BackgroundSarcomas are a diverse group of neoplasms that vary greatly in clinical presentation and responsiveness to treatment. Given the differences in the sites of involvement, rarity, and treatment modality, a multidisciplinary approach is required. Previous literature suggests patients with sarcoma suffer from poorer quality of life especially physical and functional wellbeing. Adolescent and young adult patients are an underrepresented population in cancer research and have differing factors influencing QoL.MethodsRetrospective analysis of Young Adult patients enrolled in the Sarcoma Tissue Repository at (...) University of Iowa. QoL was assessed using the self-report FACT-G questionnaire at enrollment and 12 months post-diagnosis; overall scores and the 4 wellbeing subscales were calculated. Linear mixed effects models were used to measure the association between the rate of change in FACT-G subscale scores and baseline clinical, comorbidity, and treatment characteristics.Results49 patients were identified. 57.1% of patients had a malignancy involving an extremity. Mean FACT-G scores of overall wellbeing improved from baseline to 12 months. Social and emotional wellbeing did not differ significantly between baseline and 12 months. Physical wellbeing and functional wellbeing scores improved from baseline to 12 months. No difference was seen for FACT-G overall scores for age, sex, laterality, marital status, performance status, having children, clinical stage, limb surgery, chemotherapy, or tumor size. A difference was demonstrated in physical wellbeing scores for patients with baseline limitation compared to those with no baseline limitation. A difference was demonstrated in social wellbeing based on anatomical site.ConclusionYoung adults with sarcoma treated at a tertiary center had improvements in overall reported QoL at 12 months from diagnosis. Overall baseline QoL scores on FACT-G were lower than the general adult population for YA patients with sarcoma but at 12 months became in line with general population norms. The improvements seen merit further investigation to evaluate how these change over the continuum of care. Quality of life changes may be useful outcomes of interest in sarcoma trials. (shrink)

Advancing Medical Posthumanism Through Twenty-First Century American Poetry places contemporary poetics in dialogue with posthumanism and biomedicine in order to create a framework for advancing a posthuman-affirmative ethics within the culture of medical practice. This book makes a case for a posthumanist understanding of the body—one that sees health and illness not as properties possessed by individual bodies, but as processes that connect bodies to their social and natural environment, shaping their capacity to act, think, and feel. Tana Jean Welch (...) demonstrates how contemporary American poetry is specifically poised to develop a pathway toward a posthuman intervention in biomedicine, the field of medical humanities, medical discourse, and the value systems that guide U.S. healthcare in general. (shrink)

This research is conducted to identify the inclusion of the concepts of space science in the textbooks, and to unveil its contribution in thrusting interest of youth towards this opportunistic field in Pakistan. The methodology is based on Quantitative Research Paradigm. Quantitative content analysis is carried out, which is triangulated with a brief survey. Two textbooks are selected, whereas survey is taken from 2400 secondary level students, selected through convenience sampling. Findings notified inclusion of concepts as spineless and theoretical in (...) the textbooks at primary level and also lack practical component. Furthermore, books at secondary level have limited content addressing in-depth concepts. Through quantitative survey it is revealed that besides conventional fields, students preferred opting for emerging fields, yet majority did not show their interest towards space science. They also highlighted that the concepts are either not learnt or have no idea about its inclusion. Researcher suggests improving the overall content of science and social studies books and introducing space science education as a subject. Furthermore, HEC should provide academic perks for adopting profession in emerging fields. Awareness sessions and counseling of students in this regard would be highly favorable. (shrink)

The foundation (waqf), which is a charity institution that was able to find an application area since the emergence of Islam, has developed over time in Islamic societies and has become a common institution. In the Ottoman Empire, these institutions had incorporated different services into its structure. This expansion has also led to the establishment of many different types and purposes of foundations such as charities; family, animal care, hospice, foodbank and educational institutions and mosques. Types of foundations in which (...) the incomes of the foundation were shared in different ways were also developed in this period. Family foundations are one of the types of foundations established for the purpose to share of income. Family foundations, which are characterized by many different names such as “zürri” (familial), “ehli” (domestic) and “evlatlık” (filial), have been criticized legally for various reasons in the last period of the Ottoman Empire and the Republic period, and their legitimacy has been questioned. This questioning of legitimacy, which started especially with orientalist studies, was also written among Turkish historians and lawyers, and attempts were made to base the claims that family foundations are illegitimate. In time, these criticisms came out of the family foundations and became legally questioning the entire Islamic foundation system. Investigating the justification of these criticisms, which have been popular since the end of the 19th century, is of particular importance for the development of today's foundation system. Because as a result of these criticisms, the foundations, which are one of the most effective institutions that provide social cohesion and that Islam has created and developed, have lost their importance over time and there has been a noticeable decrease in established foundations. Previously established foundations were somehow transferred to individual ownership on legal grounds. Based on these reasons, the study aims to determine the truth of these claims and to offer a critical approach to the debates on the legitimacy of family foundations in Islamic law, thus revealing the legal basis of the foundation system in Islam. In terms of nature, family foundations are a type of foundation for the purpose of the foundation. Although its name is described as family, it indicates a foundation that is broader than the concept of family. In this sense, it refers to foundations established first for private individuals and then for one of the general charity classes. Specially designated persons do not have to be among family members. It is referred to by this name as these foundations are mostly established for family members. When the evidence regarding the legitimacy of these foundations is examined, examples from the practices of the Prophet himself can be seen, as well as general verses from the Qur'an that will be included in the scope of these foundations. On the other hand, there are examples of family waqfs in foundations established by almost all of the Companions. The legitimacy of family foundations is challenged within the framework of four main reasons such as violation of the provisions of legacy, avoiding to be confiscated, preventing the fragmentation of property by the heirs and causing the feudal system and it is claimed to be illegitimate. However, the fact that these foundations have existed in Islamic societies since the golden age, including the Ottoman Empire raises a question about the authenticity of the criticisms. When examining the details of the criticisms, it can be easily seen that there is no question of legitimacy in the real sense, only a misinterpretation arising from misunderstanding. As a result, it will be seen that it is not possible to say that the practices of Muslims throughout history are illegitimate. Family waqfs have taken place in history as an institution that does not contradict the general provisions of Islam, on the contrary, by increasing Islamic foundation culture and social solidarity. It is extremely important for these foundations to find a field of application in social and economic terms now. (shrink)

Epistemologists understand radical skepticism as arising from two principles: Closure and Underdetermination. Both possess intuitive prima facie support for their endorsement. Understanding how they engender skepticism is crucial for any reasonable anti-skeptical attempt. The contemporary discussion has focused on elucidating the relationship between them to ascertain whether they establish distinct skeptical questions and which of the two constitutes the ultimately fundamental threat. Major contributions to this debate are due to Brueckner, Cohen, and Pritchard. This contribution aims at defending Brueckner’s contention (...) that underdetermination expresses the fundamental skeptical threat and that the closure-based argument can ultimately be reduced to it, at least concerning skeptical contexts. This will be achieved by undermining Cohen’s objections to Brueckner on both counts. Cohen’s argument endorses a picture of evidential underdetermination, which, while apt for non-skeptical contexts, cannot be applied to radical skepticism. A comparison with a case of scientific underdetermination is developed to argue for this idea. Our argument is then applied to the principle equivalence issue and to objections against it. It is then shown how this analysis possesses a distinctive effect on our understanding of the skeptical threat and the assessment of successful anti-skeptical strategies. (shrink)

This study examines the extent to which enabling and controlling uses of management control systems moderate the relationship between environmental innovation strategy and organizational performance. Partial least squares structural equation modeling is used to analyze survey data collected from top managers in 175 manufacturing and services sectors representing multinational and local organizations operating in Sri Lanka. We find that while the enabling use of MCS positively moderates the relationship between environmental innovation strategy and organizational performance, in contrast, the controlling use (...) of MCS negatively moderates the relationship. We compare the results for the manufacturing and services sectors. As predicted, we find a significant positive moderating impact of the enabling use of MCS in both manufacturing and services sectors. However, contrary to our expectations, we find no significant moderating impact for both sectors for the controlling use of MCS. We conclude that environmental innovation strategy per se does not lead to performance improvements; however, the extent to which organizations use enabling and controlling MCS determines the relationship. We provide theoretical insights and practical implications concerning the importance of strategic alignment between managerial controls, environmental innovation strategy, and organizational performance. (shrink)

The aim of this paper is to analyse and develop how scepticism becomes an intelligible question starting from requirements that epistemologists themselves aim to endorse. We argue for and defend the idea that the root of scepticism is the underdetermination principle by articulating its specificitya respectable epistemic principle and by defending it against objections in current literature. This engagement offers a novel understanding of underdetermination-based scepticism. While most anti-sceptical approaches challenge scepticism by understanding it as postulating uneliminated scenarios of mass (...) deception, or as endorsing unnatural epistemic requirements, we argue here that both contentions are mistaken. Underdetermination-based scepticism targets our beliefs by issuing a genuine question about the rational support they enjoy. If we cannot establish that the sources of our beliefs provide them the required epistemic merit and authority, they lack non-arbitrary grounds. This has a sizable impact on what constitutes a satisfactory anti-sceptical strategy. Strategies that merely focus on the scenario-based aspect of scepticism, or on the truth-functional evaluation of our beliefs, are shown to miss the mark of the sceptical threat. The proposed analysis ultimately provides a shift in perspective concerning the character and reach of philosophical doubt. (shrink)

Resumo: Para ampliar a compreensão das problemáticas ambientais atuais, este texto reúne as análises interpretativas de dois documentos, os quais, por possuírem perspectivas distintas, contribuem significativamente com o estudo da teoria fleckiana. São dois coletivos de pensamento desenvolvendo práticas científicas com intencionalidades advindas das opções teóricas e políticas, configurando um processo dinâmico de produção de conhecimento. A essência de cada um desses coletivos de pensamento consiste na ampliação e na disseminação da ideia transpessoal, por ela não pertencer, de forma exclusiva, (...) a nenhum dos componentes do coletivo. Propiciar a troca constante de concepções interna e externamente impulsiona o conhecimento científico, cuja evolução depende do processo coletivo em que o pensamento se desenvolve por vínculos e interferências engendradas pelo condicionamento social.: With the intention of broadening the understanding of current environmental issues, this article contains interpretive analysis of two documents which, because of their different perspectives, contribute significantly to the study of Fleckian theory. They are two collective thought manifestoes which develop scientific practices, their goals arising from theoretical and political options that configure a dynamic process of knowledge production. The essence of each of these collective thoughts consists in the expansion and spread of transpersonal ideas that do not belong exclusively to any of the components of the collective. Propitiating the constant exchange of internal and external views drives scientific knowledge, whose evolution depends on a collective process in which thought is developed by bonds and interferences engendered by social conditioning. (shrink)

Anthropological studies have shown that attitudes and behavior of majority of Muslims towards gender and women's issues are influenced by the combined patriarchal culture and patriarchal reading of Islamic teachings which is reflected in conventional fiqh. This creates room for domestic violence; men occupy a dominant position and women are obliged to show their submission to them, such submission being portrayed as divine order. Some of the men interviewed in this study defended their dominant position by exaggerating the interpretation of (...) religious texts that grant special privileges to men. Because of its serious repercussions on women, and because it runs counter to the basic principles of Islam on justice and equality and the overall objective of sharia, i.e. maslahat, such male-biased reading of religious texts should be challenged. Over 30 verses in the Qur'an support equality between women and men and refer to women's rights in various aspects of life. Many of these women-friendly Qur'anic verses are further supported by the Hadith, traditionally attributed to Prophet Muhammad. The question that emerges is: why are Muslims' attitudes quite contradictory to the spirit of gender equality and equity and women's emancipation advocated in the Qur'an's verses? Using three different perspectives: theology, legal, and anthropological case studies, this paper explores the answer to the above question and suggests how the gap between Islamic ideals on gender and their realities can be bridged. (shrink)

The following contribution aims at presenting a reading of Wittgenstein’s later philosophy as a kind of idealism within the Kantian and post-Kantian traditions. The goal is to argue that Wittgenstein’s position shares substantial theoretical and methodological grounds with Hegel’s idealism. The main concepts pertaining to the later Wittgenstein’s position are analyzed and understood as a form of idealism. After defending the reading against anti-idealist interpretations we argue that the kind of idealism presented clashes with central tenets of the Kantian position. (...) These points of departure are then shown to cover in a substantial manner the same kind of criticism Hegel raised against Kant. In the last section, an interpretation of central concepts of the Hegelian position is offered in order to dissolve any fundamental incompatibility with Wittgenstein’s idealism. (shrink)

Smart parsimonious and economical ways of irrigation have build up to fulfill the sweet water requirements for the habitants of this world. In other words, water consumption should be frugal enough to save restricted sweet water resources. The major portion of water was wasted due to incompetent ways of irrigation. We utilized a smart approach professionally capable of using ontology to make 50% of the decision, and the other 50% of the decision relies on the sensor data values. The decision (...) from the ontology and the sensor values collectively become the source of the final decision which is the result of a machine learning algorithm. Moreover, an edge server is introduced between the main IoT server and the GSM module. This method will not only avoid the overburden of the IoT server for data processing but also reduce the latency rate. This approach connects Internet of Things with a network of sensors to resourcefully trace all the data, analyze the data at the edge server, transfer only some particular data to the main IoT server to predict the watering requirements for a field of crops, and display the result by using an android application edge. (shrink)

Earlier investigations have indicated that work beliefs in organization are impacted by different national cultures. In addition, those investigations have sought to understand the meaning of work in such different cultures. This study explores the meaning of work in the Egyptian context through an assessment of work beliefs and work attitudes. The article starts with a presentation of what is meant by the meaning of work and why research into work beliefs is both needed and worthwhile. The article then presents (...) a review of the relevant literature that evaluated the meaning of work in different countries. The review also elucidates recent research efforts that have tried to shed some light on the meaning of work in Middle-Eastern contexts. Data were collected from 201 Egyptian white-collar workers. Work beliefs and some job attitudes were assessed. Results indicate the prevalence of the humanistic work-belief system. Job satisfaction was positively correlated with the humanistic work-belief system and negatively with the Marxist work-belief system. The implications of these and other findings for international managers are discussed and recommendations for future researchers are put forward. (shrink)

Modern technology offers an increasing number of tools for teaching mathematics, but technology adoption in schools encounters many barriers. The Technology Acceptance Model explains that technology usage is dependent on intentions, which rest on perceived ease of use and perceived usefulness. Less is known about the relationship between intentions and actual behaviour. In the current study we show that the level of cognitive investment on the part of the teachers, captured by the construct of Need for Cognition (NC), is crucial (...) in the use of technology in mathematical instruction, while controlling for a variety of background factors. Furthermore NC moderates the relationship between intentions and technology use, such that high NC weakens the relationship between the perceived usefulness of technology in pedagogy and its actual use. (shrink)

Scholars have widely discussed the paradigm of integration of Islam and science. Still, a model of integration of Islam and science that uses the reasoning of Martabat Tujuh [seven grades] has not been found. Therefore, this study sought to investigate the manuscripts of Shaykh Abdussamad al-Palimbani’s Martabat Tujuh in the integration of Islam and science. This study used a descriptive qualitative approach, and data collection techniques were documentation and interviews. This study found two spiritual reasons in the manuscript of Shaykh (...) Abdussamad al-Palimbani’s Martabat Tujuh: tanazzul [move down] deductive reasoning and taraqqi [move up] inductive reasoning. Contribution: The article contributed to developing the integration of Islam and science in Indonesia. The manuscripts of Martabat Tujuh [seven grades] by Shaykh Abdussamad al-Palimbani offer the circular motion of Martabat Tujuh as a model for integrating knowledge. The circular motion model of Martabat Tujuh is expected to be used as a theoretical basis for applying knowledge integration at various Islamic universities in Indonesia. (shrink)

The practice of ‘greenwashing’ may be characterized as the fabrication of green claims by organizations to portray a positive image. Greenwashing has not been examined in the United Arab Emirates, and the fashion sector is considered the second largest consumer of harmful chemicals, excessive water use, and non-compliant waste management practices behind the oil and gas sector. Using in-depth semi-structured interviews with fast fashion consumers in the UAE, an exploratory qualitative inquiry was conducted with a focus on the ‘seven sins (...) of greenwashing’ and ‘competitive altruism’ theories and the consumer perceptions of green claims made by major apparel manufacturing and retail firms in the UAE were investigated. A conceptual framework was developed to better understand the nature of corporate altruistic behavior and perceived advantages of green initiatives. The exploratory qualitative inquiry used for this study provided a great opportunity for gathering detailed information on consumer perceptions of greenwashing practices in the UAE. Future research and statistical representation are needed to cross reference the data and test the framework suggested here. (shrink)

_Misapprehensions of culture and religion are used for the early marriages of women in Pakistan, which generates few significant challenges for women to pursue their higher education. The present study identifies such challenges for married women in higher education. These challenges are relevant to women’s post-marriage lifespan in rural Pakistan. Building upon Fredrickson’s (2001) and Hobfoll’s (2001) theories focused on post marriages issues, the study has developed open-ended questions for collecting in-depth information. Therefore, 43 in-depth interviews with married women were (...) conducted and through qualitative data analysis using NVIVO software, the study has highlighted that early marriages of girls have become a cultural norm, and education priorities of the girls are insignificant for parents to decide the marriage date. Married women pursuing education at marriage do not get any support from husbands and in-laws as the patriarchal norms prohibit women from stepping out from home. In these circumstances, women may get subject to the victim of many unlawful practices, including intimate partner violence (IPV). Thus, the present study findings imply that married women's participation in higher education is negligible due to weak legislation on women’s rights and strong illegitimate tribal practices._. (shrink)

Pressures are mounting upon Australian retailers including their ability to grow profit. Price deflation for many items, a lack of wage growth, and, the rise of huge online platforms is just some of the factors now creating difficulties for retailers. In the absence of sales growth, profit can only be improved with a focus on the cost side of the business. And, it is this focus that has brought about the potential for unethical decision making. This case study examines the (...) role of accountants in influencing this decision making. Accountants are often seen as the experts when it comes to cost control. Consequently, they have a unique opportunity to use their position to help ensure that when governance processes surrounding cost (and profit) management are established, or when key decisions are made, these are undertaken on an ethical basis. This teaching case explores this issue within three scenarios relevant to the current Australian retail industry. Firstly, the ethical concerns of the use of power by the big retailers to reduce costs within international and domestic supply chains are examined. Secondly, recent instances of questionable practices to inflate profits through rebate, and other, accounting methods are analysed. Finally, the design of remuneration systems is discussed within the context of whether these are creating unethical biases within organisational decision making. (shrink)

BackgroundIn the pandemic time, many low- and middle-income countries are experiencing restricted access to COVID-19 vaccines. Access to imported vaccines or ways to produce them locally became the principal source of hope for these countries. But developing a strategy for success in obtaining and allocating vaccines was not easy task. The governments in those countries have faced the difficult decision whether to accept or reject offers of vaccine diplomacy, weighing the price and availability of COVID-19 vaccines against the concerns over (...) their efficacy and safety. We aimed to analyze public opinion regarding the governmental strategies to obtain COVID-19 vaccines in three Central Asian countries, focusing particularly on possible ethical issues.MethodsWe searched for opinions expressed either in Russian or in the respective national languages. We provided data on the debate within three countries, drawn from social media postings and other sources. The opinion data was not restricted by source and time. This allowed collecting a wide range of possible opinions that could be expressed regarding COVID-19 vaccine supply and human participation in the vaccine trial. We recognized ethical issues and possible questions concerning different ethical frameworks. We also considered scientific data and other information, in the process of reasoning.ResultsAs a result, public views on their respective government policies on COVID-19 vaccine supply ranged from strongly negative to slightly positive. We extracted the most important issues from public debates, for our analysis. The first issue involved trade-offs between quantity, speed, price, freedom, efficacy, and safety in the vaccines. The second set of issues arose in connection with the request to site a randomized trial in one of the countries (Uzbekistan). After considering additional evidence, we weighed individual and public risks against the benefits to make specific judgements concerning every issue.ConclusionsWe believe that our analysis would be a helpful example of solving ethical issues that can arise concerning COVID-19 vaccine supply around the world. The public view can be highly critical, helping to spot such issues. An ignoring this view can lead to major problems, which in turn, can become a serious obstacle for the vaccine coverage and epidemics’ control in the countries and regions. (shrink)

Scholars have widely discussed the paradigm of integration of Islam and science. Still, a model of integration of Islam and science that uses the reasoning of Martabat Tujuh [seven grades] has not been found. Therefore, this study sought to investigate the manuscripts of Shaykh Abdussamad al-Palimbani’s Martabat Tujuh in the integration of Islam and science. This study used a descriptive qualitative approach, and data collection techniques were documentation and interviews. This study found two spiritual reasons in the manuscript of Shaykh (...) Abdussamad al-Palimbani’s Martabat Tujuh: tanazzul [move down] deductive reasoning and taraqqi [move up] inductive reasoning.Contribution: The article contributed to developing the integration of Islam and science in Indonesia. The manuscripts of Martabat Tujuh [seven grades] by Shaykh Abdussamad al-Palimbani offer the circular motion of Martabat Tujuh as a model for integrating knowledge. The circular motion model of Martabat Tujuh is expected to be used as a theoretical basis for applying knowledge integration at various Islamic universities in Indonesia. (shrink)

Children and individuals with developmental disabilities compared to typical participants are disadvantaged not only by virtue of being vulnerable to risks inherent in research participation but also by the higher likelihood of exclusion from research altogether. Current regulatory and ethical guidelines although necessary for their protection do not sufficiently ensure fair distributive justice. Yet, in view of disproportionately higher burdens of co-occurring physical and mental disorders in individuals with DD, they are better positioned to benefit from research by equitable participation. (...) Greater elucidation of this ethical dilemma is called for by researchers, institutional review boards, and funding agencies to urgently redress the imbalance. This article discusses many of the regulatory principles to ensure better research participation of children and individuals with DD: human rights, validity, distributive justice, beneficence/nonmaleficence, and autonomy. (shrink)

Sierpinski networks are networks of fractal nature having several applications in computer science, music, chemistry, and mathematics. These networks are commonly used in chaos, fractals, recursive sequences, and complex systems. In this article, we compute various connectivity polynomials such as M -polynomial, Zagreb polynomials, and forgotten polynomial of generalized Sierpinski networks S k n and recover some well-known degree-based topological indices from these. We also compute the most general Zagreb index known as α, β -Zagreb index and several other general (...) indices of similar nature for this network. Our results are the natural generalizations of already available results for particular classes of such type of networks. (shrink)

This paper considers the foundation of self-realization and the sense of morality that could justify Arne Naess’s claim ‘Self-realization is morally neutral,’ by focusing on the recent debate among deep ecologists. Self-realization, the ultimate norm of Naess’s ecosophy T, is the realization of the maxim ‘everything is interrelated.’ This norm seems to be based on two basic principles: the diminishing of narrow ego, and the integrity between the human and non-human worlds. The paper argues that the former is an extension (...) of Plato’s idea of self-development or self-mastery while the latter is implicit in Aristotle’s holism. It defends that Self-realization is morally neutral only if the term ‘moral’ is considered in the Kantian sense. However, Naess reluctantly distinguishes between ethics and morality, which makes his approach less credible. The paper concludes that Aristotle’s notion of eudaimonia supports Self-realization to qualify as a virtue. (shrink)

Organisations have implemented intensive home-based teleworking in response to global COVID-19 lockdowns and other pandemic-related restrictions. Financial pressures are driving organisations to continue intensive teleworking after the pandemic. Understanding employees’ teleworking inclinations post COVID-19, and how these inclinations are influenced by different factors, is important to ensure any future, more permanent changes to teleworking policies are sustainable for both employees and organisations. This study, therefore, investigated the relationships between the context of home-based teleworking during the pandemic, productivity perceptions during home-based (...) teleworking, and employees’ future teleworking inclinations beyond the pandemic. Specifically, the study examined whether pandemic-teleworking conditions related to the job, and the physical and social environments at home, influenced employees’ FTI, and if perceptions of improved or reduced productivity mediated these relationships. Data were collected during April and May 2020 with a cross-sectional online survey of teleworkers in Germany, Switzerland, the United Kingdom, and other countries during the first COVID-19 lockdowns. Reported FTI were mixed. Most participants reported wanting to telework more post-pandemic compared to before the pandemic; however, 18% wanted to telework less. Hierarchical multiple regression analysis revealed that some teleworking conditions were positively associated with FTI. Other teleworking conditions were not associated with FTI. Perceived changes in productivity mediated the relationship between work privacy fit and FTI. Findings highlight the role of work privacy fit and job demands in influencing pandemic productivity perceptions and teleworking inclinations post-pandemic. Results raise questions about the suitability and sustainability of home-based teleworking for all staff. As organisations plan to increase the proportion of teleworking post-pandemic, this study suggests there is a need to support employees who perceived their productivity to be poor while home-working during the pandemic. (shrink)

Response to novelty in rats tested in isolation and in pairs: focus on exploration and play The main goal of the study was to compare investigatory responses towards novelty in 20 Wistar rats divided into two experimental groups. Additionally, relationship between novelty and social play/interaction was analyzed in the dyad group. Procedure involved placing animals in an experimental chamber during fifteen, six minute trials on successive days of the study. On the eleventh session a new object was introduced. The results (...) are summarized within several behavioral categories. Investigatory responses of rats in dyad to novel object in familiar environment were not quantitatively different, than those of isolated animals. The animals from both groups responded to the novel object by focusing their exploratory activity on the source of new stimulation. Amount of social play and social exploration was influenced by the experimental manipulation with important sex differences present. (shrink)

BackgroundNormally, physicians understand they have a duty to treat patients, and they perform accordingly consistent with codes of medical practice, standards of care, and inner moral motivation. In the case of COVID-19 pandemic in a developing country such as Bangladesh, however, the fact is that some physicians decline either to report for duty or to treat patients presenting with COVID-19 symptoms. At issue ethically is whether such medical practitioners are to be automatically disciplined for dereliction of duty and gross negligence; (...) or, on the contrary, such physicians may legitimately claim a professional right of autonomous judgment, on the basis of which professional right they may justifiably decline to treat patients.MethodsThis ethical issue is examined with a view to providing some guidance and recommendations, insofar as the conditions of medical practice in an under-resourced country such as Bangladesh are vastly different from medical practice in an industrialized nation such as the USA. The concept of moral dilemma as discussed by philosopher Michael Shaw Perry and philosopher Immanuel Kant’s views on moral appeal to “emergency” are considered pertinent to sorting through the moral conundrum of medical care during pandemic.ResultsOur analysis allows for conditional physician discretion in the decision to treat COVID-19 patients, i.e., in the absence of personal protective equipment (PPE) combined with claim of duty to family. Physicians are nonetheless expected to provide a minimum of initial clinical assessment and stabilization of a patient before initiating transfer of a patient to a “designated” COVID-19 hospital. The latter is to be done in coordination with the national center control room that can assure admission of a patient to a referral hospital prior to ambulance transport.ConclusionsThe presence of a moral dilemma (i.e., conflict of obligations) in the pandemic situation of clinical care requires institutional authorities to exercise tolerance of individual physician moral decision about the duty to care. Hospital or government authority should respond to such decisions without introducing immediate sanction, such as suspension from all clinical duties or termination of licensure, and instead arrange for alternative clinical duties consistent with routine medical care. (shrink)

In this study, we first introduce polygonal cylinder and torus using Cartesian products and topologically identifications and then find their Wiener and hyper-Wiener indices using a quick, interesting technique of counting. Our suggested mathematical structures could be of potential interests in representation of computer networks and enhancing lattice hardware security.