The human spindle and kinetochore associated complex is required for proper mitotic progression. Extensive studies have demonstrated its important functions in both stable kinetochore-microtubule interactions and spindle checkpoint silencing. We suggest a model to explain how various Ska functions might be fulfilled by distinct pools of Ska at kinetochores. The Ndc80-loop pool of Ska is recruited by the Ndc80 loop, or together with some of its flanking sequences, and the recruitment is also dependent on Cdk1-mediated Ska3 phosphorylation. This pool seems (...) to play a more important role in silencing the spindle checkpoint than stabilizing kinetochore-microtubule interactions. In contrast, the Ndc80-N-terminus pool of Ska is recruited by the N-terminal domains of Ndc80 and appears to be more important for stabilizing kinetochore-microtubule interactions. Here, we review and discuss the evidence that supports this model and suggest further experiments to test the functioning mechanisms of the Ska complex. The human spindle and kinetochore associated complex plays essential functions in proper mitotic progression by promoting stable kinetochore-microtubule interactions and spindle checkpoint silencing. We propose that “distinct pools” of Ska—the Ndc80-loop and Ndc80-N-terminus pools—might fulfill these various functions. (shrink)
I sitt berömda bevis för tidens overklighet påstod McTaggart att det sätt händelser tycks skifta position i tiden från framtid till nutid och till förfluten tid, innebär en motsägelse. Vad McTaggart egentligen menade har varit föremål för en livlig debatt ända sedan beviset först publicerades 1908. Beviset består av två delar. I den första argumenterar McTaggart för att ingenting kan förändras förutom genom att övergå från framtid till förfluten tid. I den andra argumenterar han för att en sådan övergång innebär (...) en motsägelse och att det därför inte kan finnas någon förändring överhuvudtaget, vilket i sin tur innebär att det heller inte finns någon tid. De flesta filosofer är i dag eniga om att McTaggart har fel, men oeniga om på vilket sätt han har fel. Olika filosofer förkastar olika delar av beviset, beroende på om de har vad som kallas en A- eller B-uppfattning av tiden. De som har en A-uppfattning förnekar att tid förstådd som övergång från framtid till förfluten tid är motsägelsefull. De som har en B-uppfattning förnekar att en övergång från framtid till förfluten tid är nödvändig för förändring, men håller med om att sådan övergång är motsägelsefull. Det är min uppfattning att denna oenighet beror på att McTaggarts argument från första början blivit missuppfattat, av både A- och B-teoretiker. Av någon anledning har det alltid betraktats som ett självständigt argument, ett som är oberoende av det ontologiska system McTaggart förespråkade. Jag föreslår ett nytt sätt att förstå hur han menade att tiden är motsägelsefull. Ett sätt som tar hans ontologiska system som utgångspunkt. (shrink)
Microbiota-gut-brain research is a fast-growing field of inquiry with important implications for how human brain function and behaviour are understood. Researchers manipulate gut microbes to reveal connections between intestinal microbiota and normal brain functions or pathological states. Many claims are made about causal relationships between gut microbiota and human behaviour. By uncovering these relationships, MGB research aims to offer new explanations of mental health and potential avenues of treatment. So far, limited evaluation has been made of MGB's methods and its (...) core experimental findings, many of which are extensively reiterated in copious reviews of the field. These factors, plus the self-help potential of MGB, have combined to encourage uncritical public uptake of MGB discoveries. Both social and professional media focus on the potential for dietary intervention in mental health, and causal relationships are assumed to be established. Our target article has two main aims. One is to examine critically the core practices and findings of experimental MGB research and to raise questions about them for brain and behavioural scientists who may not be familiar with the field. The other is to challenge the way in which MGB findings are presented. Our positive goal is to suggest how current problems and weaknesses may be addressed, in order for both scientific and public audiences to gain a clearer picture of MGB research and its strengths and limitations. (shrink)
This book is about beliefs, language, communication and cognition. It deals with the fundamental issue of the interpretation of the speaker's utterance expressing a belief and reporting on beliefs of other people in the form of oratio obliqua. The main aim of the book is to present a new account of the problem of interpreting utterances expressing beliefs and belief reports in terms of an approach called Default Semantics.
The aim of the paper is to explore the interrelation between persuasion tactics and properties of speech acts. We investigate two types of arguments ad: ad hominem and ad baculum. We show that with both of these tactics, the structures that play a key role are not inferential, but rather ethotic, i.e., related to the speaker’s character and trust. We use the concepts of illocutionary force and constitutive conditions related to the character or status of the speaker in order to (...) explain the dynamics of these two techniques. In keeping with the research focus of the Polish School of Argumentation, we examine how the pragmatic and rhetorical aspects of the force of ad hominem and ad baculum arguments exploit trust in the speaker’s status to influence the audience’s cognition. (shrink)
What does the idea of taking 'the point of view of the universe' tell us about ethics? Lazari-Radek and Singer defend objectivism in ethics, and hedonistic utilitarianism, following Henry Sidgwick's lead. They explore how to justify an ethical theory; conflicts of self-interest and universal benevolence; and whether we should discount the future.
The aim of this paper is to provide a model that allows the representation and analysis of circularity in ethotic structures, i.e. in communication structures related to the speaker’s character and in particular, his credibility. The paper studies three types of cycles: in self-referential sentences, embedded testimony and ethotic begging the question. It is shown that standard models allow the reconstruction of the circularities only if those circular utterances are interpreted as ethotic arguments. Their alternative, assertive interpretation requires enriching the (...) existing models with a purely ethotic component related to the credibility of the performer of any (not necessarily argumentative) speech act. (shrink)
Building on our diverse research traditions in the study of reasoning, language and communication, the Polish School of Argumentation integrates various disciplines and institutions across Poland in which scholars are dedicated to understanding the phenomenon of the force of argument. Our primary goal is to craft a methodological programme and establish organisational infrastructure: this is the first key step in facilitating and fostering our research movement, which joins people with a common research focus, complementary skills and an enthusiasm to work (...) together. This statement—the Manifesto—lays the foundations for the research programme of the Polish School of Argumentation. (shrink)
Evolutionary accounts of the origins of human morality may lead us to doubt the truth of our moral judgments. Sidgwick tried to vindicate ethics from this kind of external attack. However, he ended The Methods in despair over another problem—an apparent conflict between rational egoism and universal benevolence, which he called the “dualism of practical reason.” Drawing on Sidgwick, we show that one way of defending objectivity in ethics against Sharon Street’s recent evolutionary critique also puts us in a position (...) to support a bold claim: the dualism of practical reason can be resolved in favor of impartiality. (shrink)
The first comprehensive study of Santayana’s political thought as connected to his cultural criticism. It ranges over topics such as Santayana’s political ontology, his criticism of democracy, liberalism, and communism, his views on freedom and forms of human servitude.
Pragmatics and dialectics are two disciplines which have been amongst the first and most important partners for argument studies in the exploration of the complex realm of communication. Treating argumentation as a construct consisting of premises and conclusion allows for investigating some interesting properties of the phenomenon of reasoning, but does not capture a variety of aspects related to the usage of natural language and dialogical context in which real-life argumentation is typically embedded. This special issue explores some of the (...) fascinating research questions which emerge when we move beyond logic into the territory of the pragmatics and dialectics of argument. (shrink)
Utilitarianism may well be the most influential secular ethical theory in the world today. It is also one of the most controversial. It clashes, or is widely thought to clash, with many conventional moral views, and with human rights when they are seen as inviolable. Would it, for example, be right to torture a suspected terrorist in order to prevent an attack that could kill and injure a large number of innocent people? In this Very Short Introduction Peter Singer and (...)Katarzyna de Lazari-Radek provide an authoritative account of the nature of utilitarianism, from its nineteenth-century origins, to its justification and its varieties. Considering how utilitarians can respond to objections that are often regarded as devastating, they explore the utilitarian answer to the question of whether torture can ever be justified. They also discuss what it is that utilitarians should seek to maximize, paying special attention to the classical utilitarian view that only pleasure or happiness is of intrinsic value. Singer and de Lazari-Radek conclude by analysing the continuing importance of utilitarianism in the world, indicating how it is a force for new thinking on contemporary moral challenges like global poverty, the treatment of animals, climate change, reducing the risk of human extinction, end-of-life decisions for terminally-ill patients, and the shift towards assessing the success of government policies in terms of their impact on happiness. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable. (shrink)
Focusing on the analysis of Athens' relations with both Greeks and non-Greeks as recorded in extant fourth-century decrees, this paper challenges the applicability of the notion of Greek/barbarian antithesis to the interpretation of formal diplomatic exchanges between Athens and the non-Greek states. A comparison of the types of decrees and honors reveals a remarkable uniformity in the forms of Athens' foreign relations irrespective of the ethnicity of honorands. The distribution of honors among individuals and groups of recipients within single decrees (...) further demonstrates that the Athenian honorific system typically elevated individuals over communities they represented, suggesting that political differences between Athens and non-Greek states did not adversely influence the methods of exchanges between them. Apart from the provisions contained in the decrees, this paper also considers their function within the city as monuments that attest to the important place of philobarbaric discourse and practice in fourth-century Athens. (shrink)
We show that the variety of equivalential algebras with regularization gives the algebraic semantics for the -fragment of intuitionistic propositional logic. We also prove that this fragment is hereditarily structurally complete.
Sidgwick's defence of esoteric morality has been heavily criticized, for example in Bernard Williams's condemnation of it as 'Government House utilitarianism.' It is also at odds with the idea of morality defended by Kant, Rawls, Bernard Gert, Brad Hooker, and T.M. Scanlon. Yet it does seem to be an implication of consequentialism that it is sometimes right to do in secret what it would not be right to do openly, or to advocate publicly. We defend Sidgwick on this issue, and (...) show that accepting the possibility of esoteric morality makes it possible to explain why we should accept consequentialism, even while we may feel disapproval towards some of its implications. (shrink)
Dynamics of perceiving oneself on femininity and masculinity dimensions in diverse contexts The article is about issues related to gender perceived as a result of social context and thus fits in the current, processual gender paradigm. Two studies have been conducted verifying hypotheses about perceiving oneself on the femininity and masculinity dimensions in various types of contexts. Expectations were that generic contexts would make perceiving oneself within the psychological gender dimensions more dynamic. Women were expected to perceive themselves as more (...) feminine and less masculine in contexts matching their gender, i.e. "feminine", comparing to "masculine", and men were expected to perceive themselves as more masculine and less feminine in "masculine" contexts comparing to "feminine" contexts. Research results do not confirm the above hypotheses and indicate dynamism in perceiving oneself on femininity and masculinity dimensions. However, the dynamism is perceived only on dimensions inconsistent with biological gender - situation affects women's perceiving of themselves on the masculinity dimension and men's - on femininity dimensions. (shrink)
Celem artykułu jest wykazanie, że filozofia może sięgać po ustalenia neuronauki, w tym psychologii, w zakresie poczucia winy i wstydu, w czym mają pomóc postawione w artykule pytania i poruszane zagadnienia. Autorka przywołała dane na temat neuronalnych korelatów poczucia winy i wstydu i neuropsychologiczne interpretacje niektórych z nich. Szczególną uwagę zwróciła na kwestie związane z oceną moralną i moralnymi sankcjami.
Personality Dimensions and Nicotine Dependence and Withdrawal Symptoms: the Mediating Role of Self-Directness We analyzed the relationship between personality traits and smoking status and nicotine withdrawal symptoms using two comprehensive models of personality: the Five-Factor Model and the Cloninger's Temperament and Character Inventory. In total 295 people were examined, 149 smokers and 146 who have never smoked. To measure the severity of the nicotine dependence we used the Fagerstroem Tolerance Questionnaire and the DSM-IV criteria of nicotine dependence and to measure (...) the nicotine withdrawal symptoms the Nicotine Dependence History. The results showed significant differences between the groups in particular dimensions: Neuroticism, Agreeableness and Conscientiousness. The analyse of the TCI demonstrate, that smokers are higher in Novelty Seeking and lower in Reward Dependence than never smokers and show less Self-Directness and Cooperativeness. The mediation analyses showed that Self-Directness is the significant mediator between Extra-Introversion and nicotine withdrawal symptoms measured by NDHIS and between Neuroticism and DSM-IV criteria of nicotine dependence. (shrink)