Does having a mental disorder, in general, affect whether someone is morally responsible for an action? Many people seem to think so, holding that mental disorders nearly always mitigate responsibility. Against this Naïve view, we argue for a Nuanced account. The problem is not just that different theories of responsibility yield different verdicts about particular cases. Even when all reasonable theories agree about what's relevant to responsibility, the ways mental illness can affect behavior are so varied that a more nuanced (...) approach is needed. (shrink)

Artificial intelligence (AI) and its introduction into clinical pathways presents an array of ethical issues that are being discussed in the JME. 1–7 The development of AI technologies that can produce text that will pass plagiarism detectors 8 and are capable of appearing to be written by a human author 9 present new issues for medical ethics. One set of worries concerns authorship and whether it will now be possible to know that an author or student in fact produced submitted (...) work. That seems likely to be a general worry for secondary and higher education, as well as for all academic journals. Thus far generative AI chatbots do not seem to be able to produce a fully referenced and well-argued ethics article, but they probably could generate a blog or student essay that would... (shrink)

We evaluate people all the time for a wide variety of activities. We blame them for miscalculations, uninspired art, and committing crimes. We praise them for detailed brushwork, a superb pass, and their acts of kindness. We accomplish things, from solving crosswords to mastering guitar solos. We bungle our endeavors, whether this is letting a friend down or burning dinner. Sometimes these deeds are morally significant, but many times they are not. Simply Responsible defends the radical proposal that the blameworthy (...) artist is responsible in just the same way that the blameworthy thief is. We can be responsible for all kinds of different activities, from lip-synching to long division, from murders to meringues, but the relation involved, what author Matt King calls the basic responsibility relation, is the same in every case. We are responsible for the things we do first, then blameworthy or praiseworthy for having done them in light of whether they're good or bad, according to a variety of standards. Why is this a radical proposal? Firstly, because so much of the contemporary literature on moral responsibility has moralized its nature. According to most accounts, moral responsibility is either a special species of responsibility or else depends on moralized capacities. In contrast, King argues that we get a more complete and unifying picture of responsible agency from a more general theory of responsibility. Secondly, the proposal is radical due to its drastic simplicity. King foregoes many of the complications that feature in other accounts of responsibility, arguing that we can make do with less demanding theoretical elements. (shrink)

Much has been written lately about cases in which blame of the blameworthy is nonetheless inappropriate because of facts about the blamer. Meddlesome and hypocritical cases are standard examples. Perhaps the matter is none of my business or I am guilty of the same sort of offense, so though the target is surely blameworthy, my blame would be objectionable. In this paper, I defend a novel explanation of what goes wrong with such blame, in a way that draws the cases (...) together. In brief, I argue that blaming is essentially an attentive activity, and that, consequently, meddlesome and hypocritical blamers are attending to the wrong things. (shrink)

Ordinary morality judges agents blameworthy for negligently produced harms. In this paper I offer two main reasons for thinking that explaining just how negligent agents are responsible for the harms they produce is more problematic than one might think. First, I show that negligent conduct is characterized by the lack of conscious control over the harm, which conflicts with the ordinary view that responsibility for something requires at least some conscious control over it. Second, I argue that negligence is relevantly (...) indistinguishable from inadvertence, which is ordinarily thought to excuse agents from responsibility. I argue that the parallels between negligence and inadvertence suggest that negligent agents are not responsible for the harms they produce, while proposing an alternative model for distinguishing between negligence and inadvertence that does justice to our intuitions. (shrink)

Animal welfare science and ecology are both generally concerned with the lives of animals, however they differ in their objectives and scope; the former studies the welfare of animals considered ‘domestic’ and under the domain of humans, while the latter studies wild animals with respect to ecological processes. Each of these approaches addresses certain aspects of the lives of animals living in the world though neither, we argue, tells us important information about the welfare of wild animals. This paper argues (...) for the development of a new scientific discipline ‘welfare biology’ to address these issues and more, given the deficiencies of pre-existing life science disciplines to research the subject. Welfare biology is the study of the welfare of all living beings who have a welfare, with a value orientation toward promoting that welfare, regardless of the beings’ situation or relationship to humans and our activities. (shrink)

Experiments in particle physics have hitherto failed to produce any significant evidence for the many explicit models of physics beyond the Standard Model (BSM) that had been proposed over the past decades. As a result, physicists have increasingly turned to model-independent strategies as tools in searching for a wide range of possible BSM effects. In this paper, we describe the Standard Model Effective Field Theory (SM-EFT) and analyse it in the context of the philosophical discussions about models, theories, and (bottom-up) (...) effective field theories. We find that while the SM-EFT is a quantum field theory, assisting experimentalists in searching for deviations from the SM, in its general form it lacks some of the characteristic features of models. Those features only come into play if put in by hand or prompted by empirical evidence for deviations. Employing different philosophical approaches to models, we argue that the case study suggests not to take a view on models that is overly permissive because it blurs the lines between the different stages of the SM-EFT research strategies and glosses over particle physicists' motivations for undertaking this bottom-up approach in the first place. Looking at EFTs from the perspective of modelling does not require taking a stance on some specific brand of realism or taking sides in the debate between reduction and emergence into which EFTs have recently been embedded. (shrink)

It is often charged that compatibilists have a problem with manipulation. There are certain cases in which victims of manipulation seem to be not responsible for what they do, despite meeting compatibilist conditions on moral responsibility. This essay argues that these arguments, as a class, fail. Their success is depen- dent on a particular incompatibilist assumption, one that is dialectically infelici- tous in this context. My aim, however, is not to defend compatibilism but only to reject a popular argument for (...) incompatibilism. (shrink)

Our paper studies the anatomy of the discovery of the Higgs boson at the Large Hadron Collider and its influence on the broader model landscape of particle physics. We investigate the phases of this discovery, which led to a crucial reconfiguration of the model landscape of elementary particle physics and eventually to a confirmation of the standard model. A keyword search of preprints covering the electroweak symmetry breaking sector of particle physics, along with an examination of physicists own understanding of (...) the discovery as documented in semiannual conferences, has allowed us an empirical investigation of its model dynamics. From our analyses we draw two main philosophical lessons concerning the nature of scientific reasoning in a complex experimental and theoretical environment. For one, from a confirmation standpoint, some SM alternatives could be considered even more confirmed by the Higgs discovery than the SM. Nevertheless, the SM largely remains the commonly accepted account of EWSB. We present criteria for comparing degrees of confirmation and expose some limits of a purely logical approach to understanding the Higgs discovery as a victory for the SM. Second, we understand the persistence of SM alternatives in the face of disfavourable evidence by borrowing the Lakatosian concept of a research programme, where the core idea behind a group of models survives, while other aspects adapt to incoming data. In order to apply this framework to the model landscape of EWSB, we must introduce a new category of research programme, the model-group, and we test its viability using the example of composite Higgs models. (shrink)

An indispensable guide to the major work of one of the twentieth century's most influential thinkers.

The majority of recent work on the moral standing to blame (the idea that A may be unable to legitimately blame B despite B being blameworthy) has focused on blamers who themselves are blameworthy. This is unfortunate, for there is much to learn about the standing to blame once we consider a broader range of cases. Doing so reveals that challenged standing is more expansive than previously acknowledged, and accounts that have privileged the fact that the blamers are themselves morally (...) culpable likely require revision. One such account figures in Patrick Todd’s (2012) argument for incompatibilism, which ostensibly depends on considerations involving the standing to blame. I believe this argument fails. But its failure is instructive, for it allows us to appreciate the numerous ways in which one’s blame can be morally problematic, and hence ways in which one’s standing to blame can be challenged. Thus, while one objective of this paper is to show why Todd’s argument fails, the larger aim is to use that argument to frame discussion of some important (and novel) ways in which the standing to blame can be compromised. (shrink)

Control-based accounts of moral responsibility face a familiar problem. There are some actions which look like obvious cases of responsibility but which appear equally obviously to lack the requisite control. Drunk-driving cases are canonical instances. The familiar solution to this problem is to appeal to tracing. Though the drunk driver isn't in control at the time of the crash, this is because he previously drank to excess, an action over which he did plausibly exercise the requisite control. Tracing seeks to (...) show that an agent's responsibility for some outcome can be traced back to a prior exercise of control which caused the later lack of control. These and related cases have led many theorists to treat tracing as an indispensable component of any adequate theory of responsibility. This paper argues that tracing is in fact dispensable. I offer two strategies for explaining responsibility in drunk-driving cases : responsibility can either be exhaustively modeled on recklessness, or exhaustively modeled on negligence. Neither explanation, however, relies on tracing. If I'm right, the case for tracing is seriously weakened. (shrink)

Our aim in this paper is to raise a question about the relationship between theories of responsibility, on the one hand, and a commitment to conscious attitudes, on the other. Our question has rarely been raised previously. Among those who believe in the reality of human freedom, compatibilists have traditionally devoted their energies to providing an account that can avoid any commitment to the falsity of determinism while successfully accommodating a range of intuitive examples. Libertarians, in contrast, have aimed to (...) show that either physical indeterminacy or a certain kind of agent causation can find a place in the world for what they take to be genuine freedom. Few have considered whether moral responsibility requires a commitment to conscious attitudes.2 Our question derives from a confluence of two sources. First, there is reason to think that conscious attitudes matter to theories of responsibility, either directly, as a result of the latter’s commitments, or indirectly, by virtue of the assumptions that they make about certain intuitive examples. Second, there is accumulating evidence suggesting that there aren’t any conscious mental states possessing the sorts of causal roles required of propositional attitudes. Since theorists of responsibility should in general be concerned to make their views compatible with plausible claims about the natural world, the implications of this data should be carefully considered. Our aim is therefore to motivate and begin exploring answers to the following conditional question: If it should turn out that there are no conscious attitudes, then what would be the implications of this fact (if any) for theories of responsibility? We propose that theorists who aren’t skeptics about moral responsibility should examine their accounts, asking whether their theories (or the examples that motivate them) could survive the discovery that there are no conscious judgments, decisions, or evaluations. Since we take it that moral theorizing in general should operate with the weakest possible empirical assumptions about the natural world, such theorists should consider whether their accounts could be motivated in such a way as to be free of any commitment to the existence of conscious attitudes.. (shrink)

In the contemporary moral responsibility debate, most theorists seem to be giving accounts of responsibility in the ‘desert-entailing sense’. Despite this agreement, little has been said about the notion of desert that is supposedly entailed. In this paper I propose an understanding of desert sufficient to help explain why the blameworthy and praiseworthy deserve blame and praise, respectively. I do so by drawing upon what might seem an unusual resource. I appeal to so-called Fitting-Attitude accounts of value to help inform (...) a conception of desert or merit, one that can be usefully applied to discussions of moral responsibility. I argue that the view, which I call, Desert as Fittingness (DAF), merits additional attention. I do so by making two claims: First, that it does better than extant Fitting Attitude accounts of blameworthiness and praiseworthiness; second, that it has an initial plausibility with respect to informing a general account of desert. While these reasons are insufficient to show the view is true, they do make the case for taking the view seriously. (shrink)

There are two broadly competing pictures of moral responsibility. On the view I favor, to be responsible for some action is to be related to it in such a way that licenses attributing certain properties to the agent, properties like blameworthiness and praiseworthiness. Responsibility is attributability. A different view understands being responsible in terms of our practices of holding each other responsible. Responsibility is accountability, which “involves a social setting in which we demand (require) certain conduct from one another and (...) respond adversely to one another’s failures to comply with these demands” (Watson, Philos Top 24:227–248, 1996). My concern here is the relation between moral responsibility and desert. Plausibly, if someone is morally responsible for something wrong then they deserve blame, and it is on the basis of them being morally responsible and its being wrong that they deserve blame. In this paper, I try to make progress toward understanding why it would follow that being morally responsible for something supports a desert claim. I propose to do this by exploring how the “two faces” of responsibility should proceed. An important upshot is that we gain a new currency by which to evaluate extant theories of responsibility that might favor one or the other conception: do they carry plausible desert commitments? To illustrate this benefit, I argue that accountability theory carries implausible implications for deserved praise. (shrink)

The focus in the literature on scientific explanation has shifted in recent years towards model-based approaches. In recent work, Alisa Bokulich has argued that idealization has a central role to play in explanation. Bokulich claims that certain highly-idealized, structural models can be explanatory, even though they are not considered explanatory by causal, mechanistic, or covering law accounts of explanation. This paper focuses on Bokulich’s account in order to make the more general claim that there are problems with maintaining that a (...) structural criterion can capture the way that highly-idealized models explain. This paper examines Bokulich’s claim that the structural model explanation of quantum wavefunction scarring, featuring semiclassical mechanics, is deeper than the explanation provided by the local quantum model. The challenge for Bokulich is to show that the semiclassical model answers a wider range of w-questions, as this is her method of assessing structural information. I look at two reasonable approaches employing w-questions, and I argue that neither approach is ultimately satisfactory. Because structural similarity has preferences for more fundamental models, I argue that the local quantum model provides explanations that at least as deep as the semiclassical ones. The criterion either wrongly identifies all models as explanatory, or prefers models from fundamental theory. Either way, it cannot capture the way that highly-idealized models explain. (shrink)

This article considers two related and fundamental issues about morality in a virtual world. The first is whether the anonymity that is a feature of virtual worlds can shed light upon whether people are moral when they can act with impunity. The second issue is whether there are any moral obligations in a virtual world and if so what they might be. -/- Our reasons for being good are fundamental to understanding what it is that makes us moral or indeed (...) whether any of us truly are moral. Plato grapples with this problem in book two of The Republic where Socrates is challenged by his brothers Adeimantus and Glaucon. They argue that people are moral only because of the costs to them of being immoral; the external constraints of morality. -/- Glaucon asks us to imagine a magical ring that enables its wearers to become invisible and capable of acting anonymously. The ring is in some respects analogous to the possibilities created by online virtual worlds such as Second Life, so the dialogue is our entry point into considering morality within these worlds. These worlds are three dimensional user created environments where people control avatars and live virtual lives. As well as being an important social phenomenon, virtual worlds and what people chose to do in them can shed light on what people will do when they can act without fear of normal sanction. -/- This paper begins by explaining the traditional challenge to morality posed by Plato, relating this to conduct in virtual worlds. Then the paper will consider the following skeptical objection. A precondition of all moral requirements is the ability to act. There are no moral requirements in virtual worlds because they are virtual and it is impossible to act in a virtual world. Because avatars do not have real bodies and the persons controlling avatars are not truly embodied, it is impossible for people to truly act in a virtual world. We will show that it is possible to perform some actions and suggest a number of moral requirements that might plausibly be thought to result. Because avatars cannot feel physical pain or pleasure these moral requirements are interestingly different from those of real life. Hume’s arguments for why we should be moral apply to virtual worlds and we conclude by considering how this explains why morality exists in these environments. (shrink)

Setting aside some complexities, Koplin and Wilkinson1 argue: 1. Moral status is uncertain if there is a non-zero chance that an entity has, or would develop, full moral status. 2. If its moral status is uncertain, then moral caution is warranted towards that entity. 3. The moral status of both non-chimeric pigs and human-pig chimaeras is uncertain. Therefore, consistency demands that moral caution is warranted towards both non-chimeric pigs and human-pig chimaeras. 4. The commonly held view is that moral caution (...) is warranted towards human-pig chimaeras, but not non-chimeric pigs. Therefore, the commonly held view is inconsistent. This is a valid argument. The authors claim that the inconsistency they expose in conclusion 2 could be resolved in favour of either commonly held view, or by revising both to equivalency. However, it is clear from conclusion 1, and the paper more generally, that the authors are arguing for moral caution to be applied to the treatment of pigs of both types. I will focus on evaluating premises 1 and 2, and the generalisability of the argument in light of this. In doing so, I will attempt to show that the argument has implausible logical implications, and that the moral caution warranted towards human-pig chimaeras of uncertain moral status does not require confidence that they lack full moral status, as the authors claim. According to premise 1, if an entity might currently have moral …. (shrink)

There has been a growing trend to include non-causal models in accounts of scientific explanation. A worry addressed in this paper is that without a higher threshold for explanation there are no tools for distinguishing between models that provide genuine explanations and those that provide merely potential explanations. To remedy this, a condition is introduced that extends a veridicality requirement to models that are empirically underdetermined, highly-idealised, or otherwise non-causal. This condition is applied to models of electroweak symmetry breaking beyond (...) the Standard Model. (shrink)

Animal ethics committees typically focus on the welfare of animals used in experiments, neglecting the potential welfare impact of that animal use on the animal laboratory personnel. Some of this work, particularly the killing of animals, can impose significant psychological burdens that can diminish the well-being of laboratory animal personnel, as well as their capacity to care for animals. We propose that AECs, which regulate animal research in part on the basis of reducing harm, can and ought to require that (...) these harms to researchers are reduced as well. The paper starts by presenting evidence of these burdens and their harm, giving some examples showing how they may be mitigated. We then argue that AECs are well placed to account for these harms to personnel and ought to use their power to reduce their occurrence. We conclude by responding to four potential objections: that this problem should be addressed through health and safety administration, not research ethics administration; that the proposal is unjustifiably paternalistic; that these harms to laboratory animal personnel ought to occur, given their treatment of animals; and that mitigating them may lead to worse treatment of research animals. (shrink)

One way in which fact finders are supposed to determine the reasonableness of a defendant is via a counterfactual test that personifies the reasonable person. We are to imagine the reasonable person being in the defendant’s circumstances. Then we are to determine whether the reasonable person would have done as the defendant did. This paper argues that, despite its prevalence, the counterfactual test is a hopeless guide to determining defendant reasonability. In brief, the test is of the wrong sort to (...) give fact finders the requisite guidance. What we are after is not a counterfactual judgment but instead is a question of possibility. However, since the only thing impossible of the reasonable person is being unreasonable, personifying the reasonable person cannot offer any useful guidance on this question. (shrink)

Two approaches have emerged to resolve discrepancies between predictions and observations at galactic and cosmological scales: introducing dark matter or modifying the laws of gravity. Practitioners of each approach claim to better satisfy a different explanatory ideal, either unification or simplicity. In this chapter, we take a closer look at the ideals and at the successes of these approaches in achieving them. Not only are these ideals less divisive than assumed, but moreover we argue that the approaches are focusing on (...) different aspects of the same ideal. This realisation opens up the possibility of a more fruitful trading zone between dark matter and modified gravity communities. (shrink)

This paper discusses the announcement by a team of researchers that they identified a genetic influence for a range of “antisocial” behaviours in the New Zealand Māori population (dubbed the “warrior gene”). The behaviours included criminality, violence, gambling and alcoholism. The reported link between genetics and behaviour met with much controversy. The scientists were described as hiding behind a veneer of supposedly “objective” western science, using it to perpetuate “racist and oppressive discourses”. In this paper we examine what went wrong (...) in the dissemination of the research. We chose as our framework the debate around the “internal/external” responsibilities of scientists. Using this discourse we argue that when the researchers ventured to explain their research in terms of social phenomena, they assumed a duty to ensure that their findings were placed “in context”. By “in context”, we argue that evidence of any genetic influence on behavioural characteristics should not be reported in isolation, but instead presented alongside other environmental, cultural and socio-economic influences that may also contribute to the studied behaviour. Rather than imposing a new obligation on scientists, we find this duty to contextualise results is in keeping with the spirit of codes of ethics already in place. Lessons from the “warrior gene” controversy may assist researchers elsewhere to identify potential areas of conflict before they jeopardise research relationships, or disseminate findings in a manner that fuels misleading and/or potentially discriminatory attitudes in society. (shrink)

SummaryIntense, sustained nursing lengthens inter-birth intervals and is causally linked with low natural fertility. However, in traditional settings, the effects of such nursing on fertility are difficult to disentangle from those of nutrition. Results from an prospective, direct observational study of reproductive function in well-nourished Amele women who nurse intensively and persistently but who also have high fertility are here presented. Endocrine measures show that ovarian activity resumes by median 11·0 months postpartum. Median duration of postpartum amenorrhoea is 11·3 months, (...) time to next conception is 19·0 months, and the inter-birth interval is 28·0 months. Average life time fertility is 6·8. High fertility in Amele women is due both to refractoriness of reproductive function to suckling stimuli, and to maintenance of equivalent age-specific fertility rates across the reproductive life span. (shrink)

Habermas charges that Foucault's work `cannot account for its normative foundations'. Responses to Habermas have consisted mostly of, on one hand, attempts to identify foundational normative assumptions implicit in Foucault's work, and, on the other hand, attempts to show that Foucault's work discredits the very idea of normative foundations. These attempts have suffered from a lack of clarity about Habermas' notion of normative foundations. In this article I clarify the terms of the debate by considering Habermas' critique of Foucault in (...) light of his moral philosophy. I examine three representative responses to Habermas on Foucault's behalf, which attempt to identify normative foundations in Foucault's work, and I show why none of them meets Habermas' requirements. Finally, I argue that while Foucault's political judgments cannot have normative foundations, Foucault does adhere to the principles of Habermas' discourse ethics, and his doing so does not conflict with his genealogical approach. (shrink)

By comparing Object-Oriented Ontology (OOO) and Baudrillard through the lens of a study of the notion of withdrawal in Heidegger’s tool analysis and “The Question Concerning Technology”, this article explores the extent to which an Object-Oriented Baudrillard is possible, or even necessary. Considering an OOO understanding of Mauss’s gift-exchange, a possible critique of duomining in Baudrillard and a revision of Baudrillard’s understanding of art, the prospects of a new reading of Baudrillard and interpretation of OOO’s genealogy are established. These lines (...) of comparison qualify the role of withdrawal in Baudrillard and symbolic exchange for OOO, and lead towards the conclusion that an Object-Oriented Baudrillard is possible, but may not, conversely, be considered necessary. (shrink)

Cheating through the use of illegal performance enhancements (such as doping) is a persistent problem in sport. It has been suggested that one response to this problem is to separate sport into two parallel leagues. One league would resemble sport as it is currently practised ? i.e. with restrictions on use of particular enhancements ? and the other would not possess these restrictions, allowing those that wish to use currently illegal enhancements to do so. In this paper I articulate the (...) ?two leagues? proposal further and subject it to critical scrutiny. The proposal fails. It does so by failing to address conceptual confusion regarding enhancement use in sport; by replicating in the new league the current problems associated with enhancement-based cheating; and by creating new problems. In an attempt to revive it I describe other possible justifications for the proposal, based on its promotion of personal autonomy, and rights-based justifications. These fail, with the exception of a group right claiming provision of the enhanced league as a participatory good. I conclude that this latter use of the proposal is the only sensible one, but it nevertheless faces significant obstacles. (shrink)

RNA localization is a powerful strategy used by cells to localize proteins to subcellular domains and to control protein synthesis regionally. In germ cells, RNA targeting has profound implications for development, setting up polarities in genetic information that drive cell fate during embryogenesis. The frog oocyte offers a useful system for studying the mechanism of RNA localization. Here, we discuss critically the process of RNA localization during frog oogenesis. Three major pathways have been identified that are temporally and spatially separated (...) in oogenesis. Each pathway uses a different mechanism to effect RNA localization. In some cases, localization elements within the 3' untranslated region have been identified and have provided unique insights into the localization process. This important field is still in its infancy, however, and much remains to be learned. BioEssays 21:546–557, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

The focus in the literature on scientific explanation has shifted in recent years towards modelbased approaches. The idea that there are simple and true laws of nature has met with objections from philosophers such as Nancy Cartwright (1983) and Paul Teller (2001), and this has made a strictly Hempelian D-N style explanation largely irrelevant to the explanatory practices of science (Hempel & Oppenheim, 1948). Much of science does not involve subsuming particular events under laws of nature. It is increasingly recognized (...) that science across the disciplines is to some degree a patchwork of scientific models, with different methods, strategies, and with varying degrees of successful prediction and explanation. And so accounts of scientific explanation have reflected this change of perspective and model-based approaches have flourished in the explanation literature (Batterman, 2002b; Bokulich, 2008; Craver, 2006; Woodward, 2003). (shrink)

One model in particular, the Standard Model Higgs, is taken to have been confirmed by the Higgs boson discovery at the LHC, even though many models are compatible with the data. Some models even provided riskier predictions and should perhaps be regarded as having been even more strongly confirmed. This paper sketches an argument demonstrating this by comparing the confirmation of the Standard Model Higgs with that of the Higgs in minimal supersymmetry. The paper then attempts to provide a way (...) of understanding this result by modelling it as a case of eliminative induction. (shrink)

How exactly do mental disorders affect one’s agency? How might therapeutic interventions help patients regain or improve their autonomy? Do only some disorders excuse morally inappropriate behavior, such as theft or child neglect? Or is there nothing about having a disorder, as such, that affects whether we ought to praise or blame someone for their moral success or failure? Our volume gathers together empirically-informed philosophers who are well equipped to tackle such questions. Contributors specialize in free will, agency, and responsibility, (...) but they are informed by current scientific and clinical approaches to a wide range of psychopathologies, including autism, addiction, Tourette syndrome, personality disorders, depression, dementia, phobias, schizophrenia, and obsessive-compulsive disorder. These conditions exhibit a diverse array of symptoms that can contribute quite differently to being blameworthy or praiseworthy. (shrink)

Manipulation arguments have become almost a cottage industry in the moral responsibility literature. These cases are used for a variety of purposes, familiarly to undermine some proffered set of conditions on responsibility, usually compatibilist conditions. The basic idea is to conceive of a case which intuitively includes responsibility-undermining manipulation but which meets the target account’s set of sufficient conditions on responsibility. The manipulation thereby serves as a counterexample to the target theory. More specifically, recent concern with manipulation cases has often (...) been part of an argument for historical conditions on moral responsibility. Exercising control over an action is not necessarily enough to be responsible for it, one must have come to exercise that control in a non-deviant way. Manipulation cases are meant to illustrate how an agent can exercise the supposed sufficient control over an action, and yet intuitively fail to be responsible as a result of some manipulation. The argument concludes that manipulation of this sort must then be ruled out by one’s conditions on responsibility. Accounts that fail to rule out such manipulation are objectionable as a result. Manipulation arguments usually fit a general schema.1 One presents a case intuitively involving responsibility-undermining manipulation, but where all the conditions of the target account are met. Then one argues that there is no relevant difference between that case and ordinary action under the target account. Thus, one can conclude, the target account gets the wrong verdict for manipulation cases. Some variations on this schema seek a slightly grander conclusion. For example, some incompatibilists argue from the manipulation case through a principle that claims there to be no relevant difference between such a case and ordinary action in a deterministic universe. Thus, the conclusion reached is that if determinism is true, all responsibility is undermined. (shrink)

Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

ABSTRACT This article shows how the “problem of moral luck” and Sartre's concept of “bad faith” are mutually illuminating, since both have to do with confusions about how much we control, or are controlled by, our situations. I agree with three recent proposals that the problem of moral luck results from certain epistemic malfunctions. However, I argue that the problem cannot be dissolved by overcoming these malfunctions because they are rooted in bad faith. Against the currently dominant interpretation, I argue (...) that bad faith is an inescapable condition of human being because, while we are both free and factical, we can only exist as one or the other at once, thus always keeping an aspect of our nature hidden from ourselves. (shrink)

This study examines thirteenth to twentieth century Tibetan and Mongolian monastic memorializations of the bodily violence enacted upon Köten Ejen at the center of the “Buddhist conversion of the Mongols.” Koten Ejen (Tib. Lha sras go tan rgyal po, 1206–1251) was Chinggis Khan’s grandson and a military leader involved in Mongol campaigns against the Song Dynasty and against Buddhist monasteries in eastern Tibet. In 1240, Koten famously summoned the Central Tibetan Buddhist polymath Sakya Pandita, by then already an old man, (...) to his court at Liangzhou. Examining Tibetan and Mongolian accounts about their meeting from the last seven centuries, this study shows that it was neither compelling philosophy nor some turn of faith that converted the Mongols. It was, rather, Sakya Pandita’s violent therapeutic intervention into the space of Koten’s ill body that wrenched the Mongol body politic into the Dharmic fold. (shrink)

Herbert Spencer was the most influential Anglophone sociologist of the nineteenth century, but his contributions are now largely forgotten. It is argued, however, that the clarity of his understanding of the use of biological metaphors in sociology gives his work a power which is worth rediscovering. This proposition is pursued through a discussion of his treatment of the professions and their role in industrial societies. His approach is compared with the "ecological" perspective of sociologists in the Chicago tradition, notably Andrew (...) Abbott. It is suggested that Spencer's work rests on an alternative interpretation of the ecological model; this opens the way to an understanding of the regulative structures of "the system of the profession," which fills a major gap in Abbott's account. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)