Eradicating poverty is one of the prime goals included in the Sustainable Development Goals set by the United Nations in its Post-2015 Development Agenda. Clearly, this is a mission set for the world to achieve but do humans have a moral obligation to fulfill it? In other words, is there a moral obligation on the part of the affluent of the world to help the needy poor? Drawing on the relation between a moral obligation and a moral right, one view (...) is that if there is a moral obligation to help the needy poor of the world, then we can say that those afflicted by severe poverty have a moral right (human right) to be free from poverty. But being an example of a socioeconomic right, it is writ with problems leading some philosophers to doubt that there is such a right. On the other hand, many attempts have been made to justify such a right. The paper looks at some attempts that have been made to justify the existence of such a right on the metaethical principles of justice, humanity and the concepts of karma and dharmic duty. It further delves into the nature of the moral obligation to eradicate poverty where this philosophical exercise provides the vision and the insight into the extent and scope of the mission. Lastly, the paper suggests how in view of the complex theoretical issues involved, one can attempt to generate the conviction that there is a human moral obligation to eradicate poverty. (shrink)

Many philosophers in the Anglo-American tradition have held that the predominant modern western theories of ethics like Kant’s deontological theory and Mill’s Utilitarianism have failed to deliver as a “theory” of ethics. In other words, they are not successful as “decision procedures” whereby one can determine which action from a multitude of actions open before the agent would be right and therefore morally obligatory for him to do. In fact, the basic concepts of moral obligation, impartiality, and objectivity of moral (...) standards has been questioned and pitted against the “personal point of view” of the agent. It has been held that the “moral goods” have to be given up for the sake of the “personal goods.” Is this a systemic fault which is linked with the normative nature of ethics? Or, can we understand ethics in a manner where it can be objective and yet not have to give up on the plurality of moral and nonmoral goods? Can ethical theory in this sense function as an “action guide to moral practice”? These are some questions that will be taken up in the paper against the backdrop of the views of the critics of ethical theory. (shrink)

This paper proposes to argue that ecological justice that is rooted in an ecocentric approach to nature is the key to achieving integral human development which goes beyond ‘development that is only worth our while’. Ecological justice is achievable if there is a clear understanding of relations at two distinct levels - one, the relation among humans and another between the entire human community and other elements of the ecosystem. These relations are the basis of the alliances that we form (...) to address issues of integral human development. The focus of the paper is the second kind of alliance that is based on an understanding of the relation between the human and the non-human realm. However, an ‘alliance’ is normally formed between partners with equal standing. Is there a sense in which both humans and the non-human world can be considered to be ‘equal partners in an alliance? The paper considers how one might establish this by examining diverse philosophical viewpoints that have addressed the issue of the treatment of non-human animals for anthropocentric ends. It discusses whether equality between parties is necessary for the formation of an alliance drawing extensively from ethical theories and examples from the world. From rights approach, recipients of justice, to care ethics, several theories offer guidance to support what would constitute a ‘humane’ approach to non-human animals. While these approaches crucially pin the broad perspective, they have not explicitly considered the role of an alliance between humans and non-human animals in achieving a basic level of wellbeing for the latter. Taking cues from the different kinds of ‘ruling over’ from Stuart Gray’s understanding of the relation between humans and non-human nature, the paper seeks to establish that an alliance between humans and the non-human realm is possible even without committing to their equal status and this could form the basis of ecological justice and well-being. (shrink)

It is an indubitable fact that our thoughts are always about something or some state of affairs in the world. Again, it is true that we use language to express some of our thoughts, and that in such a use of language which philosophers call a speech act, language also comes to be about something or some state of affairs in the world. E.g., when someone asserts that Peter is married to Mary, the sentence, 'Peter is married to Mary', comes (...) to be about the state of affairs of Peter's being married to Mary. This property of being about something which characterizes our thoughts and speech acts is called "intentionality" by philosophers. ;In Intentionality, John Searle claims that the Intentionality of language and the Intentionality of speech acts performed by using language is derived from the intrinsic Intentionality of mental states which accompany the speech act. In the dissertation I propose to examine this claim of Searle's. ;Searle's view regarding the Intentionality of speech acts is incomplete and wrong. Searle does not show how the Intentionality of referring and predicating in a speech act is to be derived from mental reference and mental predication in the corresponding mental state. In this sense his theory is incomplete. Further, his theory is false. Taking the case of belief, I propose to show that it cannot be the source of the Intentionality of the corresponding assertion. Either a belief is a disposition and does not have any Intentionality or it is a mental act of accepting a proposition in which case the Intentionality of the belief and the Intentionality of the assertion have the same linguistic nature and the former cannot be the source of the latter. We are faced with a dilemma which shows that Searle's view cannot be correct. In the dissertation it will be argued that the Intentionality of a speech act is as intrinsic to it as the Intentionality of a mental phenomenon is to the mental phenomenon. The nature of speech act referring and predicating, mental referring and predicating, linguistic concepts and linguistic acts using those concepts will be discussed. (shrink)

'Applied Ethics and Human Rights: Conceptual Analysis and Contextual Applications' offers a philosophical perspective to ethical problems by providing an ...

In what sense must global ethics be global? In one sense, it must deal with global issues. In another, it must not be parochial but inclusive of normative views from around the world. So far, global ethics has met the first standard much better than the second. Authors based in the global South contribute approximately 5% of the internationally published research on global ethics. With this in mind, the co-editors of this special issue sought to bring more perspectives, experiences, and (...) authors from India into the international global ethics conversation, and so they launched the Indian Global Ethics Initiative. Their first step, this special issue, presents Indian experience and authors on topics including urban development, care ethics, women’s empowerment, fair trade, distorted policy research, poverty, and health. Much of this work is grounded by the authors’ experience in policy-making and advocacy for social and global justice. The co-editors invite contact from interested readers who would like to join and continue this Indian Global Ethics Initiative, as well as readers who would like to take similar initiatives in other regions. (shrink)

PurposeThis paper presumes that a public policy document must aim at protecting human rights. The question being raised is- what kind of moral reasoning or grounding can we afford to the idea that human rights are important for the whole framework of public policy. The paper aims at looking at the moral and political philosophy of Immanuel Kant as we find it in his Groundwork of the Metaphysics of Morals and the Metaphysics of Morals for providing this background.MethodThe paper provides (...) an exegetical account of some of the key concepts in Kant’s moral philosophy and the application of these in socio-political contexts.Result and DiscussionThe processes involved in the framing of the document, the document itself, as well as the persons framing the document must aspire to respect and protect human rights. The implication itself rests on the principle that a moral end cannot be achieved by immoral means and protecting human rights is a moral end that all societies must seek to achieve. Hence not only the end, which in this case is the policy document itself, but the means, i.e., the processes of framing the documents and intentions of those responsible and accountable for it, must also be moral. (shrink)

This paper aims at understanding Sustainable Development Goals as normative ends to be achieved by normative means in the context of global ethics. It distinguishes the descriptive and the normative senses of sustainability and development and puts forward a case for exploring the role of human moral obligations as the normative means to attain the goals of sustainable development. It argues that it is only when basic human moral obligations and role-related obligations are fulfilled that human well-being and that of (...) the non-human elements of the eco-system can be achieved. Furthermore, it also explains how such a concept can be inclusive, diverse and integrative. (shrink)

The Ethics of Governance: Moral Limits of Policy Decisions offers a toolbox drawn from normative ethics which finds applications in public governance, primarily focusing on policy making and executive action. It includes ethical concepts and principles culled from different philosophical traditions, ranging from more familiar Western theories to non-Western ethical perspectives, thereby providing a truly global, decolonized and expanded normative lens on issues of governance. The book takes a unique and original approach; it demonstrates the use of the ethical toolbox (...) in the context of actual examples of governance challenges. Taking three major case studies each representing an aspect of human-human and/or human-nature and/or human-animal relationship, the book attempts to show the significance of public practical reasoning in policy decisions with the aim of arriving at reasonable responses. Acknowledging the challenges that policy makers often face, the book highlights the fact that policy making is hardly an exercise yielding a black-or-white solution; rather it involves finding the most reasonable normative outcome in a given situation, especially employing an expanded understanding of values including well-being, sustainability, interdependence and community. This effort that helps bridge the gap between ethical theorists and policy practitioners exemplifies the necessary role of ‘engaged philosophy’ in public governance. In the major case studies, Boxes offer facts and figures along with pertinent ethical questions that have been raised and discussed. Aiming to aid the engagement of a diverse audience including non-philosophy readers, each chapter also includes Boxes containing examples, shorter case studies, at-a-glance charts, and tables with comprehensive ethical tools for a quick recap. (shrink)

Against any obscurantist stand, denying the interest of natural sciences for the comprehension of human meaning and language, but also against any reductionist hypothesis, frustrating the specificity of the semiotic point of view on nature, the paper argues that the deepest dynamic at the basis of meaning consists in its being a mechanism of ‘potentiality navigation’ within a universe generally characterized by motility. On the one hand, such a hypothesis widens the sphere of meaning to all beings somehow endowed (...) with the capacity of moving and/or perceiving movement. On the other hand, through a new evolutionist interpretation of the concept of generativity, such a hypothesis preserves the peculiarity of human meaning, meant as essentially founded on a certain intuition of infinity. Two corollaries stem from this hypothesis: first, religiosity can be considered as a matrix of grammars of infinity, aiming at regimenting its flight of potentialities. Second, non-genetic transmission of cultural information exerts determinant influence also at the level of that very deep mechanism of the human predicament that is the cognitive navigation of motor potentialities. A re-reading of the structuralist epistemology, scientific literature on the nervous cells of jellyfish, and some recent experiments on the mirror neurons of dancers, as well as certain intuitions of Teilhard de Chardin, are the main arguments of the paper. (shrink)

Motilal Shastri developed an ethical theory which closely resembles rule utilitarianism at roughly the same time as and yet in complete independence of English-speaking philosophers. The philosophic significance of his view lies in the manner in which he develops and justifies his position. Shastri contends that efficiency in action requires indifference or inattention to ends. He appears to use the same device for justifying rule-governed duties that Mill uses to justify a move from egoism to altruism: that actions first viewed (...) as means may later become ends in themselves. However, in Shastri’s theory, ends appear to be retained as unconscious motives. (shrink)

Motilal Shastri developed an ethical theory which closely resembles rule utilitarianism at roughly the same time as and yet in complete independence of English-speaking philosophers. The philosophic significance of his view lies in the manner in which he develops and justifies his position. Shastri contends that efficiency in action requires indifference or inattention to ends. He appears to use the same device for justifying rule-governed duties that Mill uses to justify a move from egoism to altruism: that actions first viewed (...) as means may later become ends in themselves. However, in Shastri’s theory, ends appear to be retained as unconscious motives. (shrink)

In this paper, I review a collection of recently published papers that have provided significant new information about the biogenesis and functions of motile cilia. In vertebrates, the activity of motile cilia has been associated with a fascinating diversity of developmental and physiological processes. Despite the importance, much remains to be learned about the genetic control and cellular events that are involved in the differentiation of motile cilia. We also need to better understand the mechanisms by which cilia‐driven fluid flow (...) is able to influence such a variety of developmental and physiological processes. The Foxj1 family of proteins has now been definitively established as master regulators of motile ciliogenesis.1,2 Identification of the Kintoun/PF13 protein has shed light on the assembly of dynein arms,3 whereas live imaging of ciliary motility has led to the discovery of an intriguing new role for motile cilia in otolith formation in the ear.4. (shrink)

Recent social theory that stresses the ‘nonrepresentational’, the ‘more-than visual’, and the relationship between affect and sensation have tended to assume some kind of break or rupture from historical antecedents. Especially since the contributions of Crary and Jay in the 1990s, when it comes to perceiving the built environment the complexities of sensation have been partially obscured by the dominance of a static model of vision as the principal organizing modality. This article returns to some prior historical articulations of the (...) significance of motility in perception, retracing pathways across art history, architectural theory and the history of neuroscience to argue for an alternative model based on the movement of the eye. Along with subsystems that deal with balance and orientation, I offer parallels between spatial motifs of the interior spaces of the body – labyrinths, vestibules, chambers – and those in artefacts and the built environment that contribute to the heightened physicality of the oculomotor subject. (shrink)

This paper argues that human motility is essentially bound up in a pre-reflective being-in-the-world, and that contemporary science seems to bear out some of Merleau-Ponty's phenomenological explorations in this area.

This paper argues that human motility is essentially bound up in a pre-reflective being-in-the-world, and that contemporary science seems to bear out some of Merleau-Ponty's phenomenological explorations in this area.

This paper integrates personal narratives with the methods of phenomenology in order to draw some general conclusions about ‘what it means’ and ‘what it feels like’ to be depressed. The analysis has three parts. First, it explores the ways in which depression disrupts everyday experiences of spatial orientation and motility. This disruption makes it difficult for the person to move and perform basic functional tasks, resulting in a collapse or contraction of the life-world. Second, it illustrates how depression creates (...) a situational atmosphere of emotional indifference that reduces the person’s ability to qualitatively distinguish what matters in his or her life because nothing stands out as significant or important anymore. In this regard, depression is distinct from other feelings because it is not directed towards particular objects or situations but to the world as a whole. Finally, the paper examines how depression diminishes the possibility for ‘self-creation’ or ‘self-making’. Restricted by the illness, depression becomes something of a destiny, preventing the person from being open and free to access a range of alternative self-interpretations, identities, and possible ways of being-in-the-world. (shrink)

Extensive progress has been made recently in understanding the mechanism by which cells move and extend protrusions using site‐directed polymerization of actin in response to signalling. Insights into the molecular mechanism of production of force and movement by actin polymerization have been provided by a crosstalk between several disciplines, including biochemistry, biomimetic approaches and computational studies. This review focuses on the biochemical properties of the proteins involved in actin‐based motility and shows how these properties are used to generate models (...) of force production, how the predictions of different theoretical models are tested using a biochemically controlled reconstituted motility assay and how the changes in motility resulting from changes to the concentrations of components of the assay can help understand diverse aspects of the motile behavior of living cells. BioEssays 25:336–345, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

In 1979, neuroscientists Libet, Wright, Feinstein and Pearl introduced the “delay-and-antedating” hypothesis/paradox based on the results of an on-going series of experiments dating back to 1964 that measured the neural adequacy [brain wave activity] of “conscious sensory experience”. What is fascinating about the results of this experiment is the implication, especially when considered in the light of Merleau-Ponty’s notions of “intentionality” and the “pre-reflective life of human motility”, that the body, and hence not solely the mind, is a thinking (...) thing. The experiments and conclusions of Libet et al. have attracted considerable academic attention and have been used in the development of psychological theories on automotivism and the adaptive unconscious. Moreover, they have engendered a series of important considerations in respect of the question of free will. This paper outlines the connections between the findings of Libet et al. and Merleau-Ponty’s ontology as presented in the Phenomenology of Perception. It is not our intention to argue that the former amounts to new wine in old bottles, but rather to show counterfactually that Merleau-Ponty’s ontology provides a theoretical framework which explains the experimental data obtained by Libet et al., and provides further speculative confirmation of the work stemming from neuro-physical research and emerging theories on the adaptive unconscious. (shrink)

M. xanthus has a complex multicellular lifestyle including swarming, predation and development. These behaviors depend on the ability of the cells to achieve directed motility across solid surfaces. M. xanthus cells have evolved two motility systems including Type‐IV pili that act as grappling hooks and a controversial engine involving mucus secretion and fixed focal adhesion sites. The necessity for cells to coordinate the motility systems and to respond rapidly to environmental cues is reflected by a complex genetic (...) network involving at least three complete sets of chemosensory systems and eukaryotic‐like signaling proteins. In this review, we discuss recent advances suggesting that motor synchronization results from spatial oscillations of motility proteins. We further propose that these dynamics are modulated by the action of multiple upstream complementary signaling systems. M. xanthus is thus an exciting emerging model system to study the intricate processes of directed cell migration. BioEssays 30:733–743, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

New Mechanist philosophical models of "phenomenon reconstitution" understand the process to be driven by explanatory considerations. Here I discuss an episode of phenomenon reconstitution that occurred entirely within an experimental program dedicated to characterizing the phenomenon of kinesin motility. Rather than being driven by explanatory considerations, as standard mechanist views maintain, I argue that the phenomenon of kinesin motility was reconstituted to enhance researchers’ primary experimental tool—the single molecule motility assay.

Following a position similar to that of Alexandre Kojève, K. R. Dove has made the interesting suggestion that Hegel’s Phenomenology of Spirit “was probably the first philosophical treatise whose method was radically and consistently non-dialectical.” Later in his article Dove gives us an indication of the import which his statement has for an interpretation of the work. He says.

In this essay, I offer a comparative analysis on the ontological perspective from Heidegger and Theravada Buddhism on ‘the motility of life’: namely, the essence of the organism belonging to living beings whether human or non-human animals. To question about the innermost essence of life by considering birth, maturing, aging, and death, Heidegger finds out later that his approach is incomplete and inadequate because his existential analytic of human Dasein cannot explain the animal motility as captivation. However, in (...) Theravada Buddhist philosophy there is some doctrine in ‘The Four Noble Truths’ mentioning the same point of those processes of life, birth – decay - death, as ‘Dukkha’. Next, from the analysis I offer an argument to show that if the Buddhist conception of Dukkha is read into the motility of life, we can find a new Heideggerian concept of ‘underlying motility’ as a result which can give an answer to his question. (shrink)

The aim of the study is to contribute to a better understanding of some aspects of the structure of biological knowledge and to make clearer to what extent the methods of reasoning may be useful in this field when only qualitative information is available. A fragment of biological knowledge (theory of cell motility) is analysed from the logico-methodological point of view as a coherent system and the possibility of its formal representation is investigated. The analysis is based on distinguishing (...) the main objects and their features (attributes) of which a given piece of knowledge is composed and on the values which these features may display. The features are interconnected by relations (in which various number of arguments appear) and these relations constitute the main (general, higher level) laws of a given fragment of knowledge (theory). Values of attributes are also mutually connected and these relations correspond to the detailed (lower level) laws. A computer system (in which Prolog language was used) enables to perform inference operations of progressive as well as regressive type. The main categories of reasoning procedures are described and illustrated by examples, namely a) search for conclusions which may be confronted with the actual knowledge in order to verify the system as a whole, b) formation of working hypotheses in the process of their empirical verification and explanation of facts and laws. The problem of development and modification of the system is also discussed. (shrink)

During the formation of the brain, neuronal cell migration and neurite extension are controlled by extracellular guidance cues. Here, I discuss experiments showing that the messenger nitric oxide (NO) is an additional regulator of cell motility. NO is a membrane permeant molecule, which activates soluble guanylyl cyclase (sGC) and leads to the formation of cyclic GMP (cGMP) in target cells. The analysis of specific cells types in invertebrate models such as molluscs, insects and the medicinal leech provides insight how (...) NO and cyclic nucleotides affect the wiring of nervous systems by regulating cell and growth‐cone motility. Inhibition of the NOS and sGC enzymes combined with rescue experiments show that NO signalling orchestrates neurite outgrowth and filopodial dynamics, cell migration of enteric neurons, glial migration and axonogenesis of pioneer fibers. Cultured insect embryos are accessible model systems in which cellular mechanisms of NO‐induced cytoskeletal reorganizations can be analyzed in natural settings. Finally, I will outline some indications that NO may also regulate cell motility in the developing and regenerating vertebrate nervous system. BioEssays 27:495–505, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Permeabilized cell models provide an experimental middle ground wherein the in vitro properties of mechanochemical proteins can be reconciled with the physical and topological constraints of the intact cell. Several well‐studied examples of organelle motility are described here, including the actin‐based cytoplasmic streaming of Characean algae, the microtubule‐based aggregation and dispersion of pigment granules in chromatophores and the saltatory movements of vesicles along microtubules in fibroblasts and macrophages. The permeabilized models developed for these systems have helped to integrate observations (...) in vivo with in vitro assays of motor proteins. (shrink)

Sperm motility and respiration are tightly coupled processes, both activated by an increased intracellular pH (pHi). As the sperm pHi increases, the flagellar motor driving motility is activated, leading to ATP consumption. Energy for motility is provided by mitochondrial respiration; energy transport from sperm mitochondrion to tail involves distinct isozymes of creatine kinase that effect a phosphorylcreatine shuttle. The activation of sperm motility and respiration can be described as a linked series of biochemical reactions that form (...) a cell behavioural pathway analogous to the reaction sequences of intermediary metabolism. (shrink)

Sperm motility and respiration are tightly coupled processes, both activated by an increased intracellular pH (pHi). As the sperm pHi increases, the flagellar motor driving motility is activated, leading to ATP consumption. Energy for motility is provided by mitochondrial respiration; energy transport from sperm mitochondrion to tail involves distinct isozymes of creatine kinase that effect a phosphorylcreatine shuttle. The activation of sperm motility and respiration can be described as a linked series of biochemical reactions that form (...) a cell behavioural pathway analogous to the reaction sequences of intermediary metabolism. (shrink)