Faithful DNA replication and accurate chromosome segregation are the key machineries of genetic transmission. Disruption of these processes represents a hallmark of cancer and often results from loss of tumor suppressors. PTEN is an important tumor suppressor that is frequently mutated or deleted in human cancer. Loss of PTEN has been associated with aneuploidy and poor prognosis in cancer patients. In mice, Pten deletion or mutation drives genomic instability and tumor development. PTEN deficiency induces DNA replication stress, confers stress tolerance, (...) and disrupts mitotic spindle architecture, leading to accumulation of structural and numerical chromosome instability. Therefore, PTEN guards the genome by controlling multiple processes of chromosome inheritance. Here, we summarize current understanding of the PTEN function in promoting high-fidelity transmission of genetic information. We also discuss the PTEN pathways of genome maintenance and highlight potential targets for cancer treatment. PTEN is a guardian of the genome. However, the role of PTEN in guarding the genome has not been revealed until recently. PTEN controls multiple fundamental processes of genomic transmission. By physically interacting with key molecules in DNA replication, DNA repair/decatenation, and chromosome segregation during the cell cycle, PTEN maintains genomicintegrity and fitness. (shrink)

In the last two decades, blame has become a core topic in ethics, philosophical moral psychology and, more recently, epistemology. This chapter aims at clarifying the complex state of the debate and at making a suggestion for how we should proceed from here. The core idea is that accounts of blame are often motivated by very different background goals. One standard goal is to provide a unifying account of our everyday blame practices. The chapter argues that there is reason to (...) think that this goal is not achievable. Another goal is to provide the tools for solving or clarifying important social or philosophical problems. The chapter suggests that this is what theories of blame should focus on. (shrink)

Arts-Based Research Methods for Educational Researchers is a book for early-career and established scholars who aim to use the arts to spark new ideas and empower participants in educational research. It will allow readers to conduct arts-based research and phenomenography research in their own projects. The book starts with a brief history of the arts in research, going on to provide an in-depth understanding of the philosophical foundations of arts-based research - different research designs, material preparation, ethical considerations, data collection, (...) analysis and reporting. Chapters highlight the impact of arts-based research, how it can be used to facilitate positive changes in educational research, practice, and policymaking. Tian suggests avenues for those who want to further develop these methods, guiding readers to reflect on their positionality and ethical issues involved in the research process. This insightful book is ideal for early career and experienced educational researchers who use qualitative methods in their inquiries. It offers a reader-friendly guide to methodology for scholars, educators as well as undergraduate and postgraduate students. (shrink)

The aim of this paper is to explore the role of ethical climate on the relationship between the paternalistic leadership and team identification at the team level. In contrast to the prior studies which tended to focus on ethical climate as a whole dimension, this paper further classified the domain of construct into the categories of egoism, benevolence, and principle using a sample from 143 teams in Mainland China and Taiwan. Hierarchical regression results showed that the average paternalistic leadership had (...) a significant impact on the team identification at the team level. Moreover, the results indicated that the ethical climate of benevolence fully mediated while the ethical climate of egoism partially mediated the relationship between authoritarian leadership and team identification. Also, the ethical climates of benevolence and principle had a partial mediating effect on the relationship between benevolent leadership and team identification as well as moral leadership and team identification, respectively, but the ethical climate of egoism did not play a significant role. The major findings, theoretical contributions, practical implications, and the limitations were discussed. (shrink)

This work is developed to improve the current quality of e-commerce logistics services. From the perspective of multiple consumer psychology, based on e-commerce, consumer psychology, and other related theories, vegetable e-commerce B is selected as the research object. The commodity quality, accuracy, and timeliness of commodity distribution and other factors of e-commerce B are discussed through questionnaire survey. Then, according to customers’ opinions about “e-commerce B’s distribution and professional aspects that need to be improved,” the research is conducted. Finally, the (...) direction of follow-up optimization is proposed from four different perspectives of multiple consumption psychology. The research results show that more than 89% of the surveyed customers believe that e-commerce B does a good job in terms of commodity quality, accuracy, and timeliness of commodity distribution, and has a high level of logistics service. However, 26.34% of customers hope that e-commerce B can strengthen the protection of personal privacy, 24.97% hope that the platform can add “delay insurance” for goods, and 39.54% hope that the logistics information of purchased goods can be updated in real time. Therefore, e-commerce B needs to be optimized and improved continuously in the future development. Therefore, research on the optimization of logistics service quality of e-commerce is performed under multiple consumption psychology, which provides certain help for the rapid development of subsequent e-commerce. (shrink)

Social Information Science (or Social Informatics) is a new and interdiscipline branch subject in China. This paper probe the emergence and the research outline of social information science. 1. The proposal of the social information science. We set up the research from an extension from the theoretical informatics to the concrete informatics; a internal bond of integrating various subjects in humane and social sciences; an intersection and mutual permeation between the social science and the natural science; a the intersection and (...) interaction among humane and social sciences, modern information science and information technology; a strengthening to the research into Social Epistemology. Ⅱ. On the concept of social information. Social information directly is different with selfexistent and natural information, and more related to human’s autonomous creative activities, to society’s culture inheritance, to social value, to human’s spiritual interaction and to human’s emotions. Ⅲ.On the theoretical orientation of the social information science. Social Information Science is a concrete branch of informatics, a generation of sub-disciplines of social information, a kind of traversing and comprehensive research on individual social science from the angle of information, a kind of exchange and interaction between social theoretical research and the modern information technology. Ⅳ. The research focus of the social information science. The paper lists 10 main focus in the research of social information science. Ⅴ.The system and frame of the social information science. In general, there should be four levels of researches if the social information science is to be viewed as a relatively independent subject: the philosophical level, the scientific theoretical level, concrete apply level, social information technology and methods. (shrink)

Power is often taken to be a central concept in social and political thought that can contribute to the explanation of many different social phenomena. This article argues that in order to play this role, a general theory of power is required to identify a stable causal capacity, one that does not depend on idiosyncratic social conditions and can thus exert its characteristic influence in a wide range of cases. It considers three promising strategies for such a theory, which ground (...) power in (1) the ability to use force, (2) access to resources, or (3) collective acceptance. It shows that these strategies fail to identify a stable causal capacity. The lack of an adequate general theory of power suggests that the concept lacks the necessary unity to play the broad explanatory role it is often accorded. (shrink)

ObjectiveThis study explores the relationship between physical exercise and school adaptation of junior middle school students and constructs a chain intermediary model through the intermediary role of psychological resilience and sports learning motivation.MethodsUsing the stratified cluster sampling method, 930 junior middle school students in Anhui Province were measured in group psychology by using the physical exercise rating scale, adolescent psychological resilience scale, physical learning motivation scale and school adaptation scale. The statistical software SPSS 23.0 and process plug-in were used for (...) statistical processing, and the common method deviation test was carried out by Harman single-factor control method. Finally, the bootstrap sampling test method and process plug-in were used to test the significance of intermediary effect.Results The direct prediction effect of physical exercise on school adaptation is remarkable ; psychological resilience and sports learning motivation are the intermediary variables of the relationship between physical exercise and school adaptation; psychological resilience and sports learning motivation play a chain mediation role in the relationship between physical exercise and school adaptation. The intermediary effect is composed of three indirect effects: physical exercise → psychological resilience → school adaptation, physical exercise → physical learning motivation → school adaptation, physical exercise → psychological resilience → physical learning motivation → school adaptation.ConclusionsPhysical exercise can directly improve the school adaptation of junior middle school students, which can also affect junior middle school students’ school adaptation indirectly through psychological resilience or sports learning motivation, and it can influence school adaptation through the chain mediation of psychological resilience and sports learning motivation. (shrink)

民国大先生金岳霖的一生,注定了是一段传奇.因为他的名士风,因为他的痴情.本书叙述金岳霖在成长,情趣,交友等方面的经历,说出身,说成长,说游艺,说治学,谈爱好,忆故交,展现他真实的人生——学术成就卓然的 哲学大师,天真烂漫如孩童,洒脱飘逸如名士.对爱简单而执着,一生痴情于才女林徽因,动人而神圣,一辈子"逐林而居",终身未娶.是真名士,自风流.

Ben shu chan shu de nei rong shi zhi shi zhong ya fang wen hua de shen tou yu jiao liu.

This article uses the “Green Credit Guidelines” issued in 2012 as a quasi-natural experiment, using the statistics of A-share listed companies from 2008 to 2017, using the PSM-DID model to examine the effect and mechanism of green credit policies on the investment efficiency of heavily polluting companies, and taking into consideration the heterogeneous influence of the financial ecological environment on the relationship between the two. The research indicates that, after the Green Credit Guidelines were promulgated, the investment efficiency of heavy-polluting (...) companies has been slightly improved compared with non-heavy-polluting companies and that the impact is more obvious in regions with better financial ecological environment. The research conclusions confirm the beneficial effects of the Green Credit Guidelines policy on the prudent investment of companies that cause serious pollution to the environment and improve investment efficiency, a provision of empirical evidence for financial leverage to drive the green economy transformation. (shrink)

本书是王蒙先生用自己的人生历练, 用自己的体悟感受, 用自己的政治经历, 社会经历, 人生经历, 文学经历, 也用自己的知识与智商去与庄生对话, 与庄生共舞, 揣摩逼近庄生的鱼, 兔, 意图, 意念, 雄辩与才华, 对"庄子"进行解说与阐释, 交映生辉.

Ben shu nei rong bao kuo: ren lei wei he ru ci duo shi; dong fang gu dian de Afanda Wutuobang; sheng ren jiu jing wei shui xiao lao; zhi li de xian du yu xu wei you guo lun; deng gao si wang, man mu zhu ji hai shi man mu la ji; nan yi yong yu yan wen zi biao da yu chuan shou de da dao deng.