The ventricular pressure profile is characteristic of the cardiac contraction progress and is useful to evaluate the cardiac performance. In this contribution, a tissue-level electromechanical model of the left ventricle is proposed, to assist the interpretation of left ventricular pressure waveforms. The left ventricle has been modeled as an ellipsoid composed of twelve mechano-hydraulic sub-systems. The asynchronous contraction of these twelve myocardial segments has been represented in order to reproduce a realistic pressure profiles. To take into account the different energy (...) domains involved, the tissue-level scale and to facilitate the building of a modular model, multiple formalisms have been used: Bond Graph formalism for the mechano-hydraulic aspects and cellular automata for the electrical activation. An experimental protocol has been defined to acquire ventricular pressure signals from three pigs, with different afterload conditions. Evolutionary Algorithms have been used to identify the model parameters in order to minimize the error between experimental and simulated ventricular pressure signals. Simulation results show that the model is able to reproduce experimental ventricular pressure. In addition, electro-mechanical activation times have been determined in the identification process. For example, the maximum electrical activation time is reached, respectively, 96.5, 139.3 and 131.5 ms for the first, second, and third pigs. These preliminary results are encouraging for the application of the model on non-invasive data like ECG, arterial pressure or myocardial strain. (shrink)

The ventricular pressure profile is characteristic of the cardiac contraction progress and is useful to evaluate the cardiac performance. In this contribution, a tissue-level electromechanical model of the left ventricle is proposed, to assist the interpretation of left ventricular pressure waveforms. The left ventricle has been modeled as an ellipsoid composed of twelve mechano-hydraulic sub-systems. The asynchronous contraction of these twelve myocardial segments has been represented in order to reproduce a realistic pressure profiles. To take into account the different energy (...) domains involved, the tissue-level scale and to facilitate the building of a modular model, multiple formalisms have been used: Bond Graph formalism for the mechano-hydraulic aspects and cellular automata for the electrical activation. An experimental protocol has been defined to acquire ventricular pressure signals from three pigs, with different afterload conditions. Evolutionary Algorithms have been used to identify the model parameters in order to minimize the error between experimental and simulated ventricular pressure signals. Simulation results show that the model is able to reproduce experimental ventricular pressure. In addition, electro-mechanical activation times have been determined in the identification process. For example, the maximum electrical activation time is reached, respectively, 96.5, 139.3 and 131.5 ms for the first, second, and third pigs. These preliminary results are encouraging for the application of the model on non-invasive data like ECG, arterial pressure or myocardial strain. (shrink)

The paper describes the conceptual models used to understand the processes determining plant growth rates in response to environmental changes. A series of experiments and growth models were used at three organizational levels: the specific plant organs, the whole plant and the plant canopy. The energy conversion efficiency and the total plant carbon balance were first examined. The carbon partitioning amongst the plant parts was then studied. The energy conversion efficiency is generally understood. In modelling carbon partitioning it was first (...) necessary to establish the carbon demand for each plant organ. The carbon partitioned amongst plant organs was then calculated in two ways. The first one based on empirical data consisted in defining which organ received the carbon prior to other organs. The second one was based on the relationship between the carbon mass of specific organs and their trophic activity. This hypothesis allowed the optimization of the carbon partitioning in order to maximize the whole plant growth rate. The opportunities to use these theoretical approaches in plant growth modelling are discussed. (shrink)

New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

Le chevalier Louis de Jaucourt (1704-1780), principal auteur de l'Encyclopédie avec plus de dix-sept mille articles, est une figure marquante des Lumières, qui néanmoins reste largement méconnue. Ce livre collectif explore différents aspects de l'oeuvre du chevalier, dans l'Encyclopédie et au-delà. Il analyse la richesse et la diversité de sa pensée qui paraît à travers son éclectisme philosophique ou son écriture par emprunts, dans son propos médical, son travail d'historien, de biographe, de juriste, de critique d'art, ou encore d'encyclopédiste (...) et d'éditeur. Dans tous les cas, l'étude des articles de Jaucourt révèle une pensée stimulante, à la fois représentative de l'Encyclopédie et originale par plusieurs de ses traits. (shrink)

When it was first published in French in 1980, The Ordinary Man of Cinema signaled a shift from the French film criticism of the 1960s to a new breed of film philosophy that disregarded the semiotics and post-structuralism of the preceding decades. Schefer describes the schizophrenic subjectivity the cinema offers us: the film as a work projected without memory, viewed by (and thereby lived by) a subject scarred and shaped by memory. The Ordinary Man of Cinema delineates the phenomenology of (...) movie-going and the fleeting, impalpable zone in which an individuals personal memory confronts the cinemas ideological images to create a new way of thinking. It is also a book replete with mummies and vampires, tyrants and prostitutes, murderers and freaksfigures that are fundamental to Schefers conception of the cinema, because the worlds that cinema traverses (our worlds, interior and exterior) are worlds of pain, unconscious desire, decay, repressed violence, and the endless mystery of the body. Fear and pleasure breed monsters, and such are what Schefers emblematic "ordinary man" seeks and encounters when engaging in the disordering of the ordinary that the movie theater offers him. Among other things, Schefer considers "The Gods" in 31 brief essays on film stills and "The Criminal Life" with reflections on spectatorship and autobiography. While Schefers book has long been standard reading in French film scholarship, until now it has been something of a missing link to the field (and more broadly, French theory) in English. It is one of the building blocks of more widely known and read translations of Gilles Deleuze (who cited this book as an influence on his own cinema books) and Jacques Rancière. (shrink)

D. N. Rodowick _Gilles Deleuze's Time Machine_ Durham and London: Duke University Press, 1997 ISBN: 0822319705 280 pp.

Suggests an open system of psychological exploration to cut through accepted norms of morality, language, and politics.

"Le projet le plus général de Nietzsche consiste en ceci : introduire en philosophie les concepts de sens et de valeur. Nietzsche n'a jamais caché que la philosophie du sens et des valeurs dut être une critique. Que Kant n'ait pas mené la vraie critique, parce qu'il n'a pas su en poser le problème en termes de valeurs, tel est même un des mobiles principaux de l'oeuvre de Nietzsche". Cette analyse rigoureuse et critique de la philosophie de Nietzsche est une (...) lumineuse introduction à l'oeuvre d'un philosophe trop souvent réduit au nihilisme, à la volonté de puissance et l'image du surhomme. Gilles Deleuze remarque que "la philosophie moderne présente des amalgames, qui témoignent de sa vigueur et de sa vivacité, mais qui comportent aussi des dangers pour l'esprit" et que la force du projet philosophique de Nietzsche dans le "dépassement" de la métaphysique est "de dénoncer toutes les mystifications qui trouvent dans la dialectique un dernier refuge. La philosophie de Nietzsche a une grande portée polémique". (shrink)

Machine generated contents note: -- Preface to the English edition \ Translators' Introduction \Preface to the French Edition \ 1. Theses on Movement: First Commentary onBergson \ 2. Frame and Short, Framing and Cutting \ 3. Montage \ 4. TheMovement-Image and its Three Varieties: Second Commentary on Bergson \ 5. ThePerception-Image \ 6. The Affection-Image Face and Close-Up \ 7. TheAffection-Image: Qualities, Powers, Any-Space-Whatevers \ 8. From Affect toAction: The Impulse Image \ 9. The Action-Image: The Large Form \ 10. (...) The Action-Image:The Small Form \ 11. Figures, or the Transformation of Forms \ 12. The Crisisof the Action-Image \ Glossary \ Notes \ Index. (shrink)

This paper critically examines the materialism that Gilles Deleuze espouses in his oeuvre to the benefit of educational theory. In Difference and Repetition, he presented transcendental empiricism by underwriting Kant with realism (Deleuze, 1994). Later, in Capitalism & Schizophrenia I & II that were co-written with Félix Guattari (1984, 1988) and that they named Anti-Oedipus and A Thousand Plateaus, Deleuze's philosophical approach is realigned into what I term here as transcendental materialism, and latterly as immanent materialism; that I claim effectively (...) eliminate phenomenology as perceptual input. This essay takes this transformation seriously as a way of understanding educational data, research and practices. The proposition that is central to this paper is that transcendental and immanent materialism give us a means of dealing with educational phenomena without the interference of perception or a stable category of experience, by connecting data with theory and circumventing subjectification. It is argued that this proposition has important consequences for educational research, and the construction of educational arguments that will be illustrated in this essay. Deleuze's debt to French Marxism and in particular to the work of Louis Althusser are also recognised through this writing. (shrink)

Praised for its rare combination of scholarly rigor and imaginative interpretation, _Nietzsche and Philosophy_ has long been recognized as one of the most important analyses of Nietzsche. It is also one of the best introductions to Deleuze's thought, establishing many of his central philosophical positions. In _Nietzsche and Philosophy_, Deleuze identifies and explores three crucial concepts in Nietzschean thought-multiplicity, becoming, and affirmation-and clarifies Nietzsche's views regarding the will to power, eternal return, nihilism, and difference. For Deleuze, Nietzsche challenged conventional philosophical (...) ideas and provided a means of escape from Hegel's dialectical thinking, which had come to dominate French philosophy. He also offered a path toward a politics of difference. In this new edition, Michael Hardt's foreword examines the profound influence of Deleuze's provocative interpretations on the study of Nietzsche, which opened a whole new avenue in postwar thought. (shrink)

Book review of Jean-Louis Schefer's The Ordinary Man of Cinema (2016) with particular attention to Schefer's conception of affect and its influence on Deleuze.

‘A rare and remarkable book.’ Times Literary SupplementGilles Deleuze (1925-1995) was Professor of Philosophy at the University of Paris VIII. He is a key figure in poststructuralism, and one of the most influential philosophers of the twentieth century.F\’elix Guattari (1930-1992) was a psychoanalyst at the la Borde Clinic, as well as being a major social theorist and radical activist. A Thousand Plateaus is part of Deleuze and Guattari’s landmark philosophical project, Capitalism and Schizophrenia - a project that still sets the (...) terms of contemporary philosophical debate. A Thousand Plateaus provides a compelling analysis of social phenomena and offers fresh alternatives for thinking about philosophy and culture. Its radical perspective provides a toolbox for ‘nomadic thought’ and has had a galvanizing influence on today’s anti-capitalist movement.Translated by Brian Massumi>. (shrink)

John Rawls famously holds that the basic structure is the 'primary subject of justice.'1 By this, he means that his two principles of justice apply only to a society's major political and social institutions, including chiefly the constitution, the economic and legal systems, and (more contentiously) the family structure.2 This thesis — call it the basic structure restriction — entails that the celebrated difference principle has a narrower scope than one might have expected. It doesn't apply directly to choices that (...) individuals make within the basic structure. Individuals can live up to the demands of justice simply by obeying whatever rules are set by, and by doing what is necessary to sustain, the basic .. (shrink)

La logique de Leibniz: d'apres des documents inedits / par Louis Couturat,...Date de l'edition originale: 1901Sujet de l'ouvrage: Leibniz, Gottfried Wilhelm (1646-1716)Logique moderneCollection: Collection historique des grands philosophesCe livre est la reproduction fidele d'une oeuvre publiee avant 1920 et fait partie d'une collection de livres reimprimes a la demande editee par Hachette Livre, dans le cadre d'un partenariat avec la Bibliotheque nationale de France, offrant l'opportunite d'acceder a des ouvrages anciens et souvent rares issus des fonds patrimoniaux de la (...) BnF.Les oeuvres faisant partie de cette collection ont ete numerisees par la BnF et sont presentes sur Gallica, sa bibliotheque numerique.En entreprenant de redonner vie a ces ouvrages au travers d'une collection de livres reimprimes a la demande, nous leur donnons la possibilite de rencontrer un public elargi et participons a la transmission de connaissances et de savoirs parfois difficilement accessibles.Nous avons cherche a concilier la reproduction fidele d'un livre ancien a partir de sa version numerisee avec le souci d'un confort de lecture optimal. Nous esperons que les ouvrages de cette nouvelle collection vous apporteront entiere satisfaction.Pour plus d'informations, rendez-vous sur www.hachettebnf.frhttp: //gallica.bnf.fr/ark: /12148/bpt6k110843d. (shrink)

Until recently, cognitive science focused on such mental functions as problem solving, grammar, and pattern-the functions in which the human mind most closely resembles a computer. But humans are more than computers: we invent new meanings, imagine wildly, and even have ideas that have never existed before. Today the cutting edge of cognitive science addresses precisely these mysterious, creative aspects of the mind.The Way We Think is a landmark analysis of the imaginative nature of the mind. Conceptual blending is already (...) widely known in research laboratories throughout the world; this book, written to be accessible to both lay readers and interested scientists, is its definitive statement. Gilles Fauconnier and Mark Turner show that conceptual blending is the root of the cognitively modern human mind, and that conceptual blends themselves are continually combined and reblended to create the rich mental fabric in which we live.The Way We Think shows how this blending operates; how it is affected by (and gives rise to) language, identity, culture, and invention; and how we imagine what could be and what might have been. The result is a bold and exciting new view of how the mind works. (shrink)

This article proposes an interpretation of the chapters of theNicomachean Ethicsconcerning exchange and friendship. Rejecting approaches where Aristotle anticipates modern labour or need-based theories of value, the article claims that those notions of labour and need are required for a satisfactory interpretation of the most obscure passages of Book V. Finally, Aristotle's texts on exchange and friendship are related in such a way that the latter, since it is free from any political considerations, allows us to better understand the philosopher's (...) view on exchange. (shrink)

La philosophie théorique de Spinoza est une des tentatives les plus radicales pour constituer une ontologie pure : une seule substance absolument infinie, avec tous les attributs, les êtres n'étant que des manières d'être de cette substance. Mais pourquoi une telle ontologie s'appelle-t-elle Ethique? Quel rapport y a-t-il entre la grande proposition spéculative et les propositions pratiques qui ont fait le scandale du spinozisme? L'éthique est la science pratique des manières d'être. C'est une éthologie, non pas une morale. L'opposition de (...) l'éthique avec la morale, le lien des propositions éthiques avec la proposition ontologique, sont l'objet de ce livre qui présente, de ce point de vue, un dictionnaire des principales notions de Spinoza. D'où vient la place très particulière de Spinoza, la façon dont il concerne immédiatement le non-philosophe autant que le philosophe? (shrink)

Many terminally ill patients perceive themselves to be a burden to loved ones who care for them. The self-perception of being a burden can play a significant role in terminal patients’ decisions to take courses of action, such as ceasing life-sustaining treatment or requesting physician-assisted suicide, that hasten death. I will use the term ‘burden-based decision’ as a shorthand for cases in which a terminal patient’s perception that she is a burden to her loved ones influences her decision to hasten (...) death. When should we view a terminal patient’s inclination to make a burden-based decision to be an ethical problem or a failure of treatment? And when should we view it to be an acceptable response rather than a problem or failure? I argue here that such decisions are acceptable more often than many who write on this topic imply. (shrink)

Avec Hume, l'empirisme ne se définit plus essentiellement par l'origine sensible des idées. Il développe trois problèmes, les relations, les cas, les illusions. D'une part, les relations sont toujours extérieures à leurs termes, et dépendent de principes d'association qui en déterminent l'établissement et l'exercice (croyance). D'autre part, ces principes d'association n'agissent qu'en fonction des passions, pour indiquer des "cas" dans un monde de la culture ou du droit : c'est tout l'associationnisme qui est au service d'une pratique du droit, de (...) la politique et de l'économie (suffit-il, pour devenir propriétaire d'une cité abandonnée, de lancer un javelot sur la porte, ou faut-il toucher la porte du doigt?). Enfin, de telles règles de légitimité des relations peuvent-elles être séparées des fictions, des croyances illégitimes qui les accompagnent ou les doublent? Si bien que la philosophie est moins critique des erreurs que dénonciation des illusions inévitables. Dans tous ces domaines, l'empirisme opère la substitution de la croyance pratique au savoir, dans une entreprise athée qui consiste à naturaliser la croyance. (shrink)

This chapter contains section titled: Functives and Concepts.

In a 2018 referendum, the Irish electorate voted in favour of repealing Ireland's quasi-total legal ban on abortion. The referendum campaign saw important public discussions regarding gender roles in twenty-first century Ireland. While the constitutional ban on abortion was condemned by abortion rights advocates for marginalising women's agency, the legislation which replaced it has not escaped criticism either. Therefore, questions surrounding the conceptualisation of women's agency in the 2018 referendum are still relevant today. Adopting a multimodal critical discourse analysis approach, (...) this paper analyses signage from the weeks before the vote to examine the discursive construction of women's agency in the linguistic landscape of the referendum campaign. I argue that many mainstream campaign organisations – including those arguing for liberalisation of abortion laws – were complicit in the discursive diminishment of women's agency, suggesting that the campaign did not necessarily challenge prevailing ideologies of gender and agency. (shrink)

"Gill's and Ryan's Parmenides is, simply, superb: the Introduction, more than a hundred pages long, is transparently clear, takes the reader meticulously through the arguments, avoids perverseness, and still manages to make sense of the dialogue as a whole; there is a fine selective bibliography; and those parts of the translation I have looked at in detail suggest that it too is very good indeed." --Christopher Rowe, _Phronesis_.

Examines the philosophy of Henri Bergson, explains his concepts of duration, memory, and elan vital, and discusses the influence of science on Bergson.

A posthumous collection of writings by Deleuze, including letters, youthful essays, and an interview, many previously unpublished. Letters and Other Texts is the third and final volume of the posthumous texts of Gilles Deleuze, collected for publication in French on the twentieth anniversary of his death. It contains several letters addressed to his contemporaries (Michel Foucault, Pierre Klossowski, François Châtelet, and Clément Rosset, among others). Of particular importance are the letters addressed to Félix Guattari, which offer an irreplaceable account of (...) their work as a duo from Anti-Oedipus to What is Philosophy? Later letters provide a new perspective on Deleuze's work as he responds to students' questions. his volume also offers a set of unpublished or hard-to-find texts, including some essays from Deleuze's youth, a few unusual drawings, and a long interview from 1973 on Anti-Oedipus with Guattari. (shrink)

Introduction. Exister, c'est être seul -- 1. Conformisme et aristocratisme -- 2. Penser et lire -- 3. Communauté et économie -- 4. De la politique à l'enseignement -- 5. Des degrés de communauté -- 6. L'épreuve du collectif -- 7. Du "je" au "nous" -- 8. Une communauté à deux? -- 9. Le collectif en conflit -- 10. Ennemis et adversaires -- Conclusion. Quelques-uns.

A critical examination of the figure of Oedipus in psychoanalysis and Western culture as it relates to the history of society and capitalism.