This paper looks at conflicts of interest in the not-for-profit sector. It examines the nature of conflicts of interest and why they are of ethical concern, and then focuses on the way not-for-profit organisations are especially prone to and vulnerable to conflict-of-interest scandals. Conflicts of interest corrode trust; and stakeholder trust (particularly from donors) is the lifeblood of most charities. We focus on some specific challenges faced by charitable organisations providing funding for scientific (usually medical) research, and examine a case (...) study involving such an organisation. One of the principal problems for charities of this kind is that they often distribute their funds within a relatively small research community (defined by the boundaries of a small region, like an American state or Spanish Autonomous region, or a small country), and it often proves difficult to find high-level researchers within the jurisdiction to adjudicate impartially the research grants. We suggest and recommend options appropriate for our case study and for many other organisations in similar situations. (shrink)

There is near universal recognition that human participant protection is both morally and practically essential for all forms of research involving humans. Yet most of the discourse around human participant protection has focussed on norms—rules, regulations and governance arrangements—rather than on the actual effectiveness of these norms in achieving their ends—protecting participants from undue risk and ensuring respectful treatment as well as advancing the generation of useful knowledge. In recent years there has been increasing advocacy for evidence-based human participant protection (...) that would be grounded on the careful investigation of the effects of research on human participants. We offer an analysis of evidence-based protection and then focus on Canadian examples of research on evidence-based protection. We consider the prospects for such research being put into practice in Canada. Finally we connect our remarks to the theme of “the changing landscape of human participant protection.”. (shrink)

InTowards a Canadian Research Strategy ForApplied Ethics, I put forward proposals to advance Canadian research in applied ethics. I focus on the assessment made of Canadian teaching, consulting, and research in business and professional ethics and then on the strategy proposed for advancing work in these areas. I argue for research which is [1] oriented to the ethical needs of those in business and the professions, [2] interdisciplinary, and [3] involves the creation of national and international networks. I then offer (...) some preliminary observations on the first two years of the new research strategy''s operation. (shrink)

The increased use of human biological material for cell-based research and clinical interventions poses risks to the privacy of patients and donors, including the possibility of re-identification of individuals from anonymized cell lines and associated genetic data. These risks will increase as technologies and databases used for re-identification become affordable and more sophisticated. Policies that require ongoing linkage of cell lines to donors’ clinical information for research and regulatory purposes, and existing practices that limit research participants’ ability to control what (...) is done with their genetic data, amplify the privacy concerns. (shrink)

The author seeks to make the fewest changes that would allow Christianity to withstand the challenges of the problem of evil . The project includes a critical review of the theodicies of John Hick and David Griffin, and also draws upon the thought of Sri Aurobindo. ;From Augustinian thought, the author retains the emphasis upon moral evil. He argues that any theodicy resolving moral evil also resolves natural evil, and that natural evil, as such, would not create major barriers to (...) religious faith. ;The author accepts John Hick's ideas of epistemic distance and soul-making, with supplementation. But he rejects Hick's use of the Greater Good Defense, instead positing that evil cannot be justified. The only question is whether it can be healed. ;David Griffin's strategy of adjusting divine traits to solve the POE is rejected. Instead, the author modifies Christian ideas of human identity and human destiny. Griffin's definition of evil is also rejected. Instead, the author defines evil as "a horrendous violation of an important human value." ;The author posits that Aurobindo correctly identified the Christian doctrine of "one lifetime only" as posing major problems for theodicy. The Indian view of multiple lifetimes helps to resolve dysteleological evil. Karma does not solve the POE all by itself, the author holds, but a revised notion of karma as "a law of appropriate experience" can make an essential contribution. The Indian view of human identity in terms of Self and ego personality is also adopted, again with some modification. ;The author uses an analogy of evil with a wound to argue that all evil can be healed, and must be healed in the process of psycho-spiritual growth. The conclusion is that evil may be ultimate to the ego personality, but is not ultimate to the soul, as such. From the perspective of the Soul or Self, suffering can be self-chosen for important and positive reasons. ;In short, a total picture of human identity and destiny gained by borrowing and revising Indian doctrines enables the author to suggest a new format for the interpretation of evil. (shrink)

In 1989, the Social Sciences and Humanities Research Council of Canada established a strategic research theme on applied ethics -- a theme which has been characterized by its welcome emphasis on the integration of theory and practice and interdisciplinarity. In the six competitions in that theme for research funding, bioethics has received more support than other areas of applied ethics including business ethics. Nonetheless, I argue that Canadian research in business and professional ethics has made significant strides over the past (...) six years. (shrink)

When we critically investigate a moral theory, such as utilitarianism, we are interested not only in the moral judgments such a theory would yield, but also in the attitudes and actions characteristic of the moral practitioner, in this case a utilitarian. For moral theories must be practical. Such theories can be distinguished in part from each other on the basis of he practices and attitudes adopted by their adherents. So it is fair to ask of any moral theory two basic (...) questions: is the theory ‘practicable’ and, if it is, does its practice seem moral? If a moral theory is not practicable because, say, its practice frustrates its intention, then that theory as it stands is not acceptable as a moral theory. If it is practicable but its characteristic practices seem immoral, then at best the theory stands in need of some defence by its advocates. They may either explain away the appearance of immorality by showing that contrary to first impressions the practices are not opposed to our untutored moral views, or that our untutored moral views are more questionable than the theory's practices. (shrink)

“Smallpox was always present, filling the churchyard with corpses, tormenting with constant fear all whom it had not yet stricken, leaving on those whose lives it spared the hideous traces of its power, turning the babe into a changeling at which the mother shuddered, and making the eyes and cheeks of the betrothed maiden objects of horror to the lover.” In 1848, British historian T.B. Macaulay first captured the picture of the devastation smallpox wreaked on its victims, but the “King (...) of Terrors,” as it was dubbed by future president John Adams, had already decimated populations in the ancient world from Greece to Egypt to China. Smallpox had no respect for authority: the earliest identified victim, Pharaoh Ramses V was but the first in a long line of monarchs and rulers who succumbed,. including the Hittite king Suppiluliumas I, Aztec Emperor Cuitlahuac, and Queen Mary II of England. (shrink)

In his book, Taking Rights Seriously Prof. Dworkin argues that all elements of society — citizens, legislature, and courts — ought to be ‘taking rights seriously’ in reaching decisions both about the actions and design of public institutions. This has two aspects. First in accord with traditional rights-centred views, there are certain ways of treating individuals that rights rule out. Formally, rights are ‘political trumps held by individuals’; they deny society certain kinds of access to collective goals. Materially, rights can (...) be seen as an expression of equal concern for each citizen as a human being; to deny a right is to ‘insult’ a person by failing to treat him as an equal of other persons, that is, as deserving the same basic respect as others. Secondly, and in contrast to the traditional natural rights view, Dworkin presents a particular way of reasoning about rights that does not presuppose their existence as Platonic entities; instead, rights are discovered in the process of constructing a theory which plausibly accounts for both the letter and the spirit of our society's institutional actions. (shrink)

An increasing number of community physicians are involved in clinical research.Indeed, 60 of industry-funded research is now spent on community based trials. This surge in community based clinical trials has increased the number of clinical trials applications submitted to the drug regulatory agencies by pharmaceutical sponsors. Many have argued that the commercial interests connected to the conduct and outcome of these trials also increases the potential for conflicts of interest for participating physicians. The context in which these trials take place (...) increases the potential for a host of practices that infringe on ethical, legal and clinical obligations of physicians For example, financial recruitment incentives may lead to violations of the inclusion criteria and the consent process. It may result in inappropriate recruitment of patient participants and a blurring of the ethically significant distinctions between treatment and research. In some cases, it may be hard to distinguish research from the marketing of new products and attempts to influencing prescribing patterns. (shrink)

“Smallpox was always present, filling the churchyard with corpses, tormenting with constant fear all whom it had not yet stricken, leaving on those whose lives it spared the hideous traces of its power, turning the babe into a changeling at which the mother shuddered, and making the eyes and cheeks of the betrothed maiden objects of horror to the lover.” In 1848, British historian T.B. Macaulay first captured the picture of the devastation smallpox wreaked on its victims, but the “King (...) of Terrors,” as it was dubbed by future president John Adams, had already decimated populations in the ancient world from Greece to Egypt to China. Smallpox had no respect for authority: the earliest identified victim, Pharaoh Ramses V was but the first in a long line of monarchs and rulers who succumbed,. including the Hittite king Suppiluliumas I, Aztec Emperor Cuitlahuac, and Queen Mary II of England. (shrink)

In this paper, I address the question, Who are the political and ideological opponents of liberalism? I suggest that Dworkin's way of dividing liberals from their conservative opponents over the issue of pluralism fails to get at the main issue of redistribution. But arguments for and against redistribution share a common pluralistic conception of politics and morals, viz., that they are to be conceived in terms of an agreement amongst autonomous individuals who are each trying to maximize their own welfares.I (...) argue that this ignores our relations with the non-autonomous and is parasitic on a wider and more generous notion of the political and moral community. I suggest that such a community must form a focus of its members' loyalties and an end (telos) for human virtues. I then draw some lessons for business ethics, arguing that it is an essentially specialized enterprise which ought not to used to model moral and political relations in general. (shrink)

An increasing number of community physicians are involved in clinical research.Indeed, 60 of industry-funded research is now spent on community based trials. This surge in community based clinical trials has increased the number of clinical trials applications submitted to the drug regulatory agencies by pharmaceutical sponsors. Many have argued that the commercial interests connected to the conduct and outcome of these trials also increases the potential for conflicts of interest for participating physicians. The context in which these trials take place (...) increases the potential for a host of practices that infringe on ethical, legal and clinical obligations of physicians For example, financial recruitment incentives may lead to violations of the inclusion criteria and the consent process. It may result in inappropriate recruitment of patient participants and a blurring of the ethically significant distinctions between treatment and research. In some cases, it may be hard to distinguish research from the marketing of new products and attempts to influencing prescribing patterns. (shrink)