The human spindle and kinetochore associated complex is required for proper mitotic progression. Extensive studies have demonstrated its important functions in both stable kinetochore-microtubule interactions and spindle checkpoint silencing. We suggest a model to explain how various Ska functions might be fulfilled by distinct pools of Ska at kinetochores. The Ndc80-loop pool of Ska is recruited by the Ndc80 loop, or together with some of its flanking sequences, and the recruitment is also dependent on Cdk1-mediated Ska3 phosphorylation. This pool seems (...) to play a more important role in silencing the spindle checkpoint than stabilizing kinetochore-microtubule interactions. In contrast, the Ndc80-N-terminus pool of Ska is recruited by the N-terminal domains of Ndc80 and appears to be more important for stabilizing kinetochore-microtubule interactions. Here, we review and discuss the evidence that supports this model and suggest further experiments to test the functioning mechanisms of the Ska complex. The human spindle and kinetochore associated complex plays essential functions in proper mitotic progression by promoting stable kinetochore-microtubule interactions and spindle checkpoint silencing. We propose that “distinct pools” of Ska—the Ndc80-loop and Ndc80-N-terminus pools—might fulfill these various functions. (shrink)
Aristotle ’s claim that we become virtuous by doing virtuous actions raises a familiar problem: How can we perform virtuous actions unless we are already virtuous? I reject deflationary accounts of the answer given in _Nicomachean Ethics_ 2.4 and argue instead that proper habituation involves doing virtuous actions with the right motive, i.e. for the sake of the noble, even though learners do not yet have virtuous dispositions. My interpretation confers continuity to habituation and explains in a non-mysterious way how (...) we become virtuous by doing virtuous actions in the right way. (shrink)
I sitt berömda bevis för tidens overklighet påstod McTaggart att det sätt händelser tycks skifta position i tiden från framtid till nutid och till förfluten tid, innebär en motsägelse. Vad McTaggart egentligen menade har varit föremål för en livlig debatt ända sedan beviset först publicerades 1908. Beviset består av två delar. I den första argumenterar McTaggart för att ingenting kan förändras förutom genom att övergå från framtid till förfluten tid. I den andra argumenterar han för att en sådan övergång innebär (...) en motsägelse och att det därför inte kan finnas någon förändring överhuvudtaget, vilket i sin tur innebär att det heller inte finns någon tid. De flesta filosofer är i dag eniga om att McTaggart har fel, men oeniga om på vilket sätt han har fel. Olika filosofer förkastar olika delar av beviset, beroende på om de har vad som kallas en A- eller B-uppfattning av tiden. De som har en A-uppfattning förnekar att tid förstådd som övergång från framtid till förfluten tid är motsägelsefull. De som har en B-uppfattning förnekar att en övergång från framtid till förfluten tid är nödvändig för förändring, men håller med om att sådan övergång är motsägelsefull. Det är min uppfattning att denna oenighet beror på att McTaggarts argument från första början blivit missuppfattat, av både A- och B-teoretiker. Av någon anledning har det alltid betraktats som ett självständigt argument, ett som är oberoende av det ontologiska system McTaggart förespråkade. Jag föreslår ett nytt sätt att förstå hur han menade att tiden är motsägelsefull. Ett sätt som tar hans ontologiska system som utgångspunkt. (shrink)
In this paper we introduce two issues relevantly related to the cognitive phenomenology debate, which, to our minds, have not been yet properly addressed: the relation between access and phenomenal consciousness in cognition and the relation between conscious thought and inner speech. In the first case, we ask for an explanation of how we have access to thought contents, and in the second case, an explanation of why is inner speech so pervasive in our conscious thinking. We discuss the prospects (...) of explanation for both sides of the debate and argue that cognitive phenomenology defenders are in an overall advantageous position. We also propose an account of inner speech that differs from other influential explanations in some interesting respects. (shrink)
There is currently a consensus among comparative psychologists that nonhuman animals are capable of some forms of mindreading. Several philosophers and psychologists have criticized this consensus, however, arguing that there is a “logical problem” with the experimental approach used to test for mindreading in nonhuman animals. I argue that the logical problem is no more than a version of the general skeptical problem known as the theoretician’s dilemma. As such, it is not a problem that comparative psychologists must solve before (...) providing evidence for mindreading. (shrink)
Cancer research is experiencing ‘paradigm instability’, since there are two rival theories of carcinogenesis which confront themselves, namely the somatic mutation theory and the tissue organization field theory. Despite this theoretical uncertainty, a huge quantity of data is available thanks to the improvement of genome sequencing techniques. Some authors think that the development of new statistical tools will be able to overcome the lack of a shared theoretical perspective on cancer by amalgamating as many data as possible. We think instead (...) that a deeper understanding of cancer can be achieved by means of more theoretical work, rather than by merely accumulating more data. To support our thesis, we introduce the analytic view of theory development, which rests on the concept of plausibility, and make clear in what sense plausibility and probability are distinct concepts. Then, the concept of plausibility is used to point out the ineliminable role played by the epistemic subject in the development of statistical tools and in the process of theory assessment. We then move to address a central issue in cancer research, namely the relevance of computational tools developed by bioinformaticists to detect driver mutations in the debate between the two main rival theories of carcinogenesis. Finally, we briefly extend our considerations on the role that plausibility plays in evidence amalgamation from cancer research to the more general issue of the divergences between frequentists and Bayesians in the philosophy of medicine and statistics. We argue that taking into account plausibility-based considerations can lead to clarify some epistemological shortcomings that afflict both these perspectives. (shrink)
Some presuppositions are easier to cancel than others in embedded contexts. This contrast has been used as evidence for distinguishing two fundamentally different kinds of presuppositions, ‘soft’ and ‘hard’. ‘Soft’ presuppositions are usually assumed to arise in a pragmatic way, while ‘hard’ presuppositions are thought to be genuine semantic presuppositions. This paper argues against such a distinction and proposes to derive the difference in cancellation from inherent differences in how presupposition triggers interact with the context: their focus sensitivity, anaphoricity, and (...) question–answer congruence properties. The paper also aims to derive the presuppositions of additive particles such as too, also, again, and of it-clefts. (shrink)
In what ways and how far does virtue shield someone against suffering evils? In other words, how do non-moral evils affect the lives of virtuous people and to what extent can someone endure evils while staying happy? The central purpose of this chapter is to answer these questions by exploring what Aristotle has to say about the effects of evils in human well-being in general and his treatment of extreme misfortunes.
This article presents two ways of contributing to the debate on cognitive phenomenology. First, it is argued that cognitive attitudes have a specific phenomenal character or attitudinal cognitive phenomenology and, second, an element in cognitive experiences is described, i.e., the horizon of possibilities, which arguably gives us more evidence for cognitive phenomenology views.
This book presents a novel interpretation of Aristotle's account of how shame instils virtue, and defends its philosophical import. Shame is shown to provide motivational continuity between the actions of the learners and the virtuous dispositions that they will eventually acquire.
ABSTRACTFinance may suffer from institutional deformations that subordinate its distinctive goods to the pursuit of external goods, but this should encourage attempts to reform the institutionalization of finance rather than to reject its potential for virtuous business activity. This article argues that finance should be regarded as a domain-relative practice. Alongside management, its moral status thereby varies with the purposes it serves. Hence, when practitioners working in finance facilitate projects that create common goods, it allows them to develop virtues. This (...) argument applies MacIntyre’s widely acknowledged account of the relationship between practices and the development of virtues while questioning some of his claims about finance. It also takes issue with extant accounts of particular financial functions that have failed to identify the distinctive goods of financial practice. (shrink)
The central idea behind this paper is that presuppositions of soft triggers arise from the way our attention structures the informational content of a sentence. Some aspects of the information conveyed are such that we pay attention to them by default, even in the absence of contextual information. On the other hand, contextual cues or conversational goals can divert attention to types of information that we would not pay attention to by default. Either way, whatever we do not pay attention (...) to, be it by default, or in context, is what ends up presupposed by soft triggers. This paper attempts to predict what information in the sentence is likely to end up being the main point (i.e. what we pay attention to) and what information is independent from this, and therefore likely presupposed. It is proposed that this can be calculated by making reference to event times. The notion of aboutness used to calculate independence is based on that of Demolombe and Fariñas del Cerro (In: Holdobler S (ed) Intellectics and computational logic: papers in honor of Wolfgang Bibel, 2000). (shrink)
This introduction presents a state of the art of philosophical research on cognitive phenomenology and its relation to the nature of conscious thinking more generally. We firstly introduce the question of cognitive phenomenology, the motivation for the debate, and situate the discussion within the fields of philosophy, cognitive psychology and consciousness studies. Secondly, we review the main research on the question, which we argue has so far situated the cognitive phenomenology debate around the following topics and arguments: phenomenal contrast, epistemic (...) arguments and challenges, introspection, ontology and temporal character, intentionality, inner speech, agency, holistic perspective, categorical perception, value, and phenomenological description. Thirdly, we suggest future developments by pointing to four questions that can be explored in relation to the cognitive phenomenology discussion: the self and self-awareness, attention, emotions and general the... (shrink)
Hélène Cixous is more than an influential theorist. She is also a groundbreaking author and playwright. Combining an idiosyncratic mix of autobiographical and fictional narrative with a host of philosophical and poetic observations, Cixous's writing matches the kaleidoscopic nature of her thought, offering new ways of conceptualizing sex, relationships, identity, and the self, among other topics. Yet, as Jacques Derrida once observed, a "profound misunderstanding" hangs over the accomplishments of Cixous, with many believing the intellectual excelled only at theoretical exploration. (...) Providing a truly liberal selection of her writings from throughout her career, Marta Segarra rediscovers Cixous's acts of invention for a new generation to enjoy. Divided into thematic concerns, these works fully capture Cixous's genius for merging fiction, theory, and the experience of living. They discuss dreaming in the feminine, Algeria and Germany, love and the other, the animal, Derrida, and the theater. They defy classification, locking literature, philosophy, and psychoanalysis into thrilling new patterns of engagement. Whether readers are familiar with Cixous or are approaching her thought for the first time, all will find fresh perspectives on gender, fiction, drama, philosophy, religion, and the postcolonial. (shrink)
In this paper I show that a novel ontic reading of explanation, intending to capture the de re essential features of individuals, can support the qualitative view of individual essences. It is argued further that the putative harmful consequences of the Leibniz Principle and its converse for the qualitative view can be avoided, provided that individual essences are not construed in the style of the naïve bundle theory with set-theoretical identity- conditions. Adopting either the more sophisticated two-tier BT or, alternatively, (...) the neo-Aristotelian position of taking essences as natures in the Aristotelian sense, can help to evade these main charges against the qualitative view. The functional parallels with the alternative haecceitistic view of individuation and individual essence will also be considered. (shrink)
A complete, illustrated survey of Etienne-Jules Marey's work that investigates the far reaching effects of her inventions on stream-of-consciousness literature, psychoanalysis, Bergsonian philosophy, and the art of cubists and futurists.
Advance directives have been hailed for two decades as the best way to safeguard patients’ autonomy when they are totally or partially incompetent. In many national contexts they are written into law and they are mostly associated with end-of-life decisions. Although advocates and critics of ADs exchange relevant empirical and theoretical arguments, the debate is inconclusive. We argue that this is so for good reasons: the ADs’ project is fraught with tensions, and this is the reason why they are both (...) important and deeply problematic. We outline six such tensions, and conclude with some positive suggestions about how to better promote patients’ autonomy in end-of-life decision. We argue that ADs should continue to be an option but they cannot be the panacea that they are expected to be. (shrink)
This paper aims to differentiate between lying and irony, typically addressed independently by philosophers and linguists, as well as to discuss the cases when deception co-occurs with, and capitalises on, irony or metaphor. It is argued that the focal distinction can be made with reference to Grice’s first maxim of Quality, whose floutings lead to overt untruthfulness, and whose violations result in covert untruthfulness. Both types of untruthfulness are divided into explicit and implicit subtypes depending on the level of meaning (...) on which they are manifest. Further, it is shown that deception may be based on irony or metaphor, which either promote deceptive implicatures or are deployed covertly. Finally, some argumentation is provided in favour of why these cases of deceiving can be conceptualised as lying. (shrink)
Proof-theoretic methods are developed for subsystems of Johansson’s logic obtained by extending the positive fragment of intuitionistic logic with weak negations. These methods are exploited to establish properties of the logical systems. In particular, cut-free complete sequent calculi are introduced and used to provide a proof of the fact that the systems satisfy the Craig interpolation property. Alternative versions of the calculi are later obtained by means of an appropriate loop-checking history mechanism. Termination of the new calculi is proved, and (...) used to conclude that the considered logical systems are PSPACE-complete. (shrink)
This paper examines a little studied type of perspective shift that I call protagonist projection, following Holton :625–628, 1997). PP is a way of describing the mental state of a protagonist that conveys, to some extent, her perspective. Similarly to its better known cousin free indirect discourse, the shift in perspective is achieved without an overt operator. Unlike FID, PP is not based on a presumed speech-act of a protagonist. Rather, it gives a linguistic form to pre-verbal perceptual content, sensations, (...) feelings or implicit beliefs. I propose to analyse PP in a bi-contextual framework, extending Eckardt’s approach to FID. Under the resulting analysis, FID and PP are two instances of a more general category of perspective shift. (shrink)
Remembering and forgetting are the two poles of the memory system. Consequently, any approach to memory should be able to explain both remembering and forgetting in order to gain a comprehensive and insightful understanding of the memory system. Can an enactive approach to memory processes do so? In this article I propose a possible way to provide a positive answer to this question. In line with some current enactive approaches to memory, I suggest that forgetting –similarly to remembering– might be (...) constituted within an embodied and active process. Within this process, some simulation and re-enactment paths would acquire more relevance than others. This acquired relevance would make the activation of other paths of recall less likely, thus preventing the memory system from engaging in some episodic simulations. These changes in the likelihood of activation of some paths of recall –the forgotten ones– can be accounted for in an enactive fashion by studying both “internal” and “external” re-enactment and simulation paths. With regard to the latter, I propose to examine the process of forgetting by considering the engagement and affective relation of an embodied agent with her field of affordances. I suggest that, in the case of emotion-laden memories, the agent’s decoupling from some affordances of the environment might contribute to the process of forgetting, in that it would reduce the agent’s opportunities for situated episodic simulations. (shrink)
The specific role of empeiria in Aristotle’s ethics has received much less attention than its role in his epistemology, despite the fact that Aristotle explicitly stresses the importance of empeiria as a requirement for the receptivity to ethical arguments and as a source for the formation of phronêsis.1 Thus, while empeiria is an integral part of all explanations that scholars give of the Aristotelian account of the acquisition of technê and epistêmê, it is usually not prominent in explanations of the (...) acquisition of phronêsis.2 The abundant mentions of empeiria in Aristotle’s ethical treatises are often eclipsed in the secondary literature... (shrink)
This paper explores the relation of thought and the stream of consciousness in the light of an ontological argument raised against cognitive phenomenology views. I argue that the ontological argument relies on a notion of ‘processive character’ that does not stand up to scrutiny and therefore it is insufficient for the argument to go through. I then analyse two more views on what ‘processive character’ means and argue that the process-part account best captures the intuition behind the argument. Following this (...) view, I reconstruct the ontological argument and argue that it succeeds in establishing that some mental episodes like judging, understanding and occurrent states of thought do not enter into the stream but fails to exclude episodes like entertaining. Contrary to what it might seem, this conclusion fits well with cognitive phenomenology views, given that, as I show, there is a way for non-processive mental episodes to be fundamentally related to processive ones, such that they cannot be excl.. (shrink)
This philosophical-pragmatic paper discusses several forms of irony which rest on other figures of speech contingent on overt untruthfulness, namely the figures arising as a result of flouting the first maxim of Quality. It is argued that an ironic implicature may be piggybacked on another implicature, called “as if implicature”, originating from flouting the first maxim of Quality occasioned by metaphor. Metaphorical irony, which is subject to the irony-after-metaphor order of interpretation, exhibits a number of manifestations depending on the nature (...) and scope of irony, and the scope of the subordinate metaphor. On the other hand, rather than giving rise to an as if implicature distinct from the irony-based one, hyperbole and meiosis, which are inherently evaluative, most typically overlap with ironically evaluative expressions, promoting meiotic and hyperbolic irony, frequently considered by researchers to rely on flouting Quantity maxims. However, cases of independent use of hyperbole or meiosis in ironic environment are also possible. Such invite two levels of untruthfulness and two implicatures. (shrink)
How should we characterize the nature of conscious occurrent thought? In the last few years, a rather unexplored topic has appeared in philosophy of mind: cognitive phenomenology or the phenomenal character of cognitive mental episodes. In this paper I firstly present the motivation for cognitive phenomenology views through phenomenal contrast cases, taken as a challenge for their opponents. Secondly, I explore the stance against cognitive phenomenology views proposed by Restrictivism, classifying it in two strategies, sensory restrictivism and accompanying states. On (...) the one hand, I problematize the role of attention adopted by sensory restrictivism and I present and discuss in detail an argument that defends the limitation of sensory phenomenology so as to explain the distinction between visual and cognitive mental episodes on the basis of immediate experience. On the other hand, I address accompanying states views by discussing the empirical studies of Hurlburt et al. (2006, 2008) that defend the existence of “unsymbolized thinking”. I present how they can be construed as evidence for cognitive phenomenology views and I dispel some problems that have been raised against its acceptance. I thus conclude that cognitive phenomenology views hold up well against the restrictivist positions considered. (shrink)
In the last few decades, philosophy of science has increasingly focused on multilevel models and causal mechanistic explanations to account for complex biological phenomena. On the one hand, biological and biomedical works make extensive use of mechanistic concepts; on the other hand, philosophers have analyzed an increasing range of examples taken from different domains in the life sciences to test—support or criticize—the adequacy of mechanistic accounts. The article highlights some challenges in the elaboration of mechanistic explanations with a focus on (...) cancer research and neuropsychiatry. It jointly considers fields, which are usually dealt with separately, and keeps a close eye on scientific practice. The article has a twofold aim. First, it shows that identification of the explananda is a key issue when looking at dynamic processes and their implications in medical research and clinical practice. Second, it discusses the relevance of organizational accounts of mechanisms, and questions whether thorough self-sustaining mechanistic explanations can actually be provided when addressing cancer and psychiatric diseases. While acknowledging the merits of the wide ongoing debate on mechanistic models, the article challenges the mechanistic approach to explanation by discussing, in particular, explanatory and conceptual terms in the light of stances from medical cases. (shrink)
The article addresses the problem of disability in the context of reproductive decisions based on genetic information. It poses the question of whether selective procreation should be considered as a moral obligation of prospective parents. To answer this question, a number of different ethical approaches to the problem are presented and critically analysed: the utilitarian; Julian Savulescu's principle of procreative beneficence; the rights-based. The main thesis of the article is that these approaches fail to provide any appealing principles on which (...) reproductive decisions should be based. They constitute failures of imagination which may result in counter-intuitive moral judgments about both life with disability and genetic selection. A full appreciation of the ethical significance of recognition in procreative decisions leads to a more nuanced and morally satisfying view than other leading alternatives presented in the article. (shrink)
We investigate uniform interpolants in propositional modal logics from the proof-theoretical point of view. Our approach is adopted from Pitts’ proof of uniform interpolationin intuitionistic propositional logic . The method is based on a simulation of certain quantifiers ranging over propositional variables and uses a terminating sequent calculus for which structural rules are admissible.
This paper proposes a new explanation for the oddness of presuppositional and negative islands, as well as the puzzling observation that these islands can be obviated by certain quantificational elements. The proposal rests on two independently motivated assumptions: (i) the idea that the domain of manners contains contraries and (ii) the notion that degree expressions range over intervals. It is argued that, given these natural assumptions, presuppositional and negative islands are predicted to lead to a presupposition failure in any context.
Grounding is typically associated to metaphysical explanation on the basis of the explanatory role’s being characteristic of grounding as well. Some even say that all what metaphysical explanation does is tracking the grounding relation. However, recently Maurin has argued that grounding does not “inherit” its properties from metaphysical explanation and, consequently, we should be “separatists”. In this paper separatism will be defended from the perspective of metaphysical explanation thus giving a turn to the separatist strategy. In particular, the structural difference (...) between grounding and metaphysical explanation will be pointed out as affecting also the explanatory function. It will be shown how dispositions and essentialist claims play different roles in the two theories. Lastly, it will be claimed that the two theories diverge on accounting for law-like and accidental generalizations. Provided these arguments are sound, there will be good reason to tell metaphysical explanation apart from grounding. (shrink)