Movement and positional control of mitochondria and other organelles are coordinated with cell cycle progression in the budding yeast, Saccharomyces cerevisiae. Recent studies have revealed a checkpoint that inhibits cytokinesis when there are severe defects in mitochondrial inheritance. An established checkpoint signaling pathway, the mitotic exit network (MEN), participates in this process. Here, we describe mitochondrial motility during inheritance in budding yeast, emerging evidence for mitochondrial quality control during inheritance, and organelle inheritance checkpoints for mitochondria and other organelles.

8 March, now known as International Women’s Day, is a day for feminist claims where demonstrations are organized in over 150 countries, with the participation of millions of women all around the world. These demonstrations can be viewed as collective rituals and thus focus attention on the processes that facilitate different psychosocial effects. This work aims to explore the mechanisms involved in participation in the demonstrations of 8 March 2020, collective and ritualized feminist actions, and their correlates associated with personal (...) well-being and collective well-being, collective efficacy and collective growth, and behavioral intention to support the fight for women’s rights. To this end, a cross-cultural study was conducted with the participation of 2,854 people from countries in Latin America and Europe, with a retrospective correlational cross-sectional design and a convenience sample. Participants were divided between demonstration participants and non-demonstrators or followers who monitored participants through the media and social networks. Compared with non-demonstrators and with males, female and non-binary gender respondents had greater scores in mechanisms and criterion variables. Further random-effects model meta-analyses revealed that the perceived emotional synchrony was consistently associated with more proximal mechanisms, as well as with criterion variables. Finally, sequential moderation analyses showed that proposed mechanisms successfully mediated the effects of participation on every criterion variable. These results indicate that participation in 8M marches and demonstrations can be analyzed through the literature on collective rituals. As such, collective participation implies positive outcomes both individually and collectively, which are further reinforced through key psychological mechanisms, in line with a Durkheimian approach to collective rituals. (shrink)

Sin proponérselo, este libro de Alberto Antonio Verón constituye una refutación de bulto contra el cargo de inanidad de la filosofía en Colombia esgrimido en la pregunta “¿dónde están los filósofos?”. Discípulo de Reyes Mate, Verón ha transferido la indagación por la filosofía después del Holocausto al examen de los testimonios de las víctimas de las multiformes expresiones de la violencia en nuestro país.

El ogro antropófago -- Filosofía, política y trabajo -- Fe y cultura, significado del documento de Puebla -- Efraín González Luna, precursor del documento de Puebla -- Notas sobre los valores en política -- Pluralismo y democracia, valores políticos -- Los valores en la obra de Manuel Gómez Morín -- Maquiavelo, ética y política -- Una espiritualidad para los laicos de hoy.

Lejos de nuestros modelos, la palabra desorden suele designar la riada anónima del exterior. Querría señalar la fuerza ciega de una corriente humana y terrenal, impetuosamente aleatoria, de la que debemos protegernos. Pero éste no es un libro de ética al estilo usual. No opera con la contraposición del bien al mal, no busca un conjunto de prescripciones para una vida mejor ni una idea del deber que guíe la acción. No intenta que los hombres aprendan a conducirse en términos (...) supuestamente morales, sino que cada uno asuma su indescifrable signo natal y le dé una forma de vida. El vínculo entre ética y alegría, entre moral y fuerza, ha sido peligrosamente olvidado. La disciplina no es reclamada por las señas externas de la organización, sino por el desarrollo interior de la potencia. Este libro intenta actualizar la vieja certeza, oriental y occidental, de que las contingencias externas acaecen siempre con un orden oculto, remotamente inteligible. Según tal experiencia, el pensamiento no es en primer lugar un acto reflexivo que pueda o no realizarse, sino la turbulencia secreta de cualquier presencia material, por apacible que parezca. Lo mismo es ser y pensar, se afirma ya antes de Platón. Se trata de una experiencia vertiginosa y a la vez común, admitida en la más llana –aunque no siempre expresable– sabiduría popular. Si aquí se tiene la pretensión de defenderla, de modo suficientemente comprensible, es por la intención de mostrarla en la más cotidiana y banal actualidad. (shrink)

A long-standing question in cognitive science is how high-level knowledge is integrated with sensory input. For example, listeners can leverage lexical knowledge to interpret an ambiguous speech sound, but do such effects reflect direct top-down influences on perception or merely postperceptual biases? A critical test case in the domain of spoken word recognition is lexically mediated compensation for coarticulation (LCfC). Previous LCfC studies have shown that a lexically restored context phoneme (e.g., /s/ in Christma#) can alter the perceived place of (...) articulation of a subsequent target phoneme (e.g., the initial phoneme of a stimulus from a tapes-capes continuum), consistent with the influence of an unambiguous context phoneme in the same position. Because this phoneme-to-phoneme compensation for coarticulation is considered sublexical, scientists agree that evidence for LCfC would constitute strong support for top–down interaction. However, results from previous LCfC studies have been inconsistent, and positive effects have often been small. Here, we conducted extensive piloting of stimuli prior to testing for LCfC. Specifically, we ensured that context items elicited robust phoneme restoration (e.g., that the final phoneme of Christma# was reliably identified as /s/) and that unambiguous context-final segments (e.g., a clear /s/ at the end of Christmas) drove reliable compensation for coarticulation for a subsequent target phoneme. We observed robust LCfC in a well-powered, preregistered experiment with these pretested items (N = 40) as well as in a direct replication study (N = 40). These results provide strong evidence in favor of computational models of spoken word recognition that include top–down feedback. (shrink)

Fodor and LePore's attack on conceptual role semantics relies on Quine's attack on the traditional analytic/synthetic and a priori/a posteriori distinctions, which in turn consists of four arguments: an attack on truth by convention; an appeal to revisability; a claim of confirmation holism; and a charge of explanatory vacuity. Once the different merits of these arguments are sorted out, their proper target can be seen to be not the Traditional Distinctions, but an implicit assumption about their superficial availability that we (...) have abundant reason to reject. Once we reject it, we can see how issues of the absorbtion of conventions, the revisability of belief, and confirmation holism are compatible with the Traditional Distinctions, and that Quine's discussion only serves to camouflage the question of whether some confirmation relations are constitutive of meaning and knowable a priori. (shrink)

At its proper and most radical, humanistic inquiry is about problems that do not have ready solutions. If this fundamental feature had been accepted, debates about the humanities in recent years might have taken a different kind of turn, whereby, instead of appending new and ever more purposeful modifiers to the word humanities--the digital, the environmental, the neuro, the medical, the public--the ways in which humanistic modes of intellectual labor operate could have assumed a more central focus. This would not (...) have to mean adopting a conservative or conservatively disciplinary stance toward the humanities. Rather, it would demonstrate the ways in which humanistic inquiry approaches intellectual problems conceptually, methodologically, and practically, without necessarily seeking to legitimize the relevance of its undertakings by way of social utility and consensus.This possibility of reimagining humanistic study is the basic assumption and orientation of this book. Many books make use of Foucault's theories, but few use his work to reflect on the conundrums, dead ends, and potentialities of humanistic inquiry in the current Western academy. By juxtaposing debates about literary study, visibilities and invisibilities, sound/voice/listening, race/racism, and self- governance/entrepreneurship in a unique constellation against what Chow polemicizes as the moral instrumentalization of knowledge, A Face Drawn in Sand is intended as an intervention in some of the most pressing issues facing humanistic study today: how to process and analyze texts; how to form and sustain arguments; how to reconceptualize familiar problems through lesser known as well as very well known sources. Above all, how not to have the answers before the questions. (shrink)

Excerpt from L'E nerge tique Et le Me canisme: Au Point de Vue des Conditions de la Connaissance 1. - Les physiciens contemporains s'accordent tous a reconnaitre la valeur objective complete des resultats purement experimentaux. Ceux-ci constituent veritablement la science de la physique, et, sauf dans des cas exceptionnels, momentanes, dans la science en train de se faire, il n'y a, a leur sujet, aucune divergence. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find (...) more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.". (shrink)

Resumen Este artículo analiza la construcción de la infancia en las novelas El mercurio (1968), El río de la luna (1981) y Esta pared de hielo (2005), de José María Guelbenzu, a la luz de los conceptos mítico-simbólicos de Bachelard y Durand para demostrar que funciona como un absoluto primigenio al que se busca volver constantemente, pues resguarda a los personajes hasta el inminente choque con la realidad adulta. Esto para concluir que desde la adultez los personajes observan la infancia (...) con el anhelo de volver allí, lo que tiene una función paliativa mediante la memoria y la palabra, por ello, la narrativa de Guelbenzu plantea regresar al ámbito infantil desde las imágenes literarias y así conservar ese mundo de fantasía. Abstract This article analyzes the construction of childhood in the novels El mercurio (1968), El río de la luna (1981) and Esta pared de hielo (2005), by José María Guelbenzu, in the light of the mythical-symbolic concepts of Bachelard and Durand to demonstrate that it functions as a primitive absolute to which it is sought to return constantly, since it protects the characters until the imminent clash with adult reality. This to conclude that in their adulthood the characters observe childhood with the desire to return there, this has a palliative function through memory and word, therefore, Guelbenzu’s narrative proposes the return to the child environment trough literary images to preserve that world of fantasy. (shrink)

Introducción -- La filosofía moderna: Francisco Bacon. Renato Descartes -- El liberalismo europeo: Juan Locke. Juan Jacobo Rousseau -- La estructura del estado moderno: Montesquieu. Manuel José Sieyés -- El ataque a la tradición: Voltaire. Diderot -- Progreso y Utopia: Adán Smith. Condorcet.

Resumo Este artigo procura apresentar e discutir tentativas recentes em filosofia social de analisar e interpretar o capitalismo, a partir de uma perspectiva praxeológica. O practice turn em teoria social procurou superar o dualismo entre agência e estrutura, ou entre ação e sistema, por meio da noção de prática social. Seria possível então interpretar o capitalismo como um tipo especifico de prática social? Para tentar encaminhar essa questão, explicita-se brevemente, em um primeiro momento, em que consiste o practice turn em (...) teoria social. Num segundo momento, analisa-se e se discute a proposta de Rahel Jaeggi de conceber a economia como uma rede de práticas sociais. Em seguida, expõe-se e se avalia a tentativa de Christian Lotz em ver, no dinheiro, a chave para compreender aquilo que ele chama de esquema capitalista. Por fim, conclui-se, chamando a atenção para os potenciais e desafios ligados ao empreendimento de interpretar o capitalismo em função de uma teoria da prática, sugerindo que um aprofundamento na análise da imaginação especificamente capitalista, vinculando-a com a típica plasticidade e diversidade do capitalismo, possa ajudar a avançar nesse campo.This paper aims to present and discuss recent attempts in social philosophy to analyze and interpret capitalism from a praxeological perspective. The practice turn in social theory sought to overcome the dualism between agency and structure, or between action and system, through the notion of social practice. Is it then possible to interpret capitalism as a specific type of social practice? To try to address this question, I briefly introduce, in a first moment, the practice turn in social theory. In a second moment, I analyze and discuss Rahel Jaeggi’s proposal to conceive the economy as a network of social practices. I then explain and evaluate Christian Lotz’s attempt to see money as the key to understanding what he names as “the capitalist schema”. Finally, I conclude by drawing attention to the potentials and challenges of interpreting capitalism as a social practice, suggesting that a deeper analysis of specifically capitalist imagination, linking it with the typical plasticity and diversity of capitalism, may help to move forward in this field. (shrink)

O presente artigo faz uma breve apreciação do texto La réalité et son ombre, de E. Levinas, especificamente acerca de sua consideração em torno do valor da arte como possibilidade de transcendência. Se, em obras posteriores, Levinas ainda permanece de certo modo econômico, e às vezes ambíguo, sobre a questão, neste texto sua crítica permanece dura e direta. Aqui se discute a relação entre imagem, exterioridade e o real. A obra de arte fala? Exigiria uma resposta e seria ética? Neste (...) texto de 1948, encontramos uma série de argumentos, no seu diálogo com a arte, que já pre-param, ou anunciam, o que posteriormente virá como a transcedência do Rosto “que vai além da forma que o delimita”. Palavras-chave: Arte, transcendência, exterioridade, imagem, realidade. (shrink)

La filosofía helenística es producto de un curso impartido en la Facultad de Filosofía y Letras de la UNAM por Alfonso Reyes, quien a su gran formación filosófica unía extraordinaria sapiencia del mundo griego. El libro se divide en tres partes que comprenden desde la filosofía alejandrina hasta el periodo ético y religioso de los griegos, con lo que se completa el cuadro de la filosofía helenística.

The interest in what can be considered 'posthumanism' has surged over the past few years. There is no surprise as to why, given the urgency and immanence of a likely sixth mass extinction event, and the catastrophic consequences of global warming. These processes, all of which fundamentally rest on the foundations of human practices and abuses, are forcing us to rethink our place in existence. The foundations of this position have a history firmly rooted in the daily practices and beliefs (...) of Western cultures. The Contemporary Posthuman confronts these assumptions of truth, head-on. The author follows his conceptual journey with practical steps for putting his philosophy into practice, by drawing on philosophy, design, art, and architecture. (shrink)

A IMPORTÂNCIA DA BOA-FÉ NAS RELAÇÕES DE CONSUMO.