There is a vacuum in three generations of the Grotowski men�s lives�this becomes clear within the film�s first ten minutes. First Hank wakes alone in the middle of the night, vomits for no apparent reason, and makes a ritual trip to a lonely diner. Next Hank�s boy Sonny perfunctorily screws a prostitute who�after they have finished�tells him "you look so sad." Finally, Buck�the eldest played by Peter Boyle�wanders through the house sucking breath from an oxygen tank, adds a new page (...) to his capital punishment scrapbook, and spits racist epithets at some teenagers of color who wander into his yard. (shrink)

Die 1990 gegründete Reihe, die auf eine Anregung von Mazzino Montinari zurückgeht, publiziert Quellenmaterialien zu Nietzsches Leben, seinem Umkreis und seiner Wirkung. Die Supplementa stellen somit eine Ergänzung zu den Kritischen Ausgaben von Nietzsches Werken (KGW) und Briefen (KGB) dar.

New imaging methodologies in quantitative fluorescence microscopy, such as Förster resonance energy transfer (FRET), have been developed in the last few years and are beginning to be extensively applied to biological problems. FRET is employed for the detection and quantification of protein interactions, and of biochemical activities. Herein, we review the different methods to measure FRET in microscopy, and more importantly, their strengths and weaknesses. In our opinion, fluorescence lifetime imaging microscopy (FLIM) is advantageous for detecting inter‐molecular interactions quantitatively, the (...) intensity ratio approach representing a valid and straightforward option for detecting intra‐molecular FRET. Promising approaches in single molecule techniques and data analysis for quantitative and fast spatio‐temporal protein‐protein interaction studies open new avenues for FRET in biological research. (shrink)

Forster demonstrates that Hegel did not in fact ignore epistemology, but on the contrary he fought a tireless and subtle campaign to defeat the threat of skepticism. Forster's work should dispel once and for all the view that Hegel was naive or careless in epistemological matters. Along the way, Forster makes much that has hither to remained obscure in Hegel's texts intelligible for the first time.

Du gehst zu Frauen? Vergiss die Peitsche nicht!" Kaum ein Zitat aus Friedrich Nietzsches Gesamtwerk durfte bekannter sein - und lange Zeit fur viele die Grundlage, den grossen Philosophen als Frauenhasser zu deklarieren. Nietzsches Schwester Elisabeth Forster-Nietzsche nutzt dieses Werk, um mit dem Vorurteil aufzuraumen. Sie berichtet von Nietzsches Verhaltnis zu Frauen seit der Kindheit. Freundschafts- und Liebesbeziehungen sind ebenso Thema wie auch weibliche Einflusse auf Nietzsches Personlichkeit und schliesslich auch sein Werk. Forster-Nietzsche erzahlt von Frauen wie Cosima (...) Wagner, Lou Andreas-Salome, Malwida von Meysenbug und vielen anderen. In Erinnerungen, Texten und Briefen entwirft sie so ein besonders personliches Bild des Genies, wie ihn nur wenige erleben durften und vermittelt eine weitere entscheidende Dimension zum Verstandnis seines Werks. Elisabeth Forster-Nietzsche (1846-1935) war bereits von Kindesbeinen an eine grosse Bewunderin ihres alteren Bruders, mit dem sie schon fruh ein besonders inniges Verhaltnis verband. Nach Nietzsches Tode alleinige Nachlassverwalterin, begann Forster-Nietzsche, das Bild ihres Bruders in deutsch-nationale und antisemitische Interessen einzupassen und nahm dazu u. a. auch Anderungen an seinen Texten vor, wofur sie spater scharf kritisiert wu. (shrink)

Leitfaden zu einer künftigen Geschichte der Menschheit.--Über die Humanität des Künstlers.--Über historische Glaubwürdigkeit.--Über den gelehrten Zunftzwang.--Fragment einer Rede, gehalten in Mainzer Jakobiner klub.--Anrede an die Gesellschaft der Freunde der Freiheit und Gleichheit am Neujahrstage 1793.--Parisische Umrísse.

Scientific discovery is often regarded as romantic and creative - and hence unanalyzable - whereas the everyday process of verifying discoveries is sober and more suited to analysis. Yet this fascinating exploration of how scientific work proceeds argues that however sudden the moment of discovery may seem, the discovery process can be described and modeled. Using the methods and concepts of contemporary information-processing psychology (or cognitive science) the authors develop a series of artificial-intelligence programs that can simulate the human thought (...) processes used to discover scientific laws. The programs - BACON, DALTON, GLAUBER, and STAHL - are all largely data-driven, that is, when presented with series of chemical or physical measurements they search for uniformities and linking elements, generating and checking hypotheses and creating new concepts as they go along. "Scientific Discovery examines the nature of scientific research and reviews the arguments for and against a normative theory of discovery; describes the evolution of the BACON programs, which discover quantitative empirical laws and invent new concepts; presents programs that discover laws in qualitative and quantitative data; and ties the results together, suggesting how a combined and extended program might find research problems, invent new instruments, and invent appropriate problem representations. Numerous prominent historical examples of discoveries from physics and chemistry are used as tests for the programs and anchor the discussion concretely in the history of science. Pat Langley is an Associate Professor in the Department of Information and Computer Science at the University of California, Irvine.Herbert Simon is a Professor in the Departments of Psychology, Computer Science, and Philosophy at Carnegie-Mellon University. Gary L. Bradshaw is an Assistant Professor in the Department of Psychology and Institute of Cognitive Science at the University of Colorado, Boulder. Jan M. Zytkow is an Associate Professor in the Computer Science Department at Wichita State University. (shrink)

Why do forces compose according to the parallelogram of forces? This question has been controversial; it is one episode in a longstanding, fundamental dispute regarding which facts are not to be explained dynamically. If the parallelogram law is explained statically, then the laws of statics are separate from and “transcend” the laws of dynamics. Alternatively, if the parallelogram law is explained dynamically, then statical laws become mere corollaries to the dynamical laws. I shall attempt to trace the history of this (...) controversy in order to identify what it would be for one or the other of these rival views to be correct. I shall argue that various familiar accounts of natural law not only make it difficult to see what the point of this dispute could have been, but also improperly foreclose some serious scientific options. I will sketch an alternative account of laws that helps us to understand what this dispute was all about. (shrink)

It has often been argued that Humean accounts of natural law cannot account for the role played by laws in scientific explanations. Loewer (Philosophical Studies 2012) has offered a new reply to this argument on behalf of Humean accounts—a reply that distinguishes between grounding (which Loewer portrays as underwriting a kind of metaphysical explanation) and scientific explanation. I will argue that Loewer’s reply fails because it cannot accommodate the relation between metaphysical and scientific explanation. This relation also resolves a puzzle (...) about scientific explanation that Hempel and Oppenheim (Philosophy of Science 15:135–75, 1948) encountered. (shrink)

Conflicts of interest are rampant in the American medical community. Today it is not uncommon for doctors to refer patients to clinics or labs in which they have a financial interest (40% of physicians in Florida invest in medical centers); for hospitals to offer incentives to physicians who refer patients (a practice that can lead to unnecessary hospitalization); or for drug companies to provide lucrative give-aways to entice doctors to use their "brand name" drugs (which are much more expensive than (...) generic drugs). In Medicine, Money and Morals, Marc A. Rodwin draws on his own experience as a health lawyer--and his research in health ethics, law, and policy--to reveal how financial conflicts of interest can and do negatively affect the quality of patient care. He shows that the problem has become worse over the last century and provides many actual examples of how doctors' decisions are influenced by financial considerations. We learn how two California physicians, for example, resumed referrals to Pasadena General Hospital only after the hospital started paying $70 per patient (their referrals grew from 14 in one month to 82 in the next). As Rodwin writes, incentives such as this can inhibit a doctor from taking action when a hospital fails to provide proper service, and may also lead to the unnecessary hospitalization of patients. We also learn of a Wyeth-Ayerst Labs promotion in which physicians who started patients on INDERAL (a drug for high blood pressure, angina, and migraines) received 1000 mileage points on American Airlines for each patient (studies show that promotions such as this have a direct effect on a doctor's choice of drug). Rodwin reveals why the medical community has failed to regulate conflicts of interest: peer review has little authority, state licensing boards are usually ignorant of abuses, and the AMA code of ethics has historically been recommended rather than required. He examines what can be learned from the way society has coped with the conflicts of interest of other professionals --lawyers, government officials, and businessmen--all of which are held to higher standards of accountability than doctors. And he recommends that efforts be made to prohibit and regulate certain kinds of activity (such as kickbacks and self-referrals), to monitor and regulate conduct, and to provide penalties for improper conduct. Our failure to face physicians' conflicts of interest has distorted the way medicine is practiced, compromised the loyalty of doctors to patients, and harmed society, the integrity of the medical profession, and patients. For those concerned with the quality of health care or medical ethics, Medicine, Money and Morals is a provocative look into the current health care crisis and a powerful prescription for change. (shrink)

Structural requirements of rationality prohibit various things, like having inconsistent combinations of attitudes, having means-end incoherent combinations of attitudes, and so on. But what is the distinctive feature of structural requirements of rationality? And do we fall under an obligation to be structurally rational? These issues have been at the heart of significant debates over the past fifteen years. Some philosophers have recently argued that we can unify the structural requirements of rationality by analyzing what is constitutive of our attitudes (...) (Lee, 2020; Worsnip, 2018a). It has also been suggested that, in the course of good first-personal deliberation, agents should treat structurally irrational combinations of attitudes as off-limits (Worsnip, 2021). In this paper, I raise a worry for these two theses concerning structural rationality. Roughly, I argue that some imperfect epistemic agents (like us) can be disposed to have structurally irrational combinations of attitudes. Also, when these imperfect agents deliberate, they should not treat structurally irrational combinations of attitudes as off-limits. Given our imperfections, being structurally irrational can very well be the best option we have. More generally, these observations reveal that structural rationality should not always be theorized independently from more “substantive” norms, like responsiveness to reasons or expected value optimization. (shrink)

This book not only sets the historical record straight but also champions the Herderian tradition for its philosophical depth and breadth.

The article « La Défenestration » by Belgian philosopher Marc Richir has been translated into Russian for the first time for this issue of the “Horizon. Studies in Phenomenology.” In his early work “The Defenestration” Richir raises the question of relation between the subject and conceivable world. Here, a philosopher is pictured contemplating the world through the window of his tower. In such detachment from the world the thinker finds himself according to all Modern philosophies of consciousness. Husserl’s phenomenology (...) inherits this detachment, since Husserl imposes the structure of transcendental ego as external to the world. Richir abolishes the concept of transcendental ego with the help of heideggerian Dasein, but analyzing Heidegger’s ontology he comes to the conclusion that the latter remains fixated on beings. Believing a person to live in the fundamental openness of Being, Heidegger places such a person in the secondary world of “truth.” In order to overcome the remains of traditional philosophy in Heidegger’s ontology Richir turns to Merleau-Ponty’ “cosmology of the visible.” The author takes the Merleau-Ponty’s thesis that everything visible has something fundamentally invisible in it. This allows him to discover the universe of “nothing”, which includes both the visible and what is “behind” it. As a result Richir overcomes the classical dualism of the sensual and the intelligible. The concept of defenestration places the subject and the world in the same universe. (shrink)

This paper argues that there is a conflict between two theses held by John McDowell, namely i) the claim that we are under a standing obligation to revise our beliefs if reflection demands it; and ii) the view that veridical experience is a mode of direct access to the world. Since puts no bounds on what would constitute reasonable doubt, it invites skeptical concerns which overthrow. Conversely, since says that there are some experiences which we are entitled to trust, it (...) undermines the prescriptive scope of. Drawing on C. S. Peirce's distinction between genuine and contrived doubt, I maintain that critical revisions of beliefs should be triggered only by unwanted disruptions of habits, thereby restoring unity between McDowell's two theses. (shrink)

This volume focuses on cosmological and cosmogonical concepts in hermetic writings and studies their syncretistic origins, subject matter and impact from an interdisciplinary perspective. In doing so, it incorporates articles from various fields of research and academic disciplines.

What altered states of consciousness—the dissolution of feelings of time and self—can tell us about the mystery of consciousness. During extraordinary moments of consciousness—shock, meditative states and sudden mystical revelations, out-of-body experiences, or drug intoxication—our senses of time and self are altered; we may even feel time and self dissolving. These experiences have long been ignored by mainstream science, or considered crazy fantasies. Recent research, however, has located the neural underpinnings of these altered states of mind. In this book, neuropsychologist (...) Marc Wittmann shows how experiences that disturb or widen our everyday understanding of the self can help solve the mystery of consciousness. Wittmann explains that the relationship between consciousness of time and consciousness of self is close; in extreme circumstances, the experiences of space and self intensify and weaken together. He considers the emergence of the self in waking life and dreams; how our sense of time is distorted by extreme situations ranging from terror to mystical enlightenment; the experience of the moment; and the loss of time and self in such disorders as depression, schizophrenia, and epilepsy. Dostoyevsky reported godly bliss during epileptic seizures; neurologists are now investigating the phenomenon of the epileptic aura. Wittmann describes new studies of psychedelics that show how the brain builds consciousness of self and time, and discusses pilot programs that use hallucinogens to treat severe depression, anxiety, and addiction. If we want to understand our consciousness, our subjectivity, Wittmann argues, we must not be afraid to break new ground. Studying altered states of consciousness leads us directly to the heart of the matter: time and self, the foundations of consciousness. (shrink)

Der Band "Idealismus und Romantik in Jena" nimmt die Jenaer Blütezeit zwischen 1794 und 1807 in den Blick und interpretiert sie als ein Neben- und Gegeneinander der beiden einflussreichsten Geistesströmungen um 1800. In Jena entstehen zwischen 1794 und 1807 zwei geistesgeschichtliche Strömungen von Weltgeltung: der Idealismus und die Romantik. Die rasante Entwicklung immer neuer Ideen ist durch eine beträchtliche Anzahl junger, kreativer Geister geprägt, die in fruchtbarem Austausch und gegenseitiger Kritik um ein neues, angemessenes Verständnis der Moderne ringen. Im Fokus (...) des Bandes stehen Fragen zu einzelnen Autoren genauso wie zum Verhältnis beider Strömungen zueinander. The volume Idealism and Romanticism in Jena focuses on the period between 1794 and 1807 in which creative and original minds developed new ideas for understanding the modern world. The contributions examine the relationship between German Idealism and Early Romanticism: What distinguishes/combines Idealism and Romanticism? What common aspects, synergies and goals arise? And what does the opposition between the two movements means for the question of modernity? (shrink)

It is shown that, according to NF, many of the assertions of ordinal arithmetic involving the T-function which is peculiar to NF turn out to be equivalent to the truth-in-certain-permutation-models of assertions which have perfectly sensible ZF-style meanings, such as: the existence of wellfounded sets of great size or rank, or the nonexistence of small counterexamples to the wellfoundedness of ∈. Everything here holds also for NFU if the permutations are taken to fix all urelemente.

Some mathematical proofs explain why the theorems they prove hold. This paper identifies several challenges for any counterfactual account of explanation in mathematics (that is, any account according to which an explanatory proof reveals how the explanandum would have been different, had facts in the explanans been different). The paper presumes that countermathematicals can be nontrivial. It argues that nevertheless, a counterfactual account portrays explanatory power as too easy to achieve, does not capture explanatory asymmetry, and fails to specify why (...) certain proofs are explanatory and others are not. Greater informativeness about counterfactual dependence can even yield less explanatory power. (shrink)

A number of authors argue that while species are evolutionary units, individuals and real entities, higher taxa are not. I argue that drawing the divide between species and higher taxa along such lines has not been successful. Common conceptions of evolutionary units either include or exclude both types of taxa. Most species, like all higher taxa, are not individuals, but historical entities. Furthermore, higher taxa are neither more nor less real than species. None of this implies that there is no (...) distinction between species and higher taxa; the point is that such a distinction is more subtle than many authors have claimed. (shrink)

Norms have been widely enacted in human and agent societies to regulate individuals’ actions. However, although legislators may have ethics in mind when establishing norms, moral values are only sometimes explicitly considered. This paper advances the state of the art by providing a method for selecting the norms to enact within a society that best aligns with the moral values of such a society. Our approach to aligning norms and values is grounded in the ethics literature. Specifically, from the literature’s (...) study of the relations between norms, actions, and values, we formally define how actions and values relate through the so-called value judgment function and how norms and values relate through the so-called norm promotion function. We show that both functions provide the means to compute value alignment for a set of norms. Moreover, we detail how to cast our decision-making problem as an optimisation problem: finding the norms that maximise value alignment. We also show how to solve our problem using off-the-shelf optimisation tools. Finally, we illustrate our approach with a specific case study on the European Value Study. (shrink)

ASPECTS OF THE NOVEL is a unique attempt to examine the novel afresh, rejecting the traditional methods of classification by chronology or subject-matter. Forster pares down the novel to its essential elements as he sees them: story, people, plot, fantasy, prophecy, pattern and rhythm. He illustrates each aspect with examples from their greatest exponents, not hesitating as he does so to pass controversial judgement on the works of, among others, Sir Walter Scott, Charles Dickens and Henry James. Full of (...) Forster's renowned wit and perceptiveness, ASPECTS OF THE NOVEL offers a rare insight into the art of fiction from one of our greatest novelists. 'His is a book to encourage dreaming.' Virginia Woolf. (shrink)

Freedom and compassion in the anthropocene -- Can science save animals? -- Who we eat -- Fat rats and lab cats -- Charismatic, caged, and occasionally crazy: zooed animals -- Captive and companion -- Born to be wild? -- Coexistence in the anthropocene and beyond: compassion and justice for all.

This chapter contains section titled: Introduction The Ontological Nature of Species Taxonomic Pluralism Two Major Schools of Biological Taxonomy The Linnaean Hierarchy References Further Reading.

This chapter contains section titled: Is Biology Like Physics? Laws of Nature: The Standard Picture Why Not Laws of Biology? The Problem of Exceptions Why Not Laws of Biology? The Problem of Accidentalness A Worked Example: The “Area Law” Evolutionary Accidents as Laws of Functional Biology References Further Reading.