In this article, complete synchronization and antisynchronization in the identical financial chaotic system are presented. The proposed control strategies depend on first-order sliding mode and adaptive integral sliding mode for complete synchronization and antisynchronization of the identical financial chaotic system. In the primary case, the system parameters should be known, and first-order sliding mode control is utilized for synchronization and antisynchronization while in the second case, the system parameters are considered unknown. An adaptive integral sliding mode control strategy is utilized (...) for synchronization and antisynchronization of the system considering the parameters unknown. The error system is changed into a particular structure containing a nominal part and several unknown terms to utilize the adaptive integral sliding mode control. Then, this error system is stabilized using integral sliding mode control. The stabilizing controller is usually developed based on the nominal part plus the compensator control part. To suppress the high-frequency oscillation phenomenon, smooth continuous compensator control can be used rather than conventional discontinuous control. The compensator controller along with the adapted law is derived such that the time derivative of the Lyapunov function becomes strictly negative. The effectiveness of the proposed method was tested through computer simulations. The proposed control strategies are verified for that Identical 4D hyperchaotic financial system to attain complete synchronization and antisynchronization along with the improved performance. (shrink)

Plastic consumption is an important aspect of contemporary living, and studies that systematically examine consumers’ plastic waste recycling intentions from an ethical perspective are scarce. Considering the severity of plastic waste recycling problems globally based on the stimulus-organism-response paradigm, this study analyses how the information publicity influences consumers’ plastic waste recycling intentions from an ethical perspective in an emerging market economy. We investigate this link by focusing on the indirect effect of perceived social pressure and the moderating role of media (...) disposition (i.e., media richness and content trustworthiness). Data from a three-wave field survey of 469 household consumers from China showed that social pressure mediated the positive relationship between information publicity and ethical recycling intentions. Additionally, media richness and content trustworthiness moderate the link between information publicity and consumers’ perceptions of social pressure. These findings provide encouraging evidence for applying the SOR paradigm to explain the ethical recycling intention of consumers. The findings may assist policymakers in motivating consumers to think ethically about plastic waste recycling. (shrink)

The member states of the United Nations General Assembly in 2005 unanimously adopted the resolution on Responsibility to Protect to save citizens from genocide, war crimes, ethnic cleansing, and crimes against humanity. Since adoption, the norm has been invoked in Libya, South Sudan, Yemen, and Syria, nonetheless, the UN refrains to respond to the genocide committed in the Jammu & Kashmir and triggering a greater sense of anxiety. In this context, the present paper elucidates the factors behind the UN failure. (...) It asks why the UN failed to call R2P despite systematic crimes against humanity in Kashmir. What factors or forces preclude the UN to invoke R2P? The paper argues that the inability of the UN to invoke R2P is a consequence of systemic and domestic factors. The Indo-US strategic partnership, materialism, and New Delhi’s influence in the international system are obstructing the UN’s ability to play a decisive role. Meanwhile, the economic and military potential of India and its regional influence forbid the international community to dissuade India not to commit genocide in Jammu & Kashmir. So the high politics of materialism and national interests override the norm of human rights and humanity. (shrink)

This paper examines the neo-colonial project of Narendra Modi implemented in Kashmir after the revocation of special status on August 5, 2019. The neo-colonial infrastructure supported by the threads of re-classification of legal residents and land designations intends to significantly transform the demography of Muslim majority Kashmir into a Muslim minority, consequently destroying the Muslim identity of the state. The abrogation of Article 370 and enactment of new domicile law has extended the legal and administrative control of New Delhi, making (...) Kashmir indistinguishable from the Indian legal system and leaving no room for the local legislative assembly to make laws beneficial for the state residents. The paper asks how India is implementing the neo-colonial settler agenda in Kashmir. How and to what extent legal and military instruments are employed to disempower Kashmiris from territorial and cultural identity? The paper argues that Prime Minister Narendra Modi is pursuing a neo-colonial settler agenda in Kashmir through ‘destroy and replace,’ which is supported by the neo-liberal agenda, including; new land management policy, new domicile law, spatial planning and development, new settlements of Hindus, authoritative central control, and massive militarization to carry out gross human rights abuses and repression. (shrink)

The liver is the human body’s mandatory organ, but detecting liver disease at an early stage is very difficult due to the hiddenness of symptoms. Liver diseases may cause loss of energy or weakness when some irregularities in the working of the liver get visible. Cancer is one of the most common diseases of the liver and also the most fatal of all. Uncontrolled growth of harmful cells is developed inside the liver. If diagnosed late, it may cause death. Treatment (...) of liver diseases at an early stage is, therefore, an important issue as is designing a model to diagnose early disease. Firstly, an appropriate feature should be identified which plays a more significant part in the detection of liver cancer at an early stage. Therefore, it is essential to extract some essential features from thousands of unwanted features. So, these features will be mined using data mining and soft computing techniques. These techniques give optimized results that will be helpful in disease diagnosis at an early stage. In these techniques, we use feature selection methods to reduce the dataset’s feature, which include Filter, Wrapper, and Embedded methods. Different Regression algorithms are then applied to these methods individually to evaluate the result. Regression algorithms include Linear Regression, Ridge Regression, LASSO Regression, Support Vector Regression, Decision Tree Regression, Multilayer Perceptron Regression, and Random Forest Regression. Based on the accuracy and error rates generated by these Regression algorithms, we have evaluated our results. The result shows that Random Forest Regression with the Wrapper Method from all the deployed Regression techniques is the best and gives the highest R2-Score of 0.8923 and lowest MSE of 0.0618. (shrink)

Este estudo tem por objetivo conhecer a estrutura e a dinâmica de funcionamento de famílias de nível sociocultural médio-alto, com casais de dupla carreira e filhos em idade escolar. Para tanto, realizou-se um Estudo de Casos Múltiplos (Yin, 1993) com quatro famílias. Para a coleta de dados, foi uti..

This study suggests a conceptual proposal to analyse the ethics of resistance in organisations, drawing on Foucault’s practising self as a refusal and Schaffer’s ethics of freedom in opposition to the legitimacy of managerial control and the ethics of compliance. We argue that ethics is already part of such politics in the form of ethico-politics on the basis of participation in political action in organisations. Hence, the practising self as resistance in the face of the status quo of managerial power (...) in an ongoing dialectical process with others and for others comprises our conceptual proposal as an ethics of resistance. Acknowledging dialectics as the driver of the continuous reconstruction and co-construction of politics and praxis, we propose an ethics from the bottom up with a critical and radical perspective. Our contribution is based on opening up an ethico-political space for those who are ignored or suppressed in the ethics and organisations literature. (shrink)

The most important reason underlying the success of the Crusaders taking Antakya from Muslims and entering the Syrian and Palestinian territories is undoubtedly the division among the Muslims. This division was not only among the dynasties, but also the cities. The Muslim rulers of Damascus have sat up alliances with the Crusaders to protect themselves from neighboring Muslim rulers. Of course, this alliance was more of a role for the Crusaders, making it easier for them to hold on to the (...) region, and strengthening them by acquiring new lands. Damascus's opposition posture caused power and time loosing to Muslim rulers, which served the Crusaders and to take the advantage of this controversy. Damascus continued its opponent position after Saladin (d. 589/1193), and quarrels within the dynasty caused the Crusaders to breathe deeply and as well as Jerusalem to fall into the hands of the Crusaders for a while again. During the Mamluks period, Damascus, who showed his opposing face for a short period of time, but afterwards he attained peace and obedience and also occupied comply with Rukn al-Dīn Baybars al-Bunduqdārī (d. 676/1277). In this article we will analyze the opposing stance of Damascus and his role in the Crusades. Summary: Pearl of Syria, Damascus has a rebellious and oppositional aspect as well. This feature of the city came into prominence further with the coming of the Crusaders to the region. Its oppositional stance and uncompromising aspect sometimes played into the hands of the Crusaders unintentionally. When the Crusaders first came to the surrounding of Antakya, the governor of Damascus, Duqāq did not provide the necessary support to Yaghisiyan who was encircled in Antakya by the Crusaders, due to his inexperience, jealousy and his hostile competition with his brother, Ridvan who is emir of Aleppo. Thus, the Crusaders used this opportunity.Atabeg of Duqāq, Tughtakīn who started to command the city after the death of Duqāq did not support especially Mawdūd who struggled against the Crusaders in Urfa, adequately. Besides, he was accused of getting Mawdūd killed by another separatist power of the region, the Assassins in the great mosque of the city. On top of it, he allied with the Crusaders, because he was troubled with the commander Porsuk sent to the region by the Sultan of Great Saljūq Empire, Mohammed Tapar. He caused the heroic warrior, Porsuk to be defeated near Tel-Dānis by the Crusaders and to die in Al Jazīrah after a short time.Soon after the above events, ‘Imāduddīn Zengī focused on Damascus and tried to establish the Islamic unity. The son of the ruler Böri, called Ismail became isolated because of the poor administration in the city. He resorted to inviting Zangī to the city. However, Ismail was killed by the opponents before the arrival of Zangī, so no result could be accomplished. Later, Zangī focused on the city again. Although he mercilessly treated the resisters in Ba’lebek after occupying there to demotivate the community of Damascus, he faced the serious resistance of the forces of Damascus. While Zangī spent all his energy to Damascus, the king of Jerusalem, Foulque improved his policy for Syria to some extent and could reestablish communication with the states of the Crusaders. The community Damascus helped the Crusaders and eased their work unintentionally once more.The Mamlūk called Uner began to govern Damascus on behalf of the forces of Bori who lost their influence in the city. Uner who developed a close relationship with the Crusaders to prevent the dominance of Zangī in the city did not hesitate to send an envoy to them. He promised to give Banyas to the Crusaders in return for moving Zangī away from Damascus. After the Franks accepted the proposal of Uner, Zangī remained in between the forces of Damascus and the Crusaders and was obliged to recede to Aleppo. In this way, the Crusaders occupied the castle of Banyas. Several locations until Buzaa were seized by the Crusaders in Antakya who found the opportunity.Zangī was martyred in front of Jaabar castle in 541/1146, so his son Nūr al-dīn became the new ruler of Damascus. Nevertheless, the following incidents caused Nūr al-dīn and Uner to get closer to each other, and the Crusaders had to move away from Damascus. First, the administrator of Havran under the control of Uner rose against his governor and turned to the Crusaders. Besides, the Second Crusade in Damascus contributed to the association of Damascus and Aleppo for a while. Following the elimination of both endangers, the association of Damascus and Aleppo resumed. Uner established a close contact with the Crusaders and made a two-year agreement with them to prevent Nūr al-dīn from seizing the city. Uner died after some time, but almost nothing changed. The new governor of the city Mucīruddin ‘Abaq kept the association of the Crusaders. An operation of Nūr al-dīn against the city was averted with the help of the Crusaders again. Mucīruddin got closer to the Crusaders after their help. Their close relationship was strengthened with the mutual visits of the committees of the Crusaders and Damascus. The Artuquid governor Timurtāsh decided to organize a military expedition to Jerusalem after a little while. However, Mucīruddin who worried about the possible dissolution of their association with the Crusaders stopped supporting him, so Timurtāsh failed in his expedition. Mucīruddin improved his relations with the Crusaders further and started to pay tribute to them following their invasion of ‘Asqalān’s in 548/1153. Even, ‘Abaq offered officially his commitment to Jerusalem. Even though the spoilt Crusaders plundered and destroyed the surrounding of Damascus, they kept the administrators of Damascus with them. Moreover, they went further and offered them to give Ba’lebek to them in return for moving Nūr al-dīn away from Damascus. Such acts provoked the community of Damascus who opposed to the dynasty of Bori in the city afterward. Nūr al-dīn welcomed this opportunity and seized Damascus in 549/1154 by means of the public without giving any chance to coming of the Crusaders. Damascus was governed by Nūr al-dīn for approximately twenty years. A disagreement arose among the community of Zangī in the city after the decease of Nūr al-dīn in 569/1174, thus leading to the dominance of Ṣalādīn Ayyubi in the city. The Ayyubids began to govern Damascus, but internal conflicts started among them with the death of Ṣalādīn in 589/1193. Similarly, Damascus was the focus of these conflicts. The Ayyubids in Egypt were the other party of the disagreement. Unfortunately, the Crusaders benefited from such rivalries. When the senior member of the family al-Adil dominated Damascus in 592/1196, the Crusaders who increased their domain had seized Beirut. Egypt and Damascus got closed temporarily during the Fifth Crusade. After the Crusaders withdrew from Damietta, two brothers, al-Muazzam and al-Kᾱmil fought with each other again. Damascus and Egypt chose the Khwarezmian dynasty and Friedrich in Sicilia as ally, respectively. Unexpected death of al-Muazzam during the preparations for the Sixth Crusade resulted in the siege of Damascus by the forces of Egypt. Friedrich reached Akkā over the course of the siege. al-Kᾱmil who played for time to seize Damascus delivered Jerusalem to the Crusaders. Later, the internal conflicts about the new dynasty which arose in Damascus weakened the Ayyubids and made the Crusaders advantageous. Finally, Damascus found tranquility with the dominance of Baybars in the city. (shrink)

This article examines the concept of the “education of desire,” which undergirds literary utopian studies’ response to postmodernism’s challenge to the modern utopian impulse. The analysis returns to two classic utopian texts—the work of Miguel Abensour, who coined the term “education of desire,” and Ursula K. Le Guin’s novel about ecological sustainability, “The Dispossessed”—to argue that the education of desire involves a more intimate relationship between desire and domination than literary utopian studies has allowed. This article not only transforms our (...) understanding of a mainstay of utopian studies; it relates this discussion to utopian strains in environmental thought, tracing the tension between the desire for ecological sustainability and the social, political, and economic prescriptions this would entail. (shrink)

The study aimed to investigate the impact of behavioral biases on herding for Islamic financial products with the mediation of shariah literacy. An adopted questionnaire from several published studies was used to collect data. The data were collected from 410 respondents and were analyzed with SmartPLS. The results for the direct impact showed that self-attribution, illusion of control, and information availability have a positive and significant impact on herding for Islamic financial products while shariah literacy showed an insignificant impact on (...) herding. The results for mediation showed that previously significant and positive impact turned to insignificant when shariah literacy was introduced as mediating variable between the illusion of control, self-attribution, information availability, and herding. From a theoretical perspective, this study would contribute to the existing body of knowledge of financial decision making from shariah literacy point-out. On the other hand, the findings of this study may be useful for investors to avoid herding in the Islamic financial markets. The authors synthesize the contribution made by behavioral finance studies in extending the knowledge of herding behavior in Islamic financial products with a mediating role of shariah literacy. The key limitation of the study includes data that were collected from three districts of Punjab, Pakistan. (shrink)

This study uncovers a new finding on the impact of CEO tenure on corporate social and environmental performance (CS&EP) in coastal and non-coastal areas of China using fixed-effect panel data regression models. The Two-Stage Least Squares instrumental panel regression is used to validate the veracity of the empirical results. To this end, we extract data from all non-financial Chinese listed firms for the period of 2009 to 2015. By applying the multivariant framework, the findings of the study exhibit a negative (...) and significant effect of CEO tenure on CS&EP. Moreover, this study shows that firms with head offices in coastal areas of China tend to weaken the negative impact of CEO tenure on CS&EP, indicating that CS&EP is more focused in coastal areas of China than non-coastal ones. The findings suggest that the increase in CEOs’ CS&EP in the early years of their service tenure tends to increase their compensation packages. This study is useful for policymakers to link CS&EP with firm economic practices to attain sustainable development objectives. (shrink)

The quality of arm movements typically improves in the sub-acute phase of stroke affecting the upper extremity. Here, we used whole arm kinematic analysis during reaching movements to distinguish whether these improvements are due to true recovery or to compensation. Fifty-three participants with post-acute stroke performed ∼80 reaching movement tests during 4 weeks of training with the ArmeoSpring exoskeleton. All participants showed improvements in end-effector performance, as measured by movement smoothness. Four ArmeoSpring angles, shoulder horizontal rotation, shoulder elevation, elbow rotation, (...) and forearm rotation, were recorded and analyzed. We first characterized healthy joint coordination patterns by performing a sparse principal component analysis on these four joint velocities recorded during reaching tests performed by young control participants. We found that two dominant joint correlations [SH with elbow rotation and SE with forearm rotation] explained over 95% of variance of joint velocity data. We identified two clusters of stroke participants by comparing the evolution of these two correlations in all tests. In the “Recoverer” cluster, both joint correlations converged toward the respective correlations for control participants. Thus, Recoverers relearned how to generate smooth end-effector movements while developing joint movement patterns similar to those of control participants. In the “Compensator” cluster, at least one of the two joint correlations diverged from the corresponding correlation of control participants. Compensators relearned how to generate smooth end-effector movements by discovering various new compensatory movement patterns dissimilar to those of control participants. New compensatory patterns included atypical decoupling of the SE and forearm joints, and atypical coupling of the SH rotation and elbow joints. There was no difference in clinical impairment level between the two groups either at the onset or at the end of training as assessed with the Upper Extremity Fugl-Meyer scale. However, at the start of training, the Recoverers showed significantly faster improvements in end-effector movement smoothness than the Compensators. Our analysis can be used to inform neurorehabilitation clinicians on how to provide movement feedback during practice and suggest avenues for refining exoskeleton robot therapy to reduce compensatory patterns. (shrink)

Ethical behaviour, in its simplest terms, means knowing and doing what is right. Nevertheless, the main difficulty is how to define the word 'right'. For this purpose, various individuals, cultures and religions have thus far portrayed it in different ways. The present study reflected on the Islamic society, wherein ethical leadership has been one of the most effective factors in its continuation of life and success, with a vital role in its growth, development and progress. Accordingly, the relationship between ethical (...) leadership and the voice of Muslim employees in Kuala Lumpur, Malaysia, in 2021, as the statistical population (n = 2500) was analysed. For this purpose, a standard questionnaire was used to collect the necessary data, whose validity was confirmed by the construct validity in the Linear Structural Relations (LISREL) software and its reliability was checked via the Cronbach's alpha in the Statistical Package for the Social Sciences (SPSS) software. Besides, path analysis was utilised to test the research hypothesis. Confirmatory factor analysis was correspondingly implemented to examine the data. Ultimately, the study results revealed a significant positive relationship between ethical leadership and the voice of Malaysian Muslim employees (p = 0.80; t = 5.02). CONTRIBUTION: Based on the literature review and the results of this study, ethical leadership can motivate Muslim citizens to participate in decision-making processes and even allows them to express their creative ideas in organisations and society. (shrink)

This study examined how social media marketing activities influence consumers’ engagement behaviour in developing countries. Based on the stimulus-organism-response theory, we examined the effect of SMMA on consumers’ engagement intention and further investigated the moderating effect of social media sales intensity. The study employed a time-lagged design with two waves to confirm the hypothesised framework. The study findings showed that SMMA positively influence consumers’ engagement intention and engagement behaviour. In addition, social media sales intensity strengthens the link between engagement intention (...) and engagement behaviour. This study adds to the literature on social media and discusses its practical implications. (shrink)

Mobile health research involving pervasive sensors, mobile apps and other novel data collection tools and methods present new ethical, legal, and social challenges specific to informed consent, data management and bystander rights. To address these challenges, a participatory design approach was deployed whereby stakeholders contributed to the development of a web-based commons to support the mHealth research community including researchers and ethics board members. The CORE platform now features a community forum, a resource library and a network of nearly 600 (...) global members. The utility of the participatory design process was evaluated by analyzing activities carried out over an 8-month design phase consisting of 86 distinct events including iterative design deliberations and social media engagement. This article describes how participatory design yielded 55 new features directly mapped to community needs and discusses relationships to user engagement as demonstrated by a steady increase in CORE member activity and followers on Twitter. (shrink)

Analytical study of philosophy; includes comparative study of world-renowned philosophers and their ideologies.

This is an era of globalization, and to maximize the competitive advantage, the banking industry is acknowledging and recognizing Human Resource practices and contributing their best to employ the organizational resources in best productive manner so that they can excel and enjoy competitive edge. Number of factors are affecting on performance of the employee. This research paper is mainly intended to explore the influence of employee diversity on the performance of employee in Private Banking business of Pakistan. Specifically in this (...) paper, the performance of the employee in a banking sector has been predicted by the influence of employee diversity with respect to their education, age, gender, and ethnicity. The data was collected from 203 private banking representatives by a convenience sampling method. In order to identify the relationship, the data has been tested by SPSS Regression and correlation analysis methods. Research findings suggested that the organizations with specific reference to banking sector should plan, design and execute the policies,, practices and strategies that have a wide range canvas inclusive every individual employee and workforce diversities. (shrink)

The University of Michigan conference “Where Religion, Policy, and Bioethics Meet: An Interdisciplinary Conference on Islamic Bioethics and End-of-Life Care” in April 2011 addressed the issue of brain death as the prototype for a discourse that would reflect the emergence of Islamic bioethics as a formal field of study. In considering the issue of brain death, various Muslim legal experts have raised concerns over the lack of certainty in the scientific criteria as applied to the definition and diagnosis of brain (...) death by the medical community. In contrast, the medical community at large has not required absolute certainty in its process, but has sought to eliminate doubt through cumulative diagnostic modalities and supportive scientific evidence. This has recently become a principal model, with increased interest in data analysis and evidence-based medicine with the intent to analyze and ultimately improve outcomes. Islamic law has also long employed a systematic methodology with the goal of eliminating doubt from rulings regarding the question of certainty. While ample criticism of the scientific criteria of brain death (Harvard criteria) by traditional legal sources now exists, an analysis of the legal process in assessing brain death, geared toward informing the clinician’s perspective on the issue, is lacking. In this article, we explore the role of certainty in the diagnostic modalities used to establish diagnoses of brain death in current medical practice. We further examine the Islamic jurisprudential approach vis-à-vis the concept of certainty (yaqīn). Finally, we contrast the two at times divergent philosophies and consider what each perspective may contribute to the global discourse on brain death, understanding that the interdependence that exists between the theological, juridical, ethical, and medical/scientific fields necessitates an open discussion and active collaboration between all parties. We hope that this article serves to continue the discourse that was successfully begun by this initial interdisciplinary endeavor at the University of Michigan. (shrink)

Mining social network data and developing user profile from unstructured and informal data are a challenging task. The proposed research builds user profile using Twitter data which is later helpful to provide the user with personalized recommendations. Publicly available tweets are fetched and classified and sentiments expressed in tweets are extracted and normalized. This research uses domain-specific seed list to classify tweets. Semantic and syntactic analysis on tweets is performed to minimize information loss during the process of tweets classification. After (...) precise classification and sentiment analysis, the system builds user interest-based profile by analyzing user’s post on Twitter to know about user interests. The proposed system was tested on a dataset of almost 1 million tweets and was able to classify up to 96% tweets accurately. (shrink)

Cardiovascular disease is a major complication of type 2 diabetes mellitus. In addition to traditional risk factors, psychological determinants play an important role in CVD risk. This study applied Deep Neural Network to develop a CVD risk prediction model and explored the bio-psycho-social contributors to the CVD risk among patients with T2DM. From 2017 to 2020, 834 patients with T2DM were recruited from the Department of Endocrinology, Affiliated Hospital of Harbin Medical University, China. In this cross-sectional study, the patients' bio-psycho-social (...) information was collected through clinical examinations and questionnaires. The dataset was randomly split into a 75% train set and a 25% test set. DNN was implemented at the best performance on the train set and applied on the test set. The receiver operating characteristic curve analysis was used to evaluate the model performance. Of participants, 272 were diagnosed with CVD. The developed ensemble model for CVD risk achieved an area under curve score of 0.91, accuracy of 87.50%, sensitivity of 88.06%, and specificity of 87.23%. Among patients with T2DM, the top five predictors in the CVD risk model were body mass index, anxiety, depression, total cholesterol, and systolic blood pressure. In summary, machine learning models can provide an automated identification mechanism for patients at CVD risk. Integrated treatment measures should be taken in health management, including clinical care, mental health improvement, and health behavior promotion. (shrink)

Artificial intelligence techniques in general and convolutional neural networks in particular have attained successful results in medical image analysis and classification. A deep CNN architecture has been proposed in this paper for the diagnosis of COVID-19 based on the chest X-ray image classification. Due to the nonavailability of sufficient-size and good-quality chest X-ray image dataset, an effective and accurate CNN classification was a challenge. To deal with these complexities such as the availability of a very-small-sized and imbalanced dataset with image-quality (...) issues, the dataset has been preprocessed in different phases using different techniques to achieve an effective training dataset for the proposed CNN model to attain its best performance. The preprocessing stages of the datasets performed in this study include dataset balancing, medical experts’ image analysis, and data augmentation. The experimental results have shown the overall accuracy as high as 99.5% which demonstrates the good capability of the proposed CNN model in the current application domain. The CNN model has been tested in two scenarios. In the first scenario, the model has been tested using the 100 X-ray images of the original processed dataset which achieved an accuracy of 100%. In the second scenario, the model has been tested using an independent dataset of COVID-19 X-ray images. The performance in this test scenario was as high as 99.5%. To further prove that the proposed model outperforms other models, a comparative analysis has been done with some of the machine learning algorithms. The proposed model has outperformed all the models generally and specifically when the model testing was done using an independent testing set. (shrink)

A large body of evidence on the activity of regulatory T (Treg) cells was gathered during the last decade, and a similar number of reviews and opinion papers attempted to integrate the experimental findings. The abundant literature clearly delineates an exciting area of research but also underlines some major controversies. A linear cause–result interpretation of experimental maneuvers often ignores the fact that the activity of Treg cells is orchestrated with the effector T (Teff) cells within an intricate network of physiological (...) immune homeostasis. Every modulation of the activity of the effector (cytotoxic) immune system revolves to affect the activity of regulatory (suppressive) cells through elaborate feedback loops of negative and positive regulation. The lack of IL‐2 production by innate Treg cells makes this cytokine a prime coupler of the effector and suppressive mechanisms. Here we attempt to integrate evidence that delineates the involvement of IL‐2 in primary and secondary feedback loops that regulate the activity of suppressive cells within the elaborate network of physiological immune homeostasis.©2007 Wiley Periodicals, Inc BioEssays 30:875–888, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

The exact process that leads to the eruption of autoimmune reactions against β cells and the evolution of diabetes is not fully understood. Macrophages and T cells may launch an initial immune reaction against the pancreatic islets of Langerhans, provoking inflammation and destructive insulitis. The information on the molecular mechanisms of the emergence of β cell injury is controversial and points to possibly important roles for the perforin–granzyme, Fas–Fas-ligand (FasL) and tumor-necrosis-factor-mediated apoptotic pathways. FasL has several unique features that make (...) it a potentially ideal immunomodulatory tool. Most important, FasL is selectively toxic to cytotoxic T cells and less harmful to regulatory T cells. This review discusses the intrinsic sensitivity of β cells to FasL-mediated apoptosis, the conditions that underlie this β cell sensitivity, and the feasibility of using FasL to arrest autoimmunity and prevent islet allograft rejection. In both the autoimmune and transplant settings, it is imperative to progress from the administration of nonspecific immunosuppressive therapy to the concept of β-cell-specific immunomodulation. FasL evolves as a prime candidate for antigen-specific immunomodulation. BioEssays 28: 211–222, 2006. © 2006 Wiley periodicals, Inc. (shrink)

The exact process that leads to the eruption of autoimmune reactions against β cells and the evolution of diabetes is not fully understood. Macrophages and T cells may launch an initial immune reaction against the pancreatic islets of Langerhans, provoking inflammation and destructive insulitis. The information on the molecular mechanisms of the emergence of β cell injury is controversial and points to possibly important roles for the perforin–granzyme, Fas–Fas-ligand (FasL) and tumor-necrosis-factor-mediated apoptotic pathways. FasL has several unique features that make (...) it a potentially ideal immunomodulatory tool. Most important, FasL is selectively toxic to cytotoxic T cells and less harmful to regulatory T cells. This review discusses the intrinsic sensitivity of β cells to FasL-mediated apoptosis, the conditions that underlie this β cell sensitivity, and the feasibility of using FasL to arrest autoimmunity and prevent islet allograft rejection. In both the autoimmune and transplant settings, it is imperative to progress from the administration of nonspecific immunosuppressive therapy to the concept of β-cell-specific immunomodulation. FasL evolves as a prime candidate for antigen-specific immunomodulation. BioEssays 28: 211–222, 2006. © 2006 Wiley periodicals, Inc. (shrink)

Height preferences reflecting positive assortative mating for height—wherein an individual’s own height positively predicts the preferred height of their mate—have been observed in several distinct human populations and are thought to increase reproductive fitness. However, the extent to which assortative preferences for height differ strategically for short-term versus long-term relationship partners, as they do for numerous other indices of mate quality, remains unclear. We explore this possibility in a large representative sample of over 500 men and women aged 15–77 from (...) Canada, Cuba, Norway and the United States. Participants’ own heights were measured, and they indicated their height preferences for a long-term and short-term mate using graphic stimuli containing metric indices. Replicating the “male-taller norm,” participants on average preferred taller-than-average male mates, and shorter-than-average female mates. Positive assortative preferences for height were observed across sexes and samples, however the strength of these height preferences varied with relationship context for men, and not for women. Taller men preferred relatively shorter women for short-term relationships than for long-term relationships, indicating stronger assortative preferences for height in a long-term context. These results provide preliminary evidence that, in addition to mate preferences for other physical traits related to mate quality such as masculinity in the body, face, and voice, assortative preferences for height do vary as a function of expected relationship length, but this was surprisingly only observed in preferences for female height. (shrink)

This contribution addresses the anthropocenic challenge from a dialectical perspective, combining a diagnostics of the present with a prognostic of the emerging future. It builds on the oeuvres of two prominent dialectical thinkers, namely Georg Wilhelm Friedrich Hegel and Pierre Teilhard de Chardin. Hegel himself was a pre-anthropocenic thinker who did not yet thematise the anthropocenic challenge as such, but whose work allows us to emphasise the unprecedented newness of the current crisis. I will especially focus on his views on (...) Earth as a planetary process, emphasising that the “spirit” of technoscience is basically monitoring the impacts of its own activities on geochemistry and evolution. Subsequently, I will turn attention to Teilhard de Chardin, a palaeontologist and philosopher rightfully acknowledged as one of the first thinkers of the Anthropocene whose oeuvre provides a mediating middle term between Hegel’s conceptual groundwork and the anthropocenic present. Notably, I will discuss his views on self-directed evolution, on the on-going absorption of the biosphere by the noosphere, and on emerging options for “sublating” the current crisis into a synthetic convergence towards the Omega point. I will conclude that, after disclosing the biomolecular essence of life, biotechnology must now take a radical biomimetic turn ; that reflection itself must become distributed and collective; and, that the anthropocenic crisis must be sublated into the noocene. (shrink)