23 found
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  1.  12
    Public Deliberation about Gene Editing in the Wild.Michael K. Gusmano, Gregory E. Kaebnick, Karen J. Maschke, Carolyn P. Neuhaus & Ben Curran Wills - 2021 - Hastings Center Report 51 (S2):2-10.
    The release of genetically engineered organisms into the shared environment raises scientific, ethical, and societal issues. Using some form of democratic deliberation to provide the public with a voice on the policies that govern these technologies is important, but there has not been enough attention to how we should connect public deliberation to the existing regulatory process. Drawing on lessons from previous public deliberative efforts by U.S. federal agencies, we identify several practical issues that will need to be addressed if (...)
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  2.  36
    IRB practices and policies regarding the secondary research use of biospecimens.Aaron J. Goldenberg, Karen J. Maschke, Steven Joffe, Jeffrey R. Botkin, Erin Rothwell, Thomas H. Murray, Rebecca Anderson, Nicole Deming, Beth F. Rosenthal & Suzanne M. Rivera - 2015 - BMC Medical Ethics 16 (1):32.
    As sharing and secondary research use of biospecimens increases, IRBs and researchers face the challenge of protecting and respecting donors without comprehensive regulations addressing the human subject protection issues posed by biobanking. Variation in IRB biobanking policies about these issues has not been well documented.
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  3.  15
    Clarifying the Ethics and Oversight of Chimeric Research.Josephine Johnston, Insoo Hyun, Carolyn P. Neuhaus, Karen J. Maschke, Patricia Marshall, Kaitlynn P. Craig, Margaret M. Matthews, Kara Drolet, Henry T. Greely, Lori R. Hill, Amy Hinterberger, Elisa A. Hurley, Robert Kesterson, Jonathan Kimmelman, Nancy M. P. King, Melissa J. Lopes, P. Pearl O'Rourke, Brendan Parent, Steven Peckman, Monika Piotrowska, May Schwarz, Jeff Sebo, Chris Stodgell, Robert Streiffer & Amy Wilkerson - 2022 - Hastings Center Report 52 (S2):2-23.
    This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human‐nonhuman chimeric research. Led by bioethics researchers working closely with an (...)
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  4.  15
    Human research protections:.Karen J. Maschke - 2008 - Hastings Center Report 38 (2):19-22.
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  5.  17
    Wanted: Human Biospecimens.Karen J. Maschke - 2010 - Hastings Center Report 40 (5):21-23.
    Collecting and using tissue, blood, urine, and other human biospecimens for various types of research is not new. But for personalized medicine to realize its potential, researchers will need thousands more of these samples for genetic studies. And the particular nature of genetic research—the sensitivity of the information it reveals—has raised a host of ethical questions, some which are new to human subjects research. What counts as informed consent when a biospecimen may be stored for years and used for unforeseen (...)
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  6.  54
    Ethical issues in tissue banking for research: The prospects and pitfalls of setting international standards.Karen J. Maschke & Thomas H. Murray - 2004 - Theoretical Medicine and Bioethics 25 (2):143-155.
    Bauer, Taub, and Parsi's review of an international sample of standards on informed consent, confidentiality, commercialization, and quality of research in tissue banking reveals that no clear national or international consensus exists for these issues. The authors' response to the lack of uniformity in the meaning, scope, and ethical significance of the policies they examined is to call for the creation of uniform ethical guidelines. This raises questions about whether harmonization should consist of voluntary international standards or international regulations that (...)
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  7.  9
    Facial transplantation research: A need for additional deliberation.Karen J. Maschke & Eric Trump - 2004 - American Journal of Bioethics 4 (3):33 – 35.
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  8.  32
    How to Think about Stemming an Insurgency.Gregory E. Kaebnick, Eric F. Trump, Nora Porter, Joyce Griffin, Bruce Jennings, Karen J. Maschke, Thomas H. Murray & Erik Parens - forthcoming - Hastings Center Report.
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  9.  9
    Animals with Human Cells in Their Brains: Implications for Research.Karen J. Maschke - 2019 - Hastings Center Report 49 (5):36-37.
    In “Human‐Animal Chimeras: The Moral Insignificance of Uniquely Human Capacities,” Julian Koplin argues against the views that all uniquely human traits have moral significance or that all the traits humans have in common with other animals “are morally insignificant.” He recommends instead the adoption of “a better framework for thinking about the moral status of part‐human beings,” one that emphasizes the “phenomenal value (or disvalue)” chimeric animals are likely “to enjoy (or suffer).” If the moral status of these chimeric animals (...)
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  10.  7
    Don't Say Goodbye.Karen J. Maschke & Jonathan D. Moreno - 2002 - Hastings Center Report 32 (2):5.
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  11.  19
    Field notes.Karen J. Maschke - 2005 - Hastings Center Report 35 (4):c1-c1.
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  12.  14
    Field notes.Karen J. Maschke - 2007 - Hastings Center Report 37 (3):c1-c1.
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  13.  4
    Field Notes.Karen J. Maschke - 2007 - Hastings Center Report 37 (3):2-2.
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  14.  5
    Field Notes.Karen J. Maschke - 2009 - Hastings Center Report 39 (5):2-2.
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  15.  16
    Innovation Promises and Evidence Realities.Karen J. Maschke - 2016 - Hastings Center Report 46 (5):inside front cover-inside front.
    Over the past year media outlets and scientific and bioethics journals have reported about several medical and scientific innovations touted as having the potential to fundamentally change not only how diseases and disorders are diagnosed and treated but even how to alter the genomes of future generations. The purported “miracle” blood-testing technology of Theranos and the potential use of the genome editing technology CRISPR-Cas9 to modify human and nonhuman organisms reflect dramatic advances in scientific understanding about the biological mechanisms of (...)
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  16.  2
    Making Voices Matter.Karen J. Maschke - 2018 - IRB: Ethics & Human Research 40 (2):1-2.
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  17.  39
    Reconciling protection with scientific progress.Karen J. Maschke - 2005 - Hastings Center Report 35 (5):3-3.
  18.  19
    The federalist turn in bioethics?Karen J. Maschke - 2007 - Hastings Center Report 37 (6):3-3.
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  19.  10
    What's the Professor Got to Do with It?Karen J. Maschke - 2002 - American Journal of Bioethics 2 (4):63-64.
  20.  2
    Best‐Laid Editorial Plans.Erik Parens, Thomas H. Murray, Karen J. Maschke, Josephine Johnston, Nora Porter, Susan Gilbert, Joyce A. Griffin & Gregory E. Kaebnick - 2012 - Hastings Center Report 38 (6):2-2.
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  21. How Drugs Get to the Market.Eric F. Trump, Nora Porter, Jaime Bishop, Bruce Jennings, Karen J. Maschke, Thomas H. Murray & Erik Parens - forthcoming - Hastings Center Report.
     
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  22. The Cases Philosophers Have Dreamt Of.Eric F. Trump, Nora Porter, Jaime Bishop, Bruce Jennings, Karen J. Maschke, Thomas H. Murray & Erik Parens - forthcoming - Hastings Center Report.
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  23. The State of Play on Living Wills.Eric F. Trump, Nora Porter, Jaime Bishop, Bruce Jennings, Karen J. Maschke, Thomas H. Murray & Erik Parens - forthcoming - Hastings Center Report.
     
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