ObjectiveProcessing Speed, the ability to perceive and react fast to stimuli in the environment, has been shown to be impaired in children with attention deficit hyperactivity disorder. However, it is unclear whether PS can be improved following targeted treatments for ADHD. Here we examined potential changes in PS following application of transcranial electric stimulation combined with cognitive training in children with ADHD. Specifically, we examined changes in PS in the presence of different conditions of mental fatigue.MethodsWe used a randomized double-blind (...) active-controlled crossover study of 19 unmedicated children with ADHD. Participants received either anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex or transcranial random noise stimulation, while completing CT, and the administration order was counterbalanced. PS was assessed before and after treatment using the MOXO-CPT, which measures PS in the presence of various conditions of mental fatigue and cognitive load.ResultstRNS combined with CT yielded larger improvements in PS compared to tDCS combined with CT, mainly under condition of increased mental fatigue. Further improvements in PS were also seen in a 1-week follow up testing.ConclusionThis study provides initial support for the efficacy of tRNS combined with CT in improving PS in the presence of mental fatigue in pediatric ADHD. (shrink)

This book examines the longstanding debate between philosophical optimism and pessimism in the history of philosophy, focusing on Aristotle, Maimonides, Spinoza, Schopenhauer, Nietzsche and Camus. Philosophical optimists maintain that the world is optimally arranged and is accordingly valuable, and that the existence of human beings is preferable over their nonexistence. Philosophical pessimists, by contrast, hold that the world is in a woeful condition and ultimately valueless, and that human nonexistence would have been preferable over our existence. Schopenhauer criticizes the optimism (...) he locates in the Hebrew Bible and in Spinoza for being unable to square the presumed perfection of the world and its parts, including human life, with the suffering and misfortunes observable in them, and for leading to egoism and thereby to cruelty. Nietzsche, in turn, criticizes Schopenhauer's overtly pessimistic view, inter alia, for furtively positing a perfect state for one to aspire to, thus being latently optimistic. Similarly, Camus charges Nietzsche, who announces his rejection of both optimism and pessimism, with deifying the world and oneself, thereby reverting to optimism. Interestingly, Aristotle countenances an optimistic theory, later adopted and developed by Maimonides, that is arguably capable of facing Schopenhauer's challenge. Aristotelian optimism accounts for the perfection of the world in terms of a hierarchy of value between its parts, with human beings ranked relatively low, and recommends an attitude congruent with that ranking. (shrink)

All eukaryotic cellular mRNAs, and most viral mRNAs, are blocked at their 5′ ends with a cap structure (m7GpppX, where × is any nucleotide). Poliovirus, along with a small number of other animal and plant viral mRNAs, does not contain a 5′ cap structure. Since the cap structure functions to facilitate ribosome binding to mRNA, translation of poliovirus must proceed by a cap‐independent mechanism. Consistent with this, recent studies have shown that ribosomes can bind to an internal region within the (...) long 5′ noncoding sequence of poliovirus RNA. Possible mechanisms for cap‐independent translation are discussed. Cap‐independent translation of poliovirus RNA is of major importance to the mechanism of shut‐off of host protein synthesis after infection. Moreover, it is likely to play a role in determining poliovirus neurovirulence and attenuation. (shrink)

X: The Problem of the Negro as a Problem for Thought offers an original account of the African American as an object of discourse, knowledge, and general social practice, conceiving the focus of such a concern -- with W.E.B. Du Bois -- as forms of social and historical problems on an epochal scale, above all the global-level "problem of the color line," as the mark of both historical limit and possibility.

The paper describes the author's experience in using the history of science in teaching physics to science teachers. lt was found that history becomes more useful to teachers when explicitly combined with 'investigative' experimentation, which, in turn. can benefit from various uses of the history of science.

Schopenhauer shares with Spinoza the basic idea that “the world exists by its own inner power and through itself”. Spinoza's system, Schopenhauer maintains, elaborately captures the observation, at the core of both pantheism and Schopenhauer's own theory, that all experienced phenomena share a single metaphysical substratum, and that in this sense everything is one. Any view or system of thought upholding optimism must confront the challenge of accounting for those features of the world that appear to be less than optimal. (...) For Schopenhauer, Judaism is committed to the goodness of the world given its creation by a personal God. It has been suggested that Schopenhauer ought not to criticize the rejection of personal immortality, since he himself thinks individual lives are perishable. Apart from the theoretical problems that Schopenhauer locates in maintaining optimism, he also takes issue with its practical implications. (shrink)

This book presents detailed discussions from leading intercultural philosophers, arguing for and against the priority of immanence in Chinese thought and the validity of Western interpretations that attempt to import conceptions of transcendence. The authors pay close attention to contemporary debates generated from critical analysis of transcendence and immanence, including discussions of apophasis, critical theory, post-secular conceptions of society, phenomenological approaches to transcendence, possible-world models, and questions of practice and application. This book aims to explore alternative conceptions of transcendence that (...) either call the tradition in the West into question, or discover from within Western metaphysics a thoroughly dialectical way of thinking about immanence and transcendence. (shrink)

El objetivo de este trabajo es medir el efecto del feedback correctivo escrito directo en el incremento del aprendizaje y el uso correcto de las preposiciones por y para en español como segunda lengua. Dichas preposiciones se consideran como unas de las más complejas durante el proceso de aprendizaje teniendo en cuenta la frecuencia de errores cometidos en sus usos y la naturaleza sintáctico-semántica. Para ello se llevó a cabo un estudio cuasiexperimental con pretest, postest inmediato, postest diferido y grupo (...) control, aplicando sistemáticamente las estrategias de FC metalingüístico directo y no metalingüístico directo a nivel escrito. Los resultados han demostrado evidencia de los efectos positivos de estos feedbacks correctivos en el incremento del aprendizaje y uso correcto de estas estructuras preposicionales. The aim of this research is to evaluate the effectiveness of written direct corrective feedback on the learning improvement of prepositions “por and para” in Spanish as second language. These grammatical structures are considered among the most complex prepositions to acquire during the learning process, considering the frequency of errors in their use and their syntactic-semantic nature. In order to achieve this aim, a quasi-experimental study with a pretest, immediate posttest, delayed posttest and control group was conducted. In this context, we have systematically applied the strategies of written metalinguistic and non-metalinguistic direct corrective feedback on these prepositions errors. The results have shown the positive effects of the written corrective feedback on the acquisition of these prepositional structures. (shrink)

This paper discusses a way of introducing a scientific controversy, which emphasizes objective aspects of such issues as multiple theoretical interpretation of phenomena, choosing a theory, insistence on the chosen theory, and others. The goal is to give students a better insight into the workings of science and provide guidelines for building theories in their own research.

"This book examines the longstanding debate between philosophical optimism and pessimism in the history of philosophy, focusing on Aristotle, Maimonides, Spinoza, Schopenhauer, Nietzsche and Camus. Philosophical optimists maintain that the world is optimally arranged and is accordingly valuable, and that the existence of human beings is preferable over their nonexistence. Philosophical pessimists, by contrast, hold that the world is in a woeful condition and ultimately valueless, and that human nonexistence would have been preferable over our existence. Schopenhauer criticizes the optimism (...) he locates in the Hebrew Bible and in Spinoza for being unable to square the presumed perfection of the world and its parts, including human life, with the suffering and misfortunes observable in them, and for leading to egoism and thereby to cruelty. Nietzsche, in turn, criticizes Schopenhauer's overtly pessimistic view, inter alia, for furtively positing a perfect state for one to aspire to, thus being latently optimistic. Similarly, Camus charges Nietzsche, who announces his rejection of both optimism and pessimism, with deifying the world and oneself, thereby reverting to optimism. Interestingly, Aristotle countenances an optimistic theory, later adopted and developed by Maimonides, that is arguably capable of facing Schopenhauer's challenge. Aristotelian optimism accounts for the perfection of the world in terms of a hierarchy of value between its parts, with human beings ranked relatively low, and recommends an attitude congruent with that ranking"--. (shrink)

Aristotle is a severe critic of traditional religion, believing it to be false, yet he also holds that traditional religion and its institutions are necessary if any city, including the ideal city he describes in the Politics, is to exist and flourish. This book provides, for the first time, a coherent account of the socio-political role which Aristotle attributes to traditional religion despite his rejection of its content. Mor Segev argues that Aristotle thinks traditional religion is politically necessary because it (...) prepares the ground for what he considers the pinnacle of human endeavor: attaining the knowledge of first philosophy, whose objects are real beings worthy of being called gods. Developing this interpretation, Segev goes on to analyze Aristotle's references to the myths of traditional Greek religion, and to assess his influence on medieval Jewish and Christian theology and philosophy of religion. (shrink)

A reprint of the Schocken Books edition of 1961.

In _Annotations_ Nahum Dimitri Chandler offers a philosophical interpretation of W. E. B. Du Bois’s 1897 American Negro Academy address, “The Conservation of Races.” Chandler approaches Du Bois as a generative and original philosophical thinker-writer on the status and historical implication of matters of human difference, both the fact of and the very idea thereof. Chandler proposes both a close reading of Du Bois’s engagement of the concept of so-called race and a deep meditation on Du Bois’s conceptualization of (...) historicity in general. He elaborates on the way Du Bois’s thought in this address can give an account of the organization of the historicity that yields the emergence of something like the African American, at once with its own internal dimensions and yet also as an originary articulation of forces and possibilities that have world historical implications. Chandler refigures Du Bois’s thought as a vital theoretical resource for rethinking our concepts of differences among humans and, so too, our understanding of modern historicity itself. (shrink)

In _“Beyond This Narrow Now”_ Nahum Dimitri Chandler shows that the premises of W. E. B. Du Bois's thinking at the turn of the twentieth century stand as fundamental references for the whole itinerary of his thought. Opening with a distinct approach to the legacy of Du Bois, Chandler proceeds through a series of close readings of Du Bois's early essays, previously unpublished or seldom studied, with discrete annotations of _The Souls of Black Folk: Essays and Sketches_ of 1903, (...) elucidating and elaborating basic epistemological terms of his thought. With theoretical attention to how the African American stands as an example of possibility for Du Bois and renders problematic traditional ontological thought, Chandler also proposes that Du Bois's most well-known phrase—“the problem of the color line”—sustains more conceptual depth than has yet been understood, with pertinence for our accounts of modern systems of enslavement and imperial colonialism and the incipient moments of modern capitalization. Chandler's work exemplifies a more profound engagement with Du Bois, demonstrating that he must be re-read, appreciated, and studied anew as a philosophical writer and thinker contemporary to our time. (shrink)

Discussing theories at length, including their origin, development, and replacement by other theories, can help students in understanding of both objective and subjective aspects of the scientific process. Presenting theories in the form of- models helps in this undertaking, and the history of science provides a number of suitable models. The paper describes specific examples that have been used in in-service courses for science teachers.

A classroom Community of Inquiry depends on the deliberation skills of its members and their willingness to share ideas, time and power, despite conflicting interests, in the process of social inquiry. This vision of sharing power is not without challenges to both P4C and other theoretical movements within the discourse of democratic education. The kind of theorizing that is missing should explore students’ perceptions, judgment, decision making, agency and the like, through meaning making in particular contexts of democratic education. To (...) explore such challenges, I designed a qualitative study to unfold the meanings of power that middle school students constructed within a learning environment, which was influenced by democratic education principles. In explaining their meanings of power in democratic education, the participants explicitly challenged the pre-set notion of power equality between teachers and students, and between the members of a CI, and also the foundational concept of power that is based on redistribution of time and ideas. Arendt’s view of power mirrors the students’ perspectives. This notion of power in education explains why the students supported the teachers’ ‘power’, and why students used their power to different degrees. It is the way Arendt “stylized the image of the Greek polis to the essence of politics as such” (Habermas, 1986, p.82; Arendt, 1986, p.62) that explains how power should support democratic education according to the youths’ view. (shrink)

There may be a possibility that young women find it difficult to express their female ways of knowing and gain equal public representation. This leads us to reflect on a possible gap between a well developed theory of justice in P4C and pedagogical practices of social influence. In this paper I attempt to reflect on these questions provisionally, and suggest an initial theoretical framework for discussing such issues within the P4C movement. First, I report some personal and social narratives that (...) were described by individual writers. These narratives reflect, mostly, female authors’ personal histories from childhood to adulthood, and how their carrier choices were influenced by prevailing constructed gender roles. Second, I discuss the theory of the Community of Inquiry (CI) and examine the possibilities for self transformation and women liberation that this practice allows. Third, I introduce Hannah Arendt’s argument that education should not attempt to present the future of the human condition as finite and resolved. (shrink)

In his discussions of dreaming in the Parva Naturalia, Aristotle neither claims nor denies that dreams serve a natural purpose. Modern scholarship generally interprets dreaming as useless and teleologically irrelevant for him. I argue that Aristotle's teleology permits certain types of dream to have a natural role in end-directed processes. Dreams are left-overs from waking experience, but they may, like certain bodily residues, be used by nature, which does ‘nothing in vain’ and makes use of available resources, for the benefit (...) of the beings in which they occur. Contrary to prevalent opinions, Aristotle does not assimilate dreams to sensory illusions and does not hold that they have no interaction with our reasoning capacity. Dreams constitute a special class of the products of phantasia, but this does not prevent them from functioning like other (waking) phantasmata. In Aristotle's view, dreams regularly generate 'natural signs' of diseases and cause waking actions. I show that this preparatory power of dreams, often dismissed or attributed to divine intervention in antiquity, is captured within Aristotle’s natural philosophy, and provides evidence that (some) dreams are (or should be) regarded by him as having a teleological significance. (shrink)

On a trop souvent classé l’œuvre d’Ernest Renan dans le strict domaine de la linguistique ou dans l’histoire des religions, sans voir qu’elle reposait sur un fondement épistémologique original : l’acclimatation en France d’une lecture de la Critique de la faculté de juger de Kant. L’article étudie comment Renan élabore dans ses textes sur le langage publiés entre 1848 et 1855 une théorie de la connaissance qui se réalise au moyen d’une réflexion sur le langage. Le langage va donc opérer (...) comme un outil réflexif autour duquel s’ordonne le reste de son œuvre. (shrink)

Aristotle does not explicitly state how it is that one should ideally relate to the true gods of his metaphysics, like the prime mover. He does, however, speak of an unreciprocated relationship of friendship between humans and such gods. I argue that Aristotle’s conception of the magnanimous person sheds light on that relationship. The magnanimous person, who is a philosopher, devalues humanity and devotes her life and efforts to the divine. Thus, contrary to some scholars, Aristotle’s conception of magnanimity resembles (...) quite closely the ideals of humility and even “lowliness of spirit” presented by Aristotelian medieval thinkers such as Moses Maimonides. Aristotle’s endorsement of total devotion to the divine seems to go against the natural tendency of organisms to further their own lives and species. Nevertheless, I argue that this recommendation is consistent with his teleological view of nature. (shrink)

Persons exhibiting mutations in two tumor suppressor genes, BRCA1 and BRCA2, have a greatly increased risk of developing breast and/or ovarian cancer. The incidence of BRCA gene mutation is very high in Ashkenazi Jewish women of European descent, and many issues can arise, particularly for observant Orthodox women, because of their genetic status. Their obligations under the Jewish code of ethics, referred to as Jewish law, with respect to the acceptability of various risk-reducing strategies, may be poorly understood. In this (...) article the moral direction that Jewish law gives to women regarding testing, confidentiality, and other issues is explored. The intent is to broaden nurses' knowledge of how a particular religious tradition could impact on decision making around genetics testing, with the aim of enhancing their understanding of culturally sensitive ethical care. (shrink)

AtPol.7.12, 1331a19–20, Aristotle states it as a matter of fact that the citizenry of the best city should be divided into ‘public messes’ (syssitia). His primary concern in the rest of the chapter is to uncover the optimal way in whichsyssitiashould be organized, and the way in which they should be situated in relation to other facilities, public buildings,agoraiand temples in the city. The proposed plan is roughly as follows.Syssitiawould be divided into three main sections. First, thesyssitiaof soldiers would be (...) held at the guardhouses located at strategic points along the walls surrounding the city (1331a20–3). Next come ‘the most supremesyssitiaof the magistrates’ (τὰ κυριώτατα τῶν ἀρχείων συσσίτια: 1331a24–5) and thesyssitia‘of the priests’ (τῶν ἱερέων: 1331b5). These would be held at a place appropriately having ‘an appearance directed at establishing virtue and [being] more strongly positioned than the neighbouring parts of the city’ (1331a28–30), that is, the highest place in the city. This envisioned acropolis would also house temples (1331a24–5). Situated below it would be the ‘freeagora’, which would include gymnasia (1331a35–7) and would be generally directed at leisurely activity (1331b12). Finally, below the freeagora, a ‘necessaryagora’ and buildings of officials entrusted with legal, commercial and municipal duties would be established, at a location conducive to importing and exporting goods (1331b6–12). (shrink)

The rest is commentary.--Faith and knowledge.--The dynamics of emancipation.

A sourcebook of post-biblical Jewish literature from the Second Commonwealth to modern times.