Nair-Collins and Joffe (2023) highlight the complexities inherent to the clinical diagnosis of death by neurologic criteria and inconsistencies between legal, scientific, and clinical standards for...

Ethical concerns about therapeutic misconception have been raised since the early 1980s. This concept was originally described as research participants' assumptions that decisions relating to research interventions are made on the basis of their individual therapeutic needs. The term has since been used to refer to a range of ‘misunderstandings’ that research participants may have. In this paper, we describe a new concept—therapeutic appropriation. Therapeutic appropriation occurs when patients, or clinicians, actively reframe research participation as an opportunity to enhance patients' (...) clinical care, while simultaneously acknowledging the generalised research aims. To illustrate the concept of therapeutic appropriation, we draw on data from an interview study which we conducted to investigate the experiences of patients and general practitioners involved in clinical trials in primary care. We argue that therapeutic appropriation has two key elements: comprehension that the research project is not necessarily aiming to benefit participants and the deliberate use of incidental features of the research for personal therapeutic benefit of various kinds. We conclude that therapeutic appropriation is a useful concept that refines understanding of potential ethical problems in clinical research, and points to strategies to address them. (shrink)

Public surveys conducted in many countries report widespread willingness of individuals to donate a kidney while alive to a family member or close friend, yet thousands suffer and many die each year while waiting for a kidney transplant. Advocates of financial incentive programs or “regulated markets” in kidneys present the problem of the kidney shortage as one of insufficient public motivation to donate, arguing that incentives will increase the number of donors. Others believe the solutions lie—at least in part—in facilitating (...) so-called “altruistic donation;” harnessing the willingness of relatives and friends to donate by addressing the many barriers which serve as disincentives to living donation. Strategies designed to minimize financial barriers to donation and the use of paired kidney exchange programs are increasingly enabling donation, and now, an innovative program designed to address what has been termed “chronologically incompatible donation” is being piloted at the University of California, Los Angeles, and elsewhere in the United States. In this program, a person whose kidney is not currently required for transplantation in a specific recipient may instead donate to the paired exchange program; in return, a commitment is made to the specified recipient that priority access for a living-donor transplant in a paired exchange program will be offered when or if the need arises in the future. We address here potential ethical concerns related to this form of organ “banking” from living donors, and argue that it offers significant benefits without undermining the well-established ethical principles and values currently underpinning living donation programs. (shrink)

Transnational reproductive travel is symptomatic of insufficient supplies of reproductive resources, including donor gametes and gestational surrogacy services, and inequities in access to these within domestic health-care jurisdictions. Here, we argue that an innovative approach to domestic policy making using the framework of the National Self-Sufficiency paradigm represents the best solution to domestic challenges and the ethical hazards of the global marketplace in reproductive resources.

One of the areas of concern raised by cross-border reproductive travel regards the treatment of women who are solicited to provide their ova or surrogacy services to foreign consumers. This is particularly troublesome in the context of developing countries where endemic poverty and low standards for both medical care and informed consent may place these women at risk of exploitation and harm. We explore two contrasting proposals for policy development regarding the industry, both of which seek to promote ethical outcomes (...) and social justice: While one proposal advocates efforts to minimize cross-border demand for female reproductive resources through the pursuit of national self-sufficiency, the other defends cross-border trade as a means for meeting the needs of vulnerable groups. Despite the conflicting objectives of the proposed strategies, the paper identifies common values and points of agreement between the two, including the importance of regulations to safeguard those providing ova or surrogacy services. (shrink)

Volume 20, Issue 7, July 2020, Page 199-201.

National self-sufficiency in human biological materials such as blood and organs is now commonly invoked as a goal for healthcare policy makers. Despite its history as a strategic response to the ethical hazards of global trade in human blood, the ethical dimensions of the concept have been inadequately explored. This paper introduces self-sufficiency as an ethical paradigm for policy-making and explores some of the parallels found in Aristotle’s account of autarkeia in the polis. It highlights the ethico-political challenges of pursuing (...) self-sufficiency in culturally diverse societies and suggests that the motivation of donation through solidarity rather than the use of financial incentives is consistent with contemporary and ancient versions of the self-sufficiency model. (shrink)

Where a person is unable to make medical decisions for themselves, law and practice allows others to make decisions on their behalf. This is common at the end of a person’s life where decision-making capacity is often lost. A further, and separate, decision that is often considered at the time of death (and often preceding death) is whether the person wanted to act as an organ or tissue donor. However, in some jurisdictions, the lawful decision-maker for the donation decision (the (...) ‘donation decision-maker’) is different from the person who was granted decision-making authority for medical decisions during the person’s life. To date, little attention has been given in the literature to the ethical concerns and practical problems that arise where this shift in legal authority occurs. Such a change in decision-making authority is particularly problematic where premortem measures are suggested to maximise the chances of a successful organ donation. This paper examines this shift in decision-making authority and discusses the legal, ethical and practical implications of such frameworks. (shrink)

The Red Market: On the Trail of the World’s Organ Brokers, Bone Thieves, Blood Farmers, and Child Traffickers Content Type Journal Article Category Book Review Pages 1-3 DOI 10.1007/s11673-012-9361-3 Authors Dominique E. Martin, 39 Eltham Street, Flemington, 3031 Australia Journal Journal of Bioethical Inquiry Online ISSN 1872-4353 Print ISSN 1176-7529.

Uterus transplantation (UTx) research has been introduced in several countries, with trials in Sweden and the United States producing successful outcomes. The growing interest in developing UTx trials in other countries, such as Spain, the Netherlands, Japan, and Australia, raises important questions regarding the ethics of surgical innovation research in the field of UTx. This paper examines the current state of UTx in the context of the surgical innovation paradigm and IDEAL framework and discusses the ethical challenges faced by those (...) considering the introduction of new trials. We argue that UTx remains an experimental procedure at a relatively early stage of the IDEAL framework, especially in the context of de novo trials, where protocols are likely to deviate from those used previously and where researchers are likely to have limited experience of UTx. We conclude that countries considering the introduction of UTx trials should build on the strengths of the reported outcomes to consolidate the evidence base and shed light on the uncertainties of the procedure. Authorities responsible for the ethical governance of UTx trials are advised to draw on the ethical framework used in the oversight of surgical innovation. (shrink)

Mammalian synthetic biology holds the promise of providing novel therapeutic strategies, and the first success stories are beginning to be reported. Here we focus on the latest generation of mammalian transgene control devices, highlight state‐of‐the‐art synthetic gene network design, and cover prototype therapeutic circuits. These will have an impact on future gene‐ and cell‐based therapies and help bring drug discovery into a new era. The inventory of biological parts that are essential for life on this planet is becoming increasingly complete. (...) The postgenomic era has provided encyclopedic information on gene‐function correlations and systems biology is now delivering comprehensive details on the dynamics of biochemical reaction networks in living organisms. The time has come to reassemble these catalogued items and design new biological devices and systems with novel and useful functionality in a rational and systematic manner. This is the premise of synthetic biology, a constructive systems biology discipline likely to become the life science revolution of the 21st century. (shrink)

M. Buber, figure majeure de l'intelligentsia juive et européenne, a entretenu sa vie durant une immense correspondance. Propose une sélection de près de 200 lettres, des premiers échanges du jeune Buber avec Theodore Herzl, le fondateur du sionisme, jusqu'à l'année de sa mort en 1965. Sa correspondance montre qu'il a toujours souhaité un retour de la diaspora juive en Palestine.

The idea that intelligence is embedded not only in a single brain network, but instead in a complex, well-optimized system of complementary networks, has led to the development of whole brain network analysis. Using graph theory to analyze resting-state functional MRI data, we investigated the brain graph networks (or brain networks) of high intelligence quotient (HIQ) children. To this end, we computed the “hub disruption index κ”, an index sensitive to graph network modifications. We found significant topological differences in the (...) integration and segregation properties of brain networks in HIQ compared to standard IQ children, not only for the whole brain graph, but also for each hemispheric graph, and for the homotopic connectivity. Moreover, two profiles of HIQ children, homogenous and heterogeneous, based on the differences between the two main IQ subscales (verbal comprehension index (VCI) and perceptual reasoning index (PRI)), were compared. Brain networks changes were more pronounced in the heterogeneous HIQ than in the homogeneous HIQ subgroups. Finally, we found significant correlations between the graph networks’ changes and the full-scale IQ (FSIQ), as well as the subscales VCI and PRI. Specifically, the higher the FSIQ the greater was the brain organization modification in the whole brain, the left hemisphere, and the homotopic connectivity. These results shed new light on the relation between functional connectivity topology and high intelligence, as well as on different intelligence profiles. (shrink)

Dominique Janicaud claimed that every French intellectual movement—from existentialism to psychoanalysis—was influenced by Martin Heidegger. This translation of Janicaud’s landmark work, Heidegger en France, details Heidegger’s reception in philosophy and other humanistic and social science disciplines. Interviews with key French thinkers such as Françoise Dastur, Jacques Derrida, Éliane Escoubas, Jean Greisch, Philippe Lacoue-Labarthe, Jean-Luc Marion, and Jean-Luc Nancy are included and provide further reflection on Heidegger’s relationship to French philosophy. An intellectual undertaking of authoritative scope, this work furnishes (...) a thorough history of the French reception of Heidegger’s thought. (shrink)

This volume has 41 chapters written to honor the 100th birthday of Mario Bunge. It celebrates the work of this influential Argentine/Canadian physicist and philosopher. Contributions show the value of Bunge’s science-informed philosophy and his systematic approach to philosophical problems. The chapters explore the exceptionally wide spectrum of Bunge’s contributions to: metaphysics, methodology and philosophy of science, philosophy of mathematics, philosophy of physics, philosophy of psychology, philosophy of social science, philosophy of biology, philosophy of technology, moral philosophy, social and political (...) philosophy, medical philosophy, and education. The contributors include scholars from 16 countries. Bunge combines ontological realism with epistemological fallibilism. He believes that science provides the best and most warranted knowledge of the natural and social world, and that such knowledge is the only sound basis for moral decision making and social and political reform. Bunge argues for the unity of knowledge. In his eyes, science and philosophy constitute a fruitful and necessary partnership. Readers will discover the wisdom of this approach and will gain insight into the utility of cross-disciplinary scholarship. This anthology will appeal to researchers, students, and teachers in philosophy of science, social science, and liberal education programmes. 1. Introduction Section I. An Academic Vocation Section II. Philosophy Section III. Physics and Philosophy of Physics Section IV. Cognitive Science and Philosophy of Mind Section V. Sociology and Social Theory Section VI. Ethics and Political Philosophy Section VII. Biology and Philosophy of Biology Section VIII. Mathematics Section IX. Education Section X. Varia Section XI. Bibliography. (shrink)

This study examines the case of community resource mobilization within the context of a farmers market incentive program in Washington D.C., USA to illustrate the ways in which providing opportunities for people impacted by food inequities to develop and lead programming can help to promote food access. Through an analysis of interviews with 36 participants in the Produce Plus program, some of whom also served as paid staff and volunteers with the program, this study examines the ways that group-level social (...) interactions among program participants helped to ensure the program was accessible and accountable to the primarily Black communities that it serves. Specifically, we explore a particular set of social interactions, which we collectively term social solidarity, as a community-level form of social infrastructure that program volunteers and participants mobilized to support access to fresh, local food in their communities. We also examine the elements of the Produce Plus program that contributed to the flow of social solidarity within the program, providing insight into the ways in which the structure of food access programs can serve as a social conduit to facilitate or hinder the mobilization of community cultural resources like social solidarity. (shrink)

Droit et morale Sous la direction de Dominique Bureau, France Drummond et Dominique Fenouillet Véritable « pont aux ânes de la pédagogie juridique », la question des relations qu'entretiennent Droit et Morale appelle une réponse doctrinale presque invariable: la séparation de principe n'exclurait pas l'influence réciproque. Le droit contemporain semble pourtant traversé par deux courants a priori antinomiques: ici, la référence morale est invoquée comme une sorte de « tabou » qui justifierait le retrait du droit, alors que, (...) là, elle est appelée en renfort pour justifier telle solution ou fonder telle réforme. C'est de cette étrange coexistence du « retour offensif » et du « tabou » qu'est née l'idée d'organiser un colloque sur le thème « Droit et Morale. Aspects contemporains » en privilégiant une approche interdisciplinaire. Le 4 juin 2010, dans le cadre des journées d'étude qu'il consacre au pluralisme, le Laboratoire de sociologie juridique de l'Université Paris II accueillait donc les réflexions croisées d'Olivier Descamps, Dominique Fenouillet, Michel Germain, Valérie Malabat, Horatia Muir Watt, Cécile Pérès, Marc Pichard, Jean-Emmanuel Ray et Jean-Louis Sourioux. L'ouvrage ici présenté s'est enrichi des contributions supplémentaires d'Éric Martin-Hocquenghem et de Mustapha Mekki. Puisse cette publication contribuer à éclairer les relations singulières qu'entretiennent le Droit et la Morale. Contributeurs Olivier Descamps Dominique Fenouillet Michel Germain Valérie Malabat Éric Martin-Hocquenghem Mustapha Mekki Horatia Muir Watt Cécile Pérès Marc Pichard Jean-Emmanuel Ray Jean-Louis Sourioux. (shrink)

Martin Buber, sentinelle de l'humanité Martin Buber (1878-1965) est, avec Freud, Einstein ou Kafka, l'un des penseurs juifs les plus connus du XXe siècle dont il a vécu les tragiques bouleversements. Né à Vienne, ayant passé son enfance en Galicie et parcouru l'Europe dans sa jeunesse, il est vite devenu une figure majeure du judaïsme allemand et du premier sionisme. Installé à Jérusalem à partir de 1938, il s'imposera comme un penseur incontournable et sera invité dans le monde (...) entier. Son destin exceptionnel croise ceux de Herzl, Freud, Einstein, Rosenzweig, Kafka, Zweig, Scholem, Gandhi, Bachelard, Jung, Heidegger, Levinas, Ben Gourion et de tant d'autres, comme en témoigne sa correspondance foisonnante. Buber est non seulement un grand philosophe de l'altérité (Je et Tu), de la piété mystique (Les Récits hassidiques) et du dialogue judéo-chrétien (Deux types de foi), mais il est aussi le héraut infatigable d'un sionisme humaniste cherchant sans cesse la paix avec les Arabes, et un dénonciateur des totalitarismes hitlérien et stalinien. (shrink)

The focus on translational research in clinical trials has the potential to generate clinically relevant genetic data that could have importance to patients. This raises challenging questions about communicating relevant genetic research results to individual patients. An exploratory pharmacogenetic analysis was conducted in the international ovarian cancer phase III trial, AGO-OVAR 16, which found that patients with clinically important germ-line BRCA1/2 mutations had improved progression-free survival prognosis. Mechanisms to communicate BRCA results were evaluated, because these findings may be beneficial to (...) patients and their families. Communicating individual BRCA results was not anticipated during clinical trial design. Consequently, options were not available for patients to indicate their preference for receiving their individual results when they signed pharmacogenetic informed consent. Differences in local requirements, clinical practice, and opinion regarding the ethical aspects of how to convey genetic results to patients are all potential barriers to returning individual BRCA results to patients. Communicating the aggregate BRCA result from this study provided clinical investigators with a mechanism to disseminate the overall study finding to patients while taking individual circumstances, local guidelines and clinical practice into account. This study illustrates the importance of increasing the clarity and scope of informed consent and the need for patient engagement to ensure clinical trial participants can indicate their preference regarding receipt of potentially important individual pharmacogenetic results. This study was registered in the NCT Clinical Trial Registry under NCT00866697 on March 19, 2009, following approval from participating ethics committees. (shrink)

La première version du livre de Martine Sonnet, publié en 1987 par les éditions du Cerf, était épuisée depuis des années. Sa réimpression en format poche par le même éditeur, plus de vingt ans après, répond à une nécessité compte tenu de son caractère incontournable pour tous ceux, chercheur.es, étudiant.es mais aussi public plus large, qui s’intéressent à l’éducation des filles à l’époque moderne. Ce livre, issu de la thèse de troisième cycle de l’auteure, se distingue à plus d’un titre (...) dans... (shrink)

Janicaud draws a firm connection between Heidegger's philosophical position and his political engagement. He thus goes beyond those writers who attempt to handle the issue of Heidegger's Nazism simply on the level of his personal political judgment, in isolation from his philosophy, by attempting to distinguish rigorously between Heidegger the thinker and Heidegger the man.

Depuis la seconde guerre mondiale, l'État fédéral canadien a été gouverné à sept reprises par des équipes sans majorité au parlement : en 1957, 1962, 1963, 1965, 1972, 1979 et 2004. Dans cette étude nous avons retenu deux cas : celui du gouvernement Trudeau 1972-1974 et celui du gouvernement Martin 2004 parce que dans ces deux cas, le même parti et le même chef ont assumé le pouvoir en situation majoritaire et en situation minoritaire. Le vocabulaire caractéristique de ces (...) deux équipes est mis en lumière grâce au calcul des 'spécificités du vocabulaire'. On présente ce calcul en détail : utilisation de la loi hypergéométrique et pondération en fonction de la catégorie grammaticale du mot étudié. Il apparaît que le discours gouvernemental minoritaire est nettement impersonnel ; il sous-utilise les verbes et se réfugie dans un catalogue d'actions de court terme. (shrink)

Janicaud clarifies the project of “overcoming” metaphysics, a project that Heidegger himself recognized as open to innumerable misunderstandings, and Mattei inquires into the major Heideggerian texts produced between 1935 and 1969 to detect the cosmic figure of the Geviert, the initial Fourfold where “earth and sky, the divine ones and the mortals” gather.

Machine generated contents note: 1. -- War on war, by Lewis Thomas -- 2. -- Silent genocide, by Abdus Salam -- 3. -- Error: a stage of knowledge, by Paulo Freire -- 4. -- Doing without a revolution?, by Tahar Ben Jelloun -- 5. -- Stop torture, by Manfred Nowak -- 6. -- Truth, force and law, by Rabindranath Tagore -- 7. -- Violence is an insult to the human being, by Federico Mayor -- 8. -- Totalitarianism banishes politics, by (...) Vaclav Havel -- 9. -- No one will stop us. , by Desmond Tutu -- 10. -- Colonialism and the youth bomb, by Joseph Ki-Zerbo -- 11. -- The shedding of blood -- 12. -- Letter from Nagasaki, by Takashi Nagai -- 13. -- Down with exclusion!, by Herbert de Souza -- 14. -- The nower to sav 'no'. bv loan Martin-Brown -- 15. -- Inquiry into a taboo, by Ouassila Si Saber -- 16. -- The illusions of rationalism, by Ernesto Sabato -- 17. -- The 'poisonous weed', by Ba Jin -- 18. -- Humanity, an ongoing creation, by Ali Ahmad Said Esber (Adonis) -- 19. -- Image, writing and the vandal, by Alberto Moravia -- 20. -- The charms of calumny, by Andres Bello -- 21. -- On the threshold of eternity, by the Abbe Pierre -- 22. -- The control of force, by Karl Jaspers -- 23. -- The nature of force, by Simone Weil -- 24. -- The debt of justice, by Martin Luther King -- 25. -- Democracy and barbarism, by Sergei S. Averintsev -- 26. -- If all the animals should disappear, by Richard Fitter -- 27. -- Irony and compassion, by Octavio Paz -- 28. -- Against all hatred, by Aime Cesaire -- 29. -- Creating differences, by Daniel J. Boorstin -- 30. -- I dislike the word 'tolerance', by Mahatma Gandhi. (shrink)

A «proto-história» do livro e a história da imprensa foram sobretudo assuntos dos bibliófi­los, dos bibliográficos e dos historiadores da literatura, ou seja, de especialistas ambicionando defender uma identidade, ou de distinguir, na massa da produção impressa ao longo dos sécu­los, o raro, o monumental, o anedótico, o literário... A partir de meados do século XX c com Apparition du Livre (1a Ed. 1958) de Lucien Febvre et Henri-Jean Martin, a história do livro, usufruindo dos desenvolvimentos da sociologia histórica (...) e de conceitos como o de «história das mentalidades», constituiu-se como disciplina pioneira. Com trabalhos como Histoire de l'édition française (1982-1986), Histoire des bibliothèques françaises (1988-1992), Diction­naire encyclopédique du livre (2002 -...) e outros projectos similares quer na Europa, quer além dela, o livro foi reposicionado, quer quanto à sua produção, quer quanto às práticas associadas, num vasto contexto económico, social, político e cultural. Ao mesmo tempo, as interrogações levantadas pela história do livro foram ao encontro da história da comunicação social e dos media, que hoje se tornaram dominantes. (shrink)

Lire Heidegger, c'est relire autrement tout ce que nous lisons. Ce Cahier invite à mieux comprendre la pensée heideggérienne autours des thèmes principaux qu'il aborde.Des essais, témoignages et lettres retracent l'impacte de sa pensée dans la culture moderne.Textes de : Walter Biemel, Hans-Georg Gadamer, Ernst Jünger, Roger Munier, Carl Friedrich von Weizsäcker, Herbert Marcuse, Jean-Luc Marion, John Sallis, David Farrel Krell, Jean-François Courtine, Jean Beauffret, Dominique Janicaud, Otto Pöggeler, Jean-Louis Chrétien, Jean-Pierre Charcosset, F. Wybrands, Jacques Taminiaux, Hubert L. Dreyfus, (...) Marc Froment-Meurice, Jean-Michel Palmier, Reiner Schürmann, Jean-Marie Vaysse, Henri Birault, Jacques Derrida, Gérard Granel, Daniel Charles, Gabriel Liiceanu, Jean Greisch, René Gonner.Contient un choix de textes de Heidegger. (shrink)