International documents on ethical conduct in clinical research have in common the principle that potential harms to research participants must be proportional to anticipated benefits. The anticipated benefits that can justify human research consist of direct benefits to the research participant, and societal benefits, also called social value. In first-in-human research, no direct benefits are expected and the benefit component of the risks-benefit assessment thus merely exists in social value. The concept social value is ambiguous by nature and is used (...) in numerous ways in the research ethics literature. Because social value justifies involving human participants, especially in early human trials, this is problematic. (shrink)

The innovative field of Regenerative Medicine (RM) is expected to extend the possibilities of prevention or early treatment in healthcare. Increasingly, clinical trials will be developed for people at risk of disease to investigate these RM interventions. These individuals at risk are characterised by their susceptibility for developing clinically manifest disease in future due to the existence of degenerative abnormalities. So far, there has been little debate about the ethical appropriateness of including such individuals at risk in clinical trials. We (...) discuss three main challenges of selecting this participant model for testing RM interventions: the challenge of achieving a proportional risk–benefit balance; complexities in the trial design in terms of follow-up and sample size; and the difficulty of obtaining informed consent due to the many uncertainties. We conclude that selecting the model is not ethically justifiable for first-in-man trials with RM interventions due to the high risks and uncertainties. However, the model can be ethically appropriate for testing the efficacy of RM interventions under the following conditions: interventions should be low risk; the degenerative abnormalities (and other risk factors) should be strongly related with disease within a short time frame; robust preclinical evidence of efficacy needs to be present; and the informed consent procedure should contain extra safeguards with regard to communication on uncertainties. (shrink)

In this paper, I reconsider the commonly held position that the early moral education of the Republic is arational since the youths of the Kallipolis do not yet have the capacity for reason. I argue that, because they receive an extensive mathematical education alongside their moral education, the youths not only have a capacity for reason but that capacity is being developed in their early education. If this is so, though, then we must rethink why the early moral education is (...) arational. I argue that the reason is rooted in the nature of moral explanations. These sorts of explanations are rooted in the Forms and thus one can only understand those explanations when they have knowledge of the Forms. But this requires preparation – the very sort of preparation that is provided by both the mathematical and moral educations. (shrink)

What is given to us in conscious experience? The Given is an attempt to answer this question and in this way contribute to a general theory of mental content. The content of conscious experience is understood to be absolutely everything that is given to one, experientially, in the having of an experience. Michelle Montague focuses on the analysis of conscious perception, conscious emotion, and conscious thought, and deploys three fundamental notions in addition to the fundamental notion of content: the (...) notions of intentionality, phenomenology, and consciousness. She argues that all experience essentially involves all four things, and that the key to an adequate general theory of what is given in experience lies in giving a correct specification of the nature of these four things and the relations between them. (shrink)

My concern in this paper is with the intentionality of emotions. Desires and cognitions are the traditional paradigm cases of intentional attitudes, and one very direct approach to the question of the intentionality of emotions is to treat it as sui generis—as on a par with the intentionality of desires and cognitions but in no way reducible to it. A more common approach seeks to reduce the intentionality of emotions to the intentionality of familiar intentional attitudes like desires and cognitions. (...) In this paper, I argue for the sui generis approach. (shrink)

Attachment theory, postulated by John Bowlby in collaboration with psychologists Mary Ainsworth and Harry Harlow, has been the subject of much discussion about its nature. The author considers it a psychoanalytical theory, but his peers in psychoanalysis at the time rejected this idea and offered criticism of his concepts, suggesting that they were not in alignment with the principles of psychoanalysis. At the same time, collaborators Mary Ainsworth and Harry Harlow have repeatedly questioned the necessity of Bowlby’s choice of psychoanalysis (...) as a basis for attachment theory, suggesting that it may not be the most appropriate approach. Lately, attachment theory has been used in many psychology courses and articles, without so much as a single mention to its psychoanalytical nature. This article presents a research proposal for an investigation of the nature of attachment theory on a conceptual level. It poses the question of whether the concepts used as a basis for attachment theory are consistent with psychoanalysis. (shrink)

The dissertation traces the approach to the problem of free will---in particular, the question of whether moral evil can be freely chosen---from Kant through Schelling to Kierkegaard. The goal is to clarify the historical transition from German idealism to the first version of existential philosophy, by showing the philosophical concerns of the latter to be implicit in unresolved problems in the former. I begin by examining Kant's attempt to reconcile what is essentially an incompatibilist notion of free will with the (...) claims of theoretical objectivity, and show that the only argument for the reality of human freedom this reconciliation allows him to give is one that connects freedom altogether too strongly with practical reason, threatening to render moral evil not simply irrational, but actually impossible. I then trace the development of Schelling's account of freedom, showing that the transformation in his view marked by the Freedom Essay of 1809 is motivated primarily by the goal of overcoming this difficulty in Kant's account. In his later work, I argue, Schelling's aim is to articulate a theory of knowledge consistent with this account of freedom. I then interpret Kierkegaard's critique of what he calls the "esthetic" and the "immanent ethical" standpoints and his account of the meta-ethical status of Christianity in light of this development. I argue that the standard interpretations of these aspects of Kierkegaard's position are mistaken, and that Kierkegaard's philosophical debt to Schelling has been seriously underestimated. His account of human agency as it is presented in The Concept of Anxiety and The Sickness unto Death is founded upon the account presented by Schelling in the Freedom Essay, and his critique of idealist epistemology is based upon the position laid out in Schelling's late work. Finally, I contrast Schelling's and Kierkegaard's positive accounts of theoretical and moral objectivity, and point to some difficulties in Kierkegaard's view. (shrink)

My research explores Maya perspectives on neo-traditional farming as a source of metabolic health and resilience to the global epidemic of type-two diabetes. This article is based on long-term ethnographic research and interviews in Maya Mountains Reservation communities in southern Belize, an area with low diabetes prevalence relative to national and global populations. Research participants see lower rates of diabetes in the MMR as the result of neo-traditional peasant and subsistence farming on ancestral lands. Good metabolic health represents the embodiment (...) of food systems that routinize healthy material and social relationships to the landscape. This research suggests that diabetes is endemic to modern food systems and proposes neo-traditional food ways as a societal antidote to nutritional disease. My research demonstrates and responds to a need for further disaggregated data on diabetes prevalence in Indigenous communities, contributes to the social scientific literature on the importance of small-scale agricultural models for community health, and provides a case study of success in diabetes prevention. I engage Maya perspectives with anthropological literature on embodiment and small-scale agriculture to suggest neo-traditional food ways as healthier alternatives to capitalist agricultural development. (shrink)

Argues that the War on Drugs and policies that deny convicted felons equal access to employment, housing, education and public benefits create a permanent under-caste based largely on race. Reprint. 12,500 first printing.

This article presents an overview for clinician investigators on the concepts of decision-making capacity and vulnerability as related to human subjects research. Tools for capacity assessment and unacknowledged sources of vulnerability are discussed, and the practical gaps in current informed consent requirements related to impaired capacity and potential vulnerability are described. Options are suggested for research discussions when full regulatory consent is not possible and an exception from informed consent does not apply.

The human species is more reliant on cultural adaptation than any other species, but it is unclear how observational learning can give rise to the faithful transmission of cultural adaptations. One possibility is that teaching facilitates accurate social transmission by narrowing the range of inferences that learners make. However, there is wide disagreement about how to define teaching, and how to interpret the empirical evidence for teaching across cultures and species. In this article I argue that disputes about the nature (...) and prevalence of teaching across human societies and nonhuman animals are based on a number of deep-rooted theoretical differences between fields, as well as on important differences in how teaching is defined. To reconcile these disparate bodies of research, I review the three major approaches to the study of teaching – mentalistic, culture-based, and functionalist – and outline the research questions about teaching that each addresses. I then argue for a new, integrated framework that differentiates between teaching types according to the specific adaptive problems that each type solves, and apply this framework to restructure current empirical evidence on teaching in humans and nonhuman animals. This integrative framework generates novel insights, with broad implications for the study of the evolution of teaching, including the roles of cognitive constraints and cooperative dilemmas in how and when teaching evolves. Finally, I propose an explanation for why some types of teaching are uniquely human, and discuss new directions for research motivated by this framework. (shrink)

According to some formulations of the thesis of revelation, knowledge about the essences of phenomenal properties is available through introspection. But this claim may seem doubtful given relevant limits of introspection. This paper articulates the worry and sketches responses to address it.

This rich and varied collection of essays addresses some of the most fundamental human questions through the lenses of philosophy, literature, religion, politics, and theology. Peter Augustine Lawler and Dale McConkey have fashioned an interdisciplinary consideration of such perennial and enduring issues as the relationship between nature and history, nature and grace, reason and revelation, classical philosophy and Christianity, modernity and postmodernity, repentance and self-limitation, and philosophy and politics.

Beginning with the view that human consciousness is essentially embodied and that the way we consciously experience the world is structured by our bodily dynamics and surroundings, the book argues that emotions are a fundamental manifestation of our embodiment, and play a crucial role in self-consciousness, moral evaluation, and social cognition.

After decades of neglect, positive emotion is now the focus of a rich, diverse, and rapidly growing field. Basic research has advanced understanding of positive emotions’ neural mechanisms, nonverbal expression, and implications for cognition and motivation, with increasing appreciation of positive emotion differentiation, as well as cultural and contextual moderators of positive emotions’ effects. Much research has also addressed ways positive emotions can be leveraged to improve the human condition, and the mechanisms by which interventions have beneficial effects. As always, (...) new knowledge raises more questions, and we still have a long way to go before the promise of this field can be fully realized. This comment reviews major developments in positive emotion science and offers recommendations for the future. (shrink)

Building on contemporary research in embodied cognition, enactivism, and the extended mind, this book explores how social institutions in contemporary neoliberal nation-states systematically affect our thoughts, feelings, and agency. Human beings are, necessarily, social animals who create and belong to social institutions. But social institutions take on a life of their own, and literally shape the minds of all those who belong to them, for better or worse, usually without their being self-consciously aware of it. Indeed, in contemporary neoliberal societies, (...) it is generally for the worse. In The Mind-Body Politic, Michelle Maiese and Robert Hanna work out a new critique of contemporary social institutions by deploying the special standpoint of the philosophy of mind—in particular, the special standpoint of the philosophy of what they call essentially embodied minds—and make a set of concrete, positive proposals for radically changing both these social institutions and also our essentially embodied lives for the better. (shrink)

Despite contemporary moral philosophers' renewed attention to the moral significance of emotions, the attitudinal repertoire with which they equip the mature moral agent remains stunted. One attitude moral philosophers neglect (if not disown) is contempt. While acknowledging the nastiness of contempt, I here correct the neglect by providing an account of the moral psychology of contempt. In the process, I defend the moral propriety of certain tokens of properly person-focused contempt against some prominent objections -- among them, objections stemming from (...) Kantian worries that contempt is incompatible with the respect we owe to persons as such. (shrink)

Michelle Kosch examines the conceptions of free will and the foundations of ethics in the work of Kant, Schelling, and Kierkegaard. She seeks to understand the history of German idealism better by looking at it through the lens of these issues, and to understand Kierkegaard better by placing his thought in this context. Kosch argues for a new interpretation of Kierkegaard's theory of agency, that Schelling was a major influence and Kant a major target of criticism, and that both (...) the theory and the criticisms are highly relevant to contemporary debates. (shrink)

Philosophical suspicions about the place of shame in the psychology of the mature moral agent are in tension with the commonplace assumption that to call a person shameless purports to mark a fault, arguably a moral fault. I shift philosophical suspicions away from shame and toward its absence in the shameless by focusing attention on phenomena of shamelessness. In redirecting our attention, I clarify the nature of the failing to which ascriptions of shamelessness might refer and defend the thought that, (...) as an evasion of moral self-censure, shamelessness can be morally pernicious. Far from foregoing shame, I conclude, we should be mindful of its moral importance and unapologetic in its defense. (shrink)

Spatial aspects of words are associated with their canonical locations in the real world. Yet little research has tested whether spatial associations denoted in language comprehension generalize to their corresponding images. We directly tested the spatial aspects of mental imagery in picture and word processing (Experiment 1). We also tested whether spatial representations of motion words produce similar perceptual-interference effects as demonstrated by object words (Experiment 2). Findings revealed that words denoting an upward spatial location produced slower responses to targets (...) appearing at the top of the display, whereas words denoting a downward spatial location produced slower responses to targets appearing at the bottom of the display. Perceptual-interference effects did not obtain for pictures or for words lacking a spatial relation. These findings provide greater empirical support for the perceptual-symbols system theory (Barsalou, 1999, 2008). (shrink)

'Propositionalism' is the widely held view that all intentional mental relations-all intentional attitudes-are relations to propositions or something proposition-like. Paradigmatically, to think about the mountain is ipso facto to think that it is F, for some predicate 'F'. It seems, however, many intentional attitudes are not relations to propositions at all: Mary contemplates Jonah, adores New York, misses Athens, mourns her brother. I argue, following Brentano, Husserl, Church and Montague among others, that the way things seem is the way they (...) are, and that propositionalism must be abandoned. (shrink)

The long-standing debate between cognitive and feeling theories of emotion stems, in part, from the assumption that cognition and thought are abstract, intellectual, disembodied processes, and that bodily feelings are non-intentional and have no representational content. Working with this assumption has led many emotions theorists to neglect the way in which emotions are simultaneously bodily and cognitive-evaluative. Even hybrid theories, such as those set forth by Prinz and Barlassina and Newen, fail to account fully for how the cognitive and bodily (...) elements of emotion are integrated. As a result, such accounts are unable to provide an adequate characterization of the intentionality or phenomenology of emotions. I will argue that an enactive account of emotions, one which characterizes them as a way of engaging with and making sense of one’s surroundings, can help us to overcome this false dichotomy between cognitive and body elements. What I call ‘ affective framing’ is at the core of emotional experience. It is the way in which we engage with and appraise our surroundings in and through bodily feelings of caring, so that the bodily and cognitive elements of emotion necessarily are fused. The notion of affective framing not only helps to clarify the relationship between bodily and cognitive elements of emotion, but also offers a useful way to make sense of both the intentional directedness and phenomenal character of emotional experience. (shrink)

Arts and Humanities in Higher Education, Volume 21, Issue 1, Page 3-20, February 2022. As graduate labour market conditions have become increasingly challenging, higher education institutions have intensified their focus on ‘employability’ via strategies such as work placements. Focusing on work placements in the media and creative industries, this article identifies and analyses three key discourses that animate the pedagogical literature in these sectors: work placements as facilitating a ‘smooth transition’ to the labour market; work placements as a place in (...) which inequalities in the labour market are produced; and work placements as a space for fostering resilience and adaptation to labour market precarity. The article argues that critiques of inequalities based on race, class or gender are marked by a transformative impulse that is largely absent in critiques of those based on worker precarity. This highlights a need to adopt pedagogies that similarly unnaturalise the economic conditions of neoliberal capitalism to discursively construct work in new, more socially just, ways. (shrink)

This article stresses the importance of one of Sartre's often overlooked novels, The Age of Reason (1945), and the possibility that it should be considered an early attempt by Sartre to answer the questions he raises at the very end of Being and Nothingness (1943). Considered as a preliminary response to Being and Nothingness , this novel provides an opportunity to explore how ethics might be lived, and draws a clear distinction between a theoretical understanding of being-for-itself and living authentically. (...) As such, it is argued that Sartre's fictional writings, especially The Age of Reason , must be taken seriously in Sartre scholarship. (shrink)

Much human adaptation depends on the gradual accumulation of culturally transmitted knowledge and technology. Recent models of this process predict that large, well-connected populations will have more diverse and complex tool kits than small, isolated populations. While several examples of the loss of technology in small populations are consistent with this prediction, it found no support in two systematic quantitative tests. Both studies were based on data from continental populations in which contact rates were not available, and therefore these studies (...) do not provide a test of the models. Here, we show that in Oceania, around the time of early European contact, islands with small populations had less complicated marine foraging technology. This finding suggests that explanations of existing cultural variation based on optimality models alone are incomplete because demography plays an important role in generating cumulative cultural adaptation. It also indicates that hominin populations with similar cognitive abilities may leave very different archaeological records, a conclusion that has important implications for our understanding of the origin of anatomically modern humans and their evolved psychology. (shrink)

This major study of Kant provides a detailed examination of the development and function of the doctrine of transcendental illusion in his theoretical philosophy. The author shows that a theory of 'illusion' plays a central role in Kant's arguments about metaphysical speculation and scientific theory. Indeed, she argues that we cannot understand Kant unless we take seriously his claim that the mind inevitably acts in accordance with ideas and principles that are 'illusory'. Taking this claim seriously, we can make much (...) better sense of Kant's arguments and reach a deeper understanding of the role he allots human reason in science. (shrink)

This dissertation urges philosophers to reevaluate how they frame the question of the rationality of moral action. Its motivation is the thought that approaches to the question have suffered from mistakes in the relata. On the part of theories of practical reason, philosophers adopt an inadequate theory of action. On the part of moral theory, philosophers hold narrow conceptions of moral worth. As a result, not only have we failed to vindicate the thought that the moral agent acts well, our (...) conception of moral action invites the charge of remoteness from human life. ;In response, I propose we abandon some dogmas of moral psychology. My rethinking proceeds, negatively, by rejecting desire-based instrumentalist accounts of practical rationality and, positively, from renewed attention to virtuous action, a focus some suggest might counteract the remoteness of which morality's critics complain. I attend to the virtue of true friendship to defend non-instrumental conceptions of moral psychology and practical rationality that bring both into closer contact with commonsense norms of admirable action as they bear on what agents have reason to do. ;Chapter 1 introduces desire-based instrumentalism as the theory proponents claim is best suited to avoid the problem of the alienation of practical reason. I argue their claim does not survive scrutiny. ;In Chapter 2 I distinguish between explicit desiderative content and desiderative framing versions of desire-based instrumentalism. I argue the former is false to the content of deliberation and that arguments from the nature of intentional action fail to support the latter. ;Chapter 3 examines the evaluatively non-detachable quality of the descriptions under which actions performed out of friendship are intentional. I develop an account of virtuous action as nonteleologically ally motivated action understood in terms not of what it brings about but of its expressive quality. I argue action's expressive quality is key to assessing moral worth and rationality. ;Chapter 4 develops my account of virtuous agents' reasons for acting and asks what earns expressive action its claim to rationality. I argue certain actions inherit their rationality by expressing dispositions to regulate practical attitudes , dispositions themselves rationally assessable. (shrink)

We typically think of resentment as an unjustifiable and volatile emotion, responsible for fostering the worst political divisions. Recognizing Resentment argues instead that sympathy with the resentment of victims of injustice is vital for upholding justice in liberal societies, as it entails recognition of the equal moral and political status of those with whom we sympathize. Sympathizing with the resentment of others makes us alive to injustice in a way no rational recognition of wrongs alone can, and it motivates us (...) to demand justice on others' behalves. This book rehabilitates arguments for the moral and political worth of resentment developed by three influential thinkers in the early liberal tradition - Joseph Butler, David Hume, and Adam Smith - and uses these to advance a theory of spectatorial resentment, discussing why we should be indignant about the injustice others face, and how such a shared sentiment can actually bring liberal citizens closer together. (shrink)

Results from a crowdsourced audio questionnaire show that inflected infinitives in Galician are still acceptable in a broad range of contexts, different from those described for European Portuguese. Crucially, inflected infinitives with referential subjects are widely accepted only inside strong islands in Galician (complements of nouns, adjunct clauses). They are widely rejected in non-islands, notably in the complements of epistemic/factive verbs, in contrast with Portuguese and older varieties of Galician (Gondar 1978, Raposo 1987). Statistical analysis shows, however, that, in the (...) complements of epistemic/factive (and desiderative) verbs, inflected infinitives are significantly more acceptable in instances of control, whether partial or exhaustive. In fact, there is no significant difference between these two types of control in Galician, unlike in Portuguese, where inflection is generally better in instances of partial control and is not acceptable in instances of exhaustive local subject control (Modesto 2010, Sheehan 2018). We propose an analysis of this pattern in terms of phase theory. The inflectional domain of non-finite clauses remains visible to the thematic domain of the next clause up, according to the less strict version of the Phase Impenetrability Condition (Chomsky 2001), allowing control to take place. Pronouns/or pronominal inflections in the inflectional domain of visible non-finite clauses therefore get controlled. In islands, however, material in the inflectional domain remains free/referential. Despite this basic pattern, the data are characterized by substantial interspeaker variation. Statistical analysis shows that gender, urban/rural birthplace and mother tongue are all significant factors in this variation, while age and region of birth are not. Most notably, urban-born male bilinguals with Spanish as their mother tongue consistently rate the sentences higher on the Likert scale. Overall, the results show that crowdsourcing can lead to empirically robust syntactic descriptions of minority languages which are likely to be subject to substantial sociolinguistic variation and where judgements from a single social group may be misrepresentative of the general picture. The study also highlights, however, the challenges associated with using crowd-sourced audio-questionnaires of this kind in languages of this kind and the need for statistical analysis of results to control for substantial amounts of variation. (shrink)

This paper is inspired by Philip Cam’s book Twenty Thinking Tools. Cam recommends classroom dialogue as the primary means for students to achieve conscious, strategic, and eventually habitual command of the intellectual moves needed for building and evaluating arguments. Classroom dialogue has indeed been found to be effective for developing students’ higher-order thinking skills, but only when students are engaged in dialogic argument. This paper addresses the dual concerns that dialogue is not widespread in classrooms, and that even where it (...) is practised, it rarely involves argument. To address these concerns, an enhancement to teacher professional learning programs is proposed: the use of authentic examples, i.e. examples drawn from students’ real-life dialogic argument. Reflecting on numerous examples of this kind is likely to boost teachers’ confidence and competence as facilitators, with the consequent benefits of broadening the use of dialogue in classrooms and enhancing the rigour of students’ dialogic argument. Authentic examples of dialogic argument are surprisingly scarce in the relevant published literature. This paper provides several such examples, together with suggestions for how they may be constructively embedded in professional learning programs. (shrink)

Cet article propose la critique d’un concept relativement nouveau en jeu dans la détention et l’exclusion des migrants « irréguliers », à savoir que l’État-nation a une « capacité d’accueil » limitée et objective quant à l’accueil des étrangers – une capacité qui, lorsqu’elle est dépassée, justifie une défense militarisée. Distincte des rationalités gouvernementales plus explicitement racistes qui ont sous-tendu les premiers quotas d’immigration aux États-Unis, la notion de « capacité d’accueil » nationale a une logique propre dans laquelle écologie (...) et économie sont rendues fatalement inextricables. L’expression « charge maximale » d’un territoire donné s’est développée dans le contexte de l’environnementalisme américain comme moyen de régulation des populations de gibier non humain et s’est ensuite transformée en un langage pour évaluer le potentiel des marchés émergents. La théorie de Freud sur les blessures psychiques commence par postuler par contre une « capacité de réception » infinie [Aufnahmefähigkeit] propre au système perceptif humain – une capacité illimitée à accueillir ce qui est extérieur, qui est à la fois la condition d’origine de la vie incarnée et ce qui doit être géré et régulé pour survivre. Les spéculations de Freud dans Au-delà du principe de plaisir aident à dissoudre une conception mythopoétique de la Vie qui est depuis devenue centrale dans l’imaginaire racial anti-immigrant. (shrink)

Prenatal genetic testing is becoming available for an increasingly broad set of diseases, and it is only a matter of time before parents can choose to test for hundreds, if not thousands, of genetic conditions in their fetuses. Should access to certain kinds of fetal genetic information be limited, and if so, on what basis? We evaluate a range of considerations including reproductive autonomy, parental rights, disability rights, and the rights and interests of the fetus as a potential future child. (...) We conclude that parents should be able to access information that could be useful during pregnancy, but that testing for non-medical information should be limited. Next, we argue that the government lacks a compelling state interest in regulating prenatal genetic testing and propose that regulation should occur through medical professional organizations. Finally, we present a framework for determining what testing physicians should recommend, offer neutrally, or not offer at all. (shrink)

Mun’s proposed taxonomy of theories of emotions highlights important commonalities and differences among a wide range of philosophical and psychological accounts and provides an astute mapping of the theoretical landscape. My critical comments focus primarily on the metaphysical account of the mind-body relation that Mun presents, and the implications of this “semantic dualist” account for three of the book’s central topics: (1) conscious experience, (2) underived intentionality, and (3) what it means to provide an embodied cognitive theory of emotions.