BackgroundResponsive neurostimulation has been utilized as a treatment for intractable epilepsy. The RNS System delivers stimulation in response to detected abnormal activity, via leads covering the seizure foci, in response to detections of predefined epileptiform activity with the goal of decreasing seizure frequency and severity. While thalamic leads are often implanted in combination with cortical strip leads, implantation and stimulation with bilateral thalamic leads alone is less common, and the ability to detect electrographic seizures using RNS System thalamic leads is (...) uncertain.ObjectiveThe present study retrospectively evaluated fourteen patients with RNS System depth leads implanted in the thalamus, with or without concomitant implantation of cortical strip leads, to determine the ability to detect electrographic seizures in the thalamus. Detailed patient presentations and lead trajectories were reviewed alongside electroencephalographic analyses.ResultsAnterior nucleus thalamic leads, whether bilateral or unilateral and combined with a cortical strip lead, successfully detected and terminated epileptiform activity, as demonstrated by Cases 2 and 3. Similarly, bilateral centromedian thalamic leads or a combination of one centromedian thalamic alongside a cortical strip lead also demonstrated the ability to detect electrographic seizures as seen in Cases 6 and 9. Bilateral pulvinar leads likewise produced reliable seizure detection in Patient 14. Detections of electrographic seizures in thalamic nuclei did not appear to be affected by whether the patient was pediatric or adult at the time of RNS System implantation. Sole thalamic leads paralleled the combination of thalamic and cortical strip leads in terms of preventing the propagation of electrographic seizures.ConclusionThalamic nuclei present a promising target for detection and stimulation via the RNS System for seizures with multifocal or generalized onsets. These areas provide a modifiable, reversible therapeutic option for patients who are not candidates for surgical resection or ablation. (shrink)

In this companion volume to the national public television documentary of the same name, interviews of philosophy luminaries expose the relevance of philosophy to everyday life.

Tobias examines the ancient cultures of the Mediterranean, the ascetics of Sinai and Tibet, and the Pure Land Buddhists. He introduces the reader to the Jains of India, whose lifestyle is one of the most ecologically balanced in all of human history. In profiling various artists of 19th-century Europe and America, Tobias discovers incisive continuities among such luminaries as British poet Percy Bysshe Shelley, Austrian impressionist Emilie Mediz-Pelikan, and American intimist painters Ralph Blakelock and George Inness.

This elegant treatise examines the nature of kindness through the fascinating lenses and contexts of ancient, medieval and contemporary philosophy, natural history, theories of mind, of natural selection, eco-psychology and sociobiology. It challenges the reader to consider the myriad potential consequences of human behavior, examining various iconographic moments from the history of art and science as a precursor to the concept and vital potentials for ecological conversion. Focusing on the fundamental mechanisms of reciprocity among humans, other species, communities and nations, (...) Tobias and Morrison lead readers on a remarkable journey whose itinerary, and the provocative questions explored, seek to affirm a pattern in evolution and in human thought that is emphatically oriented towards benevolence, not tyranny. Prosociality in all species - making others happy, kind gestures at any and every juncture of life - has, as a discipline of enquiry, enjoyed a social scientific renaissance during the last decade. Can natural selection move rapidly enough to meet that ultimate challenge? Can our species re-evolve in real time, moving from the ideas, to the ideals, to their applied engineering in a real world that is ecologically hemorrhaging? Which all the critical moral and cognitive changes in social communion such new human nature, as the Authors suggest, clearly requires? This groundbreaking work of ecological philosophy, with its roots in ancient Greek thought, represents a radical break with nearly every traditional scientific paradigm, in exploring the intuitive geography and dramatic questions of ourselves - each and every one of us - that will prove crucial to the survival of our species, and all those we co-habit this miraculous planet with. (shrink)

This book is a provocative and invigorating real-time exploration of the future of human evolution by two of the world’s leading interdisciplinary ecologists – Michael Charles Tobias and Jane Gray Morrison. Steeped in a rich multitude of the sciences and humanities, the book enshrines an elegant narrative that is highly empathetic, personal, scientifically wide-ranging and original. It focuses on the geo-positioning of the human Self and its corresponding species. The book's overarching viewpoints and poignant through-story examine and powerfully challenge concepts (...) associated historically with assertions of human superiority over all other life forms. Ultimately, The Hypothetical Species: Variables of Human Evolution is a deeply considered treatise on the ecological and psychological state of humanity and her options – both within, and outside the rubrics of evolutionary research – for survival. This important work is beautifully presented with nearly 200 diverse illustrations, and is introduced with a foreword by famed paleobiologist, Dr. Melanie DeVore. (shrink)

Photographs and essays by leading authorities in the field provide diverse perspectives on the aesthetics of mountains and mountain climbing.

This staggering work of erudition and passion -Terminal Philosophy Syndrome: Ecology and the Imponderable - points the finger to the human as catalyst for countless ways of self-destruction and devastation of innumerable forms of non-humans. What can be done? How can we even recognize our complicity in so many tragedies, from the Holocaust and the many events before and since including the invasion of Ukraine and the ongoing slaughter of billions of animals each year to slake unquenched human hunger? Tobias (...) and Morrison call for a mind shift, a radical move from passivity to bold changes in thinking and lifestyle. By itemizing the scope and scale of our current global emergency in the context of a long and brutal history, this book serves as a powerful incentive to stand up and be counted, and to commit oneself personally to be part of the needed solutions. Tobias and Morrison's encounter with Putin underlines the fragility and limits and urgency of human agency. The question remains: will the examples of Jain austere living and Bhutan's good government be enough to provide a roadmap into an uncertain future? (shrink)

This collection of vivid and eloquent testimonies by environmentalists, eco-theologians, and native peoples illustrates a variety of responses to the same universal question: Where are we as a species heading on this planet? Contributors include Rick Bass, Wendell Berry, Annie Dillard. Gretel Ehrlich, Barry Lopez, Peter Mattheisen, Thomas Moore, Terry Tempest Williams, and others.

How can the one influence the many? From posing seminal questions about what comprises a human individual, to asking whether human evolution is alive and well, favoring individuals or the species, this work is a daring, up-to-the-minute overview of an urgent, multidisciplinary premise. It explores the extent to which human history provides empirical evidence for the capacity of an individual to exert meaningful suasion over their species, and asks: Can an individual influence the survival of the human species and the (...) planet? If there are to be cultures of transformation dedicated to seeing us all through the Sixth Extinction Spasm, the Anthropocene, inflicting as little biological havoc as possible, what might such orientations—a collective, widespread biophilia, or reverence for nature—look like? In this powerful work, with a combination of data and direct observation, the authors invite readers to explore how such transformations might resonate throughout the human community; in what ways a person might overcome the seemingly insurmountable environmental tumult our species has unleashed; the clear and salient motives, ethics, aspirations and pragmatic idealism he/she might mirror and embrace in order to effect a profound difference—at the individual level—for all of life and life’s myriad habitats. Chapters illuminate an ambitiously broad digest of research from two-dozen disciplines. Those include ecodynamics, biosemiotics, neural plasticity, anthropology, paleontology and the history of science, among others. All converge upon a set of ethics-based scenarios for mitigating ecological damage to ourselves and other life forms. This highly readable and tightly woven treatise speaks to scientists, students and all those who are concerned about ethical activism and the future of the biosphere. Michael Charles Tobias and Jane Gray Morrison are ecological philosophers and animal liberation activists who have worked for decades to help enrich our understanding of ecosystem dynamics and humanity’s ambiguous presence amid that great orchestra that is nature. (shrink)