‘Do you see this egg? It is with this that all the theological schools and all the churches of the Earth will be overturned.’Diderot, Entretien avec d'Alembert (Conversation with d'Alembert)About fifteen years ago I took a journey through the famous work of Mary Shelley, and the interpretation of her warning call. Let me say briefly why I am interested in Mary Shelley.At the beginning of the 80s I was invited by a journal to reflect on what was totally new at (...) that time: the birth of children conceived asexually and outside the body by in vitro fertilization. At that time very little work existed on these issues, though they were soon to generate a great deal of ink. The only publications to have appeared were Jacques Testart's very first book, De l'éprouvette au bébé spectacle (From the test tube to the miracle baby), and René Frydman's L'irrésistible désir de naissance (The irresistible desire for birth). (shrink)

Even in scientific usage there are terms that we believe we understand and when we try to pinpoint what they refer to we notice that these terms do not have a precise meaning. This applies, in linguistics, to the term Indo-European. Mostly, when used as an adjective, it seems to apply to those languages that derive, hypothetically, from a disappeared idiom which some scholars for nearly two hundred years have been trying to reconstruct. Thus, it is said that Sanskrit, Greek (...) and Latin are Indo-European languages. When this epithet is applied to French it causes surprise. From a comparative viewpoint, French is usually seen as a Romance language and only Romance languages taken together or, better said, Latin from which they derive, seem to merit the epithet. When used as a noun, “Indo-European” may designate the disappeared language itself. But serious scholars give it a precision in this case like commun in French, proto in English or Ur- in German. Does this imply that we may designate as Indo-European the sum of the individual languages of this family, whether they still exist or have disappeared? One may indeed take a chance and do it, but not without startling or even shocking one's public. (shrink)

There inevitably comes a time when even the best informed minds are tempted to yield to the lure of binarism: when we are no longer concerned with the details of a system, but rather with our vision of the relationship between man and the world. Without going any further it can already be said that the problem of existence is presented to us in terms of a man/world duality, as though we were unable to exceed our subjective vision of things (...) so as to assess their intrinsic reality.When linguists discovered that they could isolate discrete units called phonemes, they were tempted to oppose the discontinuity of these phonemes – reflecting the underlying discontinuity of the signifiers – to a continuum of prelinguistic experience, a continuum that is not arranged as discrete elements except with reference to any significant units of the language selected for the purpose of communicating this experience to others. At the outset we have nothing but a nebulous mass where only the application of a linguistic grid allows us to discern identifiable units. Even if, in the final analysis, it will prove necessary to doubt the universal validity of this vision of things, we must recognize its usefulness in concretizing a concept of linguistic facts – a concept that has for some time played a beneficent role in research. At least for some of us, this vision should reflect the manner in which the world is gradually organized in our minds each time a perceptible reality is isolated from its context at the instant it receives a name. Allow me to introduce an illustration from personal experience. It was the last day of July in 1914. In our little village in the Savoy the international tension – which would eventually end in general mobilization – was very perceptible; our classes were idle, and teachers and pupils had settled down in a field near the school. I was six. Sitting on the grass, my attention was attracted by a plant with large flat leaves. At that moment someone said the word plantain “plantain.” The plant had not been heretofore exactly unknown to me; it didn't strike me, at that moment, as a discovery; but it acquired a distinct existence only at that instant in the green carpet of the field when a signifier had definitively isolated it. It was most assuredly the gravity of the hour that engraved this incident in my memory. (shrink)

Intelligence remains ill-defined. Theories of intelligence and the goal of Artificial Intelligence have been the source of much confusion both within the field and among the general public. Studies that contribute to a well-defined goal of the discipline and spread a stronger, more coherent message, to the mainstream media, policy-makers, investors, and the general public to help dispel myths about A.I. are needed. We present the preliminary results of our research survey “Defining Intelligence.” Opinions, from a cross sector of professionals, (...) to help create a unified message on the goal and definition of A.I. (shrink)

Figurative drawing is a skill that takes time to learn, and it evolves during different childhood phases that begin with scribbling and end with representational drawing. Between these phases, it is difficult to assess when and how children demonstrate intentions and representativeness in their drawings. The marks produced are increasingly goal-oriented and efficient as the child’s skills progress from scribbles to figurative drawings. Pre-figurative activities provide an opportunity to focus on drawing processes. We applied fourteen metrics to two different datasets (...) (_N_ = 65 and _N_ = 344) to better understand the intentional and representational processes behind drawing, and combined these metrics using principal component analysis (PCA) in different biologically significant dimensions. Three dimensions were identified: efficiency based on spatial metrics, diversity with color metrics, and temporal sequentiality. The metrics at play in each dimension are similar for both datasets, and PCA explains 77% of the variance in both datasets. Gender had no effect, but age influenced all three dimensions differently. These analyses for instance differentiate scribbles by children from those drawn by adults. The three dimensions highlighted by this study provide a better understanding of the emergence of intentions and representativeness in drawings. We discussed the perspectives of such findings in comparative psychology and evolutionary anthropology. (shrink)

Etymologically, autonomy is the ability to give oneself rules and follow them. It is an important principle of medical ethics, which can sometimes raise some tensions in the care relationship. We propose a new definition of ethics, the ethics of heteronomy: a self-normative, discursive and responsible autonomy. Autonomy cannot be considered without the responsibility each person must have towards others. In the care relationship, autonomy would be more the ability of each person to reach out to others than the ability (...) to decide alone. The care relationship must be seen as an accompaniment of equals where each person allows the other to be rephrased. Autonomy would then no longer be absolute but relative to each situation. Being autonomous would become an ability for adaptation of the patient-doctor pair. The accompaniment allows the birth of a relationship of trust, giving the patient and the doctor the ability to touch and let themselves be touched, thus making each one progress in this reciprocal dialectic. The care relationship becomes the possibility of considering autonomy as a collective and not as an individual notion only. Paradoxically, by promoting the autonomy of the patient-doctor pair, they both develop their own autonomy. (shrink)

Applying the solutions defined in the axiomatic bargaining theory to actual bargaining problems is a challenge when the problem is not described by its Utility Possibility Set (UPS) but as a social choice environment specifying the set of alternatives and utility profile underlying the UPS. It requires computing the UPS, which is an operational challenge, and then identifying at least one alternative that actually achieves the bargained solution’s outcome. We introduce the axioms of Independence of Non-Strongly-Efficient Alternatives (resp. Weakly) and (...) Independence of Redundant Alternatives. A solution satisfying these axioms can be applied to a simplified problem based on any reduced set of alternatives generating the strong (resp. weak) Pareto frontier of the initial problem, without changing the outcome, making the application of bargaining solutions to actual problems easier. We compare our axioms to usual independence axioms, and discuss their consistency with usual bargaining solutions. Then, we introduce monotonicity conditions corresponding to the existence of an interest group, i.e., agents ranking the alternatives in the same order. For such monotonic social choice environments, we provide a parameterized family of alternatives that generates the Pareto frontier of the bargaining problem, in line with our previous results. Our analysis illustrates that an axiomatic approach can be useful to foster the application of bargaining solutions, in complement to usual computational methods. (shrink)

The molecular biology of viruses can be effectively described by kinetic logic as several feedback loops are implicated in all viral cycles and as viral proteins generally display several functions. We applied this method to the study of the rhabdovirus cycle.Formally, the dynamics of the model are explored on the basis of a discrete caricature (kinetic logic), with special emphasis on the role of the constitutive feedback loops to determine the essential dynamical behaviour of the viral cycle. From a biological (...) point of view, our model accounts for several stable regimes or attractors: healthy cells, acute infection and different kinds of persistent infections, a multistationarity in good agreement with the existence of several positive feedback loops in our system. (shrink)

A simplified model using kinetic logic is proposed to approach the problem after Hepatitis B viral (HBV) infection. It accounts for several stable regimes or attractors corresponding to the essential dynamic behaviour of the replication of the Hepatitis B virus. Infection with the virus can result in viral clearance, fulminant hepatic failure and death, or chronic transmissible infection, that is multistationarity corresponding to the existence of the positive feedback circuit in our modelling. Another implication of this model is the existence (...) of oscillations or homeostatic mechanisms, sometimes observed in the viral cycle, consistent with the existence of the negative feedback circuit. Thus, this report shows how a simple model of kinetic logic may be used to account for the variety of manifestations of HBV infection. This model implies the presence of the Hepatitis B e antigen, whose conservation suggests that it plays an important role in the life cycle of hepadnaviruses. Its function in the viral cycle is still unknown, but our model suggests that this antigen could explain the passage from one state of the viral infection (acute or latent) to another, as well as the oscillatory behavior which may account for the intermittent symptoms of hepatitis observed in some patients. Furthermore, this model shows a virgin state. This state is also reached after recovery. The model proposed demonstrates that starting from a viral acute infection, the host's immune response, depending on the immunological status of the patient, can lead to viral clearance, or to periodic spontaneous reactivation. (shrink)

Depuis les années quatre-vingt et la mondialisation de l’économie, les échanges et litiges internationaux ont été démultipliés. La France s’est dotée dès 1995 d’une chambre internationale au sein du Tribunal de commerce de Paris. Néanmoins, Londres concentrait la majorité de ces contentieux. Avec le Brexit, la place française s’est modernisée en créant une chambre internationale au sein de la Cour d’appel de Paris. Deux protocoles procéduraux ont vu le jour, adaptant la procédure civile française aux besoins du commerce international. Plusieurs (...) incompatibilités subsistent encore entre les acteurs de common law et de civil law, renforçant considérablement les missions de l’avocat français face à ses clients étrangers. (shrink)

Psychiatry is rapidly adopting digital phenotyping and artificial intelligence/machine learning tools to study mental illness based on tracking participants’ locations, online activity, phone and text message usage, heart rate, sleep, physical activity, and more. Existing ethical frameworks for return of individual research results (IRRs) are inadequate to guide researchers for when, if, and how to return this unprecedented number of potentially sensitive results about each participant’s real-world behavior. To address this gap, we convened an interdisciplinary expert working group, supported by (...) a National Institute of Mental Health grant. Building on established guidelines and the emerging norm of returning results in participant-centered research, we present a novel framework specific to the ethical, legal, and social implications of returning IRRs in digital phenotyping research. Our framework offers researchers, clinicians, and Institutional Review Boards (IRBs) urgently needed guidance, and the principles developed here in the context of psychiatry will be readily adaptable to other therapeutic areas. (shrink)

In the early eighteenth century Newtonianism became popular in the Netherlands both in academic and non-academic circles. The ‘Book of Nature’ was interpreted with the help of Newton’s natural philosophy and his ideas about a providential deity, thereby greatly enhancing the attractiveness of physico-theology in the eighteenth-century United Provinces. Like other Europeans the Dutch welcomed physico-theology as a strategic means in their battle against irreligion and atheism. Bernard Nieuwentijt, Johan Lulofs, Petrus Camper, and Johannes Florentius Martinet were prominent experts (...) in the field. Combining Newtonian notions with Leibnizian optimism and romanticist trends, physico-theology remained popular in the Netherlands well into the nineteenth century.Author Keywords: Apologetics; Dutch Enlightenment; Physico-theology; Prophetic theology; Argument from design; Empiricism. (shrink)

Le présent volume propose une cartographie de la recherche linguistique menée au Québec, avec beaucoup de dynamisme, entre 1960 et 2000. Les années 60 correspondent à une phase d'institutionnalisation de la discipline; l'an 2000 représente une rupture symbolique avec le XXe siècle et laisse un laps de temps raisonnable pour prendre un certain recul. Le livre présente ainsi une étude de cas sur l'histoire institutionnelle de la linguistique, qui fait écho à l'ouvrage éponyme Combats pour la linguistique, de Martinet (...) à Kristeva. Essai de dramaturgie épistémologique (2006) de J.-C. Chevalier et P. Encrevé. Les huit chapitres, qui forment l'ouvrage, font état des recherches réalisées pendant quatre décennies en sémantique, en lexicologie, en lexicographie, en phonologie, en grammaire et en sociolinguistique. Ils s'attardent aux filiations de la discipline avec le passé, à ses questionnements, ses acquis et ses legs ainsi qu'à ses limites, ses obstacles et ses déceptions. Ils se veulent un aide-mémoire pour les générations futures. Ce livre constitue de plus un apport aux études épistémologiques consacrées à l'évolution des méthodologies, des courants et des écoles linguistiques au XXe siècle. (shrink)

Cette étude essaie de dégager certaines convergences et différences entre l’approche husserlienne de la conscience de signe dans les Recherches logiques au tournant du siècle (l’édition de 1913 ne modifie pas fondamentalement les descriptions acquises en 1901) et certains courants linguistiques issus de la révolution saussurienne dans l’analyse du langage. Pour l’essentiel nous limiterons nos références d’une part aux travaux que Benveniste, Jakobson, Martinet ont consacré au problème de l’ar...

Thanks to the particularly penetrating analysis of André Martinet, we now know that the complementary existence of two levels of different articulation is one of the most remarkable specific characteristics of language. To the first level belong all facts concerning significant units, the meaning and inflection of words, syntactic groupings and the composition of a discourse; the second articulation is that of non-significant elements that we call phonemes. In other words, it is at the second level that we pronounce (...) articulate sounds, while to the first we owe the possibility of formulating groups with meaning. The first articulation could be visualized as the molecular and cellular level in which the simplest elements, having a very limited autonomy, are organized according to affinities having the force of law; the second articulation would thus represent the atomic level, that of elementary particles identified by their role in groups. (shrink)

The absence of a clear distinction between notions of the individual and the social or general must, in fact, raise particularly strong reservations about any critical method as preoccupied as French structuralism is with comparisons between art and natural language. To be sure, this preoccupation has led to the isolation of many suggestive likenesses and differences between music and language. Among the likenesses, for example, is the assertion that both language and music constitute semiotic media within which the same techniques (...) for verifying competence and correctness of usage can be applied. Lévi-Strauss is insistent that musical as well as linguistic usage must be subject to verification through reference to some sort of "double articulation," or what will more generally be called here "dual structure," that is, through some method whereby, in effect, speakers and listeners can test each other's competence by altering the relationship between a more general and a more particularized level of a system and observing each other's responses.1 Nattiez essentially rejects this method of verifying competence, but he proposes two others which have analogues in the linguistic theory, respectively, of Zellig Harris and of Noam Chomsky ; interestingly these methods, which appear to be more "modern" than Lévi-Strauss', rely far more heavily on faith in fundamentally unexplainable judgments by single individuals, especially by individual "experts." · 1. Lévi-Strauss' somewhat obscure account of double articulation in Raw and Cooked differs from standard accounts such as André Martinet's and John Lyons' in Noam Chomsky , pp. 19-20. Lévi-Strauss appears to include both phonemes and morphemes in the code level, whereas it is more usual to oppose to the phonemic or sound level a level of meaning which is both semantic and morphemic. Rose Rosengard Subotnik is an assistant professor of music at the University of Chicago. She has written on Adorno's criticism of nineteenth-century music and is currently studying the relation between nineteenth-century German music and philosophy. She has contributed "Tonality, Autonomy, and Competence in Post-Classical Music" to Critical Inquiry. (shrink)

Aucune thèse n’a plus contribué à l’écho philosophique des linguistiques structurales, que la célèbre phrase de Saussure : « Dans la langue, il n’y a que des différences, sans terme positif. ». C’est aussi l’une des plus critiquées : le caractère différentiel du signe ne tiendrait-il pas, tout simplement, à ce que le langage est un moyen limité devant communiquer des messages en nombre illimité (cf. Jakobson, Martinet, puis V. Descombes ou Th. Pavel) ? On montre ici que cet (...) évitement de la question ontologique a pourtant un coût théorique : il oblige à adhérer à une conception fonctionnaliste du langage et à une sémantique référentialiste. De plus, contrairement à l’interprétation habituelle, seuls signifiant et signifié séparément sont différentiels ; le signe en totalité, lui, est positif. A travers une relecture de Bergson et Hegel, on montre que la notion de différence qualitative pure est philosophiquement intenable, et on s’efforce de reconstituer la théorie de la valeur à travers la distinction entre différence et opposition. Il en ressort une conception différente de l’idée selon laquelle ce qui caractérise l’espèce humaine, c’est sa capacité symbolique. (shrink)