Diseases of complex origin have a component of quantitative genetics that contributes to their susceptibility and phenotypic variability. However, after several studies, a major part of the genetic component of complex phenotypes has still not been found, a situation known as “missing heritability.” Although there have been many hypotheses put forward to explain the reasons for the missing heritability, its definitive causes remain unknown. Complex diseases are caused by multiple intermediate phenotypes involved in their pathogenesis and, very often, each one (...) of these intermediate phenotypes also has a component of quantitative inheritance. Here we propose that at least part of the missing heritability can be explained by the genetic component of intermediate phenotypes that is not detectable at the level of the main complex trait. At the same time, the identification of the genetic component of intermediate phenotypes provides an opportunity to identify part of the missing heritability of complex diseases. (shrink)

El legado enciclopedista de Diderot sobre el poder político y el derecho en vísperas de Revolución -- Un célebre profesor de jurisprudencia de siglo XVIII, después marginado durante siglos: el caso de Jean Jacques Burlamaqui y sus Elementos de derecho natural -- Lardizábal, jurista "ilustrado" en los albores de la Independencia de México -- Los ilustrados, infatigables inventores de derechos vitales. Escolio a una obra de Lynn Hunt -- Lichtenberg, un ilustrado minimalista. A manera de epílogo.

This book highlights the powerful impact of some important Spanish Jesuits (Suárez, Acosta, Ribadeneira, Mariana) on some relevant English thinkers such as Locke, Bacon, and others, regarding politics, law and natural rights, an influence sometimes hidden and always controversial.

This book highlights the powerful impact of some important Spanish Jesuits on some relevant English thinkers such as Locke, Bacon, and others, regarding politics, law and natural rights, an influence sometimes hidden and always controversial.

Darwin diceva che le specie si trasformavano per poter sopravvivere: arriva un terremoto, un’inondazione e solo chi sa correre rapidamente o chi sa nuotare vive. Ok, ma cosa ci dice questa teoria sui cambiamenti che non portano a migliori possibilità di sopravvivere o di riprodursi? Ben poco. Perché nel corso dei secoli i denti molari dell’uomo si sono ridotti di dimensioni, così come le dita dei piedi? Certo non per sopravvivere e riprodursi meglio. Gli autori riportano nel corso di questa (...) rassegna vari esempi che la teoria di Darwin non riesce a spiegare e delle possibili spiegazioni alternative, asseverate da esperimenti scientifici validati e consacrati dalla comunità scientifica. Darwin aveva torto? Certamente no! Ma come tutte le opere della scienza richiede revisioni e miglioramenti. (shrink)

This volume is both a state-of-the-art display of current thinking on second language development as a complex system. It is also a tribute to Diane Larsen-Freeman for her decades of intellectual leadership in the academic disciplines of applied linguistics and second language acquisition. The chapters therein range from theoretical expositions to methodological analyses, pedagogical proposals, and conceptual frameworks for future research. In a balanced and in-depth manner, the authors provide a comprehensive and interdisciplinary understanding of second language development, with a (...) wealth of insights that promise to break the status-quo of current research and take it to exciting new territory. The book will appeal to both seasoned and novice researchers in applied linguistics, second language acquisition, bilingualism, cognitive psychology, and education, as well as to practitioners in second or foreign language teaching of any language. (shrink)

Adult learners demand teaching innovations that are ever more rapid and attractive. As a response to these demands and the challenges of skills training, this article presents a conceptual analysis that introduces competitive debate as an impact training model. The aim is to learn whether debate can be considered to fall within the frame of gamification, so that the full potential of debate as gamification can be exploited. There is a significant research gap regarding competitive debate as a game, with (...) the training mechanics for adult learners remaining practically unexplored. Through a conceptual analysis of game, game experience, and gamification, and their respective characteristics, we conclude that competitive debate is an ideal instrument for gamification. (shrink)

Child-to-parent violence has dramatically risen in the last decade, becoming a concerning issue in many countries, so research on this issue has also increased. However, most of the studies on this topic have been conducted with samples of adolescents, and very few with samples of parents. In addition, the variety of assessment instruments does not reflect the elements of this type of violence. Thus, the current study was aimed to examine the factor structure, reliability, and validity of the Child-to-parent Violence (...) Questionnaire, parents’ version, in a sample of Spanish parents of adolescents. Moreover, the prevalence rates of the different types of violence and the reasons for violence were also examined. A total of 1,012 Spanish parents of adolescents aged between 12 and 17 years old were assessed using the CPV-Q-P. Data indicated a matrix of four factors with 14 items, assessing psychological violence, physical violence, financial violence, and control/domain over parents, and two factors with 8 items capturing the reasons for child-to-parent violence, with adequate psychometric properties. The more frequent type of violence was control and domain over parents, followed by psychological, financial, and physical violence, with no significant differences between mothers and fathers. Otherwise, instrumental reasons were more frequent than reactive types, with no differences between mothers and fathers. The CPV-Q-P is a useful instrument to assess child-to-parent violence from the parents’ perspective in both professional and research settings. (shrink)

This article examines the recent Council of Europe Convention on violence against women through the lens of postcolonial feminist critiques. The article argues that, while there is certainly cause for optimism, the Convention still falls into some of the traps identified by postcolonial feminists. The Convention largely circumvents the stigmatising risks that arise from framing certain VAW forms primarily as a problem of some ‘cultures’. Yet dangers linger in the Convention’s approach to ‘honour’ as an unacceptable justification for VAW. Inherent (...) risks also remain in the vulnerability frame through which the Convention views migrant, refugee, and asylum-seeker women. Applied uncritically, these approaches risk re-inscribing images of inherently powerless women victimised by their non-European ‘cultures,’ reminiscent of colonial times. (shrink)

Reseña de José Emilio Burucúa. _Vislumbres de un futuro útil y enaltecedor para las humanidades_. Rosario: UNR Editora, 2020.

Si durante siglos el Derecho Eclesiástico se identificó con el conjunto de normas emanadas de la Iglesia Católica, considerándose como sinónimo del Derecho Canónico, el proceso histórico de formación del mismo se iniciaría cuando el Estado se considera legitimado para legislar en materias eclesiásticas, defendiendo su propia soberanía frente al monopolio de la competencia del Derecho de la Iglesia, hasta entonces pacíficamente reconocido, fenómeno que se produjo de forma diversa en los países católicos que en aquellos en que triunfó la (...) reforma protestante. Su consolidación como Ciencia jurídica autónoma, primero en Italia y, posteriormente en España, desde la perspectiva actual del Estado moderno, no se explica ya, sin embargo, como el fruto de un intervencionismo estatal en materia religiosa sino sobre la base del reconocimiento, tutela y promoción de los derechos humanos y, en particular, del derecho de libertad religiosa.If the historical training process of the Ecclesiastic Law was begun when the State was considered legitimated to legislate in ecclesiastic matters, defending its own front sovereignty against the monopoly of the domain of the Law of the Church, at present, its consolidation as autonomous legal Science has been possible thanks to the recognition, tutela and promotion of the human rights and, in particular, of the right to religious freedom. (shrink)

In this paper the propositional logic LTop is introduced, as an extension of classical propositional logic by adding a paraconsistent negation. This logic has a very natural interpretation in terms of topological models. The logic LTop is nothing more than an alternative presentation of modal logic S4, but in the language of a paraconsistent logic. Moreover, LTop is a logic of formal inconsistency in which the consistency and inconsistency operators have a nice topological interpretation. This constitutes a new proof of (...) S4 as being "the logic of topological spaces", but now under the perspective of paraconsistency. (shrink)

"¿Cómo salimos del silencio? Este y otros interrogantes fluyen como una constante en esta minuciosa investigación, que ofrece un enfoque panorámico sobre el estudio de las lenguas. En palabras de Carlos Fuentes, el encanto de esta obra está en que aborda cosas que creíamos saber sobre las lenguas y descubre lo que no sabíamos sobre lo que creíamos saber" -- Prové de l'editor.

Ante el pensamiento del neocapitalismo y su poder actual, el autor se pregunta su hay razones para reivindicar la justicia social en nuestros días. Para responder a esta interrogante realiza un análisis de algunos elementos históricos que habrían sido en su opinión decisivos para llegar a la situación actual de la democracia en Occidente, desgranando algunas de las diferencias ideológicas que sobre la gobernabilidad de la democracia surgieron en la izquierda, y que condujeron a dos vías diferentes en el seno (...) de la misma y al triunfo de la identificada con las posiciones socialdemócratas. Así, señala, una socialdemocracia reconvertida en tercera vía, y un comunismo pertrechado de consignas altisonantes con poca sustancia ideológica se reparten la clientela política de izquierda a este lado del mundo. (shrink)

El Juicio de gusto como Juicio estético parte de la contemplación de un objeto en particular. Surge de forma libre y no guarda relación alguna con una intencionalidad por parte del sujeto. En el caso de un juicio sobre lo bello se considera que atribuye cierta belleza al objeto como si se tratase de una propiedad que le caracteriza. La forma en la que se da este juicio posibilita el surgimiento de cierta universalidad del mismo en la medida en que (...) todo aquel que pueda contemplarlo pueda distinguir la belleza en él. Pero se trata sólo de universalidad estética y no lógica. En la forma que adoptan estos objetos se advierte una finalidad de la naturaleza como condición a priori que posibilita su conocimiento. Dicha posibilidad basada en la reflexión sobre la forma de estos viene determinada por el uso reflexionante de la facultad de juzgar. (shrink)

Este espacio ofrece un conjunto de aspectos de la filosofía de Lévinas expresados en una sección de su obra Totalidad e Infinito que se enfrentan con el pensamiento de Hegel en el marco de las relaciones intersubjetivas en torno a un comportamiento ético de la conciencia o el yo frente a lo otro de sí. Los puntos de encuentros y más aún de desencuentros entre ambos autores revelan que el contexto histórico es determinante en las posturas que plantean en la (...) medida en que ofrecen interpretaciones mayormente divergentes de acuerdo a la relación de cada sujeto con lo externo a sí. El objetivo de este espacio de discusión entre ambos autores es resaltar la importancia y el papel que juega la figura de la Autoconciencia hegeliana frente a la construcción de sociedades que aspiran a poner en marcha proyectos de justicia social y verdadera democracia. (shrink)

La facultad de juzgar teleológica se distingue de la estética básicamente en el punto de partida que tiene el sujeto frente a los objetos que juzga. En este caso el sujeto parte de algún conocimiento sobre ellos y no juzga solo a partir de lo que exteriormente advierte en los mismos. Esto implica que la realidad de dichos objetos cobra una dimensión diferente y el hombre puede incluirle en su quehacer diario ya que puede dar cuenta de su utilidad. La (...) finalidad en sentido de intencionalidad que se muestra en ciertos productos naturales guarda una relación externa con el hombre y con otros productos pues su existencia se basa en la conveniencia de su manifestación en un momento y lugar determinados. En los organismos naturales la finalidad de la naturaleza se basa en una relación orgánica entre los componentes que los constituyen formando entre todos un conjunto como ser organizado. (shrink)

This article proposes to identify risk factors for moral distress from the literature, validate them through expert analysis and provide the basis for a new tool to assess the risk of moral distress among nurses. Moral distress is related to the psychological, emotional and physiological aspects of nursing. It arises from constraints caused by various circumstances and can lead to significant negative consequences. A scoping review and validation through expert analysis were used. The research question guiding this study was as (...) follows: What is known about risk factors for moral distress in nursing? The research was conducted using multiple sources including electronic databases and lists of references from relevant literature. The final sample consisted of 38 studies. A validation analysis was conducted by experts during December 2014 and June 2015. To exclude a risk factor item, at least 80% of the experts had to agree with the exclusion. In total, 53 risk factors for moral distress were identified, reviewed by the experts and grouped to form a new instrument that may help to identify risk for moral distress and to address its consequences. (shrink)