In 2004, the Havasupai Tribe filed a lawsuit against the Arizona Board of Regents and Arizona State University researchers upon discovering their DNA samples, initially collected for genetic studies on type 2 diabetes, had been used in several other genetic studies. The lawsuit reached a settlement in April 2010 that included monetary compensation and return of DNA samples to the Havasupai but left no legal precedent for researchers. Through semistructured interviews, institutional review board chairs and human genetics researchers at US (...) research institutions revealed their perspectives on the Havasupai lawsuit. For interviewees, the suit drew attention to indigenous concerns over genetic studies and increased their awareness of indigenous views. However, interviewees perceived no direct impact from the Havasupai case on their work; if they did, it was the perceived need to safeguard themselves by obtaining broad consent or shying away from research with indigenous communities altogether, raising important questions of justice for indigenous and minority participants. If researchers and IRBs do not change their practices in light of this case, these populations will likely continue to be excluded from a majority of research studies and left with less access to resources and potential benefit from genetic research participation. (shrink)

There has been considerable debate on which genomic research results to return to participants and when those results should be returned, but little attention to how those results should be returned, especially to minority and culturally diverse participants. This paper explores the cultural and ethical considerations around returning research results to participants and families of culturally diverse backgrounds, with a special focus on considerations when the research participant is deceased, and raises points for further discussion.

Volume 19, Issue 5, May 2019, Page 34-36.

As genomic science has evolved, so have policy and practice debates about how to describe and evaluate the ways in which genomic information is treated for individuals, institutions, and society. The term genetic exceptionalism, describing the concept that genetic information is special or unique, and specifically different from other kinds of medical information, has been utilized widely, but often counterproductively in these debates. We offer genomic contextualism as a new term to frame the characteristics of genomic science in the debates. (...) Using stasis theory to draw out the important connection between definitional issues and resulting policies, we argue that the framework of genomic contextualism is better suited to evaluating genomics and its policy-relevant features to arrive at more productive discussion and resolve policy debates. (shrink)

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

Bioethicists frequently call for empirical researchers to engage participants and community members in their research, but don't themselves typically engage community members in their normative research. In this article, we describe an effort to include members of the public in normative discussions about the risks, potential benefits, and ethical responsibilities of social and behavioral genomics (SBG) research. We reflect on what might—and might not— be gained from engaging the public in normative scholarship and on lessons learned about public perspectives on (...) the risks and potential benefits of SBG research and the responsible conduct and communication of such research. We also provide procedural lessons for others in bioethics who are interested in engaging members of the public in their research. (shrink)

We agree with Saunkeah and colleagues that research ethics principles outlined by the Belmont Report—which guide the procedural basis for “human subjects” research in the United States throu...

In this consensus report by a diverse group of academics who conduct and/or are concerned about social and behavioral genomics (SBG) research, the authors recount the often‐ugly history of scientific attempts to understand the genetic contributions to human behaviors and social outcomes. They then describe what the current science—including genomewide association studies and polygenic indexes—can and cannot tell us, as well as its risks and potential benefits. They conclude with a discussion of responsible behavior in the context of SBG research. (...) SBG research that compares individuals within a group according to a “sensitive” phenotype requires extra attention to responsible conduct and to responsible communication about the research and its findings. SBG research (1) on sensitive phenotypes that (2) compares two or more groups defined by (a) race, (b) ethnicity, or (c) genetic ancestry (where genetic ancestry could easily be misunderstood as race or ethnicity) requires a compelling justification to be conducted, funded, or published. All authors agree that this justification at least requires a convincing argument that a study's design could yield scientifically valid results; some authors would additionally require the study to have a socially favorable risk‐benefit profile. (shrink)

In Bester’s article (2018) challenging the use of the harm principle and advocating sole reliance on the use of a best interest standard (BIS) in pediatric decision-making, we believe that the auth...

“The sins of the fathers are to be laid upon the children.”Just after midnight on March 21, 2003, a drunk stood on a footbridge over a motorway in a village in Surrey in southern England. After eight pints of beer, he was drunk enough to decide to drop a brick from the overpass into traffic to see if he could hit something; unfortunately, he was not so drunk that he missed. The brick crashed through the windshield on the driver's side (...) of a truck. It hit the driver, Michael Little, in the chest, triggering a fatal heart attack. He stayed conscious long enough to pull the truck safely to the side of the road, thereby perhaps saving other motorists; then he died. The crime was widely publicized, as was the driver's role in preventing any further accidents. (shrink)

ABSTRACT:A wide range of research uses patterns of genetic variation to infer genetic similarity between individuals, typically referred to as genetic ancestry. This research includes inference of human demographic history, understanding the genetic architecture of traits, and predicting disease risk. Researchers are not just structuring an intellectual inquiry when using genetic ancestry, they are also creating analytical frameworks with broader societal ramifications. This essay presents an ethics framework in the spirit of virtue ethics for these researchers: rather than focus on (...) rule following, the framework is designed to build researchers’ capacities to react to the ethical dimensions of their work. The authors identify one overarching principle of intellectual freedom and responsibility, noting that freedom in all its guises comes with responsibility, and they identify and define four principles that collectively uphold researchers’ intellectual responsibility: truthfulness, justice and fairness, anti-racism, and public beneficence. Researchers should bring their practices into alignment with these principles, and to aid this, the authors name three common ways research practices infringe these principles, suggest a step-by-step process for aligning research choices with the principles, provide rules of thumb for achieving alignment, and give a worked case. The essay concludes by identifying support needed by researchers to act in accord with the proposed framework. (shrink)

The authors examine the scientific possibility and the legal and ethical implications of using DNA forensic technology, through partial matches to DNA from crime scenes, to turn into suspects the relatives of people whose DNA profiles are in forensic databases.

THE IMMORTAL FLY: ETERNAL WHISPERS. WHO IS SHE? Author: Rituparna Ray Chaudhuri. Hello, Recently my book named, ‘The Immortal Fly: Eternal Whispers : Based On True Events of a Family' been published from Partridge (USA) In Association with Penguin Random House (UK) and achieved a separate Google identity. -/- As being # the author of the book, I thought to define self in the book what is definition of 'Depression'. I wanted to explain self in many ways, but the best (...) quotation appeared to me : “My life will end someday, but it will end at my convenience.’’ -/- ***** I am missing "her". By now, years passed without 'her' . Even though, unlike before, everything is becoming to be more scattered, gloomy and desolate. She is no-where whom I share my feelings. Even now, when I do close my eyes, I can visualize the same that I had left years since on 7th February, 2019 at 8.20 A.M. in the hospital struggling a continuous period of fifty days : on the fifty one day, my father said, ”The End of our Fifty Years relationship has been completed with the Fifty Days”….’Whoever’ she was to others , but she is our legend…To me, she is ‘My Ma’. -/- The story could begin, 'I failed preciously on success of my life.' Simplicity, Innocence, Belief, Faith and Personality met unknowingly with filthy waves skillfully immersed in Betray, Sorcery, Jealousy, Greediness, Revenge, Lie... ‘’ ******* The Daughter writes, “I had asked Ma many times, but her ‘impenetrable personality’ and dynamic words to everyone with a tinge of smile as reflected on her face, she was reluctant to continue her conversation with me. I had thought, hence, I must not be indefinite on my spoken words. Who shall I blame!” Based on true story of a family came from South Calcutta (India) to a suburb, on staying at home of the Daughter’s maternal grandmother’s house, this book reveals in facts and true events how Destiny had unknowingly ‘further’ played an abominable role to Fate of The Daughter, when eventually one day on 7th February, 2019 everything was finished within 8.20A.M. The Daughter is, therefore, left alone on terrestrial with immortal words as written in her Diary, ‘Eternal Whispers’: “My words to self that I am to fulfill my Ma’s - wish. ’’ ‘’ -/- • Keywords: 1. Diary and True Events 2. The Chaotic Society 3. Fatality 4. Of A-Family 5. Science , Philosophy and Literature 6. Severe Depression 7. Medical Journey. -/- The Alternative Title of the Book: The Greatest Mistake or Fortune:: The book is mainly carrying with intense words of a journey of the relationship between a Mother with her Daughter has left readers in an abrupt situation where ,perhaps, I can define "Man is the innocent creature with 'his' personality under circumstances..." -/- . (shrink)

In lieu of an abstract, here is a brief excerpt of the content:New Periodical Articles by Russell (II)Kenneth BlackwellThere are 51 new C entries since the twenty-year update in Russell 34 (2014) to the first edition of A Bibliography of Bertrand Russell (3 vols., 1994). Too many to list here are the new speech reports, interviews, blurbs, and multiple-signatory letters to the editor in other parts of Volume ii and new books and contributions to them in Volume i. A sub-division (...) is made between those articles published by Russell during his lifetime and those posthumously by his editors. In the Collected Papers there are many further articles now published, whose appearance could not be traced during his lifetime. Thanks in advance to readers for any corrections and further discoveries for Russell's vast corpus. For some Chinese publications cited in C20.21′, I am indebted to Lianghua Zhou, "A Critical Bibliography of Russell's Lectures and Addresses in China" (36 [2016]) in this journal. Files for the new entries are not available in the Russell Archives.For assistance with this update I wish to thank David Blitz, William Bruneau, Ruth Derham, Carl Spadoni, Michael Stevenson, Sheila Turcon, the two Editors, and (for conversion of the first edition files) Arlene Duncan.C20.21′ [RESPONSE TO SPEECH OF WELCOME TO CHINA]. Shibao [世報], Shanghai, 14 Oct. 1920, p. 5.In "Huanyan da zhexuejia Luosu ji 歡宴大哲學家羅素紀 [Notes from the Welcome Banquet for the Great Philosopher Russell]".—Russell's speech was translated by his official translator, Zhao Yuanren [Y. R. Chao].—Reprinted in Chen Bao [Morning Post], 16 Oct. 1920, p. 3 (cited in Papers 15: li); Luosu Yuekan [Russell Monthly], Beijing, no. 1 (Jan. 1921): App., pp. 6–7; and Yuan Gang, Sun Jiaxiang, and Ren Bingqiang, eds., Zhongguo Dao Ziyou Zhi Lu: Luosu Zaihua Jiangyanji [China's Road to Freedom: a Collection of Russell's Lectures in China] (Beijing: Beijing Daxue [End Page 71] Chubanshe [Peking University Press], 2004).—Translated into English in "Welcome Banquet for the Great Philosopher Russell", in Jan Vrhovski and Jana S. Rošker, eds., Bertrand Russell's Visit to China: Selected Texts on the Centenary of Intercultural Dialogues in Logic and Epistemology (Ljubljana, Slovenia: Ljubljana U. P., 2021), pp. 61–3 (which is the source of the Chinese characters below). Click for larger view View full resolution"Bertrand Russell" in simplified Chinese charactersC23.24a BERTRAND RUSSELL ON "HELL". Haldeman-Julius Weekly, Girard, ks, no. 1,446 (18 Aug. 1923): 4.Letter to Upton Sinclair on his play Hell, dated 20 June 1923.—Photocopy of holograph letter is at ra Rec. Acq. 40.—Reprinted in Collected Papers 16 (forth.).C24.12a CHILDREN AND YOUNG PERSONS BILL. The Manchester Guardian, 7 March 1924, p. 10.Signed also by Clifford Allen and sent from his address in Battersea.—"We must beware lest in our zeal to maintain the existing moral code we inflict further suffering upon the very children and women whom the promoters of the bill wish to protect."—Re abortion and underage sex.—Reprinted in Collected Papers 16 (forth.).C24.20a MACDONALD'S POLICY WILL ALTER SPIRIT OF WORLD. The Winnipeg Evening Tribune, Winnipeg, mb, 5 April 1924, theatre sec., p. 7.Subtitled "English Philosopher States Rumors of Split in Labor Ranks Exaggerated".—An editorial note states that the article was "prepared exclusively" for the Tribune.—Reprinted in Collected Papers 16 (forth.).C24.50a "WHAT'S WRONG WITH U.S.?["] BERTRAND RUSSELL FORESEES RADICALISM MUCH OPPRESSED.The Daily Notes, Canonsburg, pa, 22 Nov. 1924, p. 6.Datelined London, 21 November.—International News Service (ins) had invited Russell's views on "What Is Wrong with America" in a letter of 14 October 1924 (ra1 410).—Also as "Toleration Now Greatest Need of This Nation; Noted British Writer Sees Most of America's Troubles Migratory; Believes Negro Question, with Persecution, Will Lead to Difficulty", Defiance Crescent-News, Defiance, oh, 24 Nov. 1924, p. 1; " 'What's Wrong with U.S.?' Bertrand Russell Sees Radicalism Much Oppressed", The Evening News, Wilkes-Barre, pa, 25 Nov. 1924, p. 13; op. cit., St. Petersburg Times, St. Petersburg, fl, 25 Nov. 1924, sec. 3, p. 7; op. cit., The Huntington Herald, Huntington, il, 26 Nov. 1924, p. 10; op. cit... (shrink)

The fourth of Herodas is entitled in the papyrus —a title which very well describes the beginning and end of the poem, but disregards the middle, the most important part. The poem divides naturally into sections as follows: 1–20a; 20b–38, 39–563, 56b–78; 79–95. In we hear one of the women of the title carrying out the offering to the god. This section has been examined in detail by R. Wünsch, ‘Ein Dankopfer an Asklepios’, Arch. Rel. Wiss. vii , 95 ff., (...) who shows that it corresponds closely to the form of prayer used in real life, starting with the invocatio of the god, comprising greeting () and mention of his dwelling-places , family (parents, Koronis and Apollo. (shrink)

Pour resituer l’analogie théologique dans sa constellation propre, cette étude explore les divers arguments dans lesquels Thomas d’Aquin recourt à Rm 1, 19-20a et/ou à Sg 13, 5. Le passage du visible aux invisibilia Dei est un moment (rationnel) qui a un ressort noétique interne, un fondement externe dans l’expressivité du créé, des vertus et des limites au sein d’une économie de la manifestation de Dieu par le sensible. La connaissance de Dieu par les sages des nations est orientée vers (...) une pédagogie salvifique de la foi, avec ses secours propres : la Loi, l’Incarnation et l’Évangile. L’exégèse et les usages de Rm 1, 19-20 demeurent toujours soumis à la thèse de Rm 1, 16 au sujet de « la puissance de la grâce évangélique ». La connaissance naturelle de Dieu, altérée par une faute envers Dieu, ne diminue en rien la nécessité de la grâce pour être sauvé. (shrink)

0. Rational Rabbis aspires to make two main points, one philosophical and contemporary, the other interpretative and historical. The book’s philosophical undertaking, presented in Part I, is to develop a central insight of Karl Popper’s into a more fuller theory of rational endeavor. The book’s interpretative and main undertaking, presented in Part II, is to argue (a) that the talmudic literature bears clear witness to a tannaitic view of humanly possible intellectual achievement intriguingly akin to the theory of rationality proposed (...) in Part I, and (b) that despite appearances to the contrary, it is a voice centrally responsible for the Bavli’s halakhic discourse and project. The TR session at AAR 2002 focused on this second last claim by means of a close reading of the ‘meitivi’ sugya presented in Bavli, Berakhot 19b-20a. A detailed reading of the sugya can now be accessed at: http://jtr.lib.virginia.edu/volume4/number2/TR04_02_a01.html What follows briefly summarizes that reading and outlines its broader philosophical and hermeneutical settings. (shrink)

Mr Shewring, C.Q. XXV. 14, gives statistics of the clausulae favoured in Aristotle's Ethics. I have applied them to test a few conjectural emendations that I happen to have published, with the following encouraging results: Emendations that substitute a good clausula for a bad one: 96a 18 στερον λγομεν for στερον λγομεν κb, στερον λεγον cet. 09b 5 αυτος φλκειν [δεν]. 48a 14 κλαστον τθεμεν [κα γκρατ κα σφρονα]. 63b 13 τν φιλαν [καθπερ ερηται]. 71a 35 ατν <δον εναι . (...) Emendations that substitute one good clausula for another: 97a 9 τ ατ τοτ for τ ατ τοτο γαθν κb, τ ατ or ατ τ γαθν cet. 25a 22 τν γαθν [κα γνοεν αυτν]. I may be pardoned for omitting my one or two alterations that substitute a bad clausula for a good one. My text adopts a MS. variant, or a conjecture of another scholar, similarly supported by Mr. Shewring's test in the following places: 99b 6, 02a 20, 10b 31, 15a 8, 20a 22, 20b 2, 22a 28, 32a 11, 33a 1, 34b 33, 50b 34, 53a 1, 59a 3, 61a 2, 63a 3, 64a 23, 66a 34, 75a 6, 79a 22. (shrink)

In recent years, scholars have shown renewed interest about the ways in which Paul’s letters utilize divine conflict traditions. In Romans 5–8 and 16:20a Paul frames the human predicament in terms of cosmic conflict and adapts divine conflict traditions, but other passages also reflect the apostle’s adaptations of these motifs. This essay will first consider the broad contours of portrayals of God as warrior in Israel’s Scriptures. Discussion will then focus on vocabulary and themes in Rom 1:18–32 and 11:25–32 to (...) demonstrate that in these texts Paul also works with images related to divine conflict. Considering these passages from Romans alongside the divine conflict traditions of earlier voices–especially the Israelite prophets–assists in understanding Paul’s comments on wrath and judgment and assists in understanding Paul’s comments on wrath, judgment, and deliverance. (shrink)