We construct a model with a saturated ideal _I_ over \({\mathcal {P}}_{\kappa }\lambda \) and study the extent of saturation of _I_.

The key mutation of the schizophrenic psyche can be described as a disturbance of the first person-ness of the I-sense, i.e., of the sense of the "I" as personal subject of experience and of action. Under these circumstances, representations of things are not definitively experienced as "my" representations—with the self-evidence of belonging to me. This uncertainty of selfhood, specific to schizophrenia, cannot be reduced to a disability of intellect, logic, judgment, or memory. In the course of developing his argument, the (...) author criticizes philosopher Michel Henry's critique of Heidegger's (1961) interpretation of Descartes's cogito ergo sum. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Journal of Aesthetic Education 37.4 (2003) 58-64 [Access article in PDF] Media Literacy Education in Art:Motion Expression and the New Vision of Art EducationThe Bauhaus, which established the foundation of modern design, has greatly influenced Japanese design and art education. It is a historical fact that the movement views "synthetic art" as an integration of the various fields and the integration of the art and machine technology experimentally. (...) However, the Bauhaus is not just of historical importance but continues to have an influence even in the integration of the art and electronic technology in today's "multimedia." In addition, it can be said that it is very much alive as "the digital Bauhaus" or "the electronic Bauhaus." 1 As we know, today's multimedia and the Internet give us a new life-environment, and expandthe possibility of expression in art. Therefore, current art education must examine how these new medias will be incorporated into the curriculum.In the cases of the photograph, video, or computer, an expression by the image media is added to the art course for the junior high school course of study. 2 Also in school art classes, image media was introduced, expanding the possibilities of self-expression through art. This result can be matched to the needs of the industrial world in Japan as well. As an educational practice, the content of this course of study is promising, even though someproblems must be solved, acquiring new equipment, re-educating the artteacher, and securing additional art school hours. The new content in art education can be summarized as follows:1. The motion picture (animation) which includes time and movement. Motion picture is asequence of continuous images, obviously different from the still images of painting. There are, of course, artworks that express motion or induce the viewer'seye movement. There are also kinetic artworks that do move, such as mobiles. Works of motion picture have, however, a fixed time shaft, and they are formed by the afterimage phenomenon. Thinking about the progress of time shaft is an indispensable element for the production. [End Page 58]2. The synchronism of image and sound. Because time is a factor in the visual expression, the works are compatible with music — the art of time. There is a synchronized relation between the motion picture and music. Image expression with multimedia became synthetic art, just as the Bauhaus looked for "architecture." Currently, this kind of expression transitions from art to entertainment, and permeates daily life.3. The method with interactive art work. Not only artworks of installation, but also TV games and web design have interactive construction as an indispensable interface. The aesthetic value of these visual works will be appreciated when the user starts the action by hitting a touchpad, pushing buttons, or clicking a mouse. To make this kind of artwork, one needs to consider the latent relationships between humans and work, and establish the input-output order for the method of construction.4. The problem of virtual reality. The term "virtual reality" is used by some art teachers as criticism against digital works such as computer graphics. These teachers insist that there is no reality there. One can, however, get an aesthetic feeling through sensory information, imagination, and sensitivity, even though what one sees is an illusion. The feeling of reality a picture of an apple gives, for example, may be equal to a computer graphic apple.Human imagination also creates "virtual reality" beyond reality in the myth, the novel, and so on. It can be said that this is the basis for human creativity.Furthermore, expression by image media raises the problem of a "reality" in which material experience is important to encounterthe world directly. Such an argument discusses multimedia as a tool of expression and a teaching material while reconsidering human reality.More recently, "media literacy" (ability to read and understand media) became an important point of discussion for Japanese educators. Usually, in this discussion, the critical ability to talk back to the television program is emphasized. However, through art... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Journal of Aesthetic Education 37.4 (2003) 58-64 [Access article in PDF] Media Literacy Education in Art:Motion Expression and the New Vision of Art EducationThe Bauhaus, which established the foundation of modern design, has greatly influenced Japanese design and art education. It is a historical fact that the movement views "synthetic art" as an integration of the various fields and the integration of the art and machine technology experimentally. (...) However, the Bauhaus is not just of historical importance but continues to have an influence even in the integration of the art and electronic technology in today's "multimedia." In addition, it can be said that it is very much alive as "the digital Bauhaus" or "the electronic Bauhaus." 1 As we know, today's multimedia and the Internet give us a new life-environment, and expandthe possibility of expression in art. Therefore, current art education must examine how these new medias will be incorporated into the curriculum.In the cases of the photograph, video, or computer, an expression by the image media is added to the art course for the junior high school course of study. 2 Also in school art classes, image media was introduced, expanding the possibilities of self-expression through art. This result can be matched to the needs of the industrial world in Japan as well. As an educational practice, the content of this course of study is promising, even though someproblems must be solved, acquiring new equipment, re-educating the artteacher, and securing additional art school hours. The new content in art education can be summarized as follows:1. The motion picture (animation) which includes time and movement. Motion picture is asequence of continuous images, obviously different from the still images of painting. There are, of course, artworks that express motion or induce the viewer'seye movement. There are also kinetic artworks that do move, such as mobiles. Works of motion picture have, however, a fixed time shaft, and they are formed by the afterimage phenomenon. Thinking about the progress of time shaft is an indispensable element for the production. [End Page 58]2. The synchronism of image and sound. Because time is a factor in the visual expression, the works are compatible with music — the art of time. There is a synchronized relation between the motion picture and music. Image expression with multimedia became synthetic art, just as the Bauhaus looked for "architecture." Currently, this kind of expression transitions from art to entertainment, and permeates daily life.3. The method with interactive art work. Not only artworks of installation, but also TV games and web design have interactive construction as an indispensable interface. The aesthetic value of these visual works will be appreciated when the user starts the action by hitting a touchpad, pushing buttons, or clicking a mouse. To make this kind of artwork, one needs to consider the latent relationships between humans and work, and establish the input-output order for the method of construction.4. The problem of virtual reality. The term "virtual reality" is used by some art teachers as criticism against digital works such as computer graphics. These teachers insist that there is no reality there. One can, however, get an aesthetic feeling through sensory information, imagination, and sensitivity, even though what one sees is an illusion. The feeling of reality a picture of an apple gives, for example, may be equal to a computer graphic apple.Human imagination also creates "virtual reality" beyond reality in the myth, the novel, and so on. It can be said that this is the basis for human creativity.Furthermore, expression by image media raises the problem of a "reality" in which material experience is important to encounterthe world directly. Such an argument discusses multimedia as a tool of expression and a teaching material while reconsidering human reality.More recently, "media literacy" (ability to read and understand media) became an important point of discussion for Japanese educators. Usually, in this discussion, the critical ability to talk back to the television program is emphasized. However, through art... (shrink)

There are many morphologically distinct membrane structures with different functions at the surface of epithelial cells. Among these, adherens junctions (AJ) and tight junctions (TJ) are responsible for the mechanical linkage of epithelial cells and epithelial barrier function, respectively. In the process of new cell–cell adhesion formation between two epithelial cells, such as after wounding, AJ form first and then TJ form on the apical side of AJ. This process is very complicated because AJ formation triggers drastic changes in the (...) organization of actin cytoskeleton, the activity of Rho family of small GTPases, and the lipid composition of the plasma membrane, all of which are required for subsequent TJ formation. In this review, the authors focus on the relationship between AJ and TJ as a representative example of specialization of plasma membrane regions and introduce recent findings on how AJ formation promotes the subsequent formation of TJ. (shrink)

Mutations in growth factor receptor signaling pathways are common in cancer cells, including the highly lethal brain tumor glioblastoma (GBM) where they drive tumor growth through mechanisms including altering the uptake and utilization of nutrients. However, the impact of changes in micro‐environmental nutrient levels on oncogenic signaling, tumor growth, and drug resistance is not well understood. We recently tested the hypothesis that external nutrients promote GBM growth and treatment resistance by maintaining the activity of mechanistic target of rapamycin complex 2 (...) (mTORC2), a critical intermediate of growth factor receptor signaling, suggesting that altered cellular metabolism is not only a consequence of oncogenic signaling, but also potentially an important determinant of its activity. Here, we describe the studies that corroborate the hypothesis and propose others that derive from them. Notably, this line of reasoning raises the possibility that systemic metabolism may contribute to responsiveness to targeted cancer therapies. (shrink)

Chef de file de la réflexion psychiatrique au Japon, le Professeur Kimura Bin s’oppose dans cet article aux réductionnismes physicalistes en découvrant au coeur de la subjectivité une articulation complexe entre le personnel et l’impersonnel qui simultanément confirme la conception spirituelle zen de la constitution de l’individualité et donne une base à la fondation d’une science psychiatrique véritable. Il démontre que l’orientation donnée par les sciences cognitives et la philosophie analytique conduit à ignorer la différence entre réalité et actualité, (...) et occulte ainsi le fait que chaque existant est unique, manquant de la sorte à la fois son unité et son unicité. Pour retrouver l’originalité propre à chacun, Kimura propose d’en retrouver l’originarité, esquissée dans le concept heideggérien de Befindlichkeit, et d’élargir la subjectivité au sens proposé par Victor von Weizsäcker en tant que rencontre avec le milieu. Il conclut cette étude phénoménologique en proposant de fonder une psychopathologie en première personne, c’est-à-dire d’introduire la subjectivité dans la science psychiatrique, seule voie pour comprendre l’existence et résoudre l’énigme de la schizophrénie. (shrink)

科学技術の発展とともに、バイオエシックスはいつも新しい課題に直面し、挑戦し続けている。このバイオエシックスの軌跡を「環境・自然」、「こどもの医療」、「生死の決断」等、私たちのいのちに関わる重要なテーマ に焦点をあてて検討、考察し、問題解決への提言を行った。.

倫理学・仏教学・美術史・近代文学など多分野の気鋭の専門家たちが、近代日本の精華・和辻哲郎の学問の現代的意義を検証する。.

Dans l'Histoire des deux Indes, le concept de civilisation s'applique d'abord à la formation de l'Europe moderne depuis la chute de l'Empire romain, dans lequel le commerce promeut l'« affranchissement» civile et politique du tiers état dans les États souverains. Pour Raynal, cette expérience historique des Européens sert de paradigme, à partir duquel il opère la dépreciation de la civilisation des anciens empires des deux Indes et élabore une variété de propositions politiques en vue des transformations, voire du dépassement de (...) l'empire colonial européen. Ainsi, en universalisant la structure politique de l'Europe moderne, et en poursuivant la réalisation de la liberté civile et politique selon divers modes, il annonce l'avènement de l'espace historique et politique du monde moderne, composé des États-nations sur le fond des réseaux globaux du commerce. (shrink)

For genetic algorithms, it is important to maintain the population diversity. Some genetic algorithms have been proposed, which have an ability to control the diversity. But these algorithms use the distance between two individuals to control the diversity. Therefore, these performances become worse on ill-scaled functions. In this paper, we propose a new genetic algorithm, DIDC(a genetic algorithm with Distance Independent Diversity Control), that does not use a distance to control the population diversity. For controlling the diversity, DIDC uses two (...) GAs that have different natures. For realizing different natures, one GA uses a crossover operator as a search operator, and the other GA uses a mutation operator in DIDC. By applying DIDC to several benchmark problems, we show that DIDC has a good performance on high dimensional, multimodal, non-separable and ill-scaled problems. Finally, we show that the control parameter of DIDC has the same effect on the search with the number of generating children n c. (shrink)

In a dynamic environment, even if an agent makes a plan to obtain a goal, the environment might change while the agent is executing the plan. In that case, the plan, which was initially valid when it was made, might later become invalid. Furthermore, in the process of replanning, it is necessary to take into account the side effects of actions already executed. Nowadays, HTN planning is becoming popular among agent researchers because its task decomposition algorithm is efficient and suitable (...) for joint planning in multi-agent systems. However, the dynamic replanning algorithm of HTN planning has not yet been established. In order to solve this problem, we have previously presented an agent life cycle that integrates HTN planning, action execution, knowledge updates, and plan modification. In that agent life cycle, the plans are always kept valid according to the most recent knowledge and situation. However, when one plan does not work and the agent starts using an alternative plan, it sometimes undoes some actions that do not have to be undone. The source of this problem lies in the need to have total-order plans. In other words, all the actions have to be sequentially ordered even when the order is not important in some parts of the plan. This paper extends our previous agent life cycle and presents new ways to avoid unnecessary action cancellation. This enables the agent to handle partial-order plans and to make use of two kinds of undoing actions: sequential undoing actions and concurrent undoing actions. (shrink)