Opioid agonist treatment, including methadone, is the safest and most effective method for treating opioid use disorders and reduces opioid overdose deaths. While access to methadone is highly regulated by federal law, a substantial portion of states impose stricter barriers.

Cells and tissue within injured organs undergo a complicated healing process that still remains poorly understood. Interestingly, smaller organisms respond to injury with tissue regeneration and restoration of function, while humans and other large organisms respond to injury by forming dysfunctional, fibrotic scar tissue. Over the past few decades, allometric scaling principles have been well established to show that larger organisms experience exponentially higher tissue forces during movement and locomotion and throughout the organism's lifespan. How these evolutionary adaptations may affect (...) tissue injury has not been thoroughly investigated in humans. We discuss how these adapations may affect healing and demonstrate that blocking the most evolutionary conserved biologic force sensor enables large organisms to heal after injury with true tissue regeneration. Future strategies to disrupt tissue force sensors may unlock the key to regenerating after injury in a wide range of organ systems. (shrink)

Gilead et al. present a rich account of abstraction. Though the account describes several elements which influence mental representation, it is worth also delineating how feelings, such as fluency and emotion, influence mental simulation. Additionally, though past experience can sometimes make simulations more accurate and worthwhile, many systematic prediction errors persist despite substantial experience.

The Virtuous Psychiatrist: Character Ethics in Psychiatric Practice Jennifer Radden & John Z. SadlerOxford: Oxford University Press, 2010256 pages, ISBN: 0195389379 (hbk); $49.95Contemporary bioeth...

One of the important determinants of development during the transition to adulthood is the undertaking of social roles characteristic of adults, also in the area of finishing formal education, which usually coincides with beginning fulltime employment. In the study discussed in this paper, it has been hypothesized that continuing full-time education above the age of 26, a phenomenon rarely observed in Poland, can be considered as an unpunctual event that may be connected with difficulties in the process of identity formation. (...) Relationships between identity dimensions and identity statuses, and age and educational context were analyzed. 693 individuals aged 19-35 took part in the study. The participants attended three types of educational institutions: full-time university studies, part-time university studies, and full-time post-secondary school. Among the students of full-time university studies predictable dependencies, also in respect of highlevels of indicators of identity crisis and a high frequency of diffused identity occurrence, were observed. Such dependencies were not found in the group of full-time post-secondary school students. (shrink)

This paper posits the concept of cognitive confinement as a useful tool for understanding the idea of decolonization of knowledge and the opposite notion of epistemic colonization. For the sake of...

It is commonly thought that logic, whatever it may be, is normative. While accounting for the normativity of logic is a challenge for any view of logic, in this paper I argue that it is particularly problematic for certain types of logical pluralists, due to what I call the normative problem for logical pluralism. I introduce the NPLP, distinguish it from other problems that logical pluralists may face, and show that it is unsolvable for one prominent type of logical pluralism.

Suppose that two competing norms, N1 and N2, can be identified such that a given person’s response can be interpreted as correct according to N1 but incorrect according to N2. Which of these two norms, if any, should one use to interpret such a response? In this paper we seek to address this fundamental problem by studying individual variation in the interpretation of conditionals by establishing individual profiles of the participants based on their case judgments and reflective attitudes. To investigate (...) the participants’ reflective attitudes we introduce a new experimental paradigm called the Scorekeeping Task. As a case study, we identify the participants who follow the Suppositional Theory of conditionals (N1) versus Inferentialism (N2) and investigate to what extent internally consistent competence models can be reconstructed for the participants on this basis. After extensive empirical investigations, an apparent reasoning error with and-to-if inferences was found in one of these two groups. The implications of this case study for debates on the proper role of normative considerations in psychology are discussed. (shrink)

There is no longer any doubt that the coming decades will bring serious threats to humanity from anthropogenic climate change. As we have suggested elsewhere, horrible scenarios are far more realistic than non-horrible ones, and science and technology are incapable, especially in our non-ideal world, of equitably distributing wealth, access to resources and adaptations to climate change. In this article, we offer an alternative to these inevitable horrible scenarios. The alternative is to implement either an anti-natalist policy, or procreative beneficence (...) and reproductive rights policies aimed at radically reducing the birth rate. These alternatives, however, are potentially unfair and quite possibly unthinkable to most of humanity. (shrink)

Konrad Feiereis (1931-2012) hat mit Glaubenden wie Nichtglaubenden über Religion und Gesellschaft diskutiert. Der Christliche Philosoph verfügte über die Gabe, selbst im kämpferischen Atheisten den suchenden Anderen, Nachbarn und Dialogpartner zu erkennen - dabei entwickelte er im Weltanschauungsstaat DDR herausragende hermeneutische Fähigkeiten. Die Herausgeber möchten an diesen bedeutenden katholischen Intellektuellen erinnern und laden dazu ein, Feiereis in seinen Texten zu begegnen.

The Chinese parallel to the Pali-Kutadantasutta marks one of the major turning points in Old Indian history of ideas: the transition from magic to ethics. In this sermon, the Buddha rejects the Vedic animal sacrifice and re-interprets it according to Buddhist ethics. He preaches sacrifices in a new sense of the word: the sacrifice of giving alms to Buddhist monks, or, even better, of building monasteries, of converting to Buddhism as a Buddhist layman, of obeying the five Buddhist rules for (...) laymen, or - finally and most meritorious - becoming a Buddhist monk. In Beginnings of Buddhist Ethics, Konrad Meisig translates the Buddhist Chinese text for the first time and contrasts it in synopsis with the Pali. The text is given in the original characters along with the Pinyin transcription. The text-critical introduction deals with the variae lectiones both of the Chinese and the Pali; the final analysis focuses on the literary stratification and criticism of forms, thus reconstructing the archetypical nucleus of the Kutadantasutta."--Publisher's description. (shrink)

The paper explores the relationships and interconnections in the philosophical and sociopolitical concepts of Günther Anders and Hannah Arendt. Both philosophers, who were married to each other for a short time, not only shared a similar fate in that they both had to flee from National Socialism, but both dealt with similar questions, albeit in different manners: with Auschwitz and the Holocaust, with the problem of totalitarianism, with the development of the Modern, which is defined by technology and industrial labour. (...) A comparison shows that many themes in the thinking of these philosophers are near to each other, but the methods and foci are other. At the foreground of Anders’ thinking is the question of the destructive influence of modern technology and weapons of mass destruction. However, Arendt concentrates on totalitarian political structures and the possibility of people to take action. Nevertheless, they both are concerned that people’s humanity is at risk under the political and technological conditions of the Modern. (shrink)

In this study we investigate the influence of reason-relation readings of indicative conditionals and ‘and’/‘but’/‘therefore’ sentences on various cognitive assessments. According to the Frege-Grice tradition, a dissociation is expected. Specifically, differences in the reason-relation reading of these sentences should affect participants’ evaluations of their acceptability but not of their truth value. In two experiments we tested this assumption by introducing a relevance manipulation into the truth-table task as well as in other tasks assessing the participants’ acceptability and probability evaluations. Across (...) the two experiments a strong dissociation was found. The reason-relation reading of all four sentences strongly affected their probability and acceptability evaluations, but hardly affected their respective truth evaluations. Implications of this result for recent work on indicative conditionals are discussed. (shrink)

Qu'est-ce que l'éducation? Étude philosophique, psychologique et pédagogique de ce problème. Comment définir l'école, sa mission, ses objectifs, ses méthodes, ses moyens?

In this paper I argue that contemporary truth pluralists have undersold the connection between their views and the semantic realism/anti-realism debate. I argue that pluralist theories of truth are essentially a combination of accepting both realist and anti-realist intuitions, and that we should take this lesson to heart. I show how we can categorize pluralist views by how realist or anti-realist they are, and introduce two notions to do so: methodological fundamentality and theoretical fundamentality. I show how viewing the pluralist (...) literature in this way reveals the core principles behind rival pluralist accounts and cuts across another influential way to divide up the truth pluralist literature. I conclude by introducing a new version of truth pluralism: methodological pluralism about truth. Methodological pluralism about truth stays methodologically neutral between its realist and anti-realist poles, and thus better accounts for both of its key theoretical motivations. (shrink)

We examine second order intuitionistic propositional logic, IPC². Let $F_\exists $ be the set of formulas with no universal quantification. We prove Glivenko's theorem for formulas in $F_\exists $ that is, for φ € $F_\exists $ φ is a classical tautology if and only if ¬¬φ is a tautology of IPC². We show that for each sentence φ € $F_\exists $ (without free variables), φ is a classical tautology if and only if φ is an intuitionistic tautology. As a corollary (...) we obtain a semantic argument that the quantifier V is not definable in IPC² from ⊥, V, ^, →. (shrink)

Residency selection is a challenging process for medical students, one further complicated in the USA by the recentDobbs v Jackson Women’s Health Organization(Dobbs) decision over-ruling the federal right to abortion. We surveyed medical students to examine howDobbsis influencing the ideological, personal and professional factors they must reconcile when choosing where and how to complete residency.Between 6 August and 22 October 2022, third-year and fourth-year US medical students applying to US residency programmes were surveyed through social media and direct outreach to (...) medical schools. Analysis of quantitative and qualitative data from 494 responses was performed to assess downstream effects ofDobbson residency applicants’ family, health and career choices.Most respondents said changes in abortion access would likely or very likely influence their decision regarding location of considered residency programme (76.9%), where to start a family (72.2%) and contraceptive planning for them or their partner (57.9%). Cis-gender females were more influenced byDobbsregarding where (5 (4, 5) p<0.001) and when (3 (3, 5) p<0.001) to start a family. In qualitative responses, medical trainees highlighted the importance of abortion access for their patients, themselves and their loved ones.Medical trainees are incorporating state abortion access into their residency programme choices. Future physicians care about both the quality of care they will be able to provide and their own health. For personal and professional reasons, reproductive healthcare access is now a key factor in residency match decisions. (shrink)