Excerpt: 1. Introduction This chapter provides insight into the diverse ethical debates on genetics and epigenetics. Much controversy surrounds debates about intervening into the germline genome of human embryos, with catchwords such as genome editing, designer baby, and CRISPR/Cas. The idea that it is possible to design a child according to one’s personal preferences is, however, a quite distorted view of what is actually possible with new gene technologies and gene therapies. These are much more limited than the editing and (...) design metaphors suggest. Such metaphors are therefore highly problematic phrases in the context of new gene technologies, for two reasons. On one hand, to design a child of choice by modifying the genome would require modifying any gene of choice, which is more than can be done with current gene technologies, such as CRISPR/Cas. On the other hand, a modification of genes would need to be enough to create any characteristic of choice in the future child. The latter presupposes the assumption of genetic determinism. Moreover, the CRISPR/Cas technology can not only be used in a potentially therapeutic manner at the germline level. In addition, there is the (more likely) scenario of a future clinical therapeutic use of these new gene technologies for modifying the DNA sequence of other cells of the body (somatic genome editing). There is also the option of modifying the epigenome, that is, the spatial configuration of DNA (epigenome editing) (see table 1). Like genetics and genome editing, epigenetics has been at the center of recent popular scientific and ethical discourse as well as scientific debates. The concept of epigenetics has given rise to very different notions of inheritability and responsibility for health, which, however, are oftentimes based on scientifically controversial basic assumptions. That there continues to be covert genetic determinism in the form of epigenetic determinism (see table 2) in debates about epigenetics has been pointed out in ethical analyses of epigenetics. Neither genetic determinism nor epigenetic determinism has been confirmed scientifically. It is therefore important to recognize the concepts that are discussed (and sometimes harshly criticized) in debates about genome editing and epigenetics—for example, concepts about the causal role of DNA for our own life course. This importance is based on the fact that if we understand such controversial concepts, we will be able to remain critical when evaluating scientific knowledge and ethical arguments about genome editing and epigenetics. This chapter, therefore, explains some of these concepts. For an ethical analysis of epigenetics as well as of genome editing, it is necessary to understand and critically reflect upon the underlying concepts of genetic determinism and other, related -isms. The following section offers a detailed introduction to these -isms (section 2; see also table 2). Section 3 provides an ethical analysis of genome editing and epigenetics based on the explanations in section 2. Section 3 focuses on inheritability and responsibility, justice, safety, the problem of consent, and the effects of genome editing and epigenetics on embryos and future generations. This section does not discuss in detail further points that can be found in ethical debates about epigenetics as well as in ethical debates about genome editing. These points include (among others): • fear that the findings of epigenetics and that the methods of genome editing are misused—this also with respect to eugenics and enhancement; • naturalness—an issue we mention in passing a few times in the following analysis; • a possible connection between the genome/epigenome and the concept of human dignity, and the derived danger of instrumentalization and infringement of autonomy when intervening in the genome or epigenome. Since current discourse about ethical issues associated with genome editing focuses mainly on germline interventions, which are, for instance, interventions into a human embryo’s genome, we mainly focus on germline interventions when comparing the debates on genome editing and on epigenetics in section 3. (shrink)

We welcome Blumenthal-Barby’s et al. (2022) plaidoyer for the integration of philosophy in bioethics because of a perceived mutual benefit. Drawing on experience from a collaborative project, funde...

Children with developmental language disorder (DLD) served as a test case for determining the role of extant vocabulary knowledge, endogenous attention, and phonological working memory abilities in cross-situational word learning. First-graders (Mage = 7 years; 3 months), 44 with typical development (TD) and 28 with DLD, completed a cross-situational word-learning task comprised six cycles, followed by retention tests and independent assessments of attention, memory, and vocabulary. Children with DLD scored lower than those with TD on all measures of learning and (...) retention, a performance gap that emerged in the first cycle of the cross-situational protocol and that we attribute to weaknesses in initial encoding. Over cycles, children with DLD learned words at a similar rate as their TD peers but they were less flexible in their strategy use, demonstrating a propose-but-verify approach but never a statistical aggregation approach. Also, they drew upon different mechanisms to support their learning. Attention played a greater role for the children with DLD, whereas extant vocabulary size played a greater role for the children with TD. Children navigate the problem space of cross-situational learning via varied routes. This conclusion is offered as motivation for theorists to capture all learners, not just the most typical ones. (shrink)

Cognitive Science, Volume 46, Issue 2, February 2022.

Targeted modifications of the human epigenome, epigenome editing (EE), are around the corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE the genetic information is changed by directly modifying DNA, intervening in the epigenome requires modifying the configuration of DNA, for example, how it is folded. This does not come with alterations in the base sequence (‘genetic code’). To date, there is almost no ethical debate about EE, whereas the discussions about GE are voluminous. (...) Our article introduces EE into bioethics by translating knowledge from science to ethics and by comparing the risks of EE with those of GE. We, first (I), make the case that a broader ethical debate on EE is due, provide scientific background on EE, compile potential use-cases and recap previous debates. We then (II) compare EE and GE and suggest that the severity of risks of novel gene technologies depends on three factors: (i) the choice of an ex vivo versus an in vivo editing approach, (ii) the time of intervention and intervention windows and (iii) the targeted diseases. Moreover, we show why germline EE is not effective and reject the position of strong epigenetic determinism. We conclude that EE is not always ethically preferable to GE in terms of risks, and end with suggestions for next steps in the current ethical debate on EE by briefly introducing ethical challenges of new areas of preventive applications of EE (III). (shrink)

Matters of Feminist Practice is a print anthology that brings together scholars, writers, and artists of different age groups, identities, and languages from around the world to expand our imaginations and conversations surrounding feminist theories and practices. In the twenty-five scholarly and creative-critical pieces included in this volume, each contributor brings unique visions, insights, approaches, voices, and forms to our collective subject. They also share suggested texts, inviting in a lineage of thinkers with whom they've been in conversation, expanding this (...) community, and guiding us toward further future explorations. After the inaugural print volume, Matters of Feminist Practice will continue as an online journal at www.mfpjournal.com. (shrink)

This article presents an impact assessment framework that allows for the evaluation of positive and negative local-level impacts that have resulted from "responsible trade" interventions such as fair trade and ethical trade. The framework investigates impact relating to (1) livelihood impacts on primary stakeholders; (2) socio-economic impacts on communities; (3) organizational impacts; (4) environmental impacts; (5) policies and institutional impacts; and (6) future prospects. It identifies relevant local-level stakeholders and facilitates the analysis of conflicting interests. The framework was developed in (...) the context of, and is applied in this article to, the fair trade coffee industry in northern Nicaragua. It was designed, however, so that it can be applied across commodity sectors and responsible trade initiatives. It is able to do this by accommodating for differences in the social, environmental, political and institutional contexts of different areas, and by taking into account the distinct nature of an initiative's overall objectives, different levels of intervention, and the full range of stakeholders involved. (shrink)

Slightly modified excerpt from the section 13.4 Zusammenfassung und Ausblick (translated into englisch): This chapter is based on an analysis of ethical debates on epigenetics and genome editing, debates, in which ethical arguments relating to future generations and justice play a central role. The analysis aims to contextualize new developments in genetic engineering, such as genome and epigenome editing, ethically. At the beginning, the assumptions of "genetic determinism," on which "genetic essentialism" is based, of "epigenetic determinism" as well as "genetic" (...) and "epigenetic exceptionalism" are analyzed and critically discussed. The remarks on the ethical discourse on epigenetics show that the notion of "epigenetic determinism" can sometimes be discerned not only in popular scientific discourse but also in ethical discourse. Ethical debates on epigenetics, however, have distanced themselves from this deterministic understanding. As a result, the focus in the ethical discourse on epigenetics shifts from responsibility for one's own health and that of subsequent generations to justice. What is meant here is justice, for example, in terms of access to healthy environmental conditions, regardless of whether these contribute to health with or without epigenetic agency. An analysis of the discourse on genome editing reveals that it is primarily germline interventions that are being ethically examined, with a concentration on the aspect of inheritance. The question is whether this is accompanied by an implicit "genetic determinism" or even a "genetic essentialism": the determinism could lie in the centrality of the aspect of heritability, since only genetic information is inherited. Does the aspect of heritability and genome modification play a more decisive role in debates on genome editing than the safety issue? Is the problem of embryos and their potential offspring not being able to consent to germline intervention given such a high priority because it is a genetic intervention? Under such a premise of "strong genetic determinism" supplemented by "epigenetic determinism," not only genome editing but also epigenome editing would be ethically relevant precisely because it too would have an influence on the genome. How this influence of genome editing and epigenome editing is ethically evaluated in each case therefore depends initially on whether the assumptions of "genetic" and "epigenetic determinism" are advocated. These assumptions are increasingly viewed critically in ethical discourse because they cannot be confirmed from a scientific perspective. In popular scientific debates in particular, however, they seem to persist, which ultimately also influences the public discussion. Since a broad public discussion is required especially on genome editing, a reflective approach to the various "-isms" analyzed in this chapter is central. DOI: 10.5771/9783748927242. (shrink)

Dupras and Bunnik’s strong statement against the normative approach of genetic exceptionalism, which can no longer be justified in the midst of multi-omic research, is of great importance fo...

Abstract: This working paper focuses on the question whether there is a therapeutic imperative that, in specific situations, would oblige us to perform genome editing at the germline level in the context of assisted reproduction. The answer to this central question is discussed primarily with reference to specific scenarios where preimplantation genetic diagnosis (PGD) does not represent an acceptable alternative to germline genome editing based on either medical, or ethical, or – from the perspective of the potential parents – moral (...) or religious grounds. This article deals with four different types of case constellations that result from these possible reasons against PGD as well as from the necessity or dispensability of a subsequent “control PGD.” These cases are discussed based on hypotheses concerning contextual factors and theoretical assumptions. In conclusion, we point out that if our assumptions are correct, there is probably no therapeutic imperative for genome editing at the germline level. We draw this rationale from the fact that germline interventions are likely not person-affecting. However, we caution the reader that our result is preliminary and needs to be more carefully examined in future work in light of the bioethical debate and potential objections. -/- // Abstract: Im Zentrum dieses Working Papers steht die Frage, ob es einen therapeutischen Imperativ geben kann, der uns, in bestimmten Situationen, verpflichten würde, eine Genomeditierung (genome editing) auf Keimbahnebene im Rahmen der assistierten Befruchtung vorzunehmen. Die Antwort auf diese zentrale Frage wird insbesondere mit Bezug auf Fälle diskutiert, in denen das Verfahren der Präimplantationsdiagnostik (PID) keine aus entweder medizinischen oder ethischen oder – aus Sicht der potentiellen Eltern – moralischen bzw. religiösen Gründen akzeptable Alternative zu einem Keimbahneingriff darstellt. Die möglichen Gründe gegen die PID sowie die Erforderlichkeit oder Verzichtbarkeit einer nachfolgenden «Kontroll-PID» ergeben vier verschiedene Fallkonstellationen, denen sich der Beitrag zuwendet. Auf Grundlage von Hypothesen zu kontextuellen Faktoren und theoretischen Annahmen diskutieren wir diese Fälle. Im Ergebnis verweisen wir darauf, dass es, wenn unsere Annahmen zutreffen, vermutlich keinen therapeutischen Imperativ zum genome editing auf Keimbahnebene gibt. Dies begründet sich daraus, dass der Keimbahneingriff vermutlich nicht als personenbezogen (person-affecting) zu bezeichnen ist. Wir weisen jedoch darauf hin, dass unser Ergebnis vorläufig ist und unter Berücksichtigung der bioethischen Debatte und möglicher Einwände genauer geprüft werden muss. -/- // Résumé: Ce Working Paper se concentre sur la question de l’existence d’un impératif thérapeutique qui, dans des situations spécifiques, nous obligerait à réaliser une édition du génome au niveau de la lignée germinale dans le cadre de la procréation assistée. Afin de répondre à cette question centrale nous développons quatre scénarios spécifiques dans lesquels le diagnostic préimplantatoire (DPI) ne représente pas une alternative acceptable à l’édition du génome germinal pour des raisons médicales, éthiques ou – du point de vue des futurs parents – morales ou religieuses. Cet article traite de quatre constellations différentes de cas résultant des raisons mises en avant pour s'opposer au DPI ainsi que de la nécessité ou de l’inutilité d’un ultérieur « DPI de contrôle » Ces cas sont discutés sur la base d’hypothèses portant sur les facteurs contextuels et sur les présupposés théoriques. En conclusion, nous soulignons que si nos hypothèses sont correctes, il n’y a probablement aucun impératif thérapeutique justifiant l’édition du génome au niveau de la lignée germinale. Nous arrivons à cette conclusion parce qu’une intervention au niveau de la lignée germinale n’est probablement pas susceptible d’affecter la personne. Cependant, nous mettons en garde le lecteur sur le fait que notre conclusion est préliminaire et qu’elle doit être examinée avec soin dans des futurs travaux instruits par le débat bioéthique et par les éventuelles objections. (shrink)

A pesar de que Max Horkheimer en Eclipse de la razón había analizado los límites de la razón subjetiva, atendien- do a las posibilidades de retornar a la razón objetiva y a su función después del eclipse, a Jay le parecían aún insuficientes estas respuestas. Por ello, regresó al estudio de las conceptualizaciones filosóficas de los fundadores de la teoría crítica y de quienes se quedaron a cargo del Instituto de Investigación Social en Frankfurt. En este sentido, este texto podría (...) verse en continuidad y a distancia respecto a su primer li- bro: Dialectical Imagination. A History of the Frankfurt School and the Institute of Social Research, 1923-1950 (1973); producto de su trabajo de doctorado, enfocado en la formación del Instituto de Investigación Social; en sus principales integrantes: Herbert Marcuse, Max Horkheimer, Theodor Adorno, Leo Löwenthal, Walter Benjamin,Franz Neumann, Otto Kirchheimer, Henryk Grossmann, Erich Fromm, Karl August Wittfogel; en la integra- ción del psicoanálisis; en su exilio a América; en los estudios empíricos sobre el autoritarismo, la estética y la industria cultural. (shrink)

En el siguiente trabajo expondré las características principales del materialismo de Alfred Schmidt, el cual, debe ser entendido en su vertiente: no dogmática, crítica y dialéctica. Me refiero a la primera característica, en el sentido de que Schmidt, deja de lado la lectura marxista ortodoxa de la ..

On pp. 47-51, "Fifth Scenario: The Nazi and His Jew", discusses Adorno's theory of mimesis applied to the phenomenon of Nazi antisemitism. Influenced by Freud's theory, Adorno discussed in "Dialektik der Aufklärung" (1947) the Nazi phobic and distorted image of the Jew. In Adorno's interpretation, the imaginary portrait of the Jew created by the Nazis is in fact their self-portrait, expressing their longing for unlimited power and identification with an imaginary aggressor in order to be themselves the real aggressor.

En el presente artículo se pretende dar cuenta de cómo opera el hábito en el cuerpo de las mujeres, particularmente con respecto a la relación amorosa heterosexual-patriarcal. Para ello, se recurrirá a Simone de Beauvoir y a Jean Paul Sartre, desde ahí explicar a qué nos referimos con cuerpo. También se tomará la noción de hábito de Pierre Bourdieu para señalar el orden simbólico patriarcal en las relaciones amorosas sexo-afectivas. En cuanto al abordaje de la idea del amor, se realizará (...) un recorrido histórico a partir del desarrollo de Marcela Lagarde, así como de su concepto de cautiverio, y, finalmente, apuntaremos algunas consideraciones de la ética del placer de Graciela Hierro a modo de conclusión. Palabras clave: hábito, cuerpo, relación amorosa, orden simbólico patriarcal, violencia simbólica. (shrink)

This article names some of the human under standings and ways of being that are fundamental to teaching and learning, which new educational tech nologies, especially the computer, tend to remake, reduce, or replace altogether in K-12 classrooms. The article asks questions and tells stories about students, teachers, and the authors themselves using computers for educational purposes, investigating three particular uses of technology in detail. The authors argue that new educational technologies change the meaning of words common to teachers' vocabularies, (...) especially words such as classroom community, knowing, and coming to know. The authors also argue that human senses used in learning are nullified, if not assaulted, by new educational technologies. (shrink)

Together, their work signals a new direction in the field and offers refreshingly original insights into a broad spectrum of texts.

La ira interior, la tristeza, el disgusto, el nerviosismo, la impotencia, más que conceptos, son en realidad sentimientos que por carne propia podemos experimentar, además de ser constantes dentro de nuestra vida anímica, incluso más que el sentido de gozo y placer, que tanto buscamos dentro de nuestras actividades ordinarias. Sin embargo, al experimentar estas emociones en sí mismas parecen no generar algún problema mayor. El problema mismo viene en la acción para poder colmar estas intensas emociones que muchas veces (...) se presentan dentro de nosotros mismos “como criterio el dolor es inmutable, variable es, en cambio, el modo y manera como el ser humano se enfrenta a él”. (shrink)

Due to COVID-19, university students continued their academic training remotely. To assess the effects of emergency remote teaching, we evaluated the expectations and, subsequently, the experiences of university students about online education. This study employed a simple prospective design as its method. We assessed the expectations of 1,904 students from different discipline areas during the beginning of the first semester, March 2020, and their experiences at the end of the same academic period, September 2020. We used convenience non-probability sampling. Participants (...) responded to the questionnaire on Expectations toward virtual education in higher education for students and the questionnaire on virtual education experiences in higher education. The results showed that students’ responses reflected low expectations regarding peer relationships and comparison with face-to-face education. This perception was maintained during the evaluation of experiences. Students reported positive experiences regarding online teaching and learning, online assessment, and their self-efficacy beliefs at T2. Statistically significant differences between measurements were found, with the expertise presenting higher averages than expectations. Furthermore, differences by gender were identified, reporting a positive change in the scores of women. In addition, results reflected differences according to the disciplinary area, showing Social Sciences and Medical and Health Sciences students a more significant size effect. Findings regarding the empirical evidence and the implications for future teaching scenarios in Higher Education are discussed. (shrink)

This article focuses on emergency medical care in black urban populations, suggesting that the classification of a "community" within clinical trial language is problematic. The article references a cultural history of black Americans with pre-hospital emergency medical treatment as relevant to contemporary emergency medicine paradigms. Part I explores a relationship between "autonomy" and "community." The idea of community emerges as a displacement for the ethical principle of autonomy precisely at the moment that institutionalized medicine focuses on diversity. Part II examines (...) a clinical trial for the blood substitute PolyHeme® (Northfield Laboratories, Inc., Evanston, IL). It illustrates the ways in which bias in research paradigms and Institutional Review Board decisions attach to the notion and utility of the language of "community." The conclusion's contemporary anecdote makes apparent the vitality of the issues of prehospital emergency medical care and the ways in which decisions and practices fall too easily into a narrative of culturally biased treatment. (shrink)

To carry out a bibliographic review of the factors associated with behavioral difficulties in children, but there are global data on these variables. Purpose: The purpose of this study was to review the literature on the factors associated with behavioral difficulties in boys and girls to identify the most influential countries, authors, magazines and institutions, their structures and research directions. Design: This review is based on bibliometric and network analysis of literature published in Scopus and Web of Science. A total (...) of 110 scientifically mapped articles were found in this area. (shrink)

O marketing esportivo, que movimenta bilhões de dólares em todo o mundo, assumiu um novo perfil com a entrada em campo das mídias sociais. A gestão das marcas nestes espaços virtuais exige agilidade, pró-atividade e sobretudo disposição para interagir com os consumidores. Este estudo analisa as estratégias da Nike e da Adidas no Facebook e no Twitter durante a realização da Copa do Mundo de 2014 no Brasil e conclui que, apesar da tradicional agressividade das marcas no mercado, a apropriação (...) deste espaço ainda se faz de modo tímido e nem sempre adequado pela ausência de uma cultura digital de comunicação. (shrink)

Este artigo é uma pesquisa bibliográfica centrada na análise de cinco textos do marxista húngaro György Lukács cujo objetivo era compreender melhor como esse autor caracteriza o complexo da educação em sua teoria. As obras selecionadas para o estudo foram o capítulo A reprodução do livro Para uma ontologia do ser social 2, além de quatro ensaios dispersos em outras obras: O Poema pedagógico de Makarenko, Os anos de aprendizado de Wilhelm Meister, Lenin e os problemas de transição e Gottfried (...) Keller. Expõe-se que Lukács não compreende a educação em sentido estrito como limitada à sociedade capitalista, mas como universal, por se caracterizar como uma práxis intencional que pode ocorrer em diversos âmbitos da sociedade. Tal resultado aponta para uma interpretação da educação em Lukács menos limitada à crítica de função reprodutora e, portanto, abrindo maiores possibilidades de conexão entre a teoria lukacsiana e a luta revolucionária. (shrink)

Discuto, neste artigo, a proposta de uma teleosemântica informacional, tal como concebida por Fred Dretske. Sustento neste texto que, embora a teleosemântica informacional defronte-se com sérias dificuldades relativas à determinação dos conteúdos das crenças, ela oferece bons critérios para distinguir sistemas meramente informacionais de sistemas representacionais.

Peter Wollen _Signs and Meaning in the Cinema_ Expanded and revised edition London: British Film Institute, 1998 ISBN 0-85170-646-0 hbk; 0-85170-647-9 pbk 188 pages.

In this paper I will discuss the intentionalist view of perception, and present some arguments to support the view that, contrary to Michael Martin’s criticism, intentionalists do not need to conceive the content of perception as either singular or general, because this is not the way that it should be thought. The right way to conceive the representational content of perception is by considering it as informational and functional.

El objetivo de este artículo consiste en abordar algunos argumentos de la filosofía de J. Rancière relacionados con la necesidad de repensar el comunismo. La hipótesis de trabajo insiste en señalar que Rancière no defiende ningún proyecto comunista. Esto al menos por tres razones: no hay igualdad de las inteligencias, el comunista funge como profesor explicador en aras de concientizar a los embrutecidos, el comunismo pertenece a una temporalidad histórica teleológica, lo que a su vez supone un aplazamiento de la (...) emancipación. Finalmente, cerramos este diálogo con las posibilidades presentes de esta otra forma de concebir la igualdad y la emancipación. (shrink)

Discuto, neste artigo, duas críticas que Ruth Millikan dirige à teleosemântica informacional proposta por Fred Dretske. A primeira relaciona-se à noção de informação natural e a segunda à impossibilidade de representar indivíduos. As duas críticas têm o mesmo fundamento - o fato de a teleosemântica informacional de Dretske ser independente de contexto. Argumento que Millikan está correta apenas em relação à primeira crítica, mas que ela não está inteiramente correta em relação à segunda crítica. Embora seja independente de contexto, a (...) teleosemântica proposta por Dretske tem papel explanatório em relação a alguns tipos de representações. (shrink)

One of the most difficult problems for those who defend evolutionary ethics is the naturalist fallacy. In this article, we examine the solutions proposed by W. Rottschaefer and R. Richards. We believe that these solutions are not good enough to completely eliminate the problem of the naturalist fallacy without compromising the specificity of morality.

Neste estudo abordaremos algumas etapas da concepção holística que caracteriza as relações entre o homem, o cosmo e a sociedade na época das Antiguidades Arcaica e Clássica; a transformação da visão holística como consequência da alteração da concepção antropológica ao longo da época moderna; para terminar com uma reflexão que destaque a necessidade de voltar à humanização. Na introdução, nossa atenção estará direcionada, especificamente, para a perspectiva holística com a qual a filosofia e a medicina inauguraram o estudo propriamente antropológico. (...) Em seguida, será examinado o momento de passagem da visão holística para uma concepção mecanicista do homem e das práticas sociais que o veem como objeto de estudo e de cuidado. Por fim, gostaríamos de destacar os esforços que estão sendo efetuados para voltar a uma visão global na qual o homem, a sociedade e a natureza fazem parte de um único e mesmo sistema orgânico. (shrink)

Bei der Vita Aesopi handelt es sich um eine Erzählung der Abenteuer Äsops bis zu seinem Tod in Delphi. Das Original, das vermutlich zu Beginn unserer Zeitrechnung ver faßt wurde, ist verloren, wurde aber in mehreren griechischen Fassungen überliefert.