Carbon and nitrogen are essential elements for life. Glucose as a carbon source and glutamine as a nitrogen source are important nutrients for cell proliferation. About 100 years ago, it was discovered that cancer cells that have acquired unlimited proliferative capacity and undergone malignant evolution in their host manifest a cancer‐specific remodeling of glucose metabolism (the Warburg effect). Only recently, however, was it shown that the metabolism of glutamine‐derived nitrogen is substantially shifted from glutaminolysis to nucleotide biosynthesis during malignant progression (...) of cancer—which might be referred to as a “second” Warburg effect. In this review, address the mechanism and relevance of this metabolic shift of glutamine‐derived nitrogen in human cancer. We also examine the clinical potential of anticancer therapies that modulate the metabolic pathways of glutamine‐derived nitrogen. This shift may be as important as the shift in carbon metabolism, which has long been known as the Warburg effect. (shrink)

Contemplating one’s own death is a core aspect in the history of Western philosophy. In the modern era, existential philosophy has inherited this tradition and established unique discussions on the concept of “_my_ death,” resting on the premise that this concept is unapproachable via scientific inquiry. Conversely, biological research is essentially conducted within the scope of life phenomena, with death being referred to in the sense of lifespan; thus, death is not among its inherent themes, which automatically excludes the concept (...) of _my_ death from its scope. To establish a dialogue between the two fields, this study questions the widely held premise that _my_ death is unrelated to science and is best examined by philosophy. I consider the movement between continuity and discontinuity as foundational to scientific development, and integrate it with the relationship between the unknown and known. Furthermore, I extend this to the concepts of consciousness and body, and subsequently clarify and define the unknown divisions. Finally, I examine the kinds of unknowns that science confronts to interpret philosophically how an aspect of reproductive theory has unwittingly revealed a completely new dimension of life: _my_ death. Overall, I argue that _my_ death is an essential point of contact between philosophy and biology that reveals the scholarly significance of the unknown. (shrink)

Inspired by Rick Grush's emulation theory, we reinterpreted a series of our neuroimaging experiments which were intended to examine the representations of complex movement, modality-specific imagery, and supramodal imagery. The emulation theory can explain motor and cognitive activities observed in cortical motor areas, through the speculation that caudal areas relate to motor-specific imagery and rostral areas embrace an emulator for amodal imagery.

The purpose of this study is to examine how trends in the use of images in modern life science journals have changed since the spread of computer-based visual and imaging technology. To this end, a new classification system was constructed to analyze how the graphics of a scientific journal have changed over the years. The focus was on one international peer-reviewed journal in life sciences, Cell, which was founded in 1974, whereby 1725 figures and 160 tables from the research articles (...) in Cell were sampled. The unit of classification was defined as a graphic and the figures and tables were divided into 5952 graphics. These graphics were further classified into hierarchical categories, and the data in each category were aggregated every five years. The following categories were observed: data graphics, explanation graphics, and hybrid graphics. Data graphics increased by more than sixfold between 1974 and 2014, and some types of data graphics including mechanical reproduction images and bar charts displayed notable changes. The representation of explanatory graphics changed from hand-painted illustrations to diagrams of Bezier-curves. It is suggested that in addition to the development of experimental technologies such as fluorescent microscopy and big data analysis, continuously evolving application software for image creation and researchers’ motivation to convince reviewers and editors have influenced these changes. (shrink)

Previous research reported that in processing structurally ambiguous sentences comprehenders often preserve an initial incorrect analysis even after adopting a correct analysis following structural disambiguation. One criticism is that the sentences tested in previous studies involved referential ambiguity and allowed comprehenders to make inferences about the initial interpretation using pragmatic information, suggesting the possibility that the initial analysis persisted due to comprehenders' pragmatic inference but not to their failure to perform complete reanalysis of the initial misanalysis. Our study investigated this (...) by testing locally ambiguous relative clause sentences in Japanese, in which the initial misinterpretation contradicts the correct interpretation. Our study using a self-paced reading technique demonstrated evidence for the persistence of the initial analysis with this structure. The results from an eye-tracking study further suggested that the phenomenon directly reflected the amount of support given to the initial incorrect analysis prior to disambiguating information: The more supported the incorrect main clause analysis was, the more likely comprehenders were to preserve the analysis even after the analysis was falsified. Our results thus demonstrated that the preservation of the initial analysis occurs not due to referential ambiguities but to comprehenders' difficulty to fully revise the highly supported initial interpretation. (shrink)

This article describes the historical development of HPS/NOS mainly in higher education. Because the establishment of universities in Japan in late-nineteenth century was a reaction against Western imperialism, higher education aimed to cultivate scientists and engineers with an emphasis on practical applications. This direction in higher science and engineering education continues into the present. It has conditioned elementary and secondary education via university entrance examinations, where no questions on NOS appear. Hence, HPS research and education has developed in Japanese higher (...) education with little connection to elementary and secondary education. Instead, NOS is communicated in literature, movies, and other media. Scientific and technological communication occurs mainly outside the school curriculum in venues like museums. (shrink)

This study addressed the question of whether L2 learners are able to utilize verb’s argument structure information in online structural analysis. Previous L2 research has shown that L2 learners have difficulty in using verb’s intransitive information to guide online syntactic processing. This is true even though L2 learners have grammatical knowledge that is correct and similar to that of native speakers. In the present study, we contrasted three hypotheses, the initial inaccessibility account, the intransitivity overriding account, and the fuzzy subcategorization (...) frame account, to investigate whether L2 learner’s knowledge of intransitive verbs is in fact ignored in L2 online structural analysis. The initial inaccessibility account and the fuzzy subcategorization frame account predicted that L2 learners cannot access intransitivity information in building syntactic structures in any situation. The intransitivity overriding account predicted that intransitivity information is accessed in L2 parsing, but this process is overridden by the strong transitivity preference when a verb is followed by a noun phrase. Importantly, the intransitivity overriding account specifically predicted that L2 learners would be able to use intransitive information in online syntactic processing when a noun phrase does not appear immediately following a verb. We tested the three accounts in an eye-tracking reading experiment using filler-gap dependency structures. We manipulated verb’s transitivity information and lexically based plausibility information and tested English native speakers as a control L1 group and Japanese-English L2 participants. The results showed that L2 learners as well as native speakers processed sentences differently depending on the subcategorization information of the verb, and adopted transitive analysis only when the verb was optionally transitive, providing support for the intransitivity overriding. The results further demonstrated that L2 learners had strong expectations for the transitive structure, which is consistent with the view proposed by the hyper-active gap-filling hypothesis. In addition, the results showed that the semantic mismatch in the incorrect transitive analysis facilitated native speaker’s processing but caused difficulty for L2 learners. Together, the current study provides evidence that L2 learners use intransitive information of the verbs to guide their structural analysis when there are no overriding constraints. (shrink)

技術が進歩すればするほど、技術者に対する信頼が必要となる。技術者は専門職として、どんな倫理をもたねばならないのか。それはほかの専門職の倫理とは違うのか?「技術者は公衆の安全・健康・福利を最優先しなけれ ばならない」という理念にもとづいて指針を示したテキストを、原発事故や製造物責任などの最新事例をふまえて改訂!

壊滅した街の瓦礫の中で人びとは、前日までと同じように分けあい、助けあった。非常時にも日常の倫理を喪わない、日本人の心性の源泉を近世の儒学思想に求め、明日への生き方を確かめる。.

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 20 (2000) 237 [Access article in PDF] News and Views The 1999 Meeting of the Japan Society for Buddhist-Christian Studies James HeisigNanzan Institute for Religion and CultureThe 18th Annual Meeting of the Japan Society for Buddhist-Christian Studies was held in Kyoto from 21 to 23 August 1999. Discussions centered around three papers delivered under the general theme of "Nature, Self, and Spirituality."Watanabe Manabu addressed the strain (...) of arbitrariness in Jung's idea of the Self, demonstrating how the meaning of the term changed according to context and to developmental stages of Jung's thinking, with religious dimension growing ever stronger. In a complementary paper, Jim Heisig suggested that prying Jung's notion of the Self open and liberating it from its monotheistic assumptions in the light of the experiences and worldview of present-day religious experience could serve not only to reawaken interest in analytical psychology but also to draw the Buddhist-Christian encounter closer to the spirituality of the age. Horio Tsutomu focused his paper on the notion of spirituality in the writings of D. T. Suzuki. As always, the papers, responses, and a selection of the discussions will be published in the pages of the Japanese journal Daijozen.The general theme will carry over to the annual meeting for the year 2000 and the sessions planned for the coming Sixth International Conference of the Society for Buddhist-Christian Studies in Tacoma.... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Japan Society for Buddhist-Christian Studies 2005 Annual MeetingPaul SwansonThe 2005 meetings of the Japan Society for Buddhist-Christian Studies focused on the theme "Personal and Impersonal Aspects of the Absolute" and were divided into two venues, with a preliminary panel at the nineteenth World Congress of the International Association for the History of Religions (IAHR) in Tokyo, March 24–30, and the regular annual meeting held in Kyoto on July 19–21. (...) At both meetings, the same four papers by JSBCS members were presented, in English at the World Congress and in Japanese at the regular meeting of the Society.The topic summary for the IAHR panel read as follows:In general, the Christian God is said to be transcendental and personal, but the Buddhist dharma is said to be immanent and impersonal. God, Christ, and Holy Spirit in the New Testament, however, have an immanent transcendent side, and it is impersonal on the immanence side. There is also a transcendent immanence side of the Buddhist Tathagata, and it is personal on the transcendent side. On the one hand, the three major personalistic monotheisms that originated in the Middle East traditionally understood the teachings of other religions as incomplete. On the other hand, in Buddhism other religions are looked down on as "other ways," unable to bring about final liberation (ADK IX). It is said that in the case of the personalistic religions, there is risk of spiritual attachment because God reveals His absolute divine will to believers through prophets; in the case of Buddhism, practitioners are urged to seek their own enlightenment and even, in some early sutras, to use critical reasoning. However, even in Buddhism the thoughts of the founders of the sects have authority. It is important to re-examine the meaning of God and dharma from the perspective of the human personality structure.Chaired by Watanabe Manabu, the IAHR panel consisted of the following four paper presentations:1. Hanaoka Eiko, "Absolute Infinite Openness in Christianity and Buddhism." The origin of a personal God in Christianity and impersonal "emptiness" or "absolute nothingness" in Buddhism are both personal and also impersonal [End Page 183] as an "absolute infinite openness." The self-awareness of absolute infinite openness is the self-awareness of the experience of the most personal dimension, and always simultaneously of the most impersonal dimension. It is that impersonal dimension that this paper investigates.2. Takemura Makio, "On the Significance of Buddha in Buddhism." Buddhism has a view of the Absolute that is comparatively unique. The Absolute is not found in the absolute in contrast to the relative. It is always found in the identity of the absolute and the relative, that is, the identity of any conditioned dharma (samskrita) and the ultimate unconditioned nature (asamskrita) as emptiness (sunyata), or the activity of jnana and the tathata or dharmata. In other words, the individuality or personality of Buddha and the universality or impersonality of tathata are never separated. The ultimate nature does not exist only by itself, and a buddha is one of many buddhas, even if people believe the Buddha as absolute. In Buddhism, buddhas as personal are filled with great compassion and work hard to guide people to become Buddha. They never judge people's guilt. Why is this so? This paper attempts to analyze the reasons in terms of questions such as whether or not the personality of the Absolute is rooted on emptiness, whether the Absolute is one or not, and so forth.3. Tanaka Yutaka, "God as the Locus of the World and the Ground of Human Freedom." This paper critically discusses Nishitani Keiji's arguments of "The Personal and the Impersonal in Religion" in his Religion and Nothingness. Comparing the Christian tradition of speculative mysticism or "panentheism" with the Zen Buddhist philosophy of "Nothingness," the paper seeks to show that God as the locus of the cosmos is the transcendental ground of human freedom and subjectivity.4. Yagi Seiichi, "Impersonal God in the New Testament." In the Pauline epistles and Johannine literature, the key words of a theology that indicates the oneness of divine-human activity can be identified: God working in us, as an expression of mutual... (shrink)