The transition of gene switch induced by external noises and external signals is investigated in the genetic regulatory system. Results show that the state-to-state transition of gene switch as well as resonant behaviors, such as the explicit coherence resonance, implicit coherence resonance and control parameter coherence biresonance, can appear when noises are injected into the genetic regulatory system. The ECR is increased with the increase of the control parameter value when starting from the supercritical Hopf bifurcation parameter point, and there (...) exists a critical control parameter value for the occurrence of ECR. However, the ICR is decreased as the control parameter value is increased when starting from the subcritical Hopf bifurcation point. In particular, the coherence of ECR is higher and more sensitive to noise than that of ICR. When an external signal is introduced into the system, the enhancement or suppression of the CPCBR and the number of peaks strongly depend on the frequency and amplitude of the external signal. Furthermore, the gene regulation system can selectively enhance or decrease the noise-induced oscillation signals at preferred frequency and amplitude of an external signal. (shrink)

Research Ethics, Volume 18, Issue 1, Page 39-50, January 2022. Internet users’ comments in online spaces have attracted researchers’ attention in recent years. Although this data is typically publicly available, its use requires careful consideration so as to not cause harm to the users, while complying with the terms and conditions of the online spaces. However, the Ts & Cs and researchers’ ethical considerations may sometimes be in conflict. I faced such a conflict when I conducted discourse analysis of online (...) discussions that were sourced from a public online learning platform owned by a private company. In this article, I reflect on how I navigated the Ts & Cs and copyright law, taking users’ likely expectations into consideration when deciding whether to seek informed consent and anonymize content. I employed an ‘attribution with anonymization’ method to acknowledge users for their comments while safeguarding their confidentiality. Given the variety of online spaces and research methods, ethical decision-making must be a contextualized process that requires researchers to consider the nature of the online platform and the potential experience of the users, rather than simply following guidelines or Ts & Cs. (shrink)

Electroencephalogram has been widely utilized in emotion recognition. Psychologists have found that emotions can be divided into conscious emotion and unconscious emotion. In this article, we explore to classify subliminal emotions with EEG signals elicited by subliminal face stimulation, that is to select appropriate features to classify subliminal emotions. First, multi-scale sample entropy, wavelet packet energy, and wavelet packet entropy of EEG signals are extracted. Then, these features are fed into the decision tree and improved random forest, respectively. The classification (...) accuracy with Ei and WpEn is higher than MSpEn, which shows that Ei and WpEn can be used as effective features to classify subliminal emotions. We compared the classification results of different features combined with the decision tree algorithm and the improved random forest algorithm. The experimental results indicate that the improved random forest algorithm attains the best classification accuracy for subliminal emotions. Finally, subliminal emotions and physiological proof of subliminal affective priming effect are discussed. (shrink)

Male sexual arousal (SA) has been known as a multidimensional experience involving closely interrelated and coordinated neurobehavioral components that rely on widespread brain regions. Recent functional neuroimaging studies have shown relation between abnormal/altered dynamics in these circuits and male sexual dysfunction. However, alterations in the topological1 organization of structural brain networks in male sexual dysfunction are still unclear. Here, we used graph theory2 to investigate the topological properties of large-scale structural brain networks, which were constructed using inter-regional correlations of cortical (...) thickness between 78 cortical regions (subcortical regions were not included due to the used cortical surface model) in 40 patients with psychogenic erectile dysfunction (pED) and 39 normal controls. Compared with normal controls, pED patients exhibited a less optimal global topological organization with reduced global and increased local efficiencies. Our results suggest disrupted neural integration among distant brain regions in pED patients, consistent with previous reports of impaired white matter structure and abnormal functional integrity in pED. Additionally, disrupted global network topology in pED was observed to be primarily relevant to altered subnetwork and nodal properties within the networks mediating the cognitive, motivational and inhibitory processes of male SA, possibly indicating disrupted integration of these networks in the whole brain networks and might account for pED patients’ abnormal cognitive, motivational and inhibitory processes for male SA. In total, our findings provide evidence for disrupted integrity in large-scale brain networks underlying the neurobehavioral processes of male SA in pED and provide new insights into the understanding of the pathophysiological mechanisms of pED. (shrink)

Cooperative spreading dynamics on complex networks is a hot topic in the field of network science. In this paper, we propose a strategy to immunize some nodes based on their degrees. The immunized nodes disable the synergistic effect of cooperative spreading dynamics. We also develop a generalized percolation theory to study the final state of the spreading dynamics. By using the Monte Carlo method, numerical simulations reveal that immunizing nodes with a large degree cannot always be beneficial for containing cooperative (...) spreading. For small values of transmission probability, immunizing hubs can suppress the spreading, while the opposite situation happens for large values of transmission probability. Furthermore, numerical simulations show that immunizing hubs increase the cost of the system. Finally, all numerical simulations can be well predicted by the generalized percolation theory. (shrink)

Scientific authorship serves to identify and acknowledge individuals who “contribute significantly” to published research. However, specific authorship norms and practices often differ within and across disciplines, labs, and cultures. As a consequence, authorship disagreements are commonplace in team research. This study aims to better understand the prevalence of authorship disagreements, those factors that may lead to disagreements, as well as the extent and nature of resulting misbehavior. Methods include an international online survey of researchers who had published from 2011 to (...) 2015. Of the 6673 who completed the main questions pertaining to authorship disagreement and misbehavior, nearly half reported disagreements regarding authorship naming; and discipline, rank, and gender had significant effects on disagreement rates. Paradoxically, researchers in multidisciplinary teams that typically reflect a range of norms and values, were less likely to have faced disagreements regarding authorship. Respondents reported having witnessed a wide range of misbehavior including: instances of hostility, undermining of a colleague’s work during meetings/talks, cutting corners on research, sabotaging a colleague’s research, or producing fraudulent work to be more competitive. These findings suggest that authorship disputes may contribute to an unhealthy competitive dynamic that can undermine researchers’ wellbeing, team cohesion, and scientific integrity. (shrink)

Background Supporting physicians in Intensive Care Units s as they face dying patients at unprecedented levels due to the COVID-19 pandemic is critical. Amidst a dearth of such data and guided by evidence that nurses in ICUs experience personal, professional and existential issues in similar conditions, a systematic scoping review is proposed to evaluate prevailing accounts of physicians facing dying patients in ICUs through the lens of Personhood. Such data would enhance understanding and guide the provision of better support for (...) ICU physicians. Methods An SSR adopts the Systematic Evidenced Based Approach to map prevailing accounts of caring for dying patients in ICUs. To enhance the transparency and reproducibility of this process, concurrent and independent use of tabulated summaries, thematic analysis and directed content analysis is adopted. Results Eight thousand three hundred fifty-eight abstracts were reviewed from four databases, 474 full-text articles were evaluated, 58 articles were included, and the Split Approach revealed six categories/themes centered around the Innate, Individual, Relational and Societal Rings of Personhood, conflicts in providing end of life care and coping mechanisms employed. Conclusion This SSR suggests that caring for dying patients in ICU impacts how physicians view their personhood. To resolve conflicts within individual concepts of personhood, physicians use prioritization, reframing and rely on accessible, personalized support from colleagues to steer coping strategies. An adapted form of the Ring Theory of Personhood is proposed to direct timely personalized, appropriate and holistic support. (shrink)

Authorship is commonly used as the basis for the measurement of research productivity. It influences career progression and rewards, making it a valued commodity in a competitive scientific environment. To better understand authorship practices amongst collaborative teams, this study surveyed authors on collaborative journal articles published between 2011 and 2015. Of the 8364 respondents, 1408 responded to the final open-ended question, which solicited additional comments or remarks regarding the fair distribution of authorship in research teams. This paper presents the analysis (...) of these comments, categorized into four main themes: (1) disagreements, (2) questionable behavior, (3) external influences regarding authorship, and (4) values promoted by researchers. Results suggest that some respondents find ways to effectively manage disagreements in a collegial fashion. Conversely, others explain how distribution of authorship can become a “blood sport” or a “horror story” which can negatively affect researchers’ wellbeing, scientific productivity and integrity. Researchers fear authorship discussions and often try to avoid openly discussing the situation which can strain team interactions. Unethical conduct is more likely to result from deceit, favoritism, and questionable mentorship and may become more egregious when there is constant bullying and discrimination. Although values of collegiality, transparency and fairness were promoted by researchers, rank and need for success often overpowered ethical decision-making. This research provides new insight into contextual specificities related to fair authorship distribution that can be instrumental in developing applicable training tools to identify, prevent, and mitigate authorship disagreement. (shrink)

本书内容包括:绪论、证明对象、举证责任、审理集中化与证据适时提出主义、证据调查、质证、认定证据等。.

本书探索了民事证据的有关问题。全书介绍了证据适格及证据排除原理、证据裁判主义原理、证据方法原理、证明责任原理、证据规则原理、司法认知原理及民事自认原理等内容。.

PurposeTo investigate spontaneous brain activity in patients with dry eye and healthy control using the fractional amplitude of low frequency fluctuation technique with the aim of elucidating the relationship between the clinical symptoms of DE and changes in brain function.Material and MethodsA total of 28 patients with DE and 28 matched healthy volunteers were enrolled. Resting-state functional magnetic resonance imaging scans were performed in both groups. Then all subjects were required to complete a comprehensive Hospital Anxiety and Depression Scale. Receiver (...) operating characteristic curve analysis was used to evaluate the differences in fALFF values between the two groups and their diagnostic value. Linear correlations between HADS and fALFF values in different brain regions of DE patients were analyzed using the Pearson correlation coefficient.ResultsPatients with DE had significantly higher fALFF values in the left calcarine sulcus than the HC group, while fALFF values in the bilateral middle frontal gyrus and right MFG/right inferior frontal gyrus were significantly lower in DE patients than in HC group. fALFF values had a high diagnostic value for differentiating patients with DE from the HC group. Right MFG and right MFG/IFG were significantly correlated with HADS values.ConclusionOur study found that DE mainly involved functional disorders in the brain areas of the left CS, bilateral MFG and right MFG/right IFG, which helped us to find possible clinical features of DE disease and reflected the potential pathological mechanism of DE. (shrink)

In the real world, individual resources are crucial for patients when epidemics outbreak. Thus, the coupled dynamics of resource diffusion and epidemic spreading have been widely investigated when the recovery of diseases significantly depends on the resources from neighbors in static social networks. However, the social relationships of individuals are time-varying, which affects such coupled dynamics. For that, we propose a coupled resource-epidemic dynamic model on a time-varying multiplex network to synchronously simulate the resource diffusion and epidemic spreading in dynamic (...) social networks. The equilibrium analysis of the coupled model is conducted in a general scenario where the resource generation varies between susceptible and infected states and the recovery rate changes between resourceful and noresource states. By using the microscopic Markov chain approach and Monte Carlo simulations, we determine a probabilistic framework of the intralayer and interlayer dynamic processes of the coupled model and obtain the outbreak threshold of epidemic spreading. Meanwhile, the experimental results show the trivially asymmetric interactions between resource diffusion and epidemic spreading. They also indicate that the stronger activity heterogeneity and the larger contact capacity of individuals in the resource layer can more greatly promote resource diffusion, effectively suppressing epidemic spreading. However, these two individual characters in the epidemic layer can cause more resource depletion, which greatly promotes epidemic spreading. Furthermore, we also find that the contact capacity finitely impacts the coupled dynamics of resource diffusion and epidemic spreading. (shrink)

本书立足《新唯识论》在近现代中国哲学发展历程中的曲折际遇，深入剖析了熊十力在本体论、心性论、方法论、修养论等层面所进行的儒佛会通的理论建构尝试，特别阐发他以唯识学反思儒家传统的思想特色、致思路向及其对 现代新儒家的影响，从而彰显《新唯识论》独特的学术价值和思想意义。.

本书侧重从中国古代政治史、思想史、文化史和文学史的结合方面,研究和探讨了中国古代德治思想与文士文学的关系。.

本书共分七章,通过对证据评判规则及其内在机理的研究,系统地阐述了民事证据的采信制度。.

Xiao Han Dynasty to rule the world. "Filial piety" in today's perspective the main areas of family ethics, but more are in the Han dynasty the country's political and legal issues. Special emphasis on filial piety Han has a special reason, that "five De Zhong Shi," the impact theory. Lack of filial piety in the Han Dynasty is considered a very serious crime, the punishment for the lack of filial piety of the people are very severe, Zhangjiashan simple "two precepts" (...) provides penalties for lack of filial piety that the original law. As a governing rule in Han Dynasty, filial piety plays a more significant part in the state's political and legal issues in the time than today when it mainly belongs to the family and moral categories. The special attention paid to filial piety then has its special reason , ie, the influence from the five elements circulation theory. For exploring how unfilial deeds to be seen as severe criminal behaviors and how unfilial persons were punished in Han Dynasty, The Second Year Law, the Han bamboo slips unearthed at Zhangjiashan provide the original legal texts. (shrink)