This manuscript reviews recent evidence supporting the utility of telomeres and mitochondrial DNA copy number (mtDNAcn) in detecting the biological impacts of adverse childhood experiences (ACEs) and outlines mechanisms that may mediate the connection between early stress and poor physical and mental health. Critical to interrupting the health sequelae of ACEs such as abuse, neglect, and neighborhood disorder, is the discovery of biomarkers of risk and resilience. The molecular markers of chronic stress exposure, telomere length and mtDNAcn, represent critical biological (...) links between ACEs and poor health outcomes. We examine how telomeres and mtDNAcn may exacerbate health disparities and contribute to the intergenerational transmission of trauma. Finally, we explore how these molecular markers of early stress exposure may help define the role of resilience and develop effective interventions to moderate ACE health risk impact. (shrink)

This essay offers a motivational conception of solidarity that can be employed across the entire range of sciences and humanities, while also filling a gap in the motivational spectrum conceived by decision theorists and economists—and expanding the two-part division between altruistic and selfish motivations into a tripartite analysis that suggests a spectrum instead. According to the present proposal, solidarity is a condition of action-readiness on behalf of a group or its interests. The proposal will admit of measuring the extent to (...) which Prisoner’s Dilemmas are overcome in real life via acts of solidarity. (shrink)

This article aims to show that fundamentality is construed differently in the two most prominent strategies of analysis we find in physical science and engineering today: (1) atomistic, reductive analysis and (2) Systems analysis. Correspondingly, atomism is the conception according to which the simplest (smallest) indivisible entity of a certain kind is most fundamental; while systemism, as will be articulated here, is the conception according to which the bonds that structure wholes are most fundamental, and scale and/or constituting entities are (...) of no significance whatsoever for fundamentality. Accordingly, atomists maintain that the basic entities—the atoms—are fundamental, and together with the “external” interactions among them, are sufficient for illuminating all the features and behaviors of the wholes they constitute; whereas systemists proclaim that it is instead structural qualities of systems, that flow from internal relations among their constituents and translate directly into behaviors, that are fundamental, and by themselves largely (if not entirely) sufficient for illuminating the features and behaviors of the wholes thereby structured. Systemism, as will be argued, is consistent with the nonexistence of a fundamental “level” of nondecomposable entities, just as it is consistent with the existence of such a level. Still, systemism is a conception of the fundamental in quite different, but still ontological terms. Systemism can serve the special sciences—the social sciences especially—better than the conception of fundamentality in terms of atoms. Systemism is, in fact, a conception of fundamentality that has rather different uses—and importantly, different resonances. This conception of fundamentality makes contact with questions pertaining to natural kinds and their situation in the metaphysics of the special sciences—their situation within an order of autonomous sciences. The controversy over fundamentality is evident in the social sciences too, albeit somewhat imperfectly, in the terms of debate between methodological individualists and functionalists/holists. This article will thus clarify the difference between systemism and holism. (shrink)

Background Little is known about communication between patients, families, and healthcare providers regarding ethical concerns that patients and families experience in the course of illness and medical care. To address this gap in the literature, we surveyed patients and family members to learn about their ethical concerns and the extent to which they discussed them with their healthcare providers. Methods We surveyed adult, English-speaking patients and family members receiving inpatient care in five hospitals in the Washington DC-Baltimore metropolitan area from (...) July 2017 to March 2020. Descriptive statistics were used to determine the frequency, comfortableness, and helpfulness of discussions regarding ethical concerns experienced when sick or receiving medical care. Univariable and multivariable stepwise logistic regression models were used to identify associations between healthcare provider and respondent characteristics and attitudes and (1) the likelihood of speaking to a healthcare provider about their ethical concern and (2) their level of comfort during these discussions. Results Of 468 respondents who experienced ethical issues, 299 (64%) reported discussing the situation with a member of their healthcare team; 74% (197/265) of respondents who had such a discussion found the discussion comfortable, and 77% (176/230) of respondents found the discussion helpful. To make discussions more comfortable and helpful, respondents proposed suggestions in open-ended responses involving (1) content and quality of communication; (2) positive healthcare provider qualities such as empathy, open-mindedness, knowledge, honesty, and trustworthiness; and (3) other contextual factors including having adequate time and available resources. Conclusions Patients and families often have ethical concerns that they discuss with clinicians, and they want clinicians to be routinely receptive and attentive to such discussions. (shrink)

In this paper we show how a student can learn the basics of the system databases using (W3school CSS) which was built as intelligent tutoring educational system by using the authoring tool called (ITSB). The learning material contains CSS and HTML. We divided the material in a group of lessons for novice learner which combines relational system and lessons in the process of learning. The student can learn using example of CSS, and types of CSS color. Furthermore, the intelligent tutoring (...) system supports not only lessons; but exercises of different difficult levels for each lesson. When a student finish successfully the first difficulty level in a lesson, the student is allowed to move to the next difficulty level of the exercises of the lesson. (shrink)

The traditional philosophical questions around human freedom are to do with how to square freedom for human organisms with increasingly scientific understandings of the universe itself. At the beginning of Western philosophical consciousness, Plato, unlike later philosophers eligible of the label rationalist, maintained that there are obstacles to free and rational agency, owing in no small measure to pressures exerted by the human psyche from what later were referred to as biological drives and drives for social status. In subsequent eras, (...) these obstacles came under the heading of “weakness of will”—a conception shared widely in popular and traditional culture. Today the realities of addiction, social stresses, forces of habit, culture, social position, and group identity, together with psychological findings about cognitive biases, have come to dominate the landscape of empirically-based obstacles to agency. Can the image of the human being under the microscope of contemporary science, including cognitive and social science, be reconciled with the “manifest image” of human beings as sources of their individual behaviors (and held responsible accordingly), particularly if the scientific image is best construed in terms of governance by laws of nature? (The phrases manifest image and scientific image were coined by the twentieth-century American philosopher Wilfrid Sellars, see Sellars 1962.) How is it possible to square the idea of laws of nature with the manifest image in which humans exercise free agency as they play their various parts in the drama that is life? Does the manifest image thus square better with a theistic image of the world, as both seventeenth-century French philosopher René Descartes and eighteenth-century German philosopher Immanuel Kant seem to have thought, and by contrast the scientific image square better with atheism? A deterministic universe, such as was proposed during the Enlightenment, was early on thought to pose a threat to the idea of human freedom. (It does not pose the same threat to the idea of a sovereign creator, however, because the notion of a creator of the universe already puts the entity who qualifies for the office outside the regime of those laws, ahead of them both in time and in ontological status.) One traditional answer to the threat has been the notion of compatibilism— which simply asserts that freedom and determinism are not incompatible. The devil, of course, has been in the details of explaining how this can be so, and many schools of thought on the matter exist. It is worthwhile noting that there are enormously compelling reasons, from the quantum regime so well described by quantum theory, to reject determinism: the laws governing the universe are simply not fully deterministic. This, of course, vitiates the need to confront the threat as originally posed. However, the trouble, if one follows along this line of thought, is to make sense of the nature of freedom in a world governed partly by deterministic laws and partly by nondeterministic ones that admit of an element of chance. Is such a world itself any more compatible with the idea of human freedom? In this section we grapple with the question of human freedom, what it could mean, and whether it is best accepted in the context of a form of theism. We find that theism has no more resources for addressing these difficulties than atheism does. (shrink)

The goal of the essay is to articulate some beginnings for an empirical approach to the study of agency, in the firm conviction that agency is subject to scientific scrutiny, and is not to be abandoned to high-brow aprioristic philosophy. Drawing on insights from decision analysis, game theory, general dynamics, physics and engineering, this essay will examine the diversity of planning phenomena, and in that way take some steps towards assembling rudiments for the budding science, in the process innovating (parts (...) of) a technical vocabulary. The key is focus upon the organization of effort in time. This paper categorizes forms of organization of effort in time, and yields an analysis of both individual agency and coalitions of agents as forms of effort organized in time. Finally, it articulates precise questions pertaining to the natural (evolutionary) history of forms of agency (once upon a time referred to as ‘Will’) that we now find on the ground. (shrink)

This study sheds light on strategies for retaining skilled pharmacists in Pakistan's pharmaceutical sector, offering valuable insights for both academia and industry stakeholders by investigating the impact of human resource management practices, including training and development, compensation and rewards, job performance, and job satisfaction, on employee retention. It also examines the moderating role of career growth in this context. Theoretical foundations are grounded in international migration theories and social exchange theory, providing a comprehensive framework for the study. A cross-sectional survey (...) design was used to collect data from 254 pharmacists in southern Punjab, Pakistan. Structural equation modeling (SEM) was employed for data analysis. Findings reveal that training and development, compensation and rewards, job performance, and job satisfaction all have significant direct effects on employee retention. Additionally, career growth acts as a crucial moderator, strengthening the relationship between training and development and job performance, as well as compensation and rewards and job satisfaction in relation to employee retention. Theoretical implications emphasize the importance of tailored training programs, fair compensation practices, and career growth opportunities. Practical recommendations include creating a positive work environment, rewarding high-performing employees, and fostering career development. Future research directions encompass longitudinal studies, the influence of organizational culture and technology, regional variations, and additional factors affecting retention. (shrink)

A modern classic of Universal Sufism that explores the mystical dimensions of music-and the musical dimensions of mysticism. Music, according to Sufi teaching, is really a small expression of the overwhelming and perfect harmony of the whole universe-and that is the secret of its amazing power to move us. The Indian Sufi master Hazrat Inayat Khan (1882-1927), the first teacher to bring the Sufi mystical tradition to the West, was an accomplished musician himself. His lucid exposition of music's divine (...) nature has become a modern classic, beloved not only by those interested in Sufism but by musicians of all kinds. This newly reissued edition includes a foreword by Pir Zia Inayat Khan, Hazrat Inayat Khan's grandson and the current leader of the Inayati Order, the widespread Western Sufi organization that Hazrat Inayat Khan founded. (shrink)

The New Towns Movement began in England and later spread world-wide in response to the increasing concern felt at the deterioration of the quality of life in the large cities under the impact of industrialization. The New Towns, it was felt, would combine the advantages of life in the country with that of life in the city. They would be small communities of between 30.000 and 60.000 inhabitants. Their principal characteristics were to be a balanced economy and a well-defined pattern (...) of industrial, commercial and residential zones. (shrink)

The German philosopher, writer, and statesman Wilhelm von Humboldt (1767–1835) has played a key role in the transformation and development of education in Prussia and beyond its borders. If time is change and can be measured as progress towards social transformation, then time serves some concrete utility transposed in the field of education. For the purpose of social transformation and development of education, Humboldt has used various strategies, among which ethics or morals had a certain impact on education. Despite the (...) importance of this aspect, the ethical understanding of the philosopher has not been researched deeply yet. The following paper analyses this question according to Humboldt’s writings and shows its relevance for education. The aim of this research is to reveal insights that have the potential to serve the development of education even now. (shrink)

This work is an exposition of Salighed, a concept at the heart of Kierkegaard's thought, and the dialectical starting point for his reflections on what it means to live a genuinely human life. Kierkegaard studies to date appear to have underestimated the importance of the word and the concepts that lie behind it—perhaps because the word appears easily translated into the English forms of "eternal happiness" or "blessedness." This, suggests Khan, does little justice to the concepts behind the word, (...) and does even less justice to the relationships of the concept of Salighed to other concepts crucial to Kierkegaard's thought. Khan's approach to this word/concept study has been greatly augmented by his use of the computer in analyzing word-relatedness, context, and frequency of occurrence, both within individual works and in comparing one work with a context of the Kierkegaard corpus. The volume will, of course, be of interest to students of Kierkegaard. It will also be of interest to those scholars intrigued by the possibilities of using computers in linguistic research and in literary studies. (shrink)

This book demonstrates how and why vitalism—the idea that life cannot be explained by the principles of mechanism—matters now. Vitalism resists closure and reductionism in the life sciences while simultaneously addressing the object of life itself. The aim of this collection is to consider the questions that vitalism makes it possible to ask: questions about the role and status of life across the sciences, social sciences, and humanities and questions about contingency, indeterminacy, relationality and change. All have special importance now, (...) as the concepts of complexity, artificial life and artificial intelligence, information theory, and cybernetics become increasingly significant in more and more fields of activity. (shrink)

Memorisation of the Qur’ān occupies a central position in Muslim conception of religious education. The awareness of preserving the Qur’ān through memorisation is becoming prevalent and is still continued in these modern days in many educational institutions in many parts of the Muslim countries. This article examines different methods of Qur’ānic memorization being practiced in Malaysia. Similarities and uniqueness of those methods will be presented. The evaluation of those Qur’ānic memorisation techniques brings to the foreground the educative value of memorisation (...) as a learning tool and the implications memorisation methods have in enhancing an individual’s learning performance. (shrink)

In an attempt to re-envision economics, the paper analyses Robert Heilbroner’s philosophy of economics through the lens of Max Weber’s philosophy of science. Specifically, Heilbroner’s position on vision, ideology and value-freedom is examined by contextualising it within a framework of … More ›.

Iqbāl kī shāʻirī meṉ falsafah-yi ḵẖvudī.

Text and Context: Quran and Contemporary Challenges is a compilation of Arif Mohammed Khan s thought-provoking articles published in various newspapers and magazines. It is a comprehensive understanding of the Message and Spirit of Quran and Prophetic Tra.

The question of the development of aesthetic perception in relation to works of art and phenomena of nature suggests a differentiation between aesthetic education and art education which will be attempted in this study. At the same time the necessary interrelationship between the two will also be analysed.

Arsalan Khan offers an ethnography of the normative vision that drives Pakistani Muslim men from diverse social and economic backgrounds to participate in a transnational Islamic piety movement: Tablighi Jamaat. Khan examines how Tablighis constitute the domain of religion in ritual and semiotic practice, how they place an ethical commitment to hierarchy at the heart of religion, and how this, in turn, becomes the basis for restructuring domestic and political life.

This book explores philosophical ethics in Arabo-Islamic thought.

The present paper aims to explore the medieval philosopher Abū al-Barakāt al-Baghdādī’s (d. pre- 560 AH/1164-5) position concerning the problem of divine foreknowledge and human free will and argues Abū al-Barakāt to have considered the argument for compatibility between divine foreknowledge and human free will to be invalid. One can defend either divine foreknowledge or human free will; no other solution is available. By examining his accounts on this issue through the logic and metaphysics of his book al-Muʿtabar fi-l-ḥikma, Abū (...) al-Barakāt defense of human free will shall become evident. (shrink)

İşbu makale Ebü’l-Berekât el-Bağdâdî’nin (ö. 560/ 1164-65’ten önce) ilâhî önbilgi ve insanın özgür iradesi sorununa dair konumunu tetkik etme amacındadır. Metin, Ebü’l-Berekât’ın ilâhî önbilgi ve insanın özgür iradesinin bağdaşması argümanın geçerli olmadığını düşündüğünü iddia ediyor. Bir kişi ya ilâhî önbilgiyi ya da insanın özgür iradesini savunabilir, başka bir çözüm yoktur. Kitâbu’l-Mu‘teber fi’l-hikme adlı kitabının mantık ve metafizik bölümleri içerisindeki bu meseleye dair açıklamalarını inceleyerek, Ebü’l- Berekât’ın ikinci alternatifi seçtiği belirgin kılınacaktır.

Recent scholarship has emphasized the contributions of the great Maliki jurist Shihāb al-Dīn al-Qarāfī to Islamic legal thought. However, al-Qarāfī’s compilation of legal maxims and distinctions, al-Furūq, has not yet been studied, nor has the collection of his teacher, the prominent Shafiʿi jurist Ibn ʿAbd al-Salām, known as al-Qawāʿid al-kubrā. Furthermore, the original thought of Ibn ʿAbd al-Salām and his formative influence on al-Qarāfī have been understated. This article compares their two works to demonstrate that al-Qarāfī based his collection in (...) large part on Ibn ʿAbd al-Salām’s al-Qawāʿid and it examines the techniques that al-Qarāfī used, which included reordering, refining, and supplementing borrowed maxims, and anonymizing references to his teacher. Most salient, however, is al-Qarāfī’s “Malikization” of maxims, which entailed replacing Shafiʿi doctrines and authorities with their Maliki counterparts and deploying maxims to defend Maliki doctrines. The article concludes by explaining al-Qarāfī’s authorial choices in light of his Maliki affiliation and the politics between the legal schools in Mamluk Cairo. (shrink)

Drawing insight from affective events theory, this study presents a new dimension of perceived organizational politics and job attitudes. The motivation for this study was based on the fact that perceived organizational politics affect job attitudes and that personal resources moderate the direct relationship between perceived organizational politics and job attitudes in the context of the higher-education sector. In this regard, the data was collected through purposive sampling from 310 faculty members from higher-education institutions in Pakistan. To test the relationships (...) among the variables, we employed structural equation modeling via the AMOS software version 24.0. The results indicated that perceived organizational politics were significantly negatively related to job satisfaction. Moreover, perceived organizational politics were non-significantly related to job involvement. Political skill and work ethic weakened the relationship between perceived organizational politics and job satisfaction. We anticipated that these personal resources could mitigate the negative effect of perceived organizational politics and job attitudes. This study also suggests organizations to train their employees to develop essential personal skills. (shrink)

The recently reported cases of coerced sterilisation of women at a privately operated immigration detention facility in the USA are egregious in their disregard for human dignity and professional ethics, but sadly not surprising. These abuses represent a continuation of efforts to control the reproductive capacity of women, fueled by racist and xenophobic motives. Physicians helped create and legitimise the pseudoscientific framework for the eugenics movement, which would implement forceful sterilisation as its tool of choice to eliminate undesirable traits that (...) were thought to be biologically inherited and predominant among racial and ethnic minorities. Although state-endorsed forcible sterilisation programs have ended, incarcerated women have remained particularly vulnerable to sterilisation abuse. The intersectional vulnerabilities of racism, xenophobia and carcerality must be addressed to prevent such abuses from recurring. There are no data in this work. (shrink)

Using C. Wright Mills' book The Sociological Imagination as a touchstone for its discussion, this article addresses the relations between the sociological problem, relevance and experience as they are and could potentially be understood within sociology. Beginning with the historical relation between sociology, science and literature — a relation which has been productively but differently complicated by poststructuralist and postconstructivist theories — this article asks: to what extent does the empirical offer a referent for the sociological problem? To what is (...) sociology obliged to be relevant? Arguing for the continued relevance of relevance, particularly in the light of recent reforms in higher education in the UK and the USA, the article explores how the sociological problem might be transformed — and perhaps, more importantly, might be transformative — if the basic commitments of a research project were not to historical social structures but to virtual structures. (shrink)

This article addresses the relations between ‘nature’ and ‘culture’ (and those characteristics associated with ‘the natural’ and ‘the cultural’) in the context of the debates about Prozac. Following Marilyn Strathern, I focus specifically on the contested issue of enablement - that is, on what Prozac does or does not enable, and on the relation between enablement and enhancement, normality and pathology. I argue that the implications of the model of the brain that accompanies explanations of Prozac are such that commentators (...) are obliged to address not only the nature of normality but also the nature of nature itself. Through a close analysis of these debates, I suggest that critiques of Prozac should be understood not as objections to reductionism - to a biology that closes things down - but rather to one that opens things up: that opens up the relations between nature, culture, biology and the individual, relations that are now cross-cut and thrown about by artificiality. Objections to Prozac, then, might be characterized as an attempt to put these concepts back into their ‘proper’ positions, to re-establish the relationality between them. In conclusion, I argue that the biology put forward by proponents of psychopharmacology, regardless of the desirability of the latter, challenges not only the frequent assumptions that are made about the claims of materialist science, but also some of the terms and concepts that are commonly deployed in the social sciences. (shrink)

Cet article esquisse les angles morts d’une histoire, celle de la qualification du savoir au xix e siècle, à partir de l’apparition conjointe du néologisme épistémologie et du syntagme philosophie des sciences. Au-delà des déterminations linguistiques et institutionnelles, il s’efforce de cerner la logique de leur assise commune, en un siècle qui consolida à la fois le rôle central de l’histoire et celui de la recherche d’un statut propre à la pensée. Ainsi, il espère suppléer aux confusions dues à l’impact (...) de la circulation des idées (traductions, traditions et réceptions) et souhaite exposer le lieu d’une profusion conceptuelle, en s’attachant à rendre compte de l’unité d’habitudes générées par l’héritage d’une époque. (shrink)

The radical probabilist counsels the prudent never to put away uncertainty, and hence always to balance judgment with probabilities of various sizes. Against this counsel I shall advise in favor of the practice of full belief — at least for some occasions. This advice rests on the fact that it is sometimes in a person's interests to accept certain propositions as a means of bringing it about that others recognize oneself as having accepted those propositions. With the pragmatists, therefore, I (...) shall reject the view that belief formation must in every instance be a truth-directed affair. Unlike the pragmatists, however, I shall conclude that the enterprise of belief formation is not directed exclusively, or even primarily, at attaining knowledge. In other words, pursuit of that which it profits to believe, on the one hand, and pursuit of knowledge on the other, are distinct enterprises, which overlap (when they do) only accidentally. (shrink)

In this article I argue that Jürgen Habermas’ notion of morality (moral norms) has more in common with Hegel’s notion of ‘ethical life’ as a ‘ sittlich ’ relation – understood as a socially integrative force – rather than Kant’s supreme principle of personal morality. I show that Habermas and Hegel, each in his own way, make a distinction between morality and ethics. However, I make the case that Habermas’ conception of ‘morality’ incorporates aspects of Hegel’s notion of ‘ethical life’, (...) while Habermas’ conception of ‘ethical’ – referring to individual and group conceptions of the good life – is a remedy to the shortcomings in Hegel’s overly unified ethical life. I offer an alternative reading of Habermas’ principle of morality, which I suggest should be read as his attempt to provide a binding process to set up the norms that ought to condition a modern political community understood as a civil association. (shrink)

Background:Africa is increasingly becoming an important region for health research, mainly due to its heavy burden of disease, socioeconomic challenges, and inadequate health facilities. Regulatory...

In the context of the question of the extent to which science studies is able to mount an adequate critique of contemporary developments in science and technology, and in view of the proliferating interest in ethics across the social sciences, this article has two aims. Firstly to address some of the implications for ethics of Bruno Latour's, and to a lesser extent Alfred North Whitehead’s, conceptions of reality, both of which have a bearing on the long-standing dichotomy between facts and (...) values. Drawing on Whitehead's work, it also, secondly, seeks to make a positive argument for ethics and to ask again, in the light of this discussion, where the ethical dimensions of Latour's work might be located. Towards the end of the article, I suggest that Latour's concept of exteriority obliges him to pursue a politics of reality which is the special providence of ‘moralists’, rather than a politics of virtual reality in which all entities, human and non-human, are engaged. (shrink)