Results for 'Mark R. Cookson'

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  1.  27
    Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, α‐synuclein, and tau.Jean-Marc Taymans & Mark R. Cookson - 2010 - Bioessays 32 (3):227-235.
    Parkinson's disease (PD) is generally sporadic but a number of genetic diseases have parkinsonism as a clinical feature. Two dominant genes, α‐synuclein (SNCA) and leucine‐rich repeat kinase 2 (LRRK2), are important for understanding inherited and sporadic PD. SNCA is a major component of pathologic inclusions termed Lewy bodies found in PD. LRRK2 is found in a significant proportion of PD cases. These two proteins may be linked as most LRRK2 PD cases have SNCA‐positive Lewy bodies. Mutations in both proteins are (...)
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  2.  88
    Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.Günter U. Höglinger, Nadine M. Melhem, Dennis W. Dickson, Patrick M. A. Sleiman, Li-San Wang, Lambertus Klei, Rosa Rademakers, Rohan de Silva, Irene Litvan, David E. Riley, John C. van Swieten, Peter Heutink, Zbigniew K. Wszolek, Ryan J. Uitti, Jana Vandrovcova, Howard I. Hurtig, Rachel G. Gross, Walter Maetzler, Stefano Goldwurm, Eduardo Tolosa, Barbara Borroni, Pau Pastor, P. S. P. Genetics Study Group, Laura B. Cantwell, Mi Ryung Han, Allissa Dillman, Marcel P. van der Brug, J. Raphael Gibbs, Mark R. Cookson, Dena G. Hernandez, Andrew B. Singleton, Matthew J. Farrer, Chang-En Yu, Lawrence I. Golbe, Tamas Revesz, John Hardy, Andrew J. Lees, Bernie Devlin, Hakon Hakonarson, Ulrich Müller & Gerard D. Schellenberg - unknown
    Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...)
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  3.  6
    Multiculturalism and Moral Conflict.Maria Dimova-Cookson & Peter M. R. Stirk (eds.) - 2009 - Routledge.
    Multiculturalism is higher on the daily political agenda than it has ever been. Leading politicians and public commentators speak with an unparalleled bluntness about the perceived limitations of multiculturalism while representatives of cultural, minorities express concern about marginalisation. This debate is taking place against a background of fear about terrorism, the integrity of national identities and a loosely construed ‘clash of civilizations’. Secularism is pitted against religious fundamentalism, respect for difference against the right of freedom of speech, integration against self-determination, (...)
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  4.  7
    Jurisprudence: readings and cases.Mark R. MacGuigan - 1963 - Toronto]: University of Toronto Press.
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  5. Conscientious objection in medicine.Mark R. Wicclair - 2024 - New York, NY: Cambridge University Press.
    What is conscientious objection? -- Should conscientious objectors be accommodated? -- Assessing objectors' beliefs and reasons -- Accommodation and conscientious provision.
     
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  6. Law, morals and natural law.Mark R. MacGuigan - 1961 - [n.p.]:
     
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  7. Conscientious Objection in Health Care: An Ethical Analysis.Mark R. Wicclair - 2011 - Cambridge: Cambridge University Press.
    Historically associated with military service, conscientious objection has become a significant phenomenon in health care. Mark Wicclair offers a comprehensive ethical analysis of conscientious objection in three representative health care professions: medicine, nursing and pharmacy. He critically examines two extreme positions: the 'incompatibility thesis', that it is contrary to the professional obligations of practitioners to refuse provision of any service within the scope of their professional competence; and 'conscience absolutism', that they should be exempted from performing any action contrary (...)
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  8. Handbook of Self and Identity.Mark R. Leary & June Price Tangney (eds.) - 2003 - Guilford Press.
    This state-of-the-science volume brings together an array of leading authorities to comprehensively review theory and research in this burgeoning area.
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  9.  82
    Integrating evidence into clinical practice: an alternative to evidence‐based approaches.Mark R. Tonelli - 2006 - Journal of Evaluation in Clinical Practice 12 (3):248-256.
    Evidence-based medicine (EBM) has thus far failed to adequately account for the appropriate incorporation of other potential warrants for medical decision making into clinical practice. In particular, EBM has struggled with the value and integration of other kinds of medical knowledge, such as those derived from clinical experience or based on pathophysiologic rationale. The general priority given to empirical evidence derived from clinical research in all EBM approaches is not epistemically tenable. A casuistic alternative to EBM approaches recognizes that five (...)
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  10. In the Name of Liberty: An Argument for Universal Unionization.Mark R. Reiff - 2020 - Cambridge, UK: Cambridge University Press.
    For years now, unionization has been under vigorous attack. Membership has been steadily declining, and with it union bargaining power. As a result, unions may soon lose their ability to protect workers from economic and personal abuse, as well as their significance as a political force. In the Name of Liberty responds to this worrying state of affairs by presenting a new argument for unionization, one that derives an argument for universal unionization in both the private and public sector from (...)
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  11. Left Libertarianism for the Twenty-First Century.Mark R. Reiff - 2023 - Journal of Social and Political Philosophy 2 (2):191-211.
    There are many different kinds of libertarianism. The first is right libertarianism, which received its most powerful expression in Robert Nozick’s Anarchy, State and Utopia (1974), a book that still sets the baseline for discussions of libertarianism today. The second, I will call faux libertarianism. For reasons I will explain in this paper, most ‘man-on-the-street’ libertarians and most politicians who claim to be libertarians are actually this kind of libertarian. And third, there is left libertarianism, which is what I shall (...)
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  12. Exploitation and Economic Justice in the Liberal Capitalist State.Mark R. Reiff - 2013 - Oxford University Press.
    Exploitation and Economic Justice in the Liberal Capitalist State offers the first new, liberal theory of economic justice to appear in more than 30 years. The theory presented is designed to offer an alternative to the most popular liberal egalitarian theories of today and aims to be acceptable to both right and left libertarians too.
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  13.  53
    The self as an organizing construct in the behavioral and social sciences.Mark R. Leary & June Price Tangney - 2003 - In Mark R. Leary & June Price Tangney (eds.), Handbook of Self and Identity. Guilford Press.
  14.  62
    The challenge of evidence in clinical medicine.Mark R. Tonelli - 2010 - Journal of Evaluation in Clinical Practice 16 (2):384-389.
  15. Conscientious objection in medicine.Mark R. Wicclair - 2000 - Bioethics 14 (3):205–227.
    Recognition of conscientious objection seems reasonable in relation to controversial and contentious issues, such as physician assisted suicide and abortion. However, physicians also advance conscience‐based objections to actions and practices that are sanctioned by established norms of medical ethics, and an account of their moral force can be more elusive in such contexts. Several possible ethical justifications for recognizing appeals to conscience in medicine are examined, and it is argued that the most promising one is respect for moral integrity. It (...)
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  16.  16
    Developing a Triage Protocol for the COVID-19 Pandemic: Allocating Scarce Medical Resources in a Public Health Emergency.Mark R. Mercurio, Mark D. Siegel, John Hughes, Ernest D. Moritz, Jennifer Kapo, Jennifer L. Herbst, Sarah C. Hull, Karen Jubanyik, Katherine Kraschel, Lauren E. Ferrante, Lori Bruce, Stephen R. Latham & Benjamin Tolchin - 2020 - Journal of Clinical Ethics 31 (4):303-317.
    The coronavirus disease-2019 (COVID-19) has caused shortages of life-sustaining medical resources, and future waves of the virus may cause further scarcity. The Yale New Haven Health System developed a triage protocol to allocate scarce medical resources during the COVID-19 pandemic, with the primary goal of saving the most lives possible, and a secondary goal of making triage assessments and decisions consistent, transparent, and fair. We outline the process of developing the protocol, summarize the protocol, and discuss the major ethical challenges (...)
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  17. The libertarian argument for reparations.Mark R. Reiff - 2024 - Journal of Social Philosophy:1-30.
    The case for reparations for grievous acts of historical injustice has been getting a lot of attention lately. But I aim to broaden the discussion in two ways. First, I am not only going to talk about reparations as a means of rectifying the injuries inflicted by slavery and the genocide of indigenous peoples, the theft of their land, and the ongoing ripple effects of these historic wrongs. I am also going to talk about reparations for a wider variety of (...)
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  18. Can Liberal Capitalism Survive?Mark R. Reiff - 2021 - The GCAS Review 1 (1):1-46.
    For a long time, economic growth has been seen as the most promising source of funds to use toward reducing economic inequality, as well as a necessity if we are aiming at achieving full employment. But one of the most troubling aspects of the recent exponential rise in economic inequality is that this rise has occurred despite continued economic growth. Increases in national income have gone almost exclusively to the super-rich, while real wages for almost everybody else have stagnated or (...)
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  19.  75
    Concerning electronegativity as a basic elemental property and why the periodic table is usually represented in its medium form.Mark R. Leach - 2012 - Foundations of Chemistry 15 (1):13-29.
    Electronegativity, described by Linus Pauling described as “The power of an atom in a molecule to attract electrons to itself” (Pauling in The nature of the chemical bond, 3rd edn, Cornell University Press, Ithaca, p 88, 1960), is used to predict bond polarity. There are dozens of methods for empirically quantifying electronegativity including: the original thermochemical technique (Pauling in J Am Chem Soc 54:3570–3582, 1932), numerical averaging of the ionisation potential and electron affinity (Mulliken in J Chem Phys 2:782–784, 1934), (...)
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  20. Neutrality and Excellence.Mark R. Reiff - 2022 - In Without Trimmings: The Legal, Moral, and Political Philosophy of Matthew Kramer. Oxford, UK: pp. 271-296.
    In Liberalism with Excellence, Matthew Kramer makes an argument for how excellence may enter in into liberalism, despite liberalism’s strong commitment to neutrality. Kramer seeks to challenge not only the uncompromising rejection of this position by liberals such a Jonathan Quong, but also the so-called “blended” approach of “soft-perfectionist” scholars such as Joseph Raz and George Sher. In this essay, I do not so much challenge Kramer’s approach as offer an alternative for accomplishing the same thing. Under my proposal, certain (...)
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  21.  50
    Advancing a casuistic model of clinical decision making: a response to commentators.Mark R. Tonelli - 2007 - Journal of Evaluation in Clinical Practice 13 (4):504-507.
  22.  34
    Mechanisms in clinical practice: use and justification.Mark R. Tonelli & Jon Williamson - 2020 - Medicine, Health Care and Philosophy 23 (1):115-124.
    While the importance of mechanisms in determining causality in medicine is currently the subject of active debate, the role of mechanistic reasoning in clinical practice has received far less attention. In this paper we look at this question in the context of the treatment of a particular individual, and argue that evidence of mechanisms is indeed key to various aspects of clinical practice, including assessing population-level research reports, diagnostic as well as therapeutic decision making, and the assessment of treatment effects. (...)
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  23. Punishment, Compensation, and Law: A Theory of Enforceability.Mark R. Reiff - 2005 - New York: Cambridge University Press.
    This book is the first comprehensive study of the meaning and measure of enforceability. While we have long debated what restraints should govern the conduct of our social life, we have paid relatively little attention to the question of what it means to make a restraint enforceable. Focusing on the enforceability of legal rights but also addressing the enforceability of moral rights and social conventions, Mark Reiff explains how we use punishment and compensation to make restraints operative in the (...)
  24.  89
    The Evolution of the Human Self: Tracing the Natural History of Self‐Awareness.Mark R. Leary & Nicole R. Buttermore - 2003 - Journal for the Theory of Social Behaviour 33 (4):365-404.
    Previous discussions of the evolution of the self have diverged greatly in their estimates of the date at which the capacity for self-thought emerged, the factors that led self-reflection to evolve, and the nature of the evidence offered to support these disparate conclusions. Beginning with the assumption that human self-awareness involves a set of distinct cognitive abilities that evolved at different times to solve different adaptive problems, we trace the evolution of self-awareness from the common ancestor of humans and apes (...)
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  25.  30
    Errors, efficiency, and the interplay between attention and category learning.Mark R. Blair, Marcus R. Watson & Kimberly M. Meier - 2009 - Cognition 112 (2):330-336.
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  26.  57
    Substituted Judgment in Medical Practice: Evidentiary Standards on a Sliding Scale.Mark R. Tonelli - 1997 - Journal of Law, Medicine and Ethics 25 (1):22-29.
    Consensus is growing among ethicists and lawyers that medical decision making for incompetent patients who were previously competent should be made in accordance with that person's prior wishes and desires. Moreover, this legal and ethical preference for the substituted judgment standard has found its way into the daily practice of medicine. However, what appears on the surface to be an agreement between jurists, bioethicists, and clinicians obscures the very real differences between disciplines regarding the actual implementation of the sub stituted (...)
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  27.  12
    The Path More Easily Reversed: Postponed Withholding at Borderline Viability.Mark R. Mercurio - 2022 - American Journal of Bioethics 22 (11):35-37.
    Those who provide medical care for infants born extremely prematurely, at what is often referred to as borderline viability, have long grown accustomed to working with the parent(s) to reach a deci...
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  28. The just price, exploitation, and prescription drugs: why free marketeers should object to profiteering by the pharmaceutical industry.Mark R. Reiff - 2019 - Review of Social Economy 77:1-36.
    Many people have been enraged lately by the enormous increases in certain generic prescription drugs. But free marketeers defend these prices by arguing that they simply represent what the market will bear, and in a capitalist society there is accordingly nothing wrong with charging them. This paper argues that such a defense is actually contrary to the very principles that free marketeers claim to embrace. These prices are not only unjust and exploitative, but government interference with them would not render (...)
     
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  29. James M. Olson Neal J. roese.Mark R. Zanna - 1996 - In E. E. Higgins & A. Kruglanski (eds.), Social Psychology: Handbook of Basic Principles. Guilford. pp. 211.
     
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  30.  47
    Organisations and Organising: Understanding and Applying Whitehead’s Processual Account.Mark R. Dibben - 2009 - Philosophy of Management 7 (2):13-24.
    Process physics2 is, like all physics, a model of reality. However, unlike traditional substance-based versions, process physics implements many process philosophical concepts, perhaps most notably, the notion of internal relations. It argues that the universe can best be understood in terms of selfreferential semantic information that is remarkably similar to mathematical stochastic neural networks research in biology. It argues that information patterns generate new information through causal efficacy and, ultimately, internal integration, generating self-organising patterns of relationships. These patterns or relations (...)
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  31.  52
    Patient decision-making capacity and risk.Mark R. Wicclair - 1991 - Bioethics 5 (2):91–104.
  32.  19
    Preventing conscientious objection in medicine from running amok: a defense of reasonable accommodation.Mark R. Wicclair - 2019 - Theoretical Medicine and Bioethics 40 (6):539-564.
    A US Department of Health and Human Services Final Rule, Protecting Statutory Conscience Rights in Health Care, and a proposed bill in the British House of Lords, the Conscientious Objection Bill, may well warrant a concern that—to borrow a phrase Daniel Callahan applied to self-determination—conscientious objection in health care has “run amok.” Insofar as there are no significant constraints or limitations on accommodation, both rules endorse an approach that is aptly designated “conscience absolutism.” There are two common strategies to counter (...)
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  33. Punishment in the Executive Suite: Moral Responsibility, Causal Responsibility, and Financial Crime.Mark R. Reiff - 2017 - In Lisa Herzog (ed.), Just Financial Markets?: Finance in a Just Society. Oxford University Press. pp. 125-153.
    Despite the enormity of the financial losses flowing from the 2008 financial crisis and the outrageousness of the conduct that led up to it, almost no individual involved has been prosecuted for criminal conduct, much less actually gone to prison. What this chapter argues is that the failure to punish those in management for their role in this misconduct stems from a misunderstanding of the need to prove that they personally knew of this wrongdoing and harbored an intent to defraud. (...)
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  34. Terrorism, Retribution, and Collective Responsibility.Mark R. Reiff - 2008 - Social Theory and Practice 34 (2):209-242.
    Terrorism is commonly viewed as a form of war, and as a form of war, the morality of terrorism seems to turn on the usual arguments regarding the furtherance of political objectives through coercive means. The terrorist argues that his options for armed struggle are limited, and that the use of force against civilians is the only way he can advance his cause. But this argument is subject to a powerful response. There is the argument from consequences, which asserts that (...)
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  35.  28
    Faking It: Unnecessary Deceptions and the Slow Code.Mark R. Mercurio - 2011 - American Journal of Bioethics 11 (11):17-18.
    The American Journal of Bioethics, Volume 11, Issue 11, Page 17-18, November 2011.
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  36.  11
    Reflections on New Evidence on Crisis Standards of Care in the COVID-19 Pandemic.Mark R. Mercurio, Mark D. Siegel, John Hughes, Ernest D. Moritz, Jennifer Kapo, Jennifer L. Herbst, Sarah C. Hull, Karen Jubanyik, Katherine Kraschel, Lauren E. Ferrante, Lori Bruce, Stephen R. Latham & Benjamin Tolchin - 2021 - Journal of Clinical Ethics 32 (4):358-360.
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  37.  51
    Compellingness: assessing the practical relevance of clinical research results.Mark R. Tonelli - 2012 - Journal of Evaluation in Clinical Practice 18 (5):962-967.
  38.  45
    Assessment response surface: Investigating utility dependence on probability.Mark R. McCord & Richard De Neufville - 1985 - Theory and Decision 18 (3):263-285.
  39.  53
    The theme of health in Nietzsche's thought.Mark R. Letteri - 1990 - Man and World 23 (4):405-417.
  40.  60
    Not a philosophy of clinical medicine: a commentary on 'The Philosophy of Evidence‐based Medicine' Howick, J. ed. (2001).Mark R. Tonelli - 2011 - Journal of Evaluation in Clinical Practice 17 (5):1013-1017.
  41.  17
    Patient Decision‐Making Capacity and Risk.Mark R. Wicclair - 1991 - Bioethics 5 (2):91-104.
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  42.  42
    Exploring the Processual Nature of Trust and Cooperation in Organisations: A Whiteheadian Analysis.Mark R. Dibben - 2004 - Philosophy of Management 4 (1):25-39.
    Process philosophy was on the periphery of academic thinking for much of the twentieth century. Whereas the focus of intellectual development was for the most part on scientific analysis, process philosophy argued for a more encompassing synthesis as well. Although the drive — the corpus delecti of formal research assessment funding exercises — for separate, discrete and latterly measurable bodies of knowledge arrived at from within increasingly autonomous academic disciplines has undoubtedly led to significant advance in many areas it has, (...)
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  43. The Difference Principle, Rising Inequality, and Supply-Side Economics: How Rawls Got Hijacked by the Right.Mark R. Reiff - 2012 - Revue de Philosophie Économique 13 (2):119-173.
    Rawls intended the difference principle to be a liberal egalitarian principle of justice. By that I mean he intended it to provide a moral justification for a moderate amount of redistribution of income from the most advantaged members of society to the least. But since the difference principle was introduced, economic inequality has increased dramatically, reaching levels now not seen since just before the Great Depression, levels that Rawls surely would have thought perverse. Many blame this increase on the rise (...)
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  44. Proportionality, Winner-Take-All, and Distributive Justice.Mark R. Reiff - 2009 - Politics, Philosophy and Economics 8 (1):5-42.
    When faced with multiple claims to a particular good, what does distributive justice require? To answer this question, we need a substantive moral theory that will enable us assign relative moral weights to the parties' claims. But this is not all we need. Once we have assessed the moral weight of each party's claim, we still need to decide what method of distribution to employ, for there are two methods open to us. We could take the winner-take-all approach, and award (...)
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  45.  9
    Supporting Real-Time Ethical Deliberation in Contingency Capacity During the COVID-19 Pandemic.Mark R. Tonelli & Catherine R. Butler - 2021 - American Journal of Bioethics 21 (8):25-27.
    The reality of resource limitation during the Coronavirus Disease 2019 pandemic has deeply challenged established approaches to healthcare system emergency response. Early preparation du...
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  46. Is conscientious objection incompatible with a physician’s professional obligations.Mark R. Wicclair - 2008 - Theoretical Medicine and Bioethics 29 (3):171--185.
    In response to physicians who refuse to provide medical services that are contrary to their ethical and/or religious beliefs, it is sometimes asserted that anyone who is not willing to provide legally and professionally permitted medical services should choose another profession. This article critically examines the underlying assumption that conscientious objection is incompatible with a physician’s professional obligations (the “incompatibility thesis”). Several accounts of the professional obligations of physicians are explored: general ethical theories (consequentialism, contractarianism, and rights-based theories), internal morality (...)
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  47.  40
    Managing Conscientious Objection in Health Care Institutions.Mark R. Wicclair - 2014 - HEC Forum 26 (3):267-283.
    It is argued that the primary aim of institutional management is to protect the moral integrity of health professionals without significantly compromising other important values and interests. Institutional policies are recommended as a means to promote fair, consistent, and transparent management of conscience-based refusals. It is further recommended that those policies include the following four requirements: (1) Conscience-based refusals will be accommodated only if a requested accommodation will not impede a patient’s/surrogate’s timely access to information, counseling, and referral. (2) Conscience-based (...)
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  48. Two Theories of Economic Liberalism.Mark R. Reiff - 2017 - The Adam Smith Review 10:189-214.
    Within the Anglo-American world, economic liberalism is generally viewed as having only one progenitor—Adam Smith—and one offspring—neoliberalism. But it actually has two. The work of G. W. F. Hegel was also very influential on the development of economic liberalism, at least in the German-speaking world, and the most powerful contemporary instantiation of economic liberalism within that world is not neoliberlaism, but ordoliberalism, although this is generally unknown and certainly unacknowledged outside of Continental Europe. Accordingly, what I am going to be (...)
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  49.  30
    Empirical evidence of two-attribute utility dependence on probability.Mark R. McCord & Oscar Franzese - 1993 - Theory and Decision 35 (3):337-351.
  50.  22
    Conscientious Objection, Moral Integrity, and Professional Obligations.Mark R. Wicclair - 2019 - Perspectives in Biology and Medicine 62 (3):543-559.
    Typically, a refusal to provide a medical service is an instance of conscientious objection only when the medical service is legal, professionally accepted, and clinically appropriate. That is, conscientious objection typically occurs only when practitioners reject prevailing norms or practices. Insofar as refusing to provide antibiotics for a viral infection does not violate prevailing clinical norms, there is no need for the physician in Case 1 to justify his refusal to provide antibiotics by appealing to his conscience.1 By contrast, insofar (...)
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