The use of evidence in medicine is something we should continuously seek to improve. This book seeks to develop our understanding of evidence of mechanism in evaluating evidence in medicine, public health, and social care; and also offers tools to help implement improved assessment of evidence of mechanism in practice. In this way, the book offers a bridge between more theoretical and conceptual insights and worries about evidence of mechanism and practical means to fit the results into evidence assessment procedures.
Evidence-based medicine has always required integration of patient values with ‘best’ clinical evidence. It is widely recognized that scientific practices and discoveries, including those of EBM, are value-laden. But to date, the science of EBM has focused primarily on methods for reducing bias in the evidence, while the role of values in the different aspects of the EBM process has been almost completely ignored.
The book juxtaposes key texts from Foucault and Habermas; it then adds a set ofreactions and commentaries by theorists who have taken up the two alternative approaches to powerand critique.
Grief research in philosophy agrees that one who grieves grieves over the irreversible loss of someone whom the griever loved deeply, and that someone thus factored centrally into the griever’s sense of purpose and meaning in the world. The analytic literature in general tends to focus its treatments on the paradigm case of grief as the death of a loved one. I want to restrict my account to the paradigm case because the paradigm case most persuades the mind that grief (...) is a past-directed emotion. The phenomenological move I propose will enable us to respect the paradigm case of grief and a broader but still legitimate set of grief-generating states of affairs, liberate grief from the view that grief is past directed or about the past, and thus account for grief in a way that separates it from its closest emotion-neighbor, sorrow, without having to rely on the affective quality of those two emotions.If the passing of the beloved causes the grief but is not what the grief is about, then we can get at the nature of grief by saying its temporal orientation is in the past, but its temporal meaning is the present and future—the new significance of a world with the pervasive absence that is the world without the beloved. The no-longer of grief is a no-longer oriented by a past that is referred a present and future. Looking at the griever’s relation to time can tell us much about the pain and the object of grief, then. As the griever puts the past before himself with a certainty about this world “henceforth,” a look at the griever’s lived sense of the fi nality of the irreversibly lost liberates grief from the tendency in the literature to be reduced to a past-directed emotion, accounts for grief ’s intensity, its affective force or poignancy, and thus enables us to separate grief from sorrow according to its intentionalobject in light of the temporal meaning of these emotions. (shrink)
The role of mechanistic evidence tends to be under‐appreciated in current evidence‐based medicine, which focusses on clinical studies, tending to restrict attention to randomized controlled studies when they are available. The EBM+ programme seeks to redress this imbalance, by suggesting methods for evaluating mechanistic studies alongside clinical studies. Drug approval is a problematic case for the view that mechanistic evidence should be taken into account, because RCTs are almost always available. Nevertheless, we argue that mechanistic evidence is central to all (...) the key tasks in the drug approval process: in drug discovery and development; assessing pharmaceutical quality; devising dosage regimens; assessing efficacy, harms, external validity, and cost‐effectiveness; evaluating adherence; and extending product licences. We recommend that, when preparing for meetings in which any aspect of drug approval is to be discussed, mechanistic evidence should be systematically analysed and presented to the committee members alongside analyses of clinical studies. (shrink)
Evidence-based medicine, the dominant approach to assessing the effectiveness of clinical and public health interventions, focuses on the results of association studies. EBM+ is a development of EBM that systematically considers mechanistic studies alongside association studies. In this paper we provide several examples of the importance of mechanistic evidence to coronavirus research. Assessment of combination therapy for MERS highlights the need for systematic assessment of mechanistic evidence. That hypertension is a risk factor for severe disease in the case of SARS-CoV-2 (...) suggests that altering hypertension treatment might alleviate disease, but the mechanisms are complex, and it is essential to consider and evaluate multiple mechanistic hypotheses. To be confident that public health interventions will be effective requires a detailed assessment of social and psychological components of the mechanisms of their action, in addition to mechanisms of disease. In particular, if vaccination programmes are to be effective, they must be carefully tailored to the social context; again, mechanistic evidence is crucial. We conclude that coronavirus research is best situated within the EBM+ evaluation framework. (shrink)
This book explores the problem of time and immanence for phenomenology in the work of Edmund Husserl, Martin Heidegger, Maurice Merleau-Ponty, and Jacques Derrida. Detailed readings of immanence in light of the more familiar problems of time-consciousness and temporality provide the framework for evaluating both Husserl's efforts to break free of modern philosophy's notions of immanence, and the influence Heidegger's criticism of Husserl exercised over Merleau-Ponty's and Derrida's alternatives to Husserl's phenomenology. Ultimately exploring various notions of intentionality, these in-depth analyses (...) of immanence and temporality suggest a new perspective on themes central to phenomenology's development as a movement and raise for debate the question of where phenomenology begins and ends. (shrink)
One of the guiding principles of modern medical and health sciences is the discovery and description of the modes of origin and the actions of pathogenic precursors of disease. This principle facilitates the design of interventions to reduce the burden of mortality and morbidity in individuals and populations. This enterprise is challenging because of the complexity of the pathogenic mechanisms involved. Although highly intricate descriptions of these mechanisms have been developed, they have mainly been at the biological level. In this (...) article, we focus on a relatively underexplored aspect of the complexity of pathogenic process: the integration of biological with social and behavioral causes in the same.. (shrink)
In this article I survey Foucault’s remarks on norms and normalisation from across his oeuvre, with a view to reconstructing his genealogy of norms, leaning at points – following Foucault himself – on Georges Canguilhem’s seminal work on the topic. I also survey in tandem the existing secondary scholarship on this question, maintaining – pace other schol-ars – that Foucault’s position has not been adequately explicated despite sophisticated attempts. I argue that Foucault’s idiosyncratic conception of the norm, overlooked or mis-understood (...) by other readers, is consistently of an ideal model guiding human action in any particular sphere. This concept is a relatively modern one that may be contrasted to the older form of restricting human behaviour according to binary discriminations that may be called ‘laws’ or ‘rules’. Foucault traces the form of the norm specifically to medieval pro-cesses for dealing with the plague, which later become highly generalised and diffused to produce a normalising society. I conclude with a more speculative discussion of how this society of the norm continues to utilise binarising rules, arguing that norms are typically used in order to ground binarising condemnations of abnormal cases, but that the nebu-lousness of norms ultimately allows any particular case to be condemned by such stand-ards. (shrink)
Following an analysis of the work of Stanley Cavell, Arthur Danto, Umberto Eco, Susan Sontag, and other philosophers of the 1960s who made aesthetics more responsive to contemporary art, Kelly considers Sontag's aesthetics in greater detail ...
These twelve essays, written by philosophers, examine the usefulness, objectivity, and range of applicability of interpretive methods in ethics and politics, with the goal of isolating the role of methodology to allow debate to focus on substantive conflicts.
This paper presents Anthony Steinbock's broad theory of moral emotions and specifically the distinction he draws between the temporal orientation and the temporal meaning of emotions. The latter distinction is used in order to provide phenomenological descriptions of, and distinctions between, patience and impatience. The paper takes leading clues from Steinbock’s work in an effort to “do” phenomenology in a way that clarifies these specific natural attitude intentionalities.
For several decades Rafael Capurro has been at the forefront of defining the relationship between information and modernity through both phenomenological and ethical formulations. In exploring both of these themes Capurro has re-vivified the transcultural and intercultural expressions of how we bring an understanding of information to bear on scientific knowledge production and intermediation. Capurro has long stressed the need to look deeply into how we contextualize the information problems that scientific society creates for us and to re-incorporate a pragmatic (...) dimension into our response that provides a balance to the cognitive turn in information science. -/- With contributions from 35 scholars from 15 countries, Information Cultures in the Digital Age focuses on the culture and philosophy of information, information ethics, the relationship of information to message, the historic and semiotic understanding of information, the relationship of information to power and the future of information education. This Festschrift seeks to celebrate Rafael Capurro’s important contribution to a global dialogue on how information conceptualisation, use and technology impact human culture and the ethical questions that arise from this dynamic relationship. (shrink)
In this essay, I take as a starting point Foucault’s rejection of two different ways of thinking about the future, prophecy and utopianism, and use this rejection as a basis for the elaboration of a more detailed rejection of them, invoking complexity-based epistemic limitations in relation to thinking about the future of political society. I follow Foucault in advocating immanent political struggle, which does not seek to build a determinate vision of the future but rather focuses on negating aspects of (...) the current conjuncture. I extend this argument into an ethical register, arguing that the same arguments apply mutatis mutandis to our personal lives. I conclude by engaging with Jacques Lacan’s account of subjectivity, and the interpretation of its political import furnished by Yannis Stavrakakis, drawing from these additional supports for my position, in particular the rejection of utopianism as an attempt to avoid limitation by the real. (shrink)
This is a clear and critical account of Foucault's political thought: what he said, how it's been used and its influence today. Michel Foucault, French philosopher, social theorist, historian of ideas and literary critic, is primarily known as a radical thinker who disturbs our understanding of society, yet little attention has been paid to his politics. Now, Mark Kelly details and criticises all of Foucault's major political ideas: the historical relativity of knowledge; exclusion and abnormality; his radical reconception of power; (...) his historical analysis of biopolitics in terms of discipline and biopower; his concept of governmentality; and his late work around ethics and subjectivity. Kelly shows how Foucault's positions changed over time, how his thought has been used in the political sphere and examines the importance of his work for politics today. It engages with Foucault's entire corpus, from his first works right up to his posthumously published College de France lectures and the unabridged version of the History of Madness. It looks at the theoretical reception of Foucault's thought and how it has been applied to real-world problems. (shrink)
Arthur C. Danto has long defended essentialism in the philosophy of art, yet he has been interpreted by many as a historicist. This essentialism/historicism conflict in the interpretation of his work reflects the same conflict both within his thought and, more importantly, within modern art itself. Danto's strategy for resolving this conflict involves, among other things, a Bildungsroman of modern art failing to discover its essence, an essentialist definition of art provided by philosophy which is indemnified against history, and a (...) thesis about the end of art once it has been defined. Is this strategy successful, or does it result, as I argue, in a philosophical disenfranchisement of art of precisely the type that Danto himself has criticized? (shrink)
Previous research on gender-based economic inequality has emphasized occupational segregation as the leading explanatory factor for the gender wage gap. Yet the globalization of the U.S. economy has affected gender inequality in fundamental ways and potentially diminished the influence of occupational gender segregation. We examine whether occupational gender segregation continues to be the main determinant of gender earnings inequality and to what extent globalization processes have emerged as important determinants of inequality between women’s and men’s earnings. We study factors contributing (...) to the gender earnings ratio as well as the median earnings of men and women for 271 U.S. metropolitan areas. The results indicate that occupational segregation is still the leading determinant of gender earnings inequality, that its effects are only slightly diminished by the presence of globalization, and that various aspects of the global economy independently influence the gender earnings gap. (shrink)
The first reference of its kind surveys the full breadth of critical thought on art, culture, and society--from classical philosophy to contemporary critical theory. Featuring 600 original articles by distinguished scholars from many fields and countries, it is a comprehensive survey of major concepts, thinkers, and debates about the meaning, uses, and value of all the arts--from painting and sculpture to literature, music, theater, dance, television, film, and popular culture. Of special interest are in-depth surveys of Western aesthetics and broad (...) coverage of non-Western traditions and theories of art. The work includes cross references, bibliographies, and an index. (shrink)
A four-volume reference work that surveys how philosophers, art historians, and others reflect critically on art and culture. The first comprehensive reference work on aesthetics that presents articles on the history of Western and non-Western aesthetics along with extensive accounts of the contemporary debates.
Often neglected as an influence on phenomenology, Bergson's thought has resurfaced and brought challenges to phenomenology. In a series of original essays and translations, leading scholars of contemporary continental philosophy seek to redress this oversight and inaugurate a long over due dialogue and yet pertinent to the future of continental philosophy. This thematically focused collection reintroduces Bergson to the dominant discourse in continental philosophy (phenomenology), reevaluates phenomenologists' readings of Bergson (e.g., Heidegger, Sartre, Merleau-Ponty, Levinas, and Henry), and examines Bergsonian challenges (...) to phenomenological methods and issues. What emerges is not only a revitalized Bergson read on his own terms, but also a view of the vibrance of Bergson's thought and its central contributions to perennial issues in phenomenology and contemporary continental philosophy: including dualism, intentionality, subjectivity and selfhood, science, time, ethics, freedom, life and affectivity. (shrink)
In this essay, I take as a starting point Foucault’s rejection of two different ways of thinking about the future, prophecy and utopianism, and use this rejection as a basis for the elaboration of a more detailed rejection of them, invoking complexity-based epistemic limitations in relation to thinking about the future of political society. I follow Foucault in advocating immanent political struggle, which does not seek to build a determinate vision of the future but rather focuses on negating aspects of (...) the current conjuncture. I extend this argument into an ethical register, arguing that the same arguments apply mutatis mutandis to our personal lives. I conclude by engaging with Jacques Lacan’s account of subjectivity, and the interpretation of its political import furnished by Yannis Stavrakakis, drawing from these additional supports for my position, in particular the rejection of utopianism as an attempt to avoid limitation by the real. (shrink)
This volume pays tribute to both Danto's brilliant capacity to move between philosophy and contemporary culture and his pathbreaking achievements in philosophy, art history, and art criticism.
The second edition of the Encyclopedia of Aesthetics is an unparalleled reference resource that surveys the full breadth of critical thought on art, culture, and nature, from classical philosophy to contemporary critical theory. The four-volume first edition, published in 1998, effected a revival of aesthetics that created a receptive context for the contemporary importance of the field. Spanning six volumes and 815 articles, the new edition of the Encyclopedia has been updated and expanded to reflect the rapidly evolving character of (...) the discipline. Renowned contributors from diverse fields provide analyses of the major artists, movements, and theories that continue to inform scholarly research on aesthetics. The updated Encyclopedia of Aesthetics contains 250 new entries that incorporate innovative fields of inquiry, such as animal aesthetics and diaspora criticism, as well as significant new developments in art, including digital media and street art. Additionally, the second edition offers enhanced coverage of non-Western cultural areas and related issues, such as post-colonialism, globalization, and primitivism. In so doing, it extends the scope of critical aesthetics, seeking to create a more open environment for aesthetics in academia, culture, and art. With bibliographic references and images, the Encyclopedia of Aesthetics is an essential work that is of use to artists, scholars, students, and all others interested in art-from painting and sculpture to literature, music, theater, film, and more. (shrink)
Over the past few decades the pace of change in the business environment has been rapid, as the effects of electronic innovations and the acceptance of the globalisation mind-set have occurred. Communism has collapsed and the power of corporations has grown in the global community that has developed. It has become imperative that business decision-makers become aware that their decisions may limit the choices of future generations by irretrievably destroying the currently existing physical and social environment. Decision-making in today's business (...) environment will have a profound affect on human well-being in general and specifically on the breadth of options that are provided to the business decision-makers of tomorrow. Against this background it is argued that senior managers should adopt a new paradigm through which to view the world and assess the import of their decisions. Managers need to consider the effects of their decisions not only on the economy but also on the environment and the social world, which the economy is meant to serve. Managers must ensure their ways of doing business are sustainable. (shrink)
