BackgroundWe describe our experience from a multi-national application of a European Union-funded research-driven paediatric trial. This paper aims to evaluate the impact of the local and national rules on the trial authorisation process in European and non-European countries. National/local provisions and procedures, number of Ethics Committees and Competent Authorities to be addressed, documentation required, special provisions for the paediatric population, timelines for completing the authorisation process and queries received were collected; compliance with the European provisions were evaluated. Descriptive analysis, Wilcoxon (...) Rank-Sum test and General Linear Model analysis were used to determine factors potentially influencing the timelines. The Cluster Analysis procedure was used to identify homogenous groups of cases.ResultThe authorisation process was completed in 7.7 to 53.8 months in European countries and in 17.1 to 27.1 months in non-European countries. The main factors influencing these timelines were the requests for changes/clarifications in European countries and the different national legislations in non-European countries.ConclusionThis work confirms that the procedures and requirements for the clinical trial application of a paediatric trial are different. In the European Union, the timeframes for submission were generally harmonised but longer. In non-European countries, delays were caused by national dispositions but the entire authorisation process resulted faster with less requests from ECs/cas. The upcoming application of Regulation 536/2014 is expected to harmonise practices in Europe and possibly outside. Networks on paediatric research acting at international level will be crucial in this effort. (shrink)

François Lamy, a Benedictine monk and Cartesian philosopher whose extensive relations with Arnauld, Bossuet, Fénélon, and Malebranche put him into contact with the intellectual elite of late-seventeenth-century France, authored the very first detailed and explicit refutation of Spinoza’s Ethics in French, Le nouvel athéisme renversé. Regrettably overlooked in the secondary literature on Spinoza, Lamy is an interesting figure in his own right, and his anti-Spinozist work sheds important light on Cartesian assumptions that inform the earliest phase of Spinoza’s critical reception (...) in the seventeenth-century. I begin by presenting Lamy’s life and the contentious state of Spinoza’s French reception in the 1680 and 1690s. I then discuss a central argument in Lamy’s refutation, namely the Cartesian objection that Spinoza’s account of the conceptual independence of attributes is incompatible with the theory of substance monism. Contrasting Lamy’s objection with questions put to Spinoza by de Vries and Tschirnhaus, I maintain that by exhibiting the direction Spinoza’s views on substance and attribute took in maturing we may accurately assess the strength of Spinoza’s position vis-à-vis his Cartesian objector, and I argue that, in fact, Spinoza’s mature account of God as an expressive ens realissimum is not vulnerable to Lamy’s criticism. In conclusion, I turn to Lamy’s objection that Spinoza’s philosophy is question-begging in view of Spinoza’s account of God, and I exhibit what this point of criticism tells us about the intentions of the first French Cartesian rebuttal of the Ethics. (shrink)

There is a long-standing view that Malebranche and his fellow occasionalists accepted occasionalism to solve the problem of interaction between immaterial souls and extended bodies. Recently, however, scholars have shown this story to be a myth. Malebranche, Geulincx, La Forge, and Cordemoy adopted occasionalism for a variety of reasons, but none did so because of a need to provide a solution to a perceived mind-body problem. Yet there is one Cartesian for whom the “traditional” reading is largely on the mark. (...) François Lamy argues in the second volume of his De la Connoissance de Soi-Meme much as the standard story has it. In this article I discuss and analyze Lamy’s argument, showing how he deals with some of the many concerns that made occasionalism attractive, and how he brings out some of the thorny questions that an occasionalist must face. (shrink)

ABSTRACTBernard Lamy is frequently included among the Cartesian Empiricists of the second half of the seventeenth century. He has also been described as an Augustinian who dabbled in Cartesianism. While acknowledging that there are both empiricist and Augustinian elements in his thought, I argue that it ought not be forgotten that there are central components of his philosophy that are both anti-empiricist and in opposition to Augustine. My aim in this paper, though, is not critical; I hope to show that (...) Lamy provides us with one more example of the diversity present among the various thinkers labelled as ‘Cartesian’. (shrink)

A growing body of research informs us that an effective, efficient fight against chronic American poverty, producing benefits far exceeding costs, is possible. It begins by protecting children from developmental risks. This book describes those risks, along with the programs and policies we know protect children and families. A policy framework for the pursuit of an intrepid new goal – the purposeful protection of America’s most vulnerable children on a large scale – would end chronic poverty as we know it.

Pierre d'Ailly, grande figure intellectuelle et ecclésiastique de la fin du XIVe siècle et du début du XVe siècle, jouit d'une grande célébrité pour ses talents de scientifique, guidant Christophe Colomb sur la voie des Indes, et pour sa volonté réformiste lors du grand schisme d'occident. Son œuvre est pourtant jusqu'ici peu fréquentée et sa pensée, peu étudiée. Dans cet ouvrage de synthèse, l'auteur souhaite offrir à ses lecteurs un parcours à la fois accessible et exigeant, qui leur permette de (...) découvrir, en cinq concepts, la richesse doctrinale de Pierre d'Ailly : Dieu, la politique, le langage, la connaissance, la science. (shrink)

Die Kontroverse mit François Lamy ist unter denen von Leibniz' Système nouveau hervorgerufenen eine der am wenigsten diskutierten. Die wenigen neueren Quellen sind schlecht dokumentiert und in wichtigen Details nicht korrekt. Wir versuchen hier, die Bibliographie richtigzustellen. Da Lamys Arbeit äußerst selten ist, fügen wir englische Übersetzungen der relevanten Stellen bei. Nach Pierre Bayle war eher Lamy als Leibniz der erste, der den Begriff , prüstabilierte Harmonie' verwendete. Es stellt sich heraus, daβ dem nicht so ist.

Starting with a review of research on love as an emotion, with an emphasis on romantic love, it is argued that despite strong emotional correlates evidence is lacking to conclude that love would meet the criteria of basic emotions. Theoretical developments are proposed where love is conceived of as a combination of an objectless drive, a desire for love, and a mythical and scripted representation that offers the possibility of labeling the current core affect. I argue that the basic motive (...) for love is not so much the partner’s personal attributes, but rather the benefits of the transformative power of being in love. (shrink)

There is currently no consensus regarding what measures are most valid to demonstrate perceptual processing without awareness. Likewise, whether conscious perception and unconscious processing rely on independent mechanisms or lie on a continuum remains a matter of debate. Here, we addressed these issues by comparing the time courses of subjective reports, objective discrimination performance and response priming during meta-contrast masking, under similar attentional demands. We found these to be strikingly similar, suggesting that conscious perception and unconscious processing cannot be dissociated (...) by their time course. Our results also demonstrate that unconscious processing, indexed by response priming, occurs, and that objective discrimination performance indexes the same conscious processes as subjective visibility reports. Finally, our results underscore the role of attention by showing that how much attention the stimulus receives relative to the mask, rather than whether processing is measured by conscious discrimination or by priming, determines the time course of meta-contrast masking. (shrink)

A growing body of research informs us that an effective, efficient fight against chronic American poverty, producing benefits far exceeding costs, is possible. It begins by protecting children from developmental risks. This book describes those risks, along with the programs and policies we know protect children and families. A policy framework for the pursuit of an intrepid new goal – the purposeful protection of America’s most vulnerable children on a large scale – would end chronic poverty as we know it.

The commentaries by Cacioppo and Cacioppo, Jankowiak, Marazziti, and Aron and Aron admirably illustrate the multifaceted nature of love and the difficulty of bringing together such diverse perspectives. Rising love is still far from being the subject of true experimental study since the experimenter often only observes the consequences thereof, and attempts to reconstitute in hindsight the circumstances of its onset.

RÉSUMÉ Cette étude met en perspective le précédent constitué par les travaux précoces du jeune Nietzsche où ce dernier fait valoir la force structurante de la métaphore comme matrice des facultés cognitives. Nous offrons d’abord une brève esquisse des postulats et des acquis des grammaires cognitives associées aux travaux d’Eleanor Rosch, ensuite de George Lakoff et Mark Johnson, ainsi qu’à la notion d’inscription corporelle de l’esprit développée par Francesco Varela. Cet exercice sert de propédeutique à une série de lectures tangentes (...) mobilisant divers angles d’approche appelés à faciliter noter évaluation des contributions de Nietzsche au domaine de la cognition. Les travaux examinés nous situent dans la période contemporaine de la publication de son premier grand ouvrage, La naissance de la tragédie : les notes pour le cours intitulé Présentation de la rhétorique ancienne, prononcé au semestre d’hiver 1872-1873 à l’Université de Bâle, ensuite ses Theoretische Studien, datant de l’été 1873, avec un renvoi aux développements plus tardifs dans le Gai Savoir. La thèse de Nietzsche peut être résumée comme suit : tous les éléments de l’appareil catégorial et du régime conceptuel à l’aide desquels nous appréhendons la réalité, a fortiori la notion de vérité qui en est le garant, sont le « précipité » ou le résidu d’un faisceau de métaphores qui constituent la force structurante des facultés cognitives. Si chez Kant nous n’avons accès qu’aux phénomènes et non au noumène, chez Nietzsche nous n’avons affaire qu’à des perspectives ou des points de vues alors que la réalité nous est monnayée sous forme de vérités qui sont des fictions ou des métaphores usées. Il ressort de cet examen que le tropisme endogène de la langue constitue une force majeure dans l’implémentation d’une conceptualité qui a la vertu d’oblitérer sa préhistoire et de se ménager un statut qui est incessamment implosé par le reflux de l’imagination créatrice nourrie par la force métaphorique qui répond à une impulsion foncière que Nietzsche associe à une « force artiste » qui tend à démultiplier les perspectives dont la généalogie se conjugue à l’exponentiel. ABSTRACT This paper highlights the precedent, managed by the precocious insights of the young Nietzsche who advocated the structuring force of the metaphor as the matrix of cognitive powers. We first provide a short sketch of the postulates and gains of cognitive grammars. We examine the guidelines of the works on cognitive research led by great Eleanor Rosch, George Lakoff and Mark Johnson, as well as the concept of embodied mind developed by Francesco Varela. This summary survey is a crash introduction to a series of angular readings from a large array of perspectives on Nietzsche's early contributions to the field of cognition. The works prospected are contemporary of the publication of Nietzsche first great work, "The Birth of the Tragedy", including his notes for the lecture course on rhetoric taught at the University of Basel during the winter semester, in 1872-73, then his "Theoretische Studien", written during summer 1873, with a consideration of later developments in his "Gay Science". The overall thesis advocated by Nietzsche in these works could be summarized as follows: all the elements of the categorical apparatus and the conceptual framework by which we assess reality, a fortiori the notion of truth which vouches for it, are the "precipitate" or the residue of a cluster of metaphors which constitute the structuring force of cognitive powers. The instinct of conservation and a subtle form of dissimulation lead to the elision of the tropic dynamics of language to the benefit of a literalism bound to a structuring amnesia. If for Kant we get access only to phenomena and not to noumenon, for Nietzsche we always deal with perspectives or points of view, whilst reality is traded to us by mean of truths which are mere fictions or worn out metaphors. So we come to acknowledge that the endogenous tropism displayed by language uses constitutes a major force in the implementation of conceptuality, that last one being eager to absorb its own prehistory into oblivion and to endow itself a status which is in close to timelessly imploded by the ebb of creative imagination fuelled by sheer metaphoric force, a spontaneous impulsion that Nietzsche ties to an "artistic force" which tends to multiply the perspectives whose genealogy is driven by an exponential factor. (shrink)

How can we make businesspeople more concerned about the truth of the information they spread or allow to circulate? In this age of ‘fake news’, ‘business bullshit’ and ‘post-truth,’ the issue is of the utmost importance, especially for business trustworthiness in the internet economy. The issue is related to a kind of epistemic responsibility, that consists in accounting for one’s own epistemic wrongdoings, such as making a third party believe something false. Despite growing interest in epistemic misbehavior in the literature (...) of business ethics, the question of epistemic responsibility has been neglected. The aim of this paper is therefore to address this gap, by proposing a notion of epistemic responsibility for business, that may help regulate undesirable epistemic behavior, such as the spreading of false information. To define this notion of epistemic responsibility, I have introduced the concept of epistemic fault. Being epistemically responsible consists in being disposed to account for alleged epistemic faults. This notion of epistemic fault relies on a theoretical framework which combines a typology of eight ‘epistemic values’, a normative stance regarding these values, and a dispositional approach to epistemic virtues and vices. I use this theoretical framework to integrate the various accounts of epistemic virtues and vices found in the literature into a single explanatory scheme. Combined with the notion of epistemic responsibility itself, such an integrative framework should facilitate the practical application of an operational epistemic ethics in business, i.e., the development of virtuous epistemic practices. (shrink)

Although expressions of facial emotion hold a special status in attention relative to other complex objects, whether they summon our attention automatically and against our intentions remains a debated issue. Studies supporting the strong view that attentional capture by facial expressions of emotion is entirely automatic reported that a unique emotional face distractor interfered with search for a target that was also unique on a different dimension. Participants could therefore search for the odd-one out face to locate the target and (...) attentional capture by irrelevant emotional faces might be contingent on the adoption of an implicit set for singletons. Here, confirming this hypothesis, an irrelevant emotional face captured attention when the target was the unique face with a discrepant orientation, both when this orientation was unpredictable and when it remained constant. By contrast, no such capture was observed when the target could not be found by monitoring displays for a discrepant face and participants had to search for a face with a specific orientation. Our findings show that attentional capture by emotional faces is not purely stimulus driven and thereby resolve the apparent inconsistency that prevails in the literature on the automaticity of attentional capture by emotional faces. (shrink)

This article explores the plurivocality of temporalities that is at work in contemporary management. The aim is to understand the relationship that a century-old industrial company has with temporality. Based on a longitudinal case study and a series of interviews conducted within the family business Fleury Michon, the article identifies the discursive mobilizations of different temporalities specific to contemporary capitalism. The logics of the long term are required as constitutive elements of the company. In a presentist regime, these temporalities interact, (...) clash and sometimes oppose each other. One of the challenges of management is to produce both a possible conciliation of these temporalities and an euphemization of the power relations that they cannot conceal. (shrink)

The quality of the products coming from different lines of production requires some tests called comparative life tests. For lines having the same facility, the lifetime of the product is distributed by Burr XII, the lifetime distribution, and units are tested under type-I generalized hybrid censoring scheme. The observed censoring data are used under maximum likelihood and the Bayes method to estimate the model parameters. The theoretical results are discussed and assessed through data analysis and Monte Carlo simulation study. Finally, (...) we reported some brief comments obtained from numerical computation. (shrink)

In an attempt to trace the historical origins of Malebranche's reputation as an opponent of imagination, mainly in connection with style and eloquence, the author of this paper maintains that most of the arguments subsequently used against Malebranche may already be found in Bernard Lamy's La Rhétorique ou l'art de parler. Although Lamy might have been influenced by Malebranche, his approach to the use of passions and imagination relies rather on a theory of language and communication than on Malebranche's account (...) of the physiological effects of imagination. Therefore, the opposing views of Malebranche and Lamy on this question could be seen as premises for the French debates on the right and wrong use of the imaginative faculty that emerged at the turn of the 17th century. (shrink)

Anxiety has been associated with enhanced unconscious processing of threat and attentional biases towards threat. Here, we focused on the phenomenology of perception in anxiety and examined whether threat-related material more readily enters anxious than non-anxious individuals’ awareness. In six experiments, we compared the stimulus exposures required for each anxiety group to become objectively or subjectively aware of masked facial stimuli varying in emotional expression. Crucially, target emotion was task irrelevant. We found that high trait-anxiety individuals required less sensory evidence (...) to become aware of the face targets. This anxiety-based difference was observed for fearful faces in all experiments, but with non-threat faces, it emerged only when these were presented among threatening faces. Our findings suggest a prominent role for affective context in high-anxiety individuals’ conscious perception of visual stimuli. Possible mechanisms underlying the influence of context in lowering awareness thresholds in anxious individuals are discussed. (shrink)

Consistent with numerous electrophysiological studies, we recently reported that conscious perception is associated with a widely distributed modulation of the P3 component . We also showed that correct objective performance in the absence of subjective awareness is associated with a spatially more restricted modulation of the P3. The relatively late occurrence of the P3 along with lack of control for post-perceptual processes suggests that this component might reflect processes related to stimulus evaluation or confidence rather than to visual awareness or (...) objective performance. The main aim of the current study was to test this hypothesis. While EEG was recorded, participants performed a forced-choice localization task and reported their subjective perception of the target on a 3-level scale that also indexed their confidence. The results showed that our previous findings are replicated when confidence is controlled for. (shrink)