The Protein Ontology (PRO) provides a formal, logically-based classification of specific protein classes including structured representations of protein isoforms, variants and modified forms. Initially focused on proteins found in human, mouse and Escherichia coli, PRO now includes representations of protein complexes. The PRO Consortium works in concert with the developers of other biomedical ontologies and protein knowledge bases to provide the ability to formally organize and integrate representations of precise protein forms so as to enhance accessibility to results of protein (...) research. PRO (http://pir.georgetown.edu/pro) is part of the Open Biomedical Ontologies (OBO) Foundry. (shrink)

The article considers the interpretation of the culture and philosophy of Ancient Egypt and Babylon in the texts of writers of the late nineteenth–early twentieth centuries. This topic was highly important and widely discussed in connection with the outstanding discoveries of archaeological expeditions in the 1900–1920s in the Valley of the Kings on the Nile. In his treatise “Tajna trekh: Egipet i Vavilon”, Dmitry Merezhkovsky, referring to religious views of the previous eras, attempted to find an ideological synthesis that could (...) unite and reconcile people in the hard times of wars and revolutions. Alexander Chayanov in his story “Puteshestvie moego brata Alekseia v stranu krest’ianskoj utopii” turned to the biblical symbolism of the Tower of Babel which sought to overcome, as it were, the chaos that engulfed society—to give a warning against rash prometheistic ideas. He examined the ability of man to fight against the power of fate, to remain true to himself and to his ideas. In his mystical stories there can be traced allusions to the mysteries of the goddess Isis. Their heroines bear chthonic features. Chayanov examined how the feeling of love can destroy or revive the hero depending on his integrity and readiness to undergo evolution in order to find harmony. (shrink)

The rapid and unplanned change to teaching and learning in the online format brought by COVID-19 has likely impacted many, if not all, aspects of university students' lives worldwide. To contribute to the investigation of this change, this study focuses on the impact of the pandemic on student well-being, which has been found to be as important to student lifelong success as their academic achievement. Student well-being has been linked to their engagement and performance in curricular, co-curricular, and extracurricular activities, (...) intrinsic motivation, satisfaction, meaning making, and mental health. The purpose of this study was to examine how student perceptions of their degree completion and future job prospects during the pandemic impact their well-being and what role university support plays in this relationship. We used the conservation of resources theory to frame our study and to develop five hypotheses that were later tested via structural equation modeling. Data were collected from 2,707 university students in France, Germany, Russia, and UK via an online survey. The results showed that university support provided by instructors and administration plays a mediating role in the relationship between the perceived impact of COVID-19 on degree completion and future job prospects and levels of student well-being. Student well-being is decreased by their concerns for their degree completion but not by their concerns for future job prospects. In turn, concerns for future job prospects affect student well-being over time. These results suggest that in a “new normal,” universities could increase student well-being by making support to student studies a priority, especially for undergraduates. Also, universities should be aware of the students' changing emotional responses to crisis and ensure visibility and accessibility of student support. (shrink)

Russia’s relations with the European Court of Human Rights since the time of Russia’s accession to the Council of Europe have received a lot of attention on the part of academic scholars, practitioners, and media. Research on the ECtHR became especially important in the context of the twentieth anniversary of Russia’s acceptance of ECtHR jurisdiction that coincided with the unprecedented worsening of relations between Russia and the European countries due to the 2014 Crimea annexation. With voices that consistently advocate Russia’s (...) exit from the CoE, we believe it necessary to examine Russia-ECtHR relations as they are presented in the academic narrative. Drawing mostly on Russian-language sources, we want to highlight the variety of overarching themes and arguments relating to the crisis caused by the 2015 Constitutional Court Decision. We would like to examine various dimensions of this “crisis,” in order to be able to conclude whether Russia’s reaction to the Markin case and cases of non-compliance that followed was indeed part of a broader strategy of “backlash against international courts” we are currently witnessing worldwide. In the conditions when Russia’s exit from the Council of Europe is as likely as ever, the possibility of the “snowball effect” on the part of other member states threatens undermine the very raison d’être of the European human rights protection system. (shrink)

The question arises from recent arguments, including one by G. E. M. Anscombe, which hold that a belief in one's ability to choose one's actions is incompatible with a causal account of the world. For, if one's arguments deny either choice or causal sequences, how can one account for human control of actions? If to control one's actions means to work to cause some chosen end, and if either point of the argument were correct, how could anyone ever control one's (...) actions at all? Yet we must be able to control actions if we are to seek out and select from evidence or develop any kind of conceptual scheme. I want to develop this necessity-of-control notion to show that arguments such as those advanced by Miss Anscombe are incoherent and to show that we must retain our notion of choice while giving a causal account of the world. I will argue that deterministic sequences and the notions of choice and control go together: in order for us to have a tenable explanation of the world we must be able to talk about choice and control and we must identify and use predictable deterministic sequences in our acting and choosing. I shall argue that we can retain both causal explanation and choice only by employing two different conceptions of causal agency: merely physical agency and the voluntary agency of embodied actors. (shrink)

Defining and implementing Corporate Responsibility can be a challenge for many businesses. The identification of patterns in the processes of adoption and implementation of Corporate Responsibility practices can help managers to administer these processes more ably. In this research note, the authors identify four factors influencing the adoption and implementation of Corporate Responsibility practices: internal drivers; organizational structures; attributes of practice; and formal processes. Results indicate that there is also a continuous improvement component, meaning that the adoption and implementation of (...) Corporate Responsibility practices are cyclical, rather than linear, processes. (shrink)

ABSTRACT In this paper, we show that Kant’s complex concept of an “intuitive understanding”, which operates in his work as a tool for defining the peculiar character of our understanding, is critically absorbed by Hegel’s concept of “objective thought.” By means of this concept, Hegel first rejects the representational conception of thought that is implied by the Kantian concept of an intuitive understanding and, second, he proposes a way of comprehending thought that allows a new conception of the relationship between (...) the subject and reality. (shrink)

In this book, W. V. Quine’s Immanuel Kant Lectures entitled Science and Sensibilia are published for the first time in English. These lectures represent an important stage in the development of Quine’s later thought, where he is more explicit about the importance of physicalist constraints in his account of the steps from sensory stimulation to scientific theory, and in further using them to assess the extent to which mental vocabulary is defensible. Taken as a unit, these lectures fill an important (...) gap in our understanding of his philosophical development from his 1973 work The Roots of Reference to his later work. The volume further contains an introduction that outlines the content and philosophical significance of the lectures. In addition, several essays written by leading scholars of Quine’s philosophy provide further insight into the important issues raised in the lectures. (shrink)

We examine physicists’ charge of ad hocness against the Higgs mechanism in the standard model of elementary particle physics. We argue that even though this charge never rested on a clear-cut and well-entrenched definition of “ad hoc”, it is based on conceptual and methodological assumptions and principles that are well-founded elements of the scientific practice of high-energy particle physics. We further evaluate the implications of the recent discovery of a Higgs-like particle at the CERN’s Large Hadron Collider for the charge (...) of ad hocness against the Higgs mechanism. (shrink)

In response to growing concern in the 1980s about the quality of public education across the United States, a tremendous amount of energy was expended by organizations such as the Holmes Group and the Carnegie Forum to organize professional development schools or “partner schools” for teacher education. On the surface, the concept of partnering is simple; however, the practice is very costly, complex, and difficult. In _Schooling, Democracy, and the Quest for Wisdom_, Robert V. Bullough, Jr. and John R. Rosenberg (...) examine the concept of partnering through various lenses and they address what they think are the major issues that need to be, but rarely are, discussed by thousands of educators in the U.S. who are involved and invested in university-public school partnerships. Ultimately, they assert that the conversation around partnering needs re-centering, refreshing, and re-theorizing. (shrink)

This book completes the Clarendon Aristotle Series edition of the Politics. One might assume that, since David Keyt’s contribution is the last of the four on the Politics, when Aristotle scholars agreed to write these volumes, he was fourth in line and so got stuck with Politics V–VI. Surely, one might think, few would choose Politics V–VI over Politics I–II, with its fascinating discussions of the fundamental nature of the polis, the infamous chapters on slavery, and the critique of the (...) communism of Plato’s Republic; or over Politics VII–VIII, which contains Aristotle’s presentation of the best political system; or even over Politics III–IV, with its important classification and discussion of the different types of political systems. But in fact, Keyt had been thinking about writing a commentary on Politics V–VI for some time: “The idea of writing a commentary on Aristotle’s study of faction and constitutional change was formed in the late 1960s during the period of political unrest in the United States connected with the Vietnam War. In the summer of 1971 I discussed the possibility of doing this volume in the Clarendon Aristotle Series with John Ackrill”. We can be happy that Keyt and Ackrill returned, over two decades later, to the idea of such a commentary, because the result is an excellent addition to the Clarendon Aristotle Series. (shrink)

Ecological rationality is a concept important to most environmental and natural resources policy and to much policy-relevant literature and research. Yet ecological rationality as a distinctive form of reason can only be understood and appreciated in the context of a larger body of work on the general concept of rationality. In particular, Herbert Simon’s differentiation between substantive and proceduralrationality and Paul Diesing’s specification of forms of practical reason are useful tools in mapping and defining ecological rationality. The significance and characteristics (...) of ecological rationality suggest that it is a fundamental kind of reason, having precedence over others. (shrink)

We introduce the concept of fraud tolerance, validate the conceptualization using prior studies in economics and criminology as well as our own independent tests, and explore the relationship of fraud tolerance with numerous cultural attributes using data from the World Values Survey. Applying partial least squares path modeling, we find that people with stronger self-enhancing values exhibit higher fraud tolerance. Further, respondents who believe in the importance of hard work exhibit lower fraud tolerance, and such beliefs mediate the relationship between (...) locus of control and fraud tolerance. Finally, we find that people prone to traditional gender stereotypes demonstrate higher fraud tolerance and document subtle differences in the influence of these cultural attributes across age, religiosity, and gender groups. Our study contributes to research on corporate governance, ethics, and the antecedents of work-place dishonesty. (shrink)

Thomas Schelling, who wrote the foreword for this book, won the Nobel Prize in economics for "having enhanced our understanding of conflict and cooperation through game-theory analysis." This came after he had taught a course in game theory and rational choice to advanced students and government officials for 45 years. In this book, Robert Dodge provides in language for a broad audience, the concepts that Schelling taught. Armed with Schelling's understanding of game theory methods and his approaches to problems, the (...) general reader can improve daily decision making. Mathematics often make game theory challenging but was not a major part of Schelling's course and is even less of a factor in this book. Along with a summary of the material Schelling presented, included are problems from the course and similar less challenging questions. While considerable analysis is done with the basic game theory tool--the two-by-two matrix--much of the book is descriptive and rational decision-making is explained with stories. Chapter supplements are added to illuminate points presented by Schelling, including writings by Paul Krugman, Thomas Friedman, Steven Levitt, and others. (shrink)