Data are lacking with regard to participants' perspectives on return of genetic research results to relatives, including after the participant's death. This paper reports descriptive results from 3,630 survey respondents: 464 participants in a pancreatic cancer biobank, 1,439 family registry participants, and 1,727 healthy individuals. Our findings indicate that most participants would feel obligated to share their results with blood relatives while alive and would want results to be shared with relatives after their death.

Background: Genomic analysis may reveal both primary and secondary findings with direct relevance to the health of probands’ biological relatives. Researchers question their obligations to return findings not only to participants but also to family members. Given the social value of privacy protection, should researchers offer a proband’s results to family members, including after the proband’s death? Methods: Preferences were elicited using interviews and a survey. Respondents included probands from two pancreatic cancer research resources, plus biological and nonbiological family members. (...) Hypothetical scenarios based on actual research findings from the two cancer research resources were presented; participants were asked return of results preferences and justifications. Interview transcripts were coded and analyzed; survey data were analyzed descriptively. Results: Fifty-one individuals (17 probands, 21 biological relatives, 13 spouses/partners) were interviewed. Subsequently, a mailed survey was returned by 464 probands, 1,040 biological family members, and 399 spouses/partners. This analysis highlights the interviews, augmented by survey findings. Probands and family members attribute great predictive power and lifesaving potential to genomic information. A majority hold that a proband’s genomic results relevant to family members’ health ought to be offered. While informants endorse each individual’s choice whether to learn results, most express a strong moral responsibility to know and to share, particularly with the younger generation. Most have few concerns about sharing genetic information within the family; rather, their concerns focus on the health consequences of not sharing. Conclusions: Although additional studies in diverse populations are needed, policies governing return of genomic results should consider how families understand genomic data, how they value confidentiality within the family, and whether they endorse an ethics of sharing. A focus on respect for individual privacy—without attention to how the broad social and cultural context shapes preferences within families—cannot be the sole foundation of policy. (shrink)

Background: There are few standardized measures available to assess executive function in a naturalistic setting for children. The Children’s Cooking Task is a complex test that has been specifically developed to assess EF in a standardized open-ended environment. The aim of the present study was to evaluate the internal consistency, inter-rater reliability, sensitivity and specificity, and also convergent and divergent validity of the Norwegian version of CCT among children with pediatric Acquired Brain Injury and healthy controls.Methods: The present study has (...) a cross-sectional design, based on baseline data derived from a multicenter RCT. Seventy-five children with pABI from two university hospitals with parent-reported executive dysfunction and minimum of 12 months since injury/completed cancer therapy, as well as 59 HCs aged 10–17 years, were assessed with CCT using total errors as the main outcome measure. The pABI group completed tests assessing EF on the impairment level within the ICF framework, and on the participation level. In addition, they completed tests of intellectual ability, processing speed, attention, learning, and memory. Finally, overall functional outcome was evaluated for the children with pABI.Results: Acceptable internal consistency and good inter-rater reliability were found for the CCT. Children with pABI performed significantly worse on the CCT than the HCs. The CCT identified group membership, but the sensitivity and specificity were overall classified as poor. Convergent validity was demonstrated by associations between the CCT and performance-based tests assessing inhibition, cognitive flexibility, and working memory, as well as teacher-reported executive dysfunction. Divergent validity was supported by the lack of association with performance-based measures of learning and memory, attention, and verbal intellectual ability. However, there was a moderate association between the CCT and performance-based tests of processing speed. Lastly, better performance on the CCT was associated with a better functional outcome.Conclusion: Our study with a relatively large sample of children with pABI and HC’s demonstrated good psychometric properties of the CCT. CCT performance was associated with the overall level of disability and function, suggesting that CCT is related to the level of activity in everyday life and participation in society. Hence, our study suggests that the CCT has the potential to advance the assessment of EF by providing a valid analysis of real-world performance. Nevertheless, further research is needed on larger samples, focusing on predictors of task performance, and evaluating the ability of CCT to detect improvement in EF over time. The patterns of error and problem-solving strategies evaluated by the CCT could be used to inform neuropsychological rehabilitation treatmentand represent a more valid outcome measure of rehabilitation interventions. (shrink)

State Medical Boards (SMBs) can take severe disciplinary actions (e.g., license revocation or suspension) against physicians who commit egregious wrongdoing in order to protect the public. However, there is noteworthy variability in the extent to which SMBs impose severe disciplinary action. In this manuscript, we present and synthesize a subset of 11 recommendations based on findings from our team’s larger consensus-building project that identified a list of 56 policies and legal provisions SMBs can use to better protect patients from egregious (...) wrongdoing by physicians. (shrink)

"In this concluding volume of his impressive study of the history of Western thought about the nature of love, Irving Singer reviews the principal efforts that have been made by 20th-Century thinkers to analyze the phenomenon of love.... [T]he bulk of the book is taken up with critical accounts of the modern thinkers who have systematically called into question the possibility itself of love as a union of distinct human selves. For the most part, these critiques are effectively executed, and (...) they bring a high level of critical acumen to bear on skeptical theses about love that are now too often accepted as truisms."—Frederick A. Olafson, _Los Angeles Times Book Review_ "Irving Singer... has developed a method of historical analysis flexible enough to deal with all kinds of love, from Greek homosexual love in Plato, to the _philia_ and _agape_ of the New Testament, to the courtly love of medieval romance, to the Romantics, for whom love was magic.... [This] final volume brings us to the present. In 'The Modern World,' Singer offers readings of Freud, Proust, and Sartre, among others. He shows how their work was formed in reaction to the 19th-century ideal of 'merging' of the identities of lover and beloved. More often than not, the great modern writers portray love as impossible, as a field of failure and regret.... This masterpiece of critical thinking is a timely, eloquent, and scrupulous account of what, after all, still makes the world go round."—Thomas D'Evelyn, _Christian Science Monitor_ "This is the third of a three-volume history of the philosophy of love. It begins with Kierkegaard, Tolstoy, and Nietzsche in the nineteenth century and treats Freud, Proust, Bergson, D. H. Lawrence, G. B. Shaw, Santayana, Sartre, and others in the twentieth. Although the author's approach is primarily historical, he intersperses critical remarks throughout. Most of the major themes which are discussed by philosophers of love make their way into this history, including friendship, sexual love, and the distinction between love that is based on the value of the beloved and love that bestows value on the beloved. Singer devotes a number of pages to his own views on falling in love, being in love, and staying in love.... Singer's exposition is lucid and organized; his criticisms are insightful."—_Ethics_ "In this third volume of historical overview of the development of the Western conception of love, Singer uses writers, philosophers, and psychologists to provide the reader with an overview of love in the late 19th and 20th century.... Analyzing authors such as Tolstoy, Proust, D. H. Lawrence, and Shaw and philosophers such as Nietzsche, Kierkegaard, Sartre, and Santayana, as well as Freud, Singer... links each contributor's thoughts to the influence of previous writers and also provides some psycho-historical insight into their personal lives that might have been either a source or direct result of their views. In this final volume, Singer proceeds to look at not just the 'great men' influence but also provides a chapter overviewing scientific contributions to our understanding of love.... Singer's work is a significant contribution to understanding the social construction of important, abstract social and personal values. By tracing love through different historical periods through a variety of voices, Singer has created a rich history of the struggle between the ideal and the real, between the dreams of what love should provide and the reality of what relationships have been in each historical period. By personalizing the voice through psychohistorical analysis, Singer also provides insight into the shaping of ideas through the intimate struggles of the shapers."—Mark V. Chaffee, _Contemporary Psychology_. (shrink)

Global properties of canonical derivability predicates in Peano Arithmetic) are studied here by means of a suitable propositional modal logic GL. A whole book [1] has appeared on GL and we refer to it for more information and a bibliography on GL. Here we propose a sequent calculus for GL and, by exhibiting a good proof procedure, prove that such calculus admits the elimination of cuts. Most of standard results on GL are then easy consequences: completeness, decidability, finite model property, (...) interpolation and the fixed point theorem. (shrink)

This essay explores a major ethical variable in personal sales: trust. By analyzing data drawn from life insurance sales, the essay supports the thesis that the role of the agent and the exigencies of personal sales create certain antinomies of trust that compromise the sales process. As a result, trust occupies a problematic and apparently paradoxical position in the sales process. On the one hand, success in personal sales is held to depend upon trust. On the other hand, because the (...) techniques required to form trust in personal sales nullify the conditions under which trust is possible, these instruments of trust formation are self-defeating. (shrink)

Julkaisematta jääneessä muistiossaan Mietteitä oikeuden yleiskäsitteestä (1702-1703?) G. W. Leibniz muotoilee uudelleen Platonin Euthyfron-dialogissa esitetyn kuuluisan kysymyksen. Hän kirjoittaa: ”Myönnetään, että kaikki mitä Jumala tahtoo, on hyvää ja oikein. Sen sijaan kysytään, onko se hyvää ja oikein siksi että Jumala niin tahtoo, vai tahtooko Jumala sitä koska se on hyvää ja oikein. Eli kysytään, onko hyvyys tai oikeus jotakin mielivaltaista, vai koostuvatko ne asioiden luonnetta koskevista välttämättömistä ja ikuisista totuuksista, kuten luvut ja suhteet.” Universaaleja, ikuisia totuuksia puolustava filosofi ei voi (...) hyväksyä ensin mainittua vaihtoehtoa. Hänen mukaansa ”Se toden totta tuhoaisi Jumalan oikeudenmukaisuuden. Sillä miksi ylistäisimme häntä oikeudenmukaisista teoista, jos oikeudenmukaisuuden käsite ei hänen tapauksessaan lisää mitään teon käsitteeseen? Ja sanonta stat pro ratione voluntas, minun tahtoni käyköön perusteesta, on todella tyrannin motto.” Leibnizin kritiikki on suunnattu erityisesti hänen aikalaisiaan René Descartesia, Thomas Hobbesia ja Samuel Pufendorfia vastaan. Hän ei voi hyväksyä näkemystä, jonka mukaan oikeudenmukaisuuden mitta on vain Jumalan tahto. Perustan on löydyttävä ikuisista totuuksista, jotka ovat myös Jumalan oikeudenmukaisuuden standardi. Erityisen kuuluisaksi tuli Leibnizin kritiikki Pufendorfin näkemyksiä kohtaan, sillä Pufendorfin laajalle levinneen teoksen De officio hominis et civis ranskalaisen laitoksen neljännen painoksen toimittaja Barbeyrac liitti siihen Leibnizin kiistakirjoituksen, joka tunnetaan lyhyellä nimellä Monita (Epistola viri excellentissimi ad amicum qua monita quaedam ad principia Pufendorfiani operis de officio hominis et civis continentur, 1706) ja puolusti Pufendorfia Leibnizia vastaan. Leibnizin onnistui kuitenkin ilmeisesti osoittaa eräs heikkous Pufendorfin näkemyksissä, jota Barbeyrac ei pystynyt sivuuttamaan: tämän mukaan Jumala on saman aikaan sekä ylin tuomari että lakien laatija. Siten Leibnizin näkökulmasta Jumala on tyranni – hänen tahtonsa on oikeuden ja etiikan mitta ja koska hän on kaikkivaltias, hän voi pakottaa ihmiset noudattamaan sellaista oikeudenmukaisuutta, joka on hänen mieleistään. Koska Jumalan yläpuolella ei ole Pufendorfin mukaan mitään, hän voi toimia aivan mielivaltaisesti. Leibnizin kritiikki kiteytyy Pufendorfin epäselvään erotteluun ulkoisen ja sisäisen velvollisuuden välillä, joka jättää hänen näkemyksensä arvoitukselliseksi. Tutkiskelen tässä esitelmässä oliko Leibnzin kritiikki johdonmukainen ja oikeutettu. Onko Pufendorfin näkemyksissä heikkous, jota hän ei itse huomannut? Vertailen myös asiaa koskevia eri kommentaareja (mm. Kari Saastamoinen, Petter Korkman, Fiametta Palladini) ja arvioin Leibnizin kritiikin reseptiota Pufendorf-tutkimuksessa. (shrink)

ABSTRACT Fine examination of our accumulated cultural knowledge is especially helpful in studying the emotions, which are only tangentially accessible to experimental manipulation. Here I use the six properties of emotions that Elster has summarized to suggest how they show a need for changes in the science of motivation. The apparent adaptive purpose of emotions lies in their action tendencies – what they add to the cold calculation of advantage. Subjectively they stand out by their intrusiveness, the duration of which (...) often has a half-life. Emotions each have a valence, which suggests that they are not only motivating but also motivated, an implication that requires re-examination of how negativity works. Emotions are also experienced as ‘triggered’, but are so malleable that triggering cannot mean a simple conditioned reflexiveness. Emotions are not only triggered – or motivated – by beliefs, but motivate beliefs in turn, and can be fed back on themselves in a ‘wildfire’ phenomenon. These feedback effects are further evidence against emotions being reflexive. With regard to the three great revolutions, I argue that enthusiasm differs from romantic love only in its object, and urgency comes from the dysphoria of using response suppression for self-control. I can add nothing further to Elster’s masterful history. (shrink)

Socrates (in the Meno) denied that virtues like courage could be taught, whereas Protagoras defended this claim. Compassion is discussed below in this context; it is distinguished from related, but different, moral qualities, and the role of imagination is emphasised. 'Sympathy's and role-modelling views of compassion's acquisition are criticised. Compassion can indeed be taught, but neither by the example of a few, isolated physicians nor by creation of Departments of Compassion. In replying to one standard objection to teaching compassion, it (...) is emphasised that scientific competence and compassion aren't mutually exclusive. (shrink)

G. E. M. Anscombe; IX—Parmenides, Mystery and Contradiction, Proceedings of the Aristotelian Society, Volume 69, Issue 1, 1 June 1969, Pages 125–132, https://do.

We review the notion of complementarity of observables in quantum mechanics, as formulated and studied by Paul Busch and his colleagues over the years. In addition, we provide further clarification on the operational meaning of the concept, and present several characterisations of complementarity—some of which new—in a unified manner, as a consequence of a basic factorisation lemma for quantum effects. We work out several applications, including the canonical cases of position–momentum, position–energy, number–phase, as well as periodic observables relevant to spatial (...) interferometry. We close the paper with some considerations of complementarity in a noisy setting, focusing especially on the case of convolutions of position and momentum, which was a recurring topic in Paul’s work on operational formulation of quantum measurements and central to his philosophy of unsharp reality. (shrink)

Before talking about national science as a specific phenomenon we find out the essence of science as a phenomenon in general. We note that science is one of the most complex phenomena of social life. Complex understanding of it complicates the fact that science is structurally extremely complex, polyfunctional, historically variable, with many of its faces included in this or that sphere of social life. It therefore appears as an extremely diverse social phenomenon. This raises some difficulties in developing a (...) general definition of it. As G. Volkov correctly pointed out, "there is nothing simpler than giving a definition to any phenomenon, when the whole thing is only in the formulation, and there is nothing more complicated than when it comes to the concentration in the concentrated form of the very essence of the object under study". (shrink)

The early coronavirus disease 2019 (COVID‐19) outbreak inflicted vulnerability on individuals and societies on a completely different scale than we have seen previously. The pandemic developed rapidly from 1 day to the next, and both society and individuals were put to the test. Older people's experiences of the early outbreak were no exception. Using an abductive analytical approach, the study explores the individual experiences of vulnerability as described by older people hospitalised with COVID–19 in the early outbreak. In these older (...) people, we found that the societal context and the individual experiences of vulnerability were inextricable linked. The study demonstrates that despite significant individual stress, informants displayed an interesting ability to also view their situation to reorient their perspective. The experience of vulnerability is both conditional and individual, which imposes a degree of unpredictability that neither they nor others were able to negotiate. The article discusses the phenomenon of unpredictability in light of a modern society with regard to how individuals and society may encounter unexpected events in the future where the potential to reorient will be vital. (shrink)

We give an alternative proof of the stability of separably closed fields of fixed Éršov invariant to the one given in [W]. We show that in case the Éršov invariant is finite, the theory is in fact equational. We also characterize the independence relation in those theories.

I found Shpet's article "A Work on Philosophy" [Rabota po filosofii], which we present to the reader's attention, in the Shpet archives stored in the Lenin State Library and passed it on to the editorial board of the journal Logos, where it was published by I. Chubarov. The small circulation of that journal makes it appropriate to republish this text, which is of major importance for an understanding of Shpet's philosophical position and provides a good clarification of the subsequent logic (...) of development of his conception. Although the article is unfinished, there is no reason to lament this fact, since all of its basic ideas and their logical development were realized by Shpet in subsequent publications. A whole series of his works is devoted to grounding and affirming so-called positive philosophy, the basic features of which I would like to clarify. (shrink)

To what extent is the neural organization of language dependent on factors specific to the modalities in which language is perceived and through which it is produced? That is, is the left-hemisphere dominance for language a function of a linguistic specialization or a function of some domain-general specialization, such as temporal processing or motor planning? Investigations of the neurobiology of signed language can help answer these questions. As with spoken languages, signed languages of the deaf display complex grammatical structure but (...) are perceived and produced via radically different modalities. Thus, by mapping out the neurological similarities and differences between signed and spoken language, it is possible to identify modality-specific contributions to brain organization for language. Research to date has shown a significant degree of similarity in the neurobiology of signed and spoken languages, suggesting that the neural organization of language is largely modality-independent. (shrink)

I have not seen the papyrus, but if β and μ are correctly reported, and if the space between would admit three letters, I tentatively suggest . sed haec quidem uituperatio.

In the first part of this paper a logic is defined for propositions whose probability of being true may not be known. A speaker's beliefs about which propositions are true are still interesting in this case. The meaning of propositions is determined by the consequences of asserting them: in this logic there are debates which incur certain costs for the protagonists.The second part of the paper describes the mathematics of the resulting logic which displays several novel features.