The human genome is not a uniform structure but, instead, is a mosaic of bands. Some of these bands can be seen by the eye. Stained with Giemsa and viewed under the microscope each human chromosome has a prototypical pattern of light and dark bands (G and R bands respectively). Other bands are not so easily viewed. The human genome is, for example, a mosaic of isochores, blocks of DNA within which the proportion of the bases G and C at (...) silent sites (introns, third positions in codons, intergene spacer) is fairly uniform. Recent work by Matassi and colleagues(1) has revealed what might be a new and unexpected banding pattern. They have found that the genes which are close together on the chromosome have similar rates of evolution. BioEssays 22:105–107, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

A longstanding paradox was first reported by David Miller in 1975 and highlighted by Karl Popper in 1979. Miller showed that the ranking of predictions from two theories, in terms of closeness to observation, appears to be reversed when the problem is transformed into a different mathematical space. He concluded that “… no false theory can … be closer to the truth than is another theory”. This flies in the face of normal scientific practice and is thus paradoxical; it is (...) named here the “Miller-Popper paradox”. This paper proposes a resolution of the paradox, through consideration of the inevitable errors and uncertainties in both observations and predictions. It is proved that, for linear transformations and Gaussian error distributions, the transformation between spaces creates no change in quantitative measures of “closeness-to-observation” when these measures are based in probability theory. The extension of this result to nonlinear transformations and to non-Gaussian error distributions is also discussed. These results demonstrate that concepts used in comparison of predictions with observations—concepts of “closeness”, “consistency”, “agreement”, “falsification”, etc.—all imply some knowledge of the uncertainty characteristics of both predictions and observations. (shrink)

As a parent, you know how much less stressful your life would be if you could count on your children to be more responsible -for their toys, their homework, their household chores, and their choice of friends. You know you want your children to grow up to be responsible adults. In Teaching Your Children Responsibility , bestselling authors Linda and Richard Eyre show you how to make sure your elementary-school-aged children learn this invaluable lesson. The Eyres identify twelve simple kinds (...) of responsibility-from responsibility for things to responsibility for actions, from responsibility for choices to responsibility for younger siblings-that children can relate to. They provide a simple, practical program-with enjoyable exercises, games, and activities-that you can use to teach your children these important concepts. Written by parents for parents, Teaching Your Children Responsibility will help you give your children the tools they need to thrive in today's challenging world-and help them grow up to be happy, fulfilled adults. (shrink)

The author of handbooks that reflected the Victorian emphasis on bettering one's prospects, Charles Eyre Pascoe addressed the topic of female education in this work of 1879, at a time when the Cambridge colleges of Girton and Newnham were in their infancy. 'Chiefly designed for the use of persons of the upper middle class', the guide aims to assist parents in making informed choices about their daughters' education. The coverage extends from kindergarten through to university, before focusing on career options (...) for women in the late nineteenth century, in fields such as teaching, the arts and medicine. Throughout, Pascoe's recommendations are based on consideration of the breadth of the curriculum, the qualifications of the teaching staff and the results achieved in examinations. For higher education, details of entrance examinations are provided, together with information on the subjects and lectures that were open to women at that time. (shrink)

This article describes "Project Breakthrough: A Survey of Corporate Practices for Shattering the Glass Ceiling." Evidence is presented that the "glass ceiling" remains intact in many areas. A list of barriers (social sterotypes) that support the glass ceiling are presented. Some corporate strategies found in the literature are also presented. Sixty-nine companies in the Houston area were surveyed. A summary score based on responses to thirty-four practices listed in the survey were computed. The top twelve organizations were identified as "distinguished," (...) and site visits were conducted. The practices of these companies are listed. (shrink)

Edmund Gettier is Professor Emeritus at the University of Massachusetts, Amherst. This short piece, published in 1963, seemed to many decisively to refute an otherwise attractive analysis of knowledge. It stimulated a renewed effort, still ongoing, to clarify exactly what knowledge comprises.

This new edition of the classic Contemporary Theories of Knowledge has been significantly updated to include analyses of the recent literature in epistemology.

This edited volume represents a unique addition to the available literature on animal ethics, animal studies, and neuroethics. Its goal is to expand discussions on animal ethics and neuroethics by weaving together different threads: philosophy of mind and animal minds, neuroscientific study of animal minds, and animal ethics. Neuroethical questions concerning animals’ moral status, animal minds and consciousness, animal pain, and the adequacy of animal models for neuropsychiatric disease have long been topics of debate in philosophy and ethics, and more (...) recently also in neuroscientific research. The book presents a transdisciplinary blend of voices, underscoring different perspectives on the broad questions of how neuroscience can contribute to our understanding of nonhuman minds, and on debates over the moral status of nonhuman animals. All chapters were written by outstanding scholars in philosophy, neuroscience, animal behavior, biology, neuroethics, and bioethics, and cover a range of issues and species/taxa. Given its scope, the book will appeal to scientists and students interested in the debate on animal ethics, while also offering an important resource for future researchers. Chapter 13 of this book is available open access under a CC BY 4.0 license at link.springer.com. (shrink)

Le philosophe Jean Baudrillard (1929-2007) a-t-il vraiment existé? Que reste-t-il de lui? "Une élégance certaine de la pensée", affirme l'un de ses meilleurs interprètes, François L'Yvonnet. Le philosophe de La Société de consommation, des Stratégies fatales et des Cool Memories s'attachait à l'idée du fragment comme mode de pensée : car dans le détail, tout est parfait, c'est dans sa reproduction que tout se complique. François L'Yvonnet explore cinq fragments de la philosophie de Jean Baudrillard et de sa biographie pour (...) mieux saisir l'éclat et la jubilation d'une pensée toujours vivante et contemporaine. (shrink)

Excerpt from Der Echte: Und der Xenophontische Sokrates Der xen0phontische Sokrates selbst wieder zwang, die Fuh rung der Untersuchung weit mehr, als bisher geschehen, zu ver breitem. Die Memorabilien sind das Gegentheil eines selbst herrlichen Kunstwerks, weisen an allen Ecken und Enden uber sich hinaus, stehen als ein schwaches Glied in der Kette der sokratischen Literatur und zunachst in der der xenophontischen Schriften. Es galt, sie zunachst als solches zu begreifen und das volle Licht der Parallelen bei Xenophon auf sie (...) einwirken zu lassen. Dabei enthullten sich die Mem. Oft nur als durftiger Abklatsch anderer xenophontischen Schriften, von denen sie erst die farbige Beleuchtung, die Erklarung ihrer Motive, die Auf hellung ihrer Ordnung erhalten. So ward nun moglichst psycho logisch aus Xenophon erklart, was sich aus ihm erklaren liess. Indessen fur die Hauptsache, das Philosophische, stellte Xeno phon's notorische Unselbstandigkeit neue Fragen und Aufgaben, und hier ergab nun eine weitschichtige Vergleichung seine fast vollige philosophische Abhangigkeit im Ganzen wie im Einzelnen vom Kynismus, die in Grad und Art und plausiblen Motiven genau der Abhangigkeit der romischen Praktiker von den stoischen Nachfolgern der Kyniker_ entspricht. Nicht nur die Memorabilien, auch die andern Socratica Xenophon's, sowie vor Allem Cyropadie Hiero Agesilaus, de rep. Lac. Prolog und Epilog des Oynegeticus offenbarten sich mehr und mehr als durchaus kynisirende Schriften, und auch hier liegt dem Verf. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

First published in 1995. Routledge is an imprint of Taylor & Francis, an informa company.

Ingthorsson, McTaggart’s Paradox and the R-theory of Time L. Nathan Oaklander University of Michigan-Flint, USA [email protected] his provocative book, McTaggart’s Paradox, R.D. Ingthors- son argues that McTaggart’s argument for the unreality of time rests on the principle of temporal parity according to which all times or events in time exist equally or co-exist in a sense that is compatible with their being successive. Moreover, since temporal parity is also an essential tenet of the B-theory, McTaggart’s argument against the reality of (...) time can also be used to undermine the B-theory. Ingthorsson argues further that only by adopting an ontologically frugal presentist metaphysics can one avoid McTaggart’s paradox and account for identity through time and change. The aim of this paper is to clarify Russell’s authentic view of time in con- trast to the B-theory which is McTaggart’s misrepresentation of Russell and argue that temporal parity it is not a fundamental tenet of the Rus- sellian theory. For that reason, the R-theory is immune to objections that are based on temporal parity. I shall then offer my own interpretation of McTaggart’s paradox that renders Ingthorsson’s version of presentism subject to it. (shrink)