psychological phenomena can be explained in (solely) neurobiological terms. But this formulation of the doctrine does not have the consequence just mentioned. (shrink)

Nerve cells - neurons - are arguably the most complex of all cells. From the action of these cells comes movement, thought and consciousness. It is a challenging task to understand what molecules direct the various diverse aspects of their function. This has produced an ever-increasing amount of molecular information about neurons, and only in Molecular Biology of the Neuron can a large part of this information be found in one source. In this book, a non-specialist can learn about (...) the molecules that control information flow in the brain or the progress of brain disease in an approachable format, while the expert has access to a wealth of detailed information from a wide range of topics impacting on his or her field of endeavour. The text is designed to achieve a balance of accessibility and broad coverage with up-to-date molecular detail. In the six years since the first edition of Molecular Biology of the Neuron there has been an explosion in the molecular information about neurons that has been discovered, and this information is incorporated into this second edition. Entirely new chapters have been introduced where recent advances have made a new aspect of neuronal function more comprehensible at the molecular level. Written by leading researchers in the field, the book provides an essential overview of the molecular structure and function of neurons, and will be an invaluable tool to students and researchers alike. (shrink)

Neurons are arguably the most complex of all cells. From the action of these cells comes movement, thought and consciousness. It is a challenging task to understand what molecules direct the various diverse aspects of their function. This has produced an ever-increasing amount of molecular information about neurons, and only in Molecular Biology of the Neuron can a large part of this information be found in one source. In this book, a non-specialist can learn about the molecules that control (...) information flow in the brain or the progress of brain disease in an approachable format, while the expert has access to a wealth of detailed information from a wide range of topics impacting on his or her field of endeavour. The text is designed to achieve a balance of accessibility and broad coverage with up-to-date molecular detail. In the six years since the first edition of Molecular Biology of the Neuron there has been an explosion in the molecular information about neurons that has been discovered, and this information is incorporated into this second edition. Entirely new chapters have been introduced where recent advances have made a new aspect of neuronal function more comprehensible at the molecular level. Written by leading researchers in the field, the book provides an essential overview of the molecular structure and function of neurons, and will be an invaluable tool to students and researchers alike. (shrink)

A myriad of coordinated signals control cellular differentiation. Reprogramming the cell's proteome drives global changes in cell morphology and function that define cell phenotype. A switch in alternative splicing of many pre‐mRNAs encoding neuronal‐specific proteins accompanies neuronal differentiation. Three groups recently showed that the global splicing repressor, polypyrimidine track‐binding protein (PTB), regulates this switch.1-3 Although a subset of neuronal genes are turned on in both non‐neuronal and neuronal cells, restricted expression of PTB in non‐neuronal cells diverts their mRNAs to nonsense‐mediated (...) decay and prevents protein expression. When the PTB brake is released, the cell splices like a neuron. BioEssays 30:1–4, 2008. © 2007 Wiley Periodicals, Inc. (shrink)

activity” has been considered to play a major role in the short-term maintenance of memories. Many studies since then have provided support for this view and greatly advanced our knowledge of the effects of stimulus type and modality on delay activity and its temporal dynamics. In humans, working memory has also been a subject of intense investigation using scalp and intracranial electroencephalography as well as magnetoencephalography, which provide estimates of local population activity. The published findings include reports of systematic changes (...) in signal amplitude during working memory in the theta, alpha, beta. (shrink)

According to Gold & Stoljar, one cannot consistently be both reductionist about psychoneural relations and invoke concepts developed in the psychological sciences. I deny the utility of their distinction between biological and cognitive neuroscience, suggesting that they construe biological neuroscience too rigidly and cognitive neuroscience too liberally. Then, I reject their characterization of reductionism. Reductions need not go down past neurobiology straight to physics, and cases of partial, local reduction are not neatly distinguishable from cases of mere implementation. Modifying the (...) argument from unification as reduction, I defend a position weaker than the radical but stronger than the trivial neuron doctrine. (shrink)

The element of truth in behaviorism tells us that some versions of a radical neuron doctrine must be false. However, the representational nature of many mental states implies that neuroscience may well bear on some topics traditionally addressed by philosophers of mind. An example is the individuation of belief states.

I argue that the trivial neuron doctrine as characterized by Gold & Stoljar is not trivial; it appears to be inconsistent with property dualism as well as some forms of functionalism and externalism. I suggest that the problem is not so much with the particular way in which Gold & Stoljar draw the distinction as with the unruliness of the distinction itself. Their failure to see this may be why they misunderstand the views of the Churchlands.

(1) It is not clear from Gold and Stoljar’s definition of biological neuroscience whether it includes computational and representational concepts. If so, then their evaluation of Kandel’s theory is problematic. If not, then a more direct refutation of the radical neuron doctrine is available. (2) Objections to the psychological sciences might derive not just from the conflation of the radical and the trivial neuron doctrine. There might also be the implicit belief that for many mental phenomena, adequate theories (...) must invoke neurophysiological concepts and cannot be purely psychological. (shrink)

This paper presents a computer model of cortical broadcast and competition based on spiking neurons and inspired by the hypothesis of a global neuronal workspace underlying conscious information processing in the human brain. In the model, the hypothesised workspace is realised by a collection of recurrently inter-connected regions capable of sustaining and disseminating a reverberating spatial pattern of activation. At the same time, the workspace remains susceptible to new patterns arriving from outlying cortical populations. Competition among these cortical populations for (...) influence on the workspace is effected by a combination of mutual inhibition and top-down amplification. (shrink)

Individual neurons display characteristic firing patterns determined by the number and kind of ion channels in their membranes. We describe experimental and computational studies that suggest that neurons use activity sensors to regulate the number and kind of ion channels and receptors in their membrane to maintain a stable pattern of activity and to compensate for ongoing processes of degradation, synthesis and insertion of ion channels and receptors. We show that similar neuronal and network outputs can be produced by a (...) number of different combinations of ion channels and synapse strengths. This suggests that individual neurons of the same class may each have found an acceptable solution to a genetically determined pattern of activity, and that networks of neurons in different animals may produce similar output patterns by somewhat variable underlying mechanisms. BioEssays 24:1145–1154, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

The mechanism by which humans perceive others differs greatly from how humans perceive inanimate objects. Unlike inanimate objects, humans have the distinct property of being “like me” in the eyes of the observer. This allows us to use the same systems that process knowledge about self-performed actions, self-conceived thoughts, and self-experienced emotions to understand actions, thoughts, and emotions in others. The authors propose that internal simulation mechanisms, such as the mirror neuron system, are necessary for normal development of recognition, (...) imitation, theory of mind, empathy, and language. Additionally, the authors suggest that dysfunctional simulation mechanisms may underlie the social and communicative deficits seen in individuals with autism spectrum disorders. (shrink)