Background. The increased number of clinical trials taking place in developing countries and the complexity of trial protocols mandate that local ethics review committees reviewing them have the capacity to ensure that they are conducted to the highest ethical standards.Methods. The Kenya AIDS Vaccine Initiative Institute of Clinical Research and the Kenyan National Council for Science and Technology embarked on an exercise to enhance the capacity of ERCs in Kenya to review such protocols. This process involved conducting an audit of (...) all ERCs in the country, and performing training needs assessments to identify knowledge and capacity gaps. Information obtained was used to develop training materials for ERC members at workshops conducted in different parts of the country.Results. Five accredited and 13 non-accredited ERCs were identified. Four of the accredited ERCs were located in the capital city of Kenya, Nairobi. The most common challenges cited by participants during the needs assessments were excess workload, and a lack of co-ordination and/or communication between the ERCs. Subsequently, 140 ERC members from 17 institutions across the country were trained as follows: 36 from institutions in the western part of Kenya, 38 from institutions in the south-eastern coastal region, 38 from the eastern region and 44 from Nairobi.Conclusion. The KAVI-ICR and the NCST have developed training modules for training ERC members in Kenya and are in the process of developing a manual to train members. The Kenyan experience may be used to enhance the capacity of ERCs in the East African region. (shrink)

Ethics dumping is the practice of undertaking research in a low- or middle-income setting which would not be permitted, or would be severely restricted, in a high-income setting. Whilst Kenya operates a sophisticated research governance system, resource constraints and the relatively low number of accredited research ethics committees limit the capacity for ensuring ethical compliance. As a result, Kenya has been experiencing cases of ethics dumping. This article presents 11 challenges in the context of preventing ethics dumping in Kenya, namely (...) variations in governance standards, resistance to double ethics review, resource constraints, unresolved issues in the management of biological samples, unresolved issues in the management of primary data, unsuitable informed consent procedures, cultural insensitivity, differing standards of care, reluctance to provide feedback to research communities, power differentials which facilitate the exploitation of local researchers and lack of local relevance and/or affordability of the resultant products. A reflective approach for researchers, built around the values of fairness, respect, care and honesty, is presented as a means of taking shared responsibility for preventing ethics dumping. (shrink)

Study on the works of Ācārya Vidyāsāgara, contemporary Jaina saint and his contributions to Jaina religion and philosophy.

This paper uses Foucault’s concepts “discipline” and “biopower” to expose the complexity of power relations in Augustan Rome and its historiography. Focusing on Augustus’ Res Gestae and Tacitus’ Annales, I argue that the absolute sovereignty of the emperor did not preclude the advancement of techniques to classify, hierarchize and normalize individuals, nor did Imperial sovereignty work against the development of a discourse about the enhancement and protection of the population. By demonstrating the conceptual and historical relevancy of Foucault’s modern power (...) triad of “sovereignty-discipline-government” to first century CE Rome, the paper suggests that biopolitical societies have a far more extensive history than the one said to have started around the turn of the eighteenth century. (shrink)

Positive Polarity indefinites, such as some in English, are licensed in simplex negative sentences as long as they take wide scope over negation. When it surfaces under a clausemate negation, some can in principle take wide scope either by movement or by some semantic mechanism; e.g., it can take pseudoscope if it is interpreted as a choice function variable. Therefore, there is some uncertainty regarding the way in which PPI indefinites get licensed: can pseudoscope suffice? In this article we show, (...) using novel data from Hindi-Urdu and English, that pseudoscope is not sufficient, and that it is the syntactic position of PPI indefinites at LF, rather than their actual scope, which is relevant for licensing. These facts support a unified view of PPI indefinites as generalized quantifiers, and disfavor analyses where they are, or can be, interpreted as choice function variables. (shrink)

We dub the kyaa in (2a) polar kyaa, which we distinguish from the homophonous thematic kyaa ‘what’. in (3). In (3), kyaa is the theme argument of the verb diyaa ‘gave’. The same has been argued for the scope marking construction, at least under the indirect dependency approach (Dayal 1994 among others). The preverbal position has been argued to be the unmarked position for wh-words in Hindi-Urdu (Kidwai 2000, among others).

In this paper, we examine how organizations’ impression management evolves in response to rising stakeholder pressures regarding organizations’ corporate responsibility initiatives. We conducted a comparative case study analysis over a period of 13 years for two organizations—Exxon and BP—that took extreme initial stances on climate change. We found that as stakeholder pressures rose, their IM tactics unfolded in four phases: advocating the initial stance, sensegiving to clarify the initial stance, image repairing, and adjusting the stance. Taken together, our analysis of (...) IM over these four phases provides three key insights about the evolution of IM in the face of rising pressures. First, when faced with stakeholder pressures, it seems that organizations do not immediately resort to conforming but tend to give in gradually when pressures increase and start to come from relatively powerful stakeholders. Second, evolution of IM seems to be characterized by path dependence, i.e., even as organizations’ positions evolve, they continue to show their conviction in their initial positions and try to convey that their subsequent positions flow logically from the previous ones. Finally, IM involves navigation between symbolism and substance, and companies tend to strive toward harmonizing their symbolic and substantive actions as stakeholder pressure increases. (shrink)

The ability to memorize changes in the environment is present at all biological levels, from social groups and individuals, down to single cells. Trans‐generational memory is embedded subcellularly through genetic and epigenetic mechanisms. Evidence that cells process and remember features of the immediate environment using protein sensors is reviewed. It is argued that this mnemonic ability is encapsulated within the protein conformational space and lasts throughout its lifetime, which can overlap with the lifespan of the organism. Means to determine diachronic (...) changes in protein activity are presented. (shrink)

We review the literature on how perceiving an AI making mistakes violates trust and how such violations might be repaired. In doing so, we discuss the role played by various forms of algorithmic transparency in the process of trust repair, including explanations of algorithms, uncertainty estimates, and performance metrics.

Does language dominance modulate knowledge of case marking in Hindi-speaking bilinguals? Hindi is a split ergative language with a rich morphological case system. Subjects of transitive perfective predicates are marked with ergative case (-ne). Human specific direct objects, indirect objects, and dative subjects are marked with the particle -ko. We compared knowledge of case marking in Hindi-English bilinguals with different dominance patterns: 23 balanced bilinguals and two groups of bilinguals with Hindi as their weaker language: 24 L2 learners of Hindi (...) with age of acquisition (AoA) of Hindi in adulthood and 26 Hindi heritage speakers with AoA of Hindi since birth) in oral production and acceptability judgments. The balanced bilinguals outperformed the English-dominant bilinguals; the L2 learners and the heritage speakers, who showed similar lower command of the Hindi case marking system, with the exception of –ko marking as a function of specificity with direct objects. We consider how dominant language transfer, age of acquisition of Hindi, and input factors may explain the acquisition and knowledge of morphology in Hindi as the weaker language. (shrink)

We investigate the research question: Why are there very few social enterprises in China? Our findings unpack four types of institutional challenges to social entrepreneurship, as perceived by social entrepreneurs: norms of a strong role for government; misunderstood or unknown role for social enterprises; non-supportive rules and regulations; and lack of socio-cultural values and beliefs in support of social goals. We contribute to the literature on social enterprises by showing how an institutional environment may be “non-munificent,” i.e., non-supportive for the (...) existence of social enterprises and their goals, and we thus address the need for more attention to the institutional environment in which social entrepreneurship takes place. Further, by using Q-methodology on 42 social entrepreneurs along with illustrative qualitative data from interviews, we address the need to go beyond anecdotal case studies and introduce methodological plurality in social entrepreneurship research. Finally, our findings on institutional challenges provide us with an opportunity to discuss how social entrepreneurs may engage with purposive activities to overcome such challenges, leading us to initiate a conversation between the social entrepreneurship and institutional work literatures. (shrink)

This paper investigates how social enterprises navigate through the ethical complexity of social change and extends the ethical quandaries faced by social enterprises beyond organisational boundaries. Building on the emerging literature on the ethics of SEs, I conceptualise ethics as an engagement with power relations. I develop theoretical arguments to understand the interaction between ethical predispositions of a SE and the normative structure of the social system in which it operates. I applied this conceptualisation in a hierarchical and heterogeneous rural (...) Indian context to provide insights into the moral ambiguity of ethical decision-making and suggest pathways for ethical actions. Taking a qualitative case study approach, I followed an exemplary SE’s implementation process in India. I observed ethical challenges in designing the implementation process, selecting the beneficiaries and sustaining the programme. I also identified three actions of the SE—the action of recognition, the action of reposition and the action of collaboration—and developed a transformative process model. I discuss the theoretical implications of this research for SEs and recommend a critical engagement with ethical theories to address systemic problems. (shrink)

This book analyses global issues holistically and offers pragmatic solutions from a Jainism perspective. Accordingly, it presents a fresh vision of individual development, social transformation and cosmic wellbeing based on the central tenets and practices of Jainism. Through this book, readers learn viable solutions to the current problems of environmental disharmony, economical distress, and religious and cultural conflicts. It deals with religious pluralism and brings to fore the need for harmony of religions and interfaith dialogues. The book is interesting for (...) people from varied walks of life who are looking forward to a world that is established in peace, harmony and wellness. It is of immense value and interest for people from all walks of life to the Jain community to revisit the basic tenets propounded in classical literature. (shrink)

Harmonic Grammar (HG) is a model of linguistic constraint interaction in which well-formedness is calculated as the sum of weighted constraint violations. We show how linear programming algorithms can be used to determine whether there is a weighting for a set of constraints that fits a set of linguistic data. The associated software package OT-Help provides a practical tool for studying large and complex linguistic systems in the HG framework and comparing the results with those of OT. We describe the (...) translation from Harmonic Grammars to systems solvable by linear programming, and we illustrate the usefulness of OT-Help with a set of studies of the predictions HG makes for phonological typology. (shrink)

In their discussion paper of November 2020, Cooket alpresent a draft protocol for navigating circumstances in which emergency services are overwhelmed. Their paper suggests that COVID-related triage decisions should be based on clinical assessment, patient and family consultation, and a range of ethical considerations. In this response, we note that the protocol exhibits an ambiguity that is likely to result in irresolvable dilemmas when put into practice. This ambiguity is exemplified in the paper’s prime ethical imperative (to ‘save more lives (...) and more years of life’), which takes the form of an undefined conjunction whose practical implications are left unspecified. We see this ambiguity in the prime imperative as one manifestation of a broader set of tensions in the protocol. We show that the discipline of human rights provides an essential supplement to the ethical framework on which Cook and colleagues rely, providing a framework for understanding and working through triage dilemmas involving age, discrimination and equality. (shrink)

Materialism is considered to be an anathema to Indian philosophy. Despite this, Indian tradition boasts of a strong materialist trend predating the Vedas. This paper traces the proto-materialist ideas as found in the ancient Tantra and pre-classical or original Sāṃkhya. Representing the naturalistic trend in Indian philosophy, ancient Tantra identified the brain as the seat of human consciousness. The pre-classical Sāṃkhya considered matter as the primal non-intelligent or non-sentient first cause from which the universe was to evolve. It considers the (...) material cause to be self-sufficient for the purpose of producing the world; the principle of consciousness is potentially contained in the primeval matter. This paper aims to provide an overview of the Indian materialist viewpoint for multidisciplinary scholars. (shrink)

In his brief comments on “Siddhis and Psi Research: An Interdisciplinary Analysis,” Ed Kelly expresses disappointment that the paper does not mirror his worldview, which includes questioning the reality of psi—especially precognition, accepting post-mortem survival and observational evidence for macro-PK including levitation. In this brief response to Kelly, I provide arguments in support of informational psi, particularly precognition, and in favor of a physicalist, signal-based approach to psi, with brief points against the validity of micro-PK and post-mortem survival.

Drawing on 121 in-depth interviews with first- and second-generation women and men physicians of Indian origin in the U.S. Southwest, I examine the incidence and nature of gender-based discrimination in American medicine. I focus on two aspects: gender discrimination by employers and colleagues against women physicians of Indian origin and the interaction of gender discrimination with race in the professional lives of first- and second-generation physicians. U.S. healthcare has become increasingly dependent on immigrants, in particular women physicians, from the developing (...) world. I document the significant impact gender and race can have in molding the professional trajectories of Indian women physicians. The experiences of these physicians help clarify the interaction of skilled migrant workers with racial/ethnic and gender relations in U.S. workplaces. (shrink)

This volume provides a clear and exhaustive exposition of Buddhist epistemology and logic, based on the works of classical thinkers such as Vasubandhu, Dinnaga,..

CHAPTER 1 Subdivisions in the Relevant Canonical Works References, dvara-gathas , subdivisions, titles, and colophons are technical devices which need not ...

First published in 1997. Routledge is an imprint of Taylor & Francis, an informa company.