The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)
Reuse of elements from existing ontologies in the construction of new ontologies is a foundational principle in ontological design. It offers the benefits, among others, of consistency and interoperability between such knowledge structures as well as sharing resources. Reuse is widely found within important collections of established ontologies, such as BioPortal and the OBO Foundry. However, reuse comes with its own potential problems involving ontological commitment, granularity, and ambiguity. Guidelines are proposed to aid ontology developers and curators in their prospective (...) reuse of content. These guidelines have been gleaned over years of practice in the ontology field. The guidelines are couched in experiential reports on designing and curating particular ontologies (e.g., EXACT and EXACT2) and using generally accepted approaches (e.g., MIREOT) in doing so. Various software tools to assist in ontology reuse are surveyed and discussed. (shrink)
The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist "Adam," which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different (...) research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge. (shrink)
Kavramlar doğru anlamlandırılmadığı takdirde meselelerin anlaşılması noktasında yanlış sonuçlara varmanın kaçınılmaz olduğu bir hakikattir. Fıtrat kavramı bu manada insanın neliği bağlamında başat kavram olarak her daim farklı değerlendirmelere konu olmuştur. İnsanın, gerek kendisini var eden Allah ile olan ilişkisi gerekse hemcinsleriyle ve içerisinde yaşadığı âlemle ilişkisi çerçevesinde bu kavramın anlam alanının tespiti yine ait olduğu dünya üzerinden yapıldığı zaman konu hakkında doğru sonuçların elde edilmesine imkân tanıyacaktır. Kur’ân ve hadislerde yerini bulan fıtrat kavramının anlam alanına yönelik çalışmaların bu alanlarda derinlemesine (...) tahlili noktasında söz konusu metinleri, kendi iç bütünlükleri ve birbirleriyle olan ilişkileri bağlamında meseleyi ele alması, en sağlıklı yol olacaktır. Bu çalışmada kavramın önce sözlük anlamı, türevleri üzerinden ele alınmış daha sonra Kur’ân ve hadislerde geçtiği durumları, belirtilen usûl üzerinden değerlendirmeye tâbi tutulmuştur. Sonuç olarak luğavî anlamı da dikkate alınarak fıtrat kavramı ile Kur’ân’da insanın Allah’la ilişkisine, hadislerde ise insanın doğasındaki sâfiyete ve insanlarla olan ilişkisinde dikkat gerektiren yönüne vurgu yapıldığı ortaya konulmaya çalışılmıştır. (shrink)
The purpose of the study is to develop and describe the author's model of teaching foreign language listening using authentic video content. As a result, the author presents a six-stage model, which includes content-goal-setting, two activity-technological, two control-evaluative and revising-target stages, concretized through the system of communicative tasks. The novelty of the study lies in the identification of the linguo-methodological potential of authentic video content for teaching foreign language listening and modeling this process on the basis of the corresponding principles (...) – main and specific. (shrink)
This paper considers the responsibilities of the FDA with regard to disseminating information about the benefits and harms of e-cigarettes. Tobacco harm reduction advocates claim that the FDA has been overcautious and has violated ethical obligations by failing to clearly communicate to the public that e-cigarettes are far less harmful than cigarettes. We argue, by contrast, that the FDA’s obligations in this arena are more complex than they may appear at first blush. Though the FDA is accountable for informing the (...) public about the health risks and benefits of products it regulates, it also has other roles that inform when and how it should disseminate information. In addition to being a knowledge purveyor, it is also a knowledge producer, an advisor to the public, and a practical agent shaping the material conditions in which people make health-related choices. In our view, those other roles call for caution in the way the FDA interprets and communicates the available evidence. (shrink)
When someone says she believes that God exists, is she expressing the same kind of mental state as when she says she thinks that a lake bigger than Lake Michigan exists⎯i.e., does she refer to the same kind of cognitive attitude in both cases? Using evidence from linguistic corpora (Study 1) and behavioral experiments (Studies 2-4), the current work provides evidence that individuals typically use the word “believe” more in conjunction with statements about religious credences and “think” more in conjunction (...) with factual statements, pointing to two different understandings of claims made with these two terms. These patterns do not appear to reflect low-level differences based on the amount of consensus surrounding a particular claim, the extent to which the truth of a particular claim is known to the participant, or linguistic differences between religious and factual statements. We discuss implications of these findings for religious cognition (e.g., as supporting the theory that religious credences are qualitatively distinct from factual beliefs) as well as cognitive processes more broadly. Finally, we relate the present findings to prior theoretical work on differences between factual belief and religious credence. (shrink)
In his later work, Metafizicheskie predpolozheniia poznaniia. Opyt preodoleniia Kanta i kantianstva [Metaphysical Presuppositions of Knowledge. An Attempt to Overcome Kant and Kantianism], Evgeny N. Trubetskoy tried to overcome the Kantian tradition in philosophy in order to advance his conception of all-unity and the philosophy of absolute and unconditional consciousness. Despite insisting on the distinction between the “historical Kant” and Neo-Kantianism, in reality Trubetskoy was strongly dependent on the Neo-Kantian interpretation of Kant’s philosophy, which meant that his fight against Kantian (...) philosophy was really fought against a conception of Kant he unconsciously adopted from the Neo-Kantians. Evidence of this can be seen in his interpretation of the theory of knowledge and its tasks, his thesis concerning the antimetaphysical direction of Kantian philosophy, and his insistence on the presence of the transcendental method in Kant’s philosophy. (shrink)
This edited volume focuses on the work of Professor Larisa Maksimova, providing a comprehensive account of her outstanding contributions to different branches of non-classical logic. The book covers themes ranging from rigorous implication, relevance and algebraic logic, to interpolation, definability and recognizability in superintuitionistic and modal logics. It features both her scientific autobiography and original contributions from experts in the field of non-classical logics. Professor Larisa Maksimova's influential work involved combining methods of algebraic and relational semantics. Readers will (...) be able to trace both influences on her work, and the ways in which her work has influenced other logicians. In the historical part of this book, it is possible to trace important milestones in Maksimova’s career. Early on, she developed an algebraic semantics for relevance logics and relational semantics for the logic of entailment. Later, Maksimova discovered that among the continuum of superintuitionisitc logics there are exactly three pretabular logics. She went on to obtain results on the decidability of tabularity and local tabularity problems for superintuitionistic logics and for extensions of S4. Further investigations by Maksimova were aimed at the study of fundamental properties of logical systems in big classes of logics, and on decidability and recognizability of such properties. To this end she determined a powerful combination of algebraic and semantic methods, which essentially determine the modern state of investigations in the area, as can be seen in the later chapters of this book authored by leading experts in non-classical logics. These original contributions bring the reader up to date on the very latest work in this field. (shrink)
Öz Çalışmanın konusu irfanî geleneğin on beşinci yüzyıldaki önemli temsilcilerinden ve aynı zamanda İbnü’l-Arabî’nin takipçilerinden biri olan İbn Türke’nin varlık mertebelerine dair görüşleridir. Konu, İbn Türke’nin varlık ve varlığın mertebeleri ile ilgili düşüncelerinden hareketle hazırlanmıştır. Birincil kaynakların esas alındığı bu çalışmada, İbn Türke ve Ekberî geleneğin önemli temsilcilerinin eserlerine müracaat edilmiştir. Çalışmanın amacı, felsefe ve kelâmın yanı sıra tasavvuf felsefesinin en önemli konularından biri olan varlık düşüncesi ve varlık mertebelerini İbn Türke’nin görüşleri çerçevesinde ele alarak âlemdeki varoluşun hakikatinin ne olduğu, (...) insanoğlunun özünün nereden geldiği gibi temel sorulara cevap olabilecek özgün bir çalışma ortaya koymaktır. Bu çalışmayla; varlığın bir ve tek hakikat olduğu, Hak’tan feyz ederek görünür âlemde ortaya çıkan her şeyin O’nun isim ve sıfatlarının tecellisi olduğu, her ne kadar Hak’tan ayrıymış gibi görünse de aslında Hakk’a doğru sonsuz bir dönüş içerisinde olduğu, dolayısıyla tek varlıktan kaynaklı çok sayıda varlığın esasen yokluğa mahkûm olduğu ve asıl varlığın Allah olduğu sonucuna varılmıştır. (shrink)
People perceive that if their memories and moral beliefs changed, they would change. We investigated why individuals respond this way. In Study 1, participants judged that identity would change more after changes to memories and widely shared moral beliefs versus preferences and controversial moral beliefs. The extent to which participants judged that changes would affect their relationships predicted identity change and mediated the relationship between type of moral belief and perceived identity change. We discuss the role that social relationships play (...) in judgments of identity and highlight implications for psychology and philosophy. (shrink)
Eser, yazarın 2008 yılında tamamlamış olduğu “Kur’an’ın Tasdik Ettiği Tevrat’taki Konular” isimli doktora tezinin 2011 yılında “Tevrat’ın Kur’an’a Arzı-Kur’an’ın Tevrat’ta Tasdik Ettiği Konular” ismiyle basılmasıyla yayın hayatına kazandırılmıştır. Kur’an ve Tevrat’taki konular bu çalışmanın öncesinde ve sonrasında genellikle mukayeseli bir biçimde çalışılmıştır. Gerek Kur’an ve Tefsir alanında gerekse Dinler Tarihi alanında kıssalar, tarihi olaylar, hükümler, uygulamalar gibi pek çok açıdan Kur’an ve Tevrat’a dair özellikle mukayese içeren tezler ve eserler bulunmaktadır. Bu çalışmanın alandaki diğer eserlerden farkı Kur’an’ın Tevrat’ı tasdik edici (...) olmasının ne mânaya geldiğini izah etmesi ve Tevrat’ta yer alan hangi konuları doğrulayıcı olduğunu derli toplu bir şekilde ortaya koymasıdır. (shrink)
Adults report that moral characteristics—particularly widely shared moral beliefs—are central to identity. This perception appears driven by the view that changes to widely shared moral beliefs would alter friendships and that this change in social relationships would, in turn, alter an individual's personal identity. Because reasoning about identity changes substantially during adolescence, the current work tested pre- and post-adolescents to reveal the role that such changes could play in moral cognition. Experiment 1 showed that 8- to 10-year-olds, like adults, judged (...) that people would change more after changes to their widely shared moral beliefs (e.g., whether hitting is wrong) than after changes to controversial moral beliefs (e.g., whether telling prosocial lies is wrong). Following up on this basic effect, a second experiment examined whether participants regard all changes to widely shared moral beliefs as equally impactful. Adults, but not children, reported that individuals would change more if their good moral beliefs (e.g., it is not okay to hit) transformed into bad moral beliefs (e.g., it is okay to hit) than if the opposite change occurred. This difference in adults was mediated by perceptions of how much changes to each type of belief would alter friendships. We discuss implications for moral judgment and social cognitive development. (shrink)
Philosophical views of responsibility often identify responsible agency with capacities like rationality and self-control. Yet in ordinary life, we frequently hold individuals responsible who are deficient in these capacities, such as children or people with mental illness. The existing literature that addresses these cases has suggested that we merely pretend to hold these agents responsible, or that they are responsible to a diminished degree. In this paper, I demonstrate that neither of these approaches is satisfactory, and offer an alternative focused (...) on the role relationships play in determining whether it is appropriate to hold someone responsible. I argue that relationships are sources of normative expectations about how parties in that relationship ought to behave, and that we can be responsible in virtue of being subject to these norms. This is so, not only for those who are impaired or immature, but for all of us. (shrink)
For centuries, humans have contemplated the minds of gods. Research on religious cognition is spread across sub-disciplines, making it difficult to gain a complete understanding of how people reason about gods' minds. We integrate approaches from cognitive, developmental, and social psychology and neuroscience to illuminate the origins of religious cognition. First, we show that although adults explicitly discriminate supernatural minds from human minds, their implicit responses reveal far less discrimination. Next, we demonstrate that children's religious cognition often matches adults' implicit (...) responses, revealing anthropomorphic notions of God's mind. Together, data from children and adults suggest the intuitive nature of perceiving God's mind as human-like. We then propose three complementary explanations for why anthropomorphism persists in adulthood, suggesting that anthropomorphism may be an instance of the anchoring and adjustment heuristic; a reflection of early testimony; and/or an evolutionary byproduct. (shrink)