Fifty-seven years ago. Hiroshima and Nagasaki were annihilated by unprecedented state terrorism. But survivors of both cities never said "Remember Hiroshima and Nagasaki!" No survivors harbored the feeling "once recovered from devastation of the holy land, Japan will not fail to revenge". Instead, they realized in the atomic inferno that violence begets violence and pledged: "Rest in peace. We will never repeat the mistakes. No more Hiroshima, No more Nagasaki".

Pyridoxal 5′‐phosphate, the vitamin B6 derivative, acts as the coenzyme of many enzymes involved in amino acid metabolism. Exceptionally, this compound was found covalently bound to glycogen phosphorylase, the key enzyme in the regulation of glycogen metabolism. Although it is essential for the function of phosphorylase, its direct role has remained an enigma. We have recently found that the glucose moiety of pyridoxal (5′)diphospho (1)‐α‐D‐glucose, a conjugate of pyridoxal 5′‐phosphate and glucose 1‐phosphate through a pyrophosphate linkage, is transferred to the (...) nonreducing end of glycogen, forming a new α‐1,4‐glucosidic linkage. This finding emphasizes the importance of the direct phosphate‐phosphate interaction between the coenzyme and the substrate in the phosphorylase catalytic reaction. We have proposed a catalytic mechanism for phosphorylase in which the phosphate group of pyridoxal 5′‐phosphate acts as an electrophile to the phosphate group of glucose 1‐phosphate. This appears to represent the first instance of the direct involvement of a phosphate group in catalysis by enzymes. (shrink)

The main goal of the present research is to examine socio-ecological hypothesis on apology and compensation. Specifically, we conducted four studies to test the idea that an apology is an effective means to induce reconciliation in a residentially stable community, whereas compensation is an effective means in a residentially mobile community. In Studies 1, 2a and 2b, American and Japanese participants (national difference in mobility; Study 1) or non-movers and movers (within-nation difference in mobility; Studies 2a and 2b) imagined the (...) situations in which they were hurt by their friends and rated to what extent they would be willing to maintain their friendships upon receipt of apology or compensation. The results showed that compensation was more effective in appeasing residentially mobile people (i.e., Americans and movers) than stable people (i.e., Japanese and non-movers), while apology was slightly more effective appeasing residentially stable people than residentially mobile people (significant in Study 1; not significant in Studies 2a and 2b). In Study 3, by conducting an economics game experiment, we directly tested the hypothesis that mobility would impair the effectiveness of apology and enhance the effectiveness of compensation. The results again partially supported our hypothesis: In the high mobility condition compensation increased one’s willingness to continue the relationship with the offender, when compared to willingness in the low mobility condition. The importance of socio-ecological perspective on the forgiveness literature is discussed. (shrink)

A recent paper by Watabe et al.(1) describes the identification, in the promoter region of the organizer‐specific gene goosecoid, of two distinct growth factor responsive elements that are required for the regulation of this gene both in vitro and in vivo. This is an important finding since it provides molecular evidence in support of the recently proposed model in which the production of dorsal type mesoderm is thought to require a synergistic interaction between a general mesoderm inducing factor and (...) a dorsalizing competence modifier(2,6–8). Furthermore, the authors provide an elegant example of how a response element can become a useful tool to map the presence of a biologically available ligand within the embryo. (shrink)

This book is an excellent book on business ethics and will be an invaluable resource for all readers who are keen to learn about the business ethics and key characteristics of a successful company. It focuses on the case study of a global company, Johnson & Johnson (J&J), which oversees more than 250 operating units throughout the world. Through extensive interviews with top executives at J&J's headquarters, including Masami Atarashi and Mitsuo Hirose and attending workshops, Prof Hiroo Takahashi acquired (...) an in-depth understanding of the management style of J&J, grasped the company's ethics and the code of business conduct which is shared by J&J's members throughout the world. (shrink)