Site‐specific phosphorylation of intermediate filament (IF) proteins on serine and threonine residues leads to alteration of the filament structure, in vitro and in vivo. Protein kinases involved in cell signaling and those activated in mitosis dynamically control spatial and temporal organization of intracellular IF phosphorylation. Thus, IF phosphorylation appears to be one of the most predominant strategies in coordinating intracellular organization of the IF network.

This paper discusses how to refine a given initial legal ontology using an existing MRD (Machine-Readable Dictionary). There are two hard issues in the refinement process. One is to find out those MRD concepts most related to given legal concepts. The other is to correct bugs in a given legal ontology, using the concepts extracted from an MRD. In order to resolve the issues, we present a method to find out the best MRD correspondences to given legal concepts, using two (...) match algorithms. Moreover, another method called a static analysis is given to refine a given legal ontology, based on the comparison between the initial legal ontology and the best MRD correspondences to given legal concepts. We have implemented a software environment to help a user refine a given legal ontology based on these methods. The empirical results have shown that the environment works well in the field of Contracts for the International Sale of Goods. (shrink)

「社会はより良くなる」という「進歩」の理想が失われ、右も左もいまや弱体化している―。200余年にわたるその過程を描き、地球規模の「正義」でなく、自らの現場から始める「ミニマルな正義」を推奨する、この時 代の正義論。.

人間の愛は「不合理」なもの?自由だと勝手に信じている人間が実際には「不自由」なのではないか?なぜ人間は生まれて死ななければならないという「不条理」に遭遇しているのか?そもそも、人間とは何か...?―「 行為」「意志」「存在」の限界をテーマに、行動経済学者や認知科学者、進化論者、実存主義者など多様な分野の学者からカント主義者や急進的フェミニスト、会社員、運動選手、大学生も加わり、楽しく深い広い議論を繰 り広げる。そこから見えてくる人間の姿とは―。.

古代の土俗的にカミ信仰は、中世になると仏教の影響を受けて、教説としての「神道」を形成する。そして近世には儒教の影響を受けて、広く学問と思想の世界を席巻していく。そこには、外来思想の流入に対する。民族の 文化的アイデンティティを追求しようとする日本人の思想的営為があった。カミ信仰の系譜。.

熊本大学生命倫理論集第3巻のテーマは「生命の価値」そのものである。生命倫理が前提とする生命という価値についての根本的問いかけに、哲学、倫理学、法学、医学、脳科学、生物学等の様々な分野の専門家が本気で取 り組み、学問の境界を越えた議論を展開する。.

This book is an excellent book on business ethics and will be an invaluable resource for all readers who are keen to learn about the business ethics and key characteristics of a successful company. It focuses on the case study of a global company, Johnson & Johnson (J&J), which oversees more than 250 operating units throughout the world. Through extensive interviews with top executives at J&J's headquarters, including Masami Atarashi and Mitsuo Hirose and attending workshops, Prof Hiroo Takahashi acquired (...) an in-depth understanding of the management style of J&J, grasped the company's ethics and the code of business conduct which is shared by J&J's members throughout the world. (shrink)

Hegel, in his work _Philosophy of Right_, defines ownership through three elements: acquisition by occupation, use, and transfer. To own something involves mere acquisition and encompasses its appropriate use and potential transfer to others. Subsequently, the final aspect mentioned was the concept of infinite judgement. The acts of owning and transferring to others are diametrically opposed, and Hegel’s unique logic forcibly connects these opposing concepts. This form of infinite judgement was advocated by the young Hegel during the era of _Phenomenology (...) of Spirit_. There, he stated, “Spirit is a bone”. However, when he later wrote _Science of Logic_ or _Encyclopedia_, the formulation of infinite judgement changed to “Spirit is not something that is bone”. This shift was influenced by Kant. In _Logic_, the discourse advances into syllogism, inferential theory, leading to “Spirit is a bone for such-and-such reasons”. In essence, Hegel binarily connected spirit and bone in his youth and introduced a mediating term in this connection later in his life, establishing inferential links. However, the notion of forcibly connecting opposing concepts remains. Therefore, the statement “Ownership is transfer” represents an infinite judgement while simultaneously signifying syllogism that “I truly own this object if I can transfer it to others”. This contributes to the reasoning that “I and objects can be connected through the intermediary of others”, progressing to the inference that “I and others can be connected through objects”, thereby laying the foundation for society. (shrink)

日本を代表する「思考の達人」“Meisterdenker”たちは如何にして、明治維新以降、輸入品ではない、日本固有の思考法・方法論を創りだしたのか?続々重版の大好評、入門講義シリーズ。日本に学問として の「哲学」を定着させるうえで決定的な役割を果たした西田幾多郎『善の研究』と日本的な「倫理学」の方法論を開拓したとされる和辻哲郎『人間の学としての倫理学』を熟読し、日本人の深層に在る思想を探る。.

プラトン以降の西欧哲学・思想史において、“すぐれた哲学・思想”と思われているものが、いかに擬似宗教化の危険性と隣り合わせにありそのことが哲学者・思想家によってどのように問題化され、論じられてきたのか。 本書では、現代思想に特に強い影響を与えたハイデガー、アーレント、デリダなどの論考をてがかりに、思想史の概観を試みる。新興宗教体験を持つ著者だからこそ、現代日本の思想業界に、“生き生きとしたラディカルな 思想”を中心とした「真の共同体」を求めるかのような、擬似宗教化の風潮が生じていることが分かるのである。.

篤胤において死の問題は、死後の存在としての霊魂の問題となり、さらには霊魂の行き場所の問題となる。もし人が死後に霊魂となることが確実であり、霊魂の行き着く場所が特定されるのであれば、先に現在の私たちに即 して述べたような死の問題は、「解決」されるに違いない。篤胤はまさにそのことを『霊の真柱』において試み、「幽冥界」という観念を提示することになる。.

Recently, agent technologies have attracted a lot of interest as an emerging programming paradigm. With such agent technologies, services are provided through collaboration among agents. At the same time, the spread of mobile technologies and communication infrastructures has made it possible to access the network anytime and from anywhere. Using agents and mobile technologies to realize ubiquitous computing systems, we propose a new framework based on KODAMA and VPC. KODAMA provides distributed management mechanisms by using the concept of community and (...) communication infrastructure to deliver messages among agents without agents being aware of the physical network. VPC provides a method of defining peer-to-peer services based on agent communication with policy packages. By merging the characteristics of both KODAMA and VPC functions, we propose a new framework for ubiquitous computing environments. It provides distributed management functions according to the concept of agent communities, agent communications which are abstracted from the physical environment, and agent collaboration with policy packages. Using our new framework, we conducted a large-scale experiment in shopping malls in Nagoya, which sent advertisement e-mails to users' cellular phones according to user location and attributes. The empirical results showed that our new framework worked effectively for sales in shopping malls. (shrink)

人道的介入がもたらす非人道性、対テロ戦争における標的殺害の是非、平和構築や民主化の直面する矛盾―現代の国際社会が直面する、戦争と平和をめぐる「道義的難問」に挑む。.

自己決定概念は、患者の自律やインフォームド・コンセント、プライバシー概念等の基礎にあり、生命倫理において核となる重要な概念である。しかし、その歴史的由来について、またその概念の意味するところについて、 これまで本巻のように主題的に扱われることはほとんどなかった。ここでの諸論考は、「自己決定権」や「自律」概念の理解にも大いに役立つはずである。.

Since Japan adopted the concept of informed consent from the West, its inappropriate acquisition from patients in the Japanese clinical setting has continued, due in part to cultural aspects. Here, we discuss the current status of and contemporary issues surrounding informed consent in Japan, and how these are influenced by Japanese culture.

本居宣長が師とした儒学者堀景山の初めての研究書。現在調査可能な資料を詳細に検討し、学問観や人物像の全貌を明らかにする。.

3. Benshōhōteki yuibutsuron e no michi.

教育における「教養」のあり方を、思想史や教育史、文化概念の問題から多角的に考察。多文化時代に人間性を養うことの意義を論じる。.

Fundamental notions Husserl introduced in Ideen I, such as epochè, reality, and empty X as substrate, might be useful for elucidating how mathematical physics concepts are produced. However, this is obscured in the context of Husserl’s phenomenology itself. For this possibility, the author modifies Husserl’s fundamental notions introduced for pure phenomenology, which found all sciences on the absolute Ego. Subsequently, the author displaces Husserl's phenomenological notions toward the notions operating inside scientific activities themselves and shows this using a case study (...) of the construction of noncommutative geometry. The perspective in Ideen I about geometry and mathematical physics includes points that are inappropriate to modern geometry and to modern physics, especially to noncommutative geometry and to quantum physics. The first point relates to the intuitive character of geometrical objects in Husserl. The second is linked to the notion of locality related to the notion of extension, by which Husserl characterizes the essence of physical things. The points show that the notion of empty X as a substrate, developed in “Phenomenology of Reason” in Ideen I, is helpful for considering the notions of physical reality and of geometrical space, especially reality in quantum physics and space in noncommutative geometry. The salient conclusions include the proposition that aphilosophical study of the relationship between the physical object X, which imparts a unity to what is given to sensibility, and the geometrical space X, which imparts a unity of sense to various mathematical operations, opens a reinterpretation of Husserl’s interpretation, supporting an epistemology of mathematical physics. (shrink)

Abstract:Many scientists argue that the world is becoming increasingly dominated by human activity, much to the detriment of the natural world. In what scholars have dubbed the Anthropocene, the current geological epoch during which time human activity has been the dominating force over climate and the environment, many questions of environmental ethics have arisen. Who does the earth belong to? What is the relationship between humans and the environment? What is the moral standing of non-human life? Locke and Rousseau provide (...) varying answers to these questions, which are central to discussions of environmental ethics. In many ways, Locke and Rousseau's answers are opposed to each other, suggesting a differing world view when it comes to environmental ethics. Locke's understanding of environmental ethics seems to dominate, and perhaps even cause, the onset of the Anthropocene, but Rousseau's response, and a potential turn toward his understanding of environmental ethics marks an ideological shift in the way that humans understand their relationship with the world around them. This paper argues that the writings of Locke and Rousseau correspond to different stages of the Anthropocene with significant effects on both environmental ethics and environmental governance and policy. (shrink)