The versatile clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system has emerged as a promising technology for therapy and molecular diagnosis. It is especially suited for overcoming viral infections outbreaks, since their effective control relies on an efficient treatment, but also on a fast diagnosis to prevent disease dissemination. The CRISPR toolbox offers DNA‐ and RNA‐targeting nucleases that constitute dual weapons against viruses. They allow both the manipulation of viral and host genomes for therapeutic purposes and the detection of viral (...) nucleic acids in “Point of Care” sensor devices. Here, we thoroughly review recent advances in the use of the CRISPR/Cas system for the treatment and diagnosis of viral deleterious infections such as HIV or SARS‐CoV‐2, examining their strengths and limitations. We describe the main points to consider when designing CRISPR antiviral strategies and the scientific efforts to develop more sensitive CRISPR‐based viral detectors. Finally, we discuss future prospects to improve both applications. Also see the video abstract here: https://www.youtube.com/watch?v=C0z1dLpJWl4. (shrink)

El Patronato de Misiones Pedagógicas desarrolló una importante labor de recuperación y difusión de la cultura musical, especialmente del folklore musical español, en los primeros años de la II República española, al poner en marcha un servicio de música y un coro que se encargaron de acercar diferentes estilos y géneros musicales a los habitantes de las zonas rurales más deprimidas. En este artículo se presenta un estudio documental sobre el trabajo llevado a cabo por los integrantes del coro y (...) por las personas que se encargaron de custodiar los recursos musicales cedidos por el Patronato y de programar las diferentes actividades musicales en los municipios que gozaron de dichos recursos. A su vez, se recogen diversos testimonios que dan fe del cometido realizado por esta institución y del impacto cultural y musical que supuso en los habitantes de las localidades donde se desarrollaron las diferentes actividades misionales. (shrink)

Na tentativa de propor uma conciliação das práticas comunitária e clínica em Psicologia, pretendemos desenvolver os seguintes elementos em ambas as propostas: uma prática de escuta às situações emergentes, uma postura ética e política de escuta aos sujeitos e a promoção da saúde engajada na realidade social brasileira. Ambas as perspectivas podem ser complementares desde que partamos da unidade e não da dicotomia entre elas. Defendemos que as propostas de Psicologia Comunitária, inaugurada por Martin-Baró, e de Psicologia Clínica em uma (...) perspectiva fenomenológico-existencial, inaugurada por Binswanger, prescindem da necessidade de se excluírem mutuamente visto que ambas partem da concepção de comunidade como elemento unificador do binômio ser e mundo. Apostamos na construção de práticas ético-políticas pela necessidade de se promover uma união entre clínica e comunidade, entre natureza humana e social, tal como defendidas por Krenak e Kopenawa. E ainda, dando voz à cultura brasileira e em uma defesa do movimento Modernista, dialogamos com Oswald de Andrade, Clarice Lispector, Manoel de Barros, Manoel Bandeira, Rubem Alves e Guimarães Rosa. Em conclusão, a proposta é de que a clínica psicológica na perspectiva do nós se estabelece como processo sociopolítico de injunção dos assujeitados, resistência à massificação e a derrocada do poder do impessoal no gerenciamento da vida. (shrink)

Neste estudo procedemos a uma revisão narrativa da literatura, de modo a mostrar as diferentes etapas da psiquiatria tal como desenvolvida por Ludwig Binswanger, ao mesmo tempo realizamos uma análise crítica dessas etapas. Discorremos sobre os motivos do afastamento desse estudioso das bases biológicas que sustentavam a psiquiatria da época, em direção a uma perspectiva psicanalítica. Nessa etapa, Binswanger defende as bases psíquicas das enfermidades mentais, das quais em breve tempo também se afasta por avaliar que na psicanálise, também, havia (...) uma redução ao psíquico. Esse estudioso passa, imediatamente, para os estudos das bases fenomenológicas com seu mestre Edmund Husserl, acreditando que nessa perspectiva ficaria livre de qualquer redução. Em um breve intervalo de tempo, esse estudioso da psiquiatria passou a estudar a analítica do Dasein com Martin Heidegger, assumindo a Daseinsanalyse nas bases de seus estudos. No entanto, com a crítica de Heidegger à daseinsanálise de Binswanger, este acabou por denominar o seu projeto de psiquiatria como fenomenologia antropológica, interessando-se pelas vivências do espaço e do tempo daqueles que apresentavam enfermidades psíquicas. (shrink)

Arquivo integral da edição dos 25 anos de IFEN.

Este artículo presenta dos objetivos principales, ambos relacionados con los planteamientos de la corriente transhumanista. El primero consiste en realizar una aproximación al aspecto tecnológico del transhumanismo, en concreto a su estado actual en cuanto a los avances en el ámbito de la ingeniería cibernética. Tras una introducción al concepto de transhumanismo, se expondrán algunos proyectos actuales que buscan desde la reparación de daños hasta el mejoramiento humano. Como ejemplo de la implementación de la tecnología con el objetivo de amplificar (...) los sentidos, se presenta el concepto de cíborg. El segundo objetivo se centrará en presentar las cuestiones de carácter bioético que los avances en ingeniería cibernética plantean y que irán surgiendo a lo largo del artículo con el fin de ver cómo estos avances realmente pueden ponerse al servicio de la naturaleza humana y de su desarrollo integral. (shrink)

El Tercer Sector de Acción Social español es un agente clave para el impulso de la inclusión en el modelo social europeo. Su fortaleza radica en las alianzas internas entre entidades, así como al establecimiento de vínculos con el estado y el mercado. Se mostrará, mediante análisis documental de fuentes secundarias, la tesitura en la que están ambos tipos de gobernanza con respecto a las políticas para la inclusión en la UE. Los resultados muestran una progresión en cuanto a estructuras, (...) canales, ideario y metas comunes, pero también déficits que señalan el camino a recorrer hacia la colaboración y participación. (shrink)

El lenguaje conceptual es la singularidad de la filosofía. En sus comienzos nos encontramos con la obra filosófica de Platón, la cual es aquí interrogada desde la experiencia del diálogo como una pedagogía del concepto, mostrando cómo la conversación platónica lleva implicada un camino hacia el concepto. Tomados algunos de sus Diálogos, mostramos cómo en ellos existe una orientación en torno a la manera como el pensador asume la tarea de una formación conceptual: de la doxa al saber, la llamada (...) Teoría de las Ideas de Platón, en sus distintos momentos, es la respuesta histórica a la necesidad del pensamiento de comprender lo sensible a la luz de lo inteligible y de encontrar en el concepto esa palabra común para el entendimiento mutuo, en el conjunto de las diversas experiencias humanas. (shrink)

El presente artículo determina cómo una empresa ética, convertida en escuela de virtudes morales, puede contribuir a mejorar la sociedad. La empresa sólo puede mejorar la sociedad y generar un impacto positivo en la misma desde la ejemplaridad de todas y cada una de sus personas. Se entiende la empresa como una comunidad de personas en la que ha de existir un equilibrio esencial entre lo individual y lo colectivo. Se parte de la premisa de que la empresa es, también, (...) un espacio ético que puede llegar a convertirse en una escuela de valores y virtudes en la que los profesionales desarrollen sus capacidades humanas en interrelación con los demás. Se argumenta la relevancia de la virtud empresarial, desde la perspectiva de la transformación del ethos individual, de los hábitos de las personas que forman la organización. Se considera que la empresa puede llegar a convertirse en una “escuela de valores y virtudes”. La forja del ethos ético y virtuoso de los profesionales es, a su vez, la esencia de la construcción del ethos ético de la empresa que tendrá su correspondiente impacto en el ethos de una buena sociedad. A partir de estas aseveraciones nos hacemos las siguientes preguntas en nuestra investigación: ¿De qué manera puede influir el ethos de la empresa en la configuración de los ethos particulares de los profesionales que forman parte de ella? y ¿cómo puede la empresa contribuir al desarrollo de las virtudes morales de sus personas? Asumiendo estas dos cuestiones como base de la investigación, se argumenta que la empresa puede llegar a ser, a través del trabajo, una ‘escuela’ para el desarrollo de las virtudes morales y, desde ahí, contribuir a la construcción de una sociedad más humana. (shrink)

What relationship can be established between the theory of epistemic injustices and the theory of the coloniality of power to think Latin America? This article proposes a dialogue between both theories to think about the actions of subaltern groups in Latin America that, by generating processes of struggle and organization, make epistemic injustices visible as part of their demands. This inquiry is presented in three moments: in the first, the conceptual field of epistemic injustices is defined —from Fricker, Medina and (...) Broncano— and the political/epistemic conception of coloniality of power by Anibal Quijano. In the second moment, the relations between these theories are explained. In the end, some examples of experiences of resistance in Latin America are given that can be analyzed from this dialogue. (shrink)

Introduction and ObjectiveThe early identification of depressive patients having a poor evolution, with frequent relapses and/or recurrences, is one of the priority challenges in this study of high prevalence mental disorders, and specifically in depression. So, this study aims to analyze the factors that may be associated with an increased risk of recurrence of major depression episodes in patients treated in primary care.MethodsA retrospective, descriptive study of cases-controls was proposed. The cases consisted of patients who had been diagnosed with major (...) depression and who had presented recurrences, in comparison with patients who had experienced a single major depression episode with no recurrence. The variables of the study are age at first episode; number of episodes; perception of severity of the depression episode suffered prior to recurrence; number of residual symptoms; physical and psychiatric comorbidity; history of anxiety disorders; family psychiatric history; high incidence of stressful life events ; and experiences of physical, psychological, or sexual abuse in childhood. The differences of the variables were compared between the case subjects and the control subjects, using the Mann–Whitney, chi-square, and Fisher’s U statistics. A multivariate analysis was performed.ResultsThe average age of those suffering more than one depressive episode is significantly older, and a higher percentage of subjects who have experienced more than one depressive episode have a history of anxiety disorders. In the multivariate analysis, the variables that obtained a significant value in the logistic regression analysis were age and having suffered sexual abuse during childhood.ConclusionThese indicators should be considered by primary care physicians when attending patients suffering from major depression. (shrink)

_María Zambrano. __A Life of Poetic Reason and Political Commitment _de Beatriz Caballero Rodríguez y _The Cultural Legacy of María Zambrano_, editado por Xon de Ros y Daniela Omlor, son dos recientes aportaciones críticas al pensamiento de María Zambrano, pioneras en su contexto al constituir los dos primeros libros monográficos en lengua inglesa sobre esta filósofa y escritora. Por ello se abordarán en una reseña conjunta con el fin de mostrar la vigencia del pensamiento de Zambrano en el (...) siglo XXI. (shrink)

Este trabajo tiene como objetivo caracterizar el proceso de evaluación del aprendizaje del contenido estadístico en la carrera de Medicina. Los resultados obtenidos evidencian que el nivel de asimilación alcanzado por los estudiantes en muchas ocasiones es el reproductivo, lo que refleja la necesidad de seguir profundizando en los estudios de esta problemática. Issues related to the learning evaluation have been present throughout the teaching learning process history. The following research aims at characterizing the learning process of evaluation of the (...) statistical content in medicine. Results demonstrate that the assimilation level reached by students, on many occasions, is the reproductive one, as a need to deepen on methodology of the design of the system of evaluation of the statistical content learning in medicine. (shrink)

Objective: To measure the stability of life-sustaining treatment preferences amongst older people and analyse the factors that influence stability. Design: Longitudinal cohort study. Setting: Primary care centres, Granada (Spain). Eighty-five persons age 65 years or older. Participants filled out a questionnaire with six contexts of illness (LSPQ-e). They had to decide whether or not to receive treatment. Participants completed the questionnaire at baseline and 18 months later. Results: 86 percent of the patients did not change preferences. Sex, age, marital status, (...) hospitalisation, and self-perception of health and pain did not affect preferences. Morbidity and the death of a relative did. Conclusion: Stability of preferences of older persons in relation to end-of-life decisions seems to be more probable than instability. Some factors, such as the death of a relative or the increase in morbidity, can change preferences. These findings have implications for advance directives (ADs) and advance care planning. (shrink)

Recension: LÓPEZ VIGIL, Maria; LÓPEZ VIGIL, José Ignacio. Just Jesus. New York: Crossroads, 1997. [LÓPEZ VIGIL, Maria; LÓPEZ VIGIL, José Ignacio. Un tal Jesús . Salamanca: Lóguez Ediciones, 1982] LÓPEZ VIGIL, Maria; LÓPEZ VIGIL, José Ignacio. Outro Dios es posible: 100 entrevistas exclusivas con Jesucristo en su segunda venida a la Tierra. Quito: Gráficas Silva, 2008.

In the sport context, an essential aspect of an athlete’s development and performance happens during the interaction with the coach while receiving information on the aspects of performance that need to be modified. Grounded in the Self-Determination Theory and particularly on the basic psychological needs theory, a structural equation model was tested with the following sequence: perception of the amount of corrective feedback generated by the coach, perceived legitimacy of corrective feedback, satisfaction of basic psychological needs, and vitality in soccer (...) players. Additionally, simple mediation and serial mediation models were also tested. Participants were 377 Mexican soccer players, who completed the instruments that evaluated the study variables. SEM results reported positive and significant variables’ interrelations in the sequence. The analysis of serial mediation model showed that the perceived legitimacy of feedback and the satisfaction of basic psychological needs fully mediated the relationship between the perception of the amount of corrective feedback generated by the coach and the perception of the subjective vitality of Mexican soccer players. Results suggest that coaches have to ensure that athletes accept the corrective feedback provided and meet their basic psychological needs. Based on SDT tenets, this research highlights the importance for coaches to be aware of the athlete’s perceptions when they are providing corrective feedback and their implications for athlete’s technical development and well-being. It is suggested to incorporate those aspects to training programs for coaches. (shrink)

Informed consent forms have been useful in clinical practice and they constitute a part of the shared decision making in the informed consent process. They provide information to patients about clinical procedures and techniques. They also act as a remainder of the information discussed after the medical interview. Sometimes these documents are not readable to everybody. Belgian law specifies that all information that patients receive has to be proportionate verbally, but written information is also handled. The present research analyzes the (...) readability of the Flemish informed consent forms located in the webs of all General Hospitals using a simple random sample of 75 informed consent forms. By using the Douma tool, which bases its analysis in the length of words and sentences, the readability mean of the sample was 46, level “Difficult”. The 59% of them had a difficult level. The 11% were normal. It is a fact, then, that the 59% of the informed consent forms evaluated in this study are not suitable for everybody in Flanders, especially those people with low literacy. There were some researches made in other countries that agreed with these results. Written clinical information was poorly written so the informed consent forms were not working helping patients to recall information nor helping patients to become a part in the shared decision making about their health. The use of readability formulas represented a simple way to discriminate those informed consent forms that had normal readability scores from those that should be adapted. (shrink)

The present study aims to verify the psychometric properties of the Spanish versions of the Social Roles Questionnaire (SRQ; Baber & Tucker, 2006), Modern Sexism scale (MS) and Old-fashioned Sexism scale (OFS; Swim et al. Swim & Cohen, 1997). Enough support was found to maintain the original factor structure of all instruments in their Spanish version. Differences between men and women in the scores are commented on, mainly because certain sexist attitudes have been overcome with greater success in the current (...) Spanish society, while other issues, such as distribution of power in organizational hierarchies or distribution of tasks in the household, where traditional unequal positions are still maintained. In all cases, it was found that men showed greater support for sexist attitudes. The correlations between the three instruments were as expected in assessing sexist attitudes that tend to relate to each other. Eventually, we found no empirical evidence for the postulated link between sexist attitudes and traditional gender stereotypes. Our results call for the validity and effectiveness of the classic theories of gender psychology, such as gender schema theories (Well, 1981; Markus et al., 1982) and the notion of a gender belief system (Deaux & Kite, 1987; 2001). (shrink)

El siguiente informe pericial se basa en la experiencia de investigación de los firmantes en relación a las exhumaciones de fosas comunes de la Guerra Civil y la postguerra, y al conocido como “movimiento para la recuperación de la memoria histórica” que están teniendo lugar en España desde el año 2000, que ha enfatizado sus demandas sobre la suerte de los desaparecidos y ha puesto en marcha un ciclo de exhumaciones de fosas comunes derivadas de la Guerra Civil y la (...) dictadura. En este peritaje se usan las exhumaciones del siglo XXI como indicadores de la persistencia en el tiempo de las políticas y culturas del miedo instaladas en la sociedad española durante la Guerra Civil y la dictadura, más allá de las profundas transformaciones políticas e institucionales acaecidas en el país tras la muerte de Francisco Franco. Fue presentado como parte de la documentación de la demanda de Fausto Canales contra España el 15 de septiembre de 2012 en el Tribunal Europeo de Derechos Humanos. (shrink)

Shows the relevance of Schiller’s thought for contemporary philosophy, particularly aesthetics, ethics, and politics. This book seeks to draw attention to Friedrich Schiller (1759–1805) as a philosophical thinker in his own right. For too long, his philosophical contribution has been neglected in favor of his much-deserved reputation as a political playwright. The essays in this collection make two arguments. First, Schiller presents a robust philosophical program that can be favorably compared to those of his age, including Rousseau, Kant, Schelling, and (...) Hegel, and he proves to be their equal in his thinking on morality, aesthetics, and politics. Second, Schiller can also guide us in our more contemporary philosophical concerns and approaches, such as phenomenology, hermeneutics, aesthetics, and politics. Here, Schiller instructs us in our engagement with figures such as Walter Benjamin, Michel Foucault, Jacques Rancière, Roberto Esposito, and others. María del Rosario Acosta López is Associate Professor of Philosophy at DePaul University. She has published several books, including La tragedia como conjuro: el problema de lo sublime en Friedrich Schiller. Jeffrey L. Powell is Professor of Philosophy at Marshall University and the editor of Heidegger and Language. (shrink)