The majority of the studies underlined how adolescent and young adult Cancer Survivors had no significant differences in their well-being and quality of life compared with a control group of healthy counterparts, although French et al. found less years of education among cancer survivors. The present study aimed at comparing AYA cancer survivors and a control group of peers who had no history of serious illness, in terms of well-being, cognitive functioning, and perceptions of life. Participants in this study were (...) 205 AYA cancer survivors, 126 males, off therapy from a mean of 10.87 years, with a mean age of 18.96, recruited during follow-up visits and healthy counterparts, matched for age and gender. They all completed self-report questionnaires: Ladder of Life, BSI-18 and Cognitive problems. Paired t test evidenced significant differences between survivors and controls in perceptions of quality of life regarding 5 years before the current time [t = −3.39; p = 0.001], with a lower level for childhood cancer survivors. Specifically, Hierarchical regression identified a shorter time since the completion of treatment and a trend of stem cell transplantation experience as factors associated with negative perception of precedent quality of life. The AYA cancer survivors reported lower cognitive difficulties than controls [t = −3.41; p = 0.001]: in memory [t = −4.52; p = 0.001], in concentration [t = −4.66; p = 0.001] and in mental organization skills [t = −2.56; p = 0.01], even if they had a lower educational attainment [X2 = 131.28; p = 0.001]. They showed similar satisfaction with their psychological well-being and their lives as healthy counterparts, except for past life perceptions associated with the cancer period. Important recommendations for future research and clinical suggestions could be given. (shrink)