Introduction: There is evidence from earlier trials for the efficacy of music therapy in the treatment of depression among working-age people. Starting therapy sessions with relaxation and revisiting therapeutic themes outside therapy have been deemed promising for outcome enhancement. However, previous music therapy trials have not investigated this issue.Objective: To investigate the efficacy of two enhancers, resonance frequency breathing and listening homework, when combined with an established music therapy model.Methods: In a 2 × 2 factorial randomised controlled trial, working-age individuals (...) with depression were allocated into groups based on four conditions derived from either the presence or absence of two enhancers. All received music therapy over 6 weeks. Outcomes were observed at 6 weeks and 6 months. The primary outcome was the Montgomery Åsberg Depression Rating Scale score.Results: There was a significant overall effect of treatment for the primary outcome favouring the breathing group. The effect was larger after adjustment for potential confounders. Treatment effects for secondary outcomes, including anxiety and quality of life, were also significant, favouring the breathing group. The homework enhancer did not reach significant treatment effects.Conclusion: We found that the addition of RFB to a music therapy intervention resulted in enhanced therapeutic outcome for clients with depression. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

A philosophical exploration of the entire seven-book _Harry Potter_ series _Harry Potter_ has been heralded as one of the most popular book series of all time and the philosophical nature of Harry, Hermione, and Ron's quest to rid the world of its ultimate evil is one of the many things that make this series special. _The Ultimate Harry Potter and Philosophy _covers all seven titles in J.K. Rowling's groundbreaking_ _series and takes fans back to Godric's Hollow to discuss life after (...) death, to consider what moral reasoning drove Harry to choose death, and to debate whether Sirius Black is a man or a dog. With publication timed to coincide with the release of the movie _Harry Potter and the Deathly Hallows, _this book will be the definitive guide for all fans looking to appreciate the series on a deeper level. Covers a range of intriguing topics such as the redemption of Severus Snape, the power of love, and destiny in the wizarding world Gives you a new perspective on _Harry Potter_ characters, plot lines, and themes Makes a perfect companion to the _Harry Potter _books and movies Packed with interesting ideas and insights, _The Ultimate Harry Potter and Philosophy _is an ideal companion for anyone interested in unraveling the subtext and exploring the greater issues at work in the story. (shrink)